KR100755414B1 - 체내기생충 구제제 - Google Patents
체내기생충 구제제 Download PDFInfo
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- KR100755414B1 KR100755414B1 KR1020027010032A KR20027010032A KR100755414B1 KR 100755414 B1 KR100755414 B1 KR 100755414B1 KR 1020027010032 A KR1020027010032 A KR 1020027010032A KR 20027010032 A KR20027010032 A KR 20027010032A KR 100755414 B1 KR100755414 B1 KR 100755414B1
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- South Korea
- Prior art keywords
- spp
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- vivo
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- 241000238631 Hexapoda Species 0.000 title description 4
- 238000000338 in vitro Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 claims abstract description 42
- 108010002156 Depsipeptides Proteins 0.000 claims abstract description 19
- 238000001727 in vivo Methods 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims abstract description 6
- -1 N-morpholinyl Chemical group 0.000 claims description 105
- 150000001875 compounds Chemical class 0.000 claims description 32
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 30
- 241001465754 Metazoa Species 0.000 claims description 20
- 235000019445 benzyl alcohol Nutrition 0.000 claims description 10
- 244000045947 parasite Species 0.000 claims description 9
- 239000002904 solvent Substances 0.000 claims description 8
- UYAAVKFHBMJOJZ-UHFFFAOYSA-N diimidazo[1,3-b:1',3'-e]pyrazine-5,10-dione Chemical compound O=C1C2=CN=CN2C(=O)C2=CN=CN12 UYAAVKFHBMJOJZ-UHFFFAOYSA-N 0.000 claims description 7
- 229940116423 propylene glycol diacetate Drugs 0.000 claims description 7
- RNVYQYLELCKWAN-UHFFFAOYSA-N solketal Chemical compound CC1(C)OCC(CO)O1 RNVYQYLELCKWAN-UHFFFAOYSA-N 0.000 claims description 7
- 230000003071 parasitic effect Effects 0.000 claims description 4
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- FSVJFNAIGNNGKK-UHFFFAOYSA-N 2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one Chemical compound C1C(C2=CC=CC=C2CC2)N2C(=O)CN1C(=O)C1CCCCC1 FSVJFNAIGNNGKK-UHFFFAOYSA-N 0.000 claims description 2
- AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 claims description 2
- SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 claims description 2
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 2
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- 125000003229 2-methylhexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 6
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 description 6
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- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 6
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 6
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- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 6
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 6
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- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 4
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Classifications
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10008128.2 | 2000-02-22 | ||
| DE10008128A DE10008128A1 (de) | 2000-02-22 | 2000-02-22 | Endoparasitizide Mittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20020072577A KR20020072577A (ko) | 2002-09-16 |
| KR100755414B1 true KR100755414B1 (ko) | 2007-09-04 |
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| Application Number | Title | Priority Date | Filing Date |
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| KR1020027010032A Expired - Lifetime KR100755414B1 (ko) | 2000-02-22 | 2001-02-09 | 체내기생충 구제제 |
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|---|---|
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| EP (1) | EP1259250B1 (enExample) |
| JP (2) | JP5596249B2 (enExample) |
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| CN (1) | CN1309415C (enExample) |
| AR (2) | AR028218A1 (enExample) |
| AT (1) | ATE343394T1 (enExample) |
| AU (2) | AU4060501A (enExample) |
| BR (1) | BR0108562B1 (enExample) |
| CA (1) | CA2400610C (enExample) |
| CZ (1) | CZ300242B6 (enExample) |
| DE (2) | DE10008128A1 (enExample) |
| DK (1) | DK1259250T3 (enExample) |
| ES (1) | ES2274871T3 (enExample) |
| HK (1) | HK1054326B (enExample) |
| HU (1) | HUP0204554A3 (enExample) |
| IL (2) | IL150988A0 (enExample) |
| MX (1) | MXPA02008210A (enExample) |
| NO (1) | NO328949B1 (enExample) |
| NZ (1) | NZ520856A (enExample) |
| PL (1) | PL203999B1 (enExample) |
| PT (1) | PT1259250E (enExample) |
| RU (1) | RU2292905C2 (enExample) |
| WO (1) | WO2001062268A1 (enExample) |
| ZA (1) | ZA200205982B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10104362A1 (de) * | 2001-02-01 | 2002-08-08 | Bayer Ag | Kristallmodifikation eines cyclischen Depsipeptids mit besserer Wirksamkeit |
| EP1561820B1 (en) * | 2002-11-12 | 2008-12-31 | The Kitasato Institute | Anthelmintic substance fki-1033 and process for producing the same |
| DE10358525A1 (de) | 2003-12-13 | 2005-07-07 | Bayer Healthcare Ag | Endoparasitizide Mittel zur topischen Applikation |
| DE102005011779A1 (de) * | 2005-03-11 | 2006-09-14 | Bayer Healthcare Ag | Endoparasitizide Mittel |
| MX2011002166A (es) | 2008-08-28 | 2011-04-07 | Pfizer | Derivados de dioxa-biciclo[3.2.1]octano-2,3,1-triol. |
| DE102009012423A1 (de) | 2009-03-10 | 2010-09-16 | Bayer Animal Health Gmbh | Zubereitung auf Ölbasis |
| HRP20211041T1 (hr) | 2015-05-20 | 2021-10-01 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintski depsipeptidni spojevi |
| RU2715556C2 (ru) | 2015-12-28 | 2020-03-02 | Мериал, Инк. | Противогельминтные депсипептидные соединения |
| JP2020504710A (ja) | 2016-11-16 | 2020-02-13 | ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド | 駆虫性デプシペプチド化合物 |
| EP4013388A1 (en) | 2019-08-14 | 2022-06-22 | Vetoquinol SA | Compositions comprising tigolaner for controlling parasites |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4317458A1 (de) * | 1992-06-11 | 1993-12-16 | Bayer Ag | Verwendung von cyclischen Depsipeptiden mit 18 Ringatomen zur Bekämpfung von Endoparasiten, neue cyclische Depsipeptide mit 18 Ringatomen und Verfahren zu ihrer Herstellung |
| DE4317432A1 (de) * | 1993-05-26 | 1994-12-01 | Bayer Ag | Octacyclodepsipeptide mit endoparasitizider Wirkung |
| EP0662326A2 (de) * | 1994-01-11 | 1995-07-12 | Bayer Ag | Endoparasitizide Mittel die Praziquantel und Epsiprantel enthalten |
| DE19520275A1 (de) * | 1995-06-02 | 1996-12-05 | Bayer Ag | Endoparasitizide Mittel |
| WO2000069425A2 (de) * | 1999-05-12 | 2000-11-23 | Bayer Aktiengesellschaft | Endoparasitizide synergistische kombination enthaltend cyclischen depsipeptiden und piperazinen |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3531545A1 (de) * | 1985-09-04 | 1987-03-05 | Goedecke Ag | Arzneimittel mit einem gehalt an calcium-antagonisten und deren verwendung |
| DE3705227A1 (de) * | 1987-02-19 | 1988-09-01 | Bayer Ag | Anthelminthische wirkstoffkombinationen |
| DE69331414T2 (de) * | 1992-03-17 | 2002-08-08 | Fujisawa Pharmaceutical Co., Ltd. | Depsipeptide, herstellung und anwendung |
| DE4309830C1 (de) * | 1993-03-26 | 1994-05-05 | Lohmann Therapie Syst Lts | Wirkstoffpflaster für die Abgabe von Estradiol an die Haut |
| DE4317457A1 (de) * | 1993-05-26 | 1994-12-01 | Bayer Ag | Octacyclodepsipeptide mit endoparasitizider Wirkung |
| WO1995021624A1 (en) * | 1994-02-08 | 1995-08-17 | Nippon Kayaku Kabushiki Kaisha | High-concentration aureobasidin preparation in solution form |
| DE4417742A1 (de) * | 1994-05-20 | 1995-11-23 | Bayer Ag | Nicht-systemische Bekämpfung von Parasiten |
| DE19545044A1 (de) * | 1995-12-02 | 1997-06-05 | Bayer Ag | Endoparasitizide Mittel |
| GB9803448D0 (en) * | 1998-02-18 | 1998-04-15 | Pharma Mar Sa | Pharmaceutical formulation |
| JP4098474B2 (ja) * | 1998-03-19 | 2008-06-11 | メルク エンド カムパニー インコーポレーテッド | 外部寄生虫侵入防除用硫黄ペンタフルオロフェニルピラゾール |
| FR2776191B1 (fr) * | 1998-03-23 | 2002-05-31 | Theramex | Composition hormonale topique a effet systemique |
-
2000
- 2000-02-22 DE DE10008128A patent/DE10008128A1/de not_active Withdrawn
-
2001
- 2001-02-09 HK HK03106540.9A patent/HK1054326B/zh unknown
- 2001-02-09 DE DE50111315T patent/DE50111315D1/de not_active Expired - Lifetime
- 2001-02-09 ES ES01911623T patent/ES2274871T3/es not_active Expired - Lifetime
- 2001-02-09 RU RU2002125493/15A patent/RU2292905C2/ru not_active IP Right Cessation
- 2001-02-09 PL PL357551A patent/PL203999B1/pl unknown
- 2001-02-09 CN CNB018054005A patent/CN1309415C/zh not_active Expired - Lifetime
- 2001-02-09 AU AU4060501A patent/AU4060501A/xx active Pending
- 2001-02-09 EP EP01911623A patent/EP1259250B1/de not_active Expired - Lifetime
- 2001-02-09 IL IL15098801A patent/IL150988A0/xx unknown
- 2001-02-09 NZ NZ520856A patent/NZ520856A/en not_active IP Right Cessation
- 2001-02-09 AT AT01911623T patent/ATE343394T1/de active
- 2001-02-09 KR KR1020027010032A patent/KR100755414B1/ko not_active Expired - Lifetime
- 2001-02-09 MX MXPA02008210A patent/MXPA02008210A/es active IP Right Grant
- 2001-02-09 HU HU0204554A patent/HUP0204554A3/hu unknown
- 2001-02-09 WO PCT/EP2001/001392 patent/WO2001062268A1/de not_active Ceased
- 2001-02-09 JP JP2001561333A patent/JP5596249B2/ja not_active Expired - Lifetime
- 2001-02-09 DK DK01911623T patent/DK1259250T3/da active
- 2001-02-09 PT PT01911623T patent/PT1259250E/pt unknown
- 2001-02-09 AU AU2001240605A patent/AU2001240605B2/en not_active Expired
- 2001-02-09 BR BRPI0108562-0A patent/BR0108562B1/pt not_active IP Right Cessation
- 2001-02-09 CZ CZ20022867A patent/CZ300242B6/cs not_active IP Right Cessation
- 2001-02-09 US US10/204,880 patent/US20030125244A1/en not_active Abandoned
- 2001-02-09 CA CA2400610A patent/CA2400610C/en not_active Expired - Lifetime
- 2001-02-20 AR ARP010100751A patent/AR028218A1/es active IP Right Grant
-
2002
- 2002-07-26 ZA ZA200205982A patent/ZA200205982B/xx unknown
- 2002-07-30 IL IL150988A patent/IL150988A/en active IP Right Grant
- 2002-08-21 NO NO20023976A patent/NO328949B1/no not_active IP Right Cessation
-
2012
- 2012-01-16 JP JP2012006256A patent/JP2012107024A/ja active Pending
- 2012-04-11 AR ARP120101244A patent/AR085989A2/es unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| DE4317458A1 (de) * | 1992-06-11 | 1993-12-16 | Bayer Ag | Verwendung von cyclischen Depsipeptiden mit 18 Ringatomen zur Bekämpfung von Endoparasiten, neue cyclische Depsipeptide mit 18 Ringatomen und Verfahren zu ihrer Herstellung |
| DE4317432A1 (de) * | 1993-05-26 | 1994-12-01 | Bayer Ag | Octacyclodepsipeptide mit endoparasitizider Wirkung |
| EP0662326A2 (de) * | 1994-01-11 | 1995-07-12 | Bayer Ag | Endoparasitizide Mittel die Praziquantel und Epsiprantel enthalten |
| DE19520275A1 (de) * | 1995-06-02 | 1996-12-05 | Bayer Ag | Endoparasitizide Mittel |
| WO2000069425A2 (de) * | 1999-05-12 | 2000-11-23 | Bayer Aktiengesellschaft | Endoparasitizide synergistische kombination enthaltend cyclischen depsipeptiden und piperazinen |
Also Published As
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| NO342645B1 (no) | Sammensetninger, fremgangsmåte for fremstilling derav, og anvendelse derav for å kontrollere endoparasitter | |
| KR100755414B1 (ko) | 체내기생충 구제제 | |
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Legal Events
| Date | Code | Title | Description |
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| PA0105 | International application |
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