KR100723950B1 - 벼과 식물 추출물을 포함하는 허혈성 질환 및 퇴행성뇌질환의 예방 및 치료를 위한 조성물 - Google Patents
벼과 식물 추출물을 포함하는 허혈성 질환 및 퇴행성뇌질환의 예방 및 치료를 위한 조성물 Download PDFInfo
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- KR100723950B1 KR100723950B1 KR1020050135745A KR20050135745A KR100723950B1 KR 100723950 B1 KR100723950 B1 KR 100723950B1 KR 1020050135745 A KR1020050135745 A KR 1020050135745A KR 20050135745 A KR20050135745 A KR 20050135745A KR 100723950 B1 KR100723950 B1 KR 100723950B1
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Abstract
Description
Claims (14)
- 소맥 (Triticum aestivum N.), 부소맥, 호밀 (Secale cereale L.), 현미, 보리 (Horden vulgare var. hexastichon ASCH.), 맥아, 귀리 (Avena sativa), 옥수수 (Zea mays L.), 수수 (Sorghum bicolor MOENCH), 율무 (Coix lacryma-jobi var. mayuen STAPF), 기장 (Panicum miliaceum L.) 또는 조 (Setaria italica Beauv.)의 조추출물 또는 상기 조추출물을 pH12로 조정하고; 여기에 추출농축액과 동량의 에틸아세테이트 또는 클로로포름을 가하여 수가용성 분획물을 회수하고; 상기 수가용성 분획물에 동량의 부탄올을 가하여 수득된 소맥 조추출물의 부탄올 가용성 분획물을 유효성분으로 함유하고 약학적으로 허용되는 담체 또는 부형제를 함유하는 허혈성 질환의 예방 및 치료용 약학조성물.
- 제 1항에 있어서, 상기 허혈성 질환은 심근경색, 뇌경색, 허혈성 급성신부전증, 허혈성 급성간부전증, 당뇨성 족부궤양, 당뇨성 신증, 외과수술 부작용에 기인한 허혈성 질환 또는 기관 조직 손상인 약학조성물.
- 제 2항에 있어서, 상기 외과수술 부작용에 기인한 허혈성 질환은 허혈성 심부전, 허혈성 신부전, 허혈성 간부전 또는 허혈성 뇌졸중인 약학조성물.
- 제 2항에 있어서, 상기 기관 조직 손상은 허혈 후 재관류를 동반하는 장기 수술 또는 이식, 외상성 절단사지 재접합으로 인한 것임을 특징으로 하는 약학조성물.
- 제 4항에 있어서, 상기 장기는 신장, 간장, 췌장, 폐 또는 심장인 약학조성물.
- 소맥 (Triticum aestivum N.), 부소맥, 호밀 (Secale cereale L.), 현미, 보리 (Horden vulgare var. hexastichon ASCH.), 맥아, 귀리 (Avena sativa), 옥수수 (Zea mays L.), 수수 (Sorghum bicolor MOENCH), 율무 (Coix lacryma-jobi var. mayuen STAPF), 기장 (Panicum miliaceum L.) 또는 조 (Setaria italica Beauv.)의 조추출물 또는 상기 조추출물을 pH12로 조정하고; 여기에 추출농축액과 동량의 에틸아세테이트 또는 클로로포름을 가하여 수가용성 분획물을 회수하고; 상기 수가용성 분획물에 동량의 부탄올을 가하여 수득된 소맥 조추출물의 부탄올 가용성 분획물을 유효성분으로 함유하는 퇴행성 뇌질환의 예방 및 치료용 약학조성물.
- 제 6 항에 있어서, 퇴행성 뇌질환은 알츠하이머형 치매, 뇌혈관성 치매, 파킨슨병, 근위축성 측상경화증, 헌팅턴병, 피크(Pick)병, 크로이츠펠트-야콥 (Creutzfeldt-Jakob)병 또는 척수손상인 약학조성물.
- 삭제
- 제 1항 또는 제 6항에 있어서, 상기 조추출물은 물, 에탄올, 메탄올 또는 이들의 혼합용매에 가용한 추출물인 약학 조성물.
- 삭제
- 삭제
- 제 1항의 소맥 (Triticum aestivum N.), 부소맥, 호밀 (Secale cereale L.), 현미, 보리 (Horden vulgare var. hexastichon ASCH.), 맥아, 귀리 (Avena sativa), 옥수수 (Zea mays L.), 수수 (Sorghum bicolor MOENCH), 율무 (Coix lacryma-jobi var. mayuen STAPF), 기장 (Panicum miliaceum L.) 또는 조 (Setaria italica Beauv.) 조추출물에 수산화나트륨 또는 수산화칼륨의 강염기를 가하여 pH 7 및 pH 12로 조정하는 제 1단계; 여기에 추출농축액과 동량의 에틸아세테이트 또는 클로로포름을 가하여 비극성 물질을 제거하고 수가용성 분획물을 회수하는 제 2단계; 상기 수가용성 분획물을 동량의 부탄올로 추출 분획하여 pH 12에서 수득한 부탄올가용성 분획물 또는 수가용성 분획물, pH7에서 수득한 부탄올가용성 분획물 또는 수가용성 분획물을 수득하는 제 3단계를 포함하는 공정으로 이루어진 소맥 (Triticum aestivum N.), 부소맥, 호밀 (Secale cereale L.), 현미, 보리 (Horden vulgare var. hexastichon ASCH.), 맥아, 귀리 (Avena sativa), 옥수수 (Zea mays L.), 수수 (Sorghum bicolor MOENCH), 율무 (Coix lacryma-jobi var. mayuen STAPF), 기장 (Panicum miliaceum L.) 또는 조 (Setaria italica Beauv.)의 정제 분획물을 얻는 제조방법.
- 제 1항의 소맥 (Triticum aestivum N.), 부소맥, 호밀 (Secale cereale L.), 현미, 보리 (Horden vulgare var. hexastichon ASCH.), 맥아, 귀리 (Avena sativa), 옥수수 (Zea mays L.), 수수 (Sorghum bicolor MOENCH), 율무 (Coix lacryma-jobi var. mayuen STAPF), 기장 (Panicum miliaceum L.) 또는 조 (Setaria italica Beauv.)의 조추출물 또는 상기 조추출물을 pH12로 조정하고; 여기에 추출농축액과 동량의 에틸아세테이트 또는 클로로포름을 가하여 수가용성 분획물을 회수하고; 상기 수가용성 분획물에 동량의 부탄올을 가하여 수득된 소맥 조추출물의 부탄올 가용성 분획물을 유효성분으로 함유하는 허혈성 질환 또는 퇴행성 뇌질환의 예방 및 개선용 건강기능식품.
- 삭제
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KR1020050135745A KR100723950B1 (ko) | 2005-01-04 | 2005-12-30 | 벼과 식물 추출물을 포함하는 허혈성 질환 및 퇴행성뇌질환의 예방 및 치료를 위한 조성물 |
PCT/KR2006/000027 WO2006073265A1 (en) | 2005-01-04 | 2006-01-04 | Composition comprising an extract of gramineae plant for the prevention and treatment of ischemic diseases and degenerative brain diseases and the use thereof |
JP2007549276A JP2008526737A (ja) | 2005-01-04 | 2006-01-04 | 虚血性疾患及び退行性脳疾患の予防と治療のためのイネ科植物抽出物を含む組成物およびその使用 |
US11/813,285 US20080113005A1 (en) | 2005-01-04 | 2006-01-04 | Composition Comprising an Extract of Gramineae Plant for the Prevention and Treatment of Ischemic Diseases and Degenerative Brain Diseases and the Use Thereof |
US12/623,341 US20100068315A1 (en) | 2005-01-04 | 2009-11-20 | Composition Comprising an Extract of Gramineae Plant for the Prevention and Treatment of Ischemic Diseases and Degenerative Brain Diseases and the Use Thereof |
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KR101817997B1 (ko) * | 2017-05-10 | 2018-01-15 | 연천군 | 퇴행성 뇌신경계 질환 개선용 건강기능성 식품 |
KR20200144352A (ko) * | 2019-06-18 | 2020-12-29 | 대한민국(농촌진흥청장) | 단수수 추출물을 유효성분으로 포함하는 인지능력 개선용 조성물 |
KR20210071302A (ko) * | 2019-12-06 | 2021-06-16 | 대한민국(농촌진흥청장) | 누에, 감초 및 수수 추출물의 혼합물을 유효성분으로 포함하는 인지능력 개선용 조성물 |
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WO2009005329A2 (en) * | 2007-07-04 | 2009-01-08 | Hypoxi Co., Ltd | Composition comprising starch or dietary fiber from gramineae plant for prevention and treatment of ischemic diseases and degenerative brain diseases |
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KR101817997B1 (ko) * | 2017-05-10 | 2018-01-15 | 연천군 | 퇴행성 뇌신경계 질환 개선용 건강기능성 식품 |
KR20200144352A (ko) * | 2019-06-18 | 2020-12-29 | 대한민국(농촌진흥청장) | 단수수 추출물을 유효성분으로 포함하는 인지능력 개선용 조성물 |
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KR20210071302A (ko) * | 2019-12-06 | 2021-06-16 | 대한민국(농촌진흥청장) | 누에, 감초 및 수수 추출물의 혼합물을 유효성분으로 포함하는 인지능력 개선용 조성물 |
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KR20060080122A (ko) | 2006-07-07 |
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US20080113005A1 (en) | 2008-05-15 |
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US20100068315A1 (en) | 2010-03-18 |
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