KR100725298B1 - 이미다조퀴놀린 유도체 - Google Patents
이미다조퀴놀린 유도체 Download PDFInfo
- Publication number
- KR100725298B1 KR100725298B1 KR1020047009788A KR20047009788A KR100725298B1 KR 100725298 B1 KR100725298 B1 KR 100725298B1 KR 1020047009788 A KR1020047009788 A KR 1020047009788A KR 20047009788 A KR20047009788 A KR 20047009788A KR 100725298 B1 KR100725298 B1 KR 100725298B1
- Authority
- KR
- South Korea
- Prior art keywords
- group
- branched
- straight
- alkyl group
- ppm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 0 ***c1c(*)c2nc(C(N)=O)c[n]2c2c(*)c(*)c(*)c(*)c12 Chemical compound ***c1c(*)c2nc(C(N)=O)c[n]2c2c(*)c(*)c(*)c(*)c12 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0105406A HUP0105406A3 (en) | 2001-12-21 | 2001-12-21 | Imidazo[1,2-a]quinolin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates |
| HUP0105406 | 2001-12-21 | ||
| PCT/HU2002/000144 WO2003053969A1 (en) | 2001-12-21 | 2002-12-17 | Imidazoquinoline derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020077004953A Division KR20070034136A (ko) | 2001-12-21 | 2002-12-17 | 이미다조퀴놀린 유도체 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20040072670A KR20040072670A (ko) | 2004-08-18 |
| KR100725298B1 true KR100725298B1 (ko) | 2007-06-07 |
Family
ID=47711504
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020047009788A Expired - Fee Related KR100725298B1 (ko) | 2001-12-21 | 2002-12-17 | 이미다조퀴놀린 유도체 |
| KR1020077004953A Ceased KR20070034136A (ko) | 2001-12-21 | 2002-12-17 | 이미다조퀴놀린 유도체 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020077004953A Ceased KR20070034136A (ko) | 2001-12-21 | 2002-12-17 | 이미다조퀴놀린 유도체 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7176213B2 (enExample) |
| EP (1) | EP1456205A1 (enExample) |
| JP (1) | JP4530663B2 (enExample) |
| KR (2) | KR100725298B1 (enExample) |
| CN (1) | CN1307174C (enExample) |
| AU (1) | AU2002353241B2 (enExample) |
| BR (1) | BR0215272A (enExample) |
| CA (1) | CA2470067C (enExample) |
| EA (1) | EA007226B1 (enExample) |
| HR (1) | HRP20040671A2 (enExample) |
| HU (1) | HUP0105406A3 (enExample) |
| IL (2) | IL162443A0 (enExample) |
| IS (1) | IS7317A (enExample) |
| MA (1) | MA27240A1 (enExample) |
| MX (1) | MXPA04006115A (enExample) |
| NO (1) | NO329743B1 (enExample) |
| NZ (1) | NZ534015A (enExample) |
| PL (1) | PL370761A1 (enExample) |
| RS (1) | RS56104A (enExample) |
| TN (1) | TNSN04105A1 (enExample) |
| UA (1) | UA78745C2 (enExample) |
| WO (1) | WO2003053969A1 (enExample) |
| ZA (1) | ZA200404807B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1430032A2 (en) * | 2001-09-24 | 2004-06-23 | Elan Pharmaceuticals, Inc. | Substituted amides for the treatment of neurological disorders |
| HUP0203976A3 (en) * | 2002-11-15 | 2004-08-30 | Sanofi Aventis | Adenozine a3 receptors, process for their preparation and pharmaceutical compositions containing them |
| HUP0400812A2 (en) * | 2004-04-19 | 2006-02-28 | Sanofi Aventis | Crystalline forms of 2-amino-3-cyano-quinoline derivatives, process for their preparation and pharmaceutical compositions containing them |
| JP2008531502A (ja) * | 2005-02-22 | 2008-08-14 | ザ レジェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 胃腸の炎症を処置する方法 |
| HUP0700395A2 (en) * | 2007-06-07 | 2009-03-02 | Sanofi Aventis | Substituted [1,2,4] triazolo [1,5-a] quinolines, process for their preparation, pharmaceutical compositions thereof, and intermediates |
| US8357132B1 (en) | 2009-10-21 | 2013-01-22 | Lekweuwa Agatha N | Urine capturing assembly |
| CA3217159A1 (en) | 2013-02-01 | 2014-08-07 | Wellstat Therapeutics Corporation | Substituted quinazolin-4-amine compounds and pharmaceutical compositions thereof having anti-inflammatory, antifungal, antiparasitic and anticancer activity |
| ES2578363B1 (es) | 2015-01-22 | 2017-01-31 | Palobiofarma, S.L. | Moduladores de los receptores A3 de adenosina |
| TW201718536A (zh) * | 2015-08-03 | 2017-06-01 | 必治妥美雅史谷比公司 | 可作為TNFα調節劑之雜環化合物 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4333934A (en) | 1979-02-09 | 1982-06-08 | Roussel Uclaf | Imidazoquinoxalines and pyrroloquinoxalines |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4075343A (en) | 1976-09-13 | 1978-02-21 | Pfizer Inc. | Anti-allergenic 5-alkoxyimidazo[1,2-A]quinoline-2-carboxylic acids and derivatives thereof |
| GB1596652A (en) * | 1977-01-20 | 1981-08-26 | Roussel Lab Ltd | Imidazo (1,2-a) quinoline-2-carboxylic acid and derivatives |
| GR76063B (enExample) | 1981-04-03 | 1984-08-03 | Roussel Uclaf | |
| HUP0203976A3 (en) * | 2002-11-15 | 2004-08-30 | Sanofi Aventis | Adenozine a3 receptors, process for their preparation and pharmaceutical compositions containing them |
-
2001
- 2001-12-21 HU HU0105406A patent/HUP0105406A3/hu unknown
-
2002
- 2002-12-17 AU AU2002353241A patent/AU2002353241B2/en not_active Ceased
- 2002-12-17 EP EP02788261A patent/EP1456205A1/en not_active Withdrawn
- 2002-12-17 IL IL16244302A patent/IL162443A0/xx unknown
- 2002-12-17 BR BR0215272-0A patent/BR0215272A/pt not_active IP Right Cessation
- 2002-12-17 MX MXPA04006115A patent/MXPA04006115A/es active IP Right Grant
- 2002-12-17 US US10/499,251 patent/US7176213B2/en not_active Expired - Fee Related
- 2002-12-17 WO PCT/HU2002/000144 patent/WO2003053969A1/en not_active Ceased
- 2002-12-17 HR HR20040671A patent/HRP20040671A2/xx not_active Application Discontinuation
- 2002-12-17 UA UA20040706065A patent/UA78745C2/uk unknown
- 2002-12-17 NZ NZ534015A patent/NZ534015A/en not_active IP Right Cessation
- 2002-12-17 CN CNB02825645XA patent/CN1307174C/zh not_active Expired - Fee Related
- 2002-12-17 PL PL02370761A patent/PL370761A1/xx not_active Application Discontinuation
- 2002-12-17 EA EA200400847A patent/EA007226B1/ru not_active IP Right Cessation
- 2002-12-17 KR KR1020047009788A patent/KR100725298B1/ko not_active Expired - Fee Related
- 2002-12-17 KR KR1020077004953A patent/KR20070034136A/ko not_active Ceased
- 2002-12-17 JP JP2003554685A patent/JP4530663B2/ja not_active Expired - Fee Related
- 2002-12-17 CA CA2470067A patent/CA2470067C/en not_active Expired - Fee Related
- 2002-12-17 RS YU56104A patent/RS56104A/sr unknown
-
2004
- 2004-06-07 MA MA27725A patent/MA27240A1/fr unknown
- 2004-06-08 TN TNP2004000105A patent/TNSN04105A1/en unknown
- 2004-06-10 IL IL162443A patent/IL162443A/en not_active IP Right Cessation
- 2004-06-16 IS IS7317A patent/IS7317A/is unknown
- 2004-06-17 ZA ZA200404807A patent/ZA200404807B/xx unknown
- 2004-07-20 NO NO20043117A patent/NO329743B1/no not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4333934A (en) | 1979-02-09 | 1982-06-08 | Roussel Uclaf | Imidazoquinoxalines and pyrroloquinoxalines |
Non-Patent Citations (2)
| Title |
|---|
| Journal of Medicinal Chemistry, vol. 31, pp. 1098-1115, 1988 |
| Journal of Medicinal Chemistry, vol. 31, pp. 1220-1226, 1988 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1307174C (zh) | 2007-03-28 |
| AU2002353241B2 (en) | 2008-07-10 |
| NO20043117L (no) | 2004-07-20 |
| IL162443A (en) | 2010-05-17 |
| ZA200404807B (en) | 2005-08-29 |
| HUP0105406A3 (en) | 2003-12-29 |
| HUP0105406A2 (hu) | 2003-10-28 |
| EA007226B1 (ru) | 2006-08-25 |
| IS7317A (is) | 2004-06-16 |
| KR20070034136A (ko) | 2007-03-27 |
| US20050070566A1 (en) | 2005-03-31 |
| US7176213B2 (en) | 2007-02-13 |
| HRP20040671A2 (en) | 2005-08-31 |
| MXPA04006115A (es) | 2005-06-08 |
| BR0215272A (pt) | 2004-12-14 |
| KR20040072670A (ko) | 2004-08-18 |
| CA2470067C (en) | 2011-02-15 |
| HUP0105406D0 (en) | 2002-03-28 |
| RS56104A (sr) | 2006-10-27 |
| PL370761A1 (en) | 2005-05-30 |
| JP2005516956A (ja) | 2005-06-09 |
| NZ534015A (en) | 2005-04-29 |
| CA2470067A1 (en) | 2003-07-03 |
| NO329743B1 (no) | 2010-12-13 |
| JP4530663B2 (ja) | 2010-08-25 |
| CN1606555A (zh) | 2005-04-13 |
| WO2003053969A1 (en) | 2003-07-03 |
| UA78745C2 (en) | 2007-04-25 |
| EA200400847A1 (ru) | 2004-12-30 |
| TNSN04105A1 (en) | 2006-06-01 |
| EP1456205A1 (en) | 2004-09-15 |
| AU2002353241A1 (en) | 2003-07-09 |
| IL162443A0 (en) | 2005-11-20 |
| MA27240A1 (fr) | 2005-03-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
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