KR100673676B1 - 이중 생체 친화성 칼라를 갖는 치아 임플란트 - Google Patents

이중 생체 친화성 칼라를 갖는 치아 임플란트 Download PDF

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KR100673676B1
KR100673676B1 KR1020027017670A KR20027017670A KR100673676B1 KR 100673676 B1 KR100673676 B1 KR 100673676B1 KR 1020027017670 A KR1020027017670 A KR 1020027017670A KR 20027017670 A KR20027017670 A KR 20027017670A KR 100673676 B1 KR100673676 B1 KR 100673676B1
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South Korea
Prior art keywords
implant
proximal
segment
growth
distal
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KR1020027017670A
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English (en)
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KR20030036244A (ko
Inventor
존 리치
헤롤드 알렌산더
챨스 나이만
브루스엘. 홀랜더
인고 코작
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바이오락 인터내셔널, 인코포레이티드
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24422437&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR100673676(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 바이오락 인터내셔널, 인코포레이티드 filed Critical 바이오락 인터내셔널, 인코포레이티드
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    • AHUMAN NECESSITIES
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    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
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    • A61C8/0012Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
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    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
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Abstract

벼의 손실 가능성을 줄이고 골절수술부위에 삽입하기 위한 치아 임플란트는 종방향 축을 갖는 솔리드형태의 가늘고 긴 몸체를 갖는데, 상기 축은 원위 및 근접단부를 갖고, 상기 근접단부는 약 1-3mm 범위의 축 길이로 된 칼라를 형성하며, 상기 칼라는 근접 세그먼트 및 원위 세그먼트로 구성되며, 상기 근접 세그먼트는 조직의 성장을 촉지하기 위한 표면 텍스쳐로 구성되며, 상기 원위 세그먼트는 뼈의 성장을 촉진시키기 위한 표면 텍스쳐를 갖으며, 상기 근접 및 원위 세그먼트는 여러개의 오목한 부분과 튀어나온 부분이 번갈아 이루어진 형태의 초미세 반복패턴을 형성하는데, 각각의 폭은 2.0 내지 25 마이크론이며, 깊이는 2.0내지 25 마이크론 범위에 있고, 상기 초미세 반복패턴은 이러한 표면 패턴과 접촉하고 있는 골절수술 부위의 뼈의 세포 및 연조직의 성장 방향 및 성장률을 촉진시키기 위한 가이드를 형성한다.

Description

이중 생체 친화성 칼라를 갖는 치아 임플란트{DENTAL IMPLANT HAVING A DUAL BIO-AFFINITY COLLAR}
본 발명은 치아 인플란트에 관련된다. 좀더 자세히 말해서 아래턱, 악골 및 안면골에 삽입하기 위한 임플란트에 관련된다. 본 발명은 이중 생체 친화성 표면을 갖는 칼라가 제공되는데, 치료할 때 치아 임플란트를 삽입한 다음 뼈가 잘 붙고 뼈에있는 피부가 잘 결합도록 하는 치아 임플란트에 관련된다.
종래의 기술에서 뼈 내부에서 임플란트의 골질의 안정성(osseo-stability)을 향상시키기 위하 여러 가지 표면 혹은 무늬를 제공하며, 치료과정에서 동일 부분은 악골면(maxillofacial) 영역을 포함한다. 치아 임플란트의 근접영역 혹은 칼라는 특히 임플란트의 가장 위쪽에 대해서 뼈를 닫는 것이 임플란트 주변의 뼈를 적합하게 씰링(sealing)하도록 하는데 중요한 역할을 한다. 삽입되는 지점에서 뼈 위의 연조적 혹은 조직, 잇몸을 적합하게 차단하는데 이러한 씰링의 또 다른 관점이 있다. 일반적으로 만약 임플란트의 상단 방사형 표면의 평면에 대해서 조직을 차단하게 되면, 임플란트에 대해서 외피골을 적합하게 차단하게 된다. 따라서 골절수술하는 곳에 삽입한 후에 치아 임플란트와 접촉하고 있는 연조직 및 경조직을 바이 생리학적으로 통합시키는 것을 촉진하는데 바람직하다. 다른 인자들 중에 상기 사항 은 치아 어버트먼트(dental abutment) 및 관련된 보철을 고정시키는 기초부와 같은 임플란트 역학을 최적화할 것이다.
종래의 기술은 잡다한 여러 가지 외과적 임플란트에 대한 다양한 표면 효과를 제안하는데, 본 발명은 몇가지만 제안한다. 본 발명에서 잘 알려진 기술들은 다음 특허에 공지되어 있다. U.S.P.N 5,011,494(본 레큠-Von Recum), U.S.P.N 5,057,208(쉐리-Sherry), U.S.P.N. 4,778,469(리아-Lia), U.S.P.N. 5,751,017(니쯔닉-niznick),U.S.P.N. 4,320,891(브레인마크-Branemark), U.S.P.N. 4,752,294(룬트그렌-Lundgren), U.S.P.N. 4,553,272(미어스-Mears), U.S.P.M. 5,004,475(베르미어-Vermeire)
상기 특허들은 본 발명에서와 같이 이중 조직 생체 친화적 표면의 원리를 일반적으로 적용하지 않는다.
본 발명은 원위 및 근접 단부를 갖는 종방향 축을 포함하는 솔리더 형태의 가늘도 긴 몸체로 구성된 치아 임플란트에 관련된다. 근접단부는 약 1-3mm의 범위 정도가 되는 축방향 길이의 칼라를 형성한다. 칼라는 근접 및 원위 세그먼트로 구성되는데, 상기 근접 세그먼트는 조직의 성장을 촉진시키는데 적합한 표면 텍스쳐를 나타내며, 상기 원귀 세그먼트는 골질이 선호적으로 뼈의 외피면에서 잘 연합되도록 촉진하기에 적합한 표면 텍스쳐를 나타낸다. 상기 서브 세그먼트들 중 최소한 하나는 여러개의 오목한 부분과 튀어나온 부분 형태로 초미세 반복 패턴으로 된 표면으로 구비되고, 이들 각각은 폭이 약 2.0-25 마이크론 범위에 있고, 깊이가 약 2.0-25 마이크론 범위에 있다. 상기 초미세 반복 패턴은 이러한 표면 패턴과 접촉하고 있는 악골면(maxillofacial) 뼈의 성장 방향, 성장률을 증진시키기 위한 가이드를 형성한다.
따라서본 발명의 목적은 근접 및 원위 원통형 세그먼트로 구성된 칼라를 갖는 치아 임플란트를 제공하는 것이며, 하나는 연조직 성장을 촉진시키기에 적합한 표면을 갖고, 선호적으로 뼈의 외피에서 경조직의 성장이나 뼈의 성장을 촉진시키기에 적합하다.
임플란트 및 골절수술 부위 사이에서 커핑효과(cupping effect)를 제거하기 위해 부착된 세포의 성장 활동을 변화시키는 초미세 표면을 제공하는 것 또한 본 발명의 목적이다.
또 다른 목적은 특정한 세포나 조적 형태에 선호적인 횡단면 구조를 갖는 상기 형태의 초미세 표면을 제공하는 것이다.
또 다른 목적은 생체 세포 부착, 성장방향, 이동 및 조직의 기능을 제어하기 위한 초미세 임플란트 기질을 제공하는 것이 목적인데, 제 2 축을 따라 성장을 유인하고 제 1 축에서 세포의 성장을 막기 위한 크기로 되어 있다.
추가적인 목적으로 여러 가지 의학적으로 사용되는 임플란트의 반복적인 초미세 텍스쳐 구조를 제공하는 것이 있다.
또 다른 목적은 임플란트가 있는 부분의 전염 가능성을 줄이면서 안정성을 개선하기 위한 전술된 형태의 치아 임플란트를 제공하는 것이다.
본 발명의 이점 및 목적은 실시예 부분과 도면 및 청구항 부분을 통해 더욱 명확해질 것이다.
도 1은 본 발명과 관련된 종래의 기술에 대한 도면.
도 2는 임플란트 주변을 둘러쌓고 있는 뼈와 조직과의 관계를 나타낸 본 발명의 정면도.
도 3은 본 발명의 선택적인 실시예를 도시하는 것으로써 임플란트의 전체 길이를 도시하는 도 2와 비슷한 정면도.
도 4는 도 3의 왼쪽 상단을 확대한 도면으로써 임플란트 칼라 경계부에 대한 뼈 외피의 조직 영역을 도시한 확대도.
* 부호 설명 *
10 : 치아 임플란트 12 : 칼라
14 : 뼈 15 : 외피골
16 : 칼라 18 : 잇몸조직
19 : 잇몸라인 20 : 경계면
26 : 근접 세그먼트 28 : 원위 세그먼트
도 1에 도시된 바와 같이 칼라(12)를 포함하는 치아 임플란트(10), 및 소위 골절제술(ostectomy)이라고 하는 영역에서 뼈(14) 내부에 있는 앙커영역(anchor portion)(24)에 대한 종래의 기술이 도시되었다. 뼈(14)의 외부 혹은 가장 위쪽의 표면은 단단한 쉘 형태의 레이어로 구성된 외피골(cortical bone)(15)로 구성된다. 본 발명의 배경설명에서 언급된 바와 같이 뼈에 대한 임플란트의 생체 친화성은 치아 임플란트에 대한 표면처리에 관해서만 연구되어 왔다. 또한 도 1에 도시된 바와 같이 종래의 기술에서 칼라(12)의 상단 방사형 표면(16)은 잇몸조직(18)의 잇몸라인(gum line)(19)의 일반적인 위치를 나타낸다. 그러나 골절제술 영역 내에서 임플란트가 위치하는 문제점은 임플란트 칼라(12)의 상기 표면(16) 아래에서 잇몸라인(18) 및 외피골(15) 사이에 존재하는 경계면(20)에 관련된다. 경계면(20)을 따라, 특히 영역(22)에서 경계면이 칼라(16)를 만나는 곳을 따라, 임플란트에 커핑현상(cupping effect)가 발생하는데, 뼈의 조직이 칼라(12)에서 다이백(die-back) 현상이 발생하는 것이다.
도 2는 본 발명을 통해 해결되는 방법을 도시한다. 도 2에 도시된 바와 같이 칼라(120)가 제공된 본 발명의 임플란트(100)는 원위 원통형 세그먼트(distal cylindrical segment)(28) 및 근접 원통형 세그먼트(proximal cylindrical segment)(26)를 포함한다. 육각형 헤드(30)가 방사형 표면(16) 위에 도시되었는데, 대표적인 것으로 이해되지만 치아 회복이 있기 전에 임플란트가 일치되는 치아 어버트먼트(dental abutment) 및 임플란트 사이의 고정부에 영향을 주기 위해 사용되는 여러 가지 수단중의 하나이다.
도 2에서 주목할만한 점은 두 개의 다른 형태의 생체 친화적 표면 효과 혹은 텍스쳐가 임플란트의 칼라(12)에 제공되는데, 즉 칼라(120)의 원위 세그먼트(28)에 제 2 생체 친화성 텍스쳐(수직 음영으로 표시된)를 제공하고 근접 세그먼트(26) 위에 점으로 표시된 잇몸조직(18) 혹은 유연한 피부의 성장을 도울 목적의 한 표면에 제공된다. 근접 세그먼트(26)는 잇몸 조직(18)과 축방향으로 배열되고, 외피층(15)과 정렬된 원위 세그먼트의 상단은 뼈(14)이다. 최적의 결과를 얻기 위해 최소한 하나의 무늬가 새겨진 표면은 오목한 부분과 튀어나온 부분이 서로 교대로 형성된 형태의 반복적으로 순서있게 만들어진 패턴을 형성한다. 각각은 폭이 2.0에서 25 마이크론 범위에 있고, 깊이는 2.0에서 25 마이크론 범위에 있는데, 상기 초미세 반복패턴은 이러한 패턴과 접촉하고 있는 악골면(maxillofacial) 뼈의 성장 방향, 성장률을 증진시키기 위한 가이드를 형성한다. 만약 상기 양쪽 세그먼트가 이러한 표면패턴으로 만들어진다면, 각각의 텍스쳐는 폭과 깊이가 연조직과 경조직의 상호작용에 최적이 되도록 다를 것이다.
본 발명의 추가적인 실시예가 도 3에 도시되었는데, 임플란트의 전체 앙커영역(124)이 동일한 치아 결합 표면에 제공되며, 이것은 (102)로 표시 되었다. 따라서 상기 실시예에서 근접 세그먼트(16) 아래에 있는 전체 임플란트는 원위 서브 세그먼트(28)와 동일한 방법으로 처리된다.
도 2의 확대도인 도 4에 근접 칼라 세그먼트(26), 원위 칼라 세그먼트, 임플란트(100)의 최적으로 무늬가 새겨진 표면(102), 뼈(14)와 동일한 부분, 외피골(15), 연조직(18)이 도시되었다. 그러나 도 4에 원위 칼라 세그먼트(28) 및 뼈(14) 사이의 치아연합 영역(34), 근접 세그먼트(26) 및 잇몸조직(18) 사이의 치아연합 영역(36)이 도시되었다. 조직(18)과 세그먼트(26,28) 사이의 성장 혹은 생체 친화성을 갖는 영역(34,36)은 외피골(15) 및 조직(18) 사이의 경계면(20)의 영역(22)에 대한 조직, 특히 외피골에 칼라가 들어가는 지점을 씰링(sealing)하는 이 점을 갖는다. 이와 같이 이중 친화성 칼라는 뼈(22)를 임플란트 칼라(12)에 효과적으로 씰링하고, 또한 임플란트에 들어가는 원주부분을 효과적으로 씰링한다. 이러한 씰링으로 커핑효과가 불가능하게 된다.
만약 칼라 세그먼트(26 혹은 28)들 중 하나가 상기 초미세 반복 표면 물질로 구비되지 않는다면, 여러 가지 다른 표면 텍스쳐가 다음 사항을 포함한 처리방법을 이용하여 다른 세그먼트에 영향을 준다.
레이저 절단, 산성 엣칭(acid etching), 포토리소그래피(photolithography), 마멸(abrasion/roughening), 플라즈마 스프레이(plazma spraying), 황산칼슘(calcium sulfate), 바이오화 유리(biocompatible glass), 콜라겐(collagen), 아이드록아파티트(hydroxapatite), 성장인자 화합물(growth factor compound) 이나 이들의 조합.
칼라의 원위 세드먼트에 대한 근접 세그먼트의 축방향 길이 비율에 대해서, 이러한 축방향 길이는 동일할 필요가 없으며, 원위 세그먼트에 대한 근접 세그먼트의 축방향 길이의 범위는 1:4에서 4:1 정도가 되고, 약 1-3mm 사이의 전체 축방향 길이 내에 있다.
본 발명의 선호적인 실시예가 설명되었는데, 본 발명은 상기 실시에의 범위 내에서 변형이 가능하며 본 발명의 기본적인 개념이나 청구항에 공지된 원래를 벗어나지 않는 한도 내에서 형태나 배열의 변형이 가능하다.

Claims (11)

  1. 뼈의 손실 가능성을 줄이고 골절수술부위에 삽입하기 위한 치아 임플란트는 종방향 축을 갖는 솔리드형태의 가늘고 긴 몸체를 갖는데, 상기 축은 원위 및 근접단부를 갖고, 상기 근접단부는 약 1-3mm 범위의 축 길이로 된 칼라를 형성하며, 상기 칼라는 근접 세그먼트 및 원위 세그먼트로 구성되며, 상기 근접 세그먼트는 조직의 성장을 촉지하기 위한 표면 텍스쳐로 구성되며, 상기 원위 세그먼트는 뼈의 성장을 촉진시키기 위한 표면 텍스쳐를 갖으며, 상기 원위 세그먼트는 여러개의 오목한 부분과 튀어나온 부분이 번갈아 이루어진 형태의 초미세 반복패턴을 형성하는데, 각각의 폭은 2.0 내지 25 마이크론이며, 깊이는 2.0내지 25 마이크론 범위에 있고, 상기 초미세 반복패턴은 이러한 표면 패턴과 접촉하고 있는 골절수술 부위의 연조직 세포 성장 방향 및 성장률을 촉진시키기 위한 가이드를 형성하는 것을 특징으로 하는 치아 임플란트.
  2. 제 1 항에 있어서, 상기 근접 세그먼트의 표면 텍스쳐는 레이저 절단, 산성 엣칭(acid etching), 포토리소그래피(photolithography), 마멸(abrasion/roughening), 플라즈마 스프레이(plazma spraying), 황산칼슘(calcium sulfate), 바이오화 유리(biocompatible glass), 콜라겐(collagen), 아이드록아파티트(hydroxapatite), 성장인자 화합물(growth factor compound) 같은 표면처리에서 선택된 표면 텍스펴로 구성되는 것을 특징으 로 하는 임플란트.
  3. 제 2 항에 있어서, 상기 원위 세그먼트에 대한 근접 세그먼트의 축방향 길이 비율은 약 1:4에서 4:1 정도의 범위로 구성되는 것을 특징으로 하는 임플란트.
  4. 제 3 항에 있어서, 상기 임플란트 수단의 근접 방사형 표면은 치아 어버트먼트를 보조적으로 고정시키기 위한 수단을 포함하는 것을 특징으로 하는 임플란트.
  5. 뼈의 손실 가능성을 줄이고 골절수술부위에 삽입하기 위한 치아 임플란트는 종방향 축을 갖는 솔리드형태의 가늘고 긴 몸체를 갖는데, 상기 축은 원위 및 근접단부를 갖고, 상기 근접단부는 약 1-3mm 범위의 축 길이로 된 칼라를 형성하며, 상기 칼라는 근접 세그먼트 및 원위 세그먼트로 구성되며, 상기 근접 세그먼트는 조직의 성장을 촉지하기 위한 표면 텍스쳐로 구성되며, 상기 원위 세그먼트는 뼈의 성장을 촉진시키기 위한 표면 텍스쳐를 갖으며, 상기 근접 세그먼트는 여러개의 오목한 부분과 튀어나온 부분이 번갈아 이루어진 형태의 초미세 반복패턴을 형성하는데, 각각의 폭은 2.0 내지 25 마이크론이며, 깊이는 2.0내지 25 마이크론 범위에 있고, 상기 초미세 반복패턴은 이러한 표면 패턴과 접촉하고 있는 골절수술 부위의 뼈의 세포 성장 방향 및 성장률을 촉진시키기 위한 가이드를 형성하는 것을 특징으로 하는 치아 임플란트.
  6. 제 1 항에 있어서, 상기 원위 세그먼트의 표면 텍스쳐는 레이저 절단, 산성 엣칭(acid etching), 포토리소그래피(photolithography), 마멸(abrasion/roughening), 플라즈마 스프레이(plazma spraying), 황산칼슘(calcium sulfate), 바이오화 유리(biocompatible glass), 콜라겐(collagen), 아이드록아파티트(hydroxapatite), 성장인자 화합물(growth factor compound) 같은 표면처리에서 선택된 표면 텍스펴로 구성되는 것을 특징으로 하는 임플란트.
  7. 제 2 항에 있어서, 상기 원위 세그먼트에 대한 근접 세그먼트위 축방향 길이 비율은 약 1:4에서 4:1 정도의 범위로 구성되는 것을 특징으로 하는 임플란트.
  8. 제 3 항에 있어서, 상기 임플란트 수단의 근접 방사형 표면은 치아 어버트먼트를 보조적으로 고정시키기 위한 수단을 포함하는 것을 특징으로 하는 임플란트.
  9. 뼈의 손실 가능성을 줄이고 골절수술부위에 삽입하기 위한 치아 임플란트는 종방향 축을 갖는 솔리드형태의 가늘고 긴 몸체를 갖는데, 상기 축은 원위 및 근접단부를 갖고, 상기 근접단부는 약 1-3mm 범위의 축 길이로 된 칼라를 형성하며, 상기 칼라는 근접 세그먼트 및 원위 세그먼트로 구성되며, 상기 근접 세그먼트는 조직의 성장을 촉지하기 위한 표면 텍스쳐로 구성되며, 상기 원위 세그먼트는 뼈의 성장을 촉진시키기 위한 표면 텍스쳐를 갖으며, 상기 근접 및 원위 세그먼트는 여러개의 오목한 부분과 튀어나온 부분이 번갈아 이루어진 형태의 초미세 반복패턴을 형성하는데, 각각의 폭은 2.0 내지 25 마이크론이며, 깊이는 2.0내지 25 마이크론 범위에 있고, 상기 초미세 반복패턴은 이러한 표면 패턴과 접촉하고 있는 골절수술 부위의 뼈의 세포 및 연조직의 성장 방향 및 성장률을 촉진시키기 위한 가이드를 형성하는 것을 특징으로 하는 치아 임플란트.
  10. 제 9 항에 있어서, 상기 원위 세그먼트에 대한 근접 세그먼트의 축방향 길이 비율은 약 1:4에서 4:1 정도의 범위로 구성되는 것을 특징으로 하는 임플란트.
  11. 제 10 항에 있어서, 상기 임플란트 수단의 근접 방사형 표면은 치아 어버트먼트를 보조적으로 고정시키기 위한 수단을 포함하는 것을 특징으로 하는 임플란트.
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