KR100645887B1 - Compositions for gastric ulcer treatment - Google Patents

Abstract

The present invention relates to a composition for treating peptic ulcers containing acid and red rock, and optionally moles, specifically 5 to 50 parts by weight, 1 to 50 parts by weight of red paper, and optionally 1 to 25 parts by weight of moles. The composition of the present invention can be usefully used as a gastrointestinal protective agent and gastroduodenal ulcer therapeutic agent by promoting the healing of peptic ulcers and having the effect of quickly removing excess secreted gastric acid in the gastrointestinal tract.

Digestive ulcers, pesticides, red soil, shaving, antacid effect

Description

Composition for the treatment of peptic ulcer containing powdered acid and redwood land {COMPOSITIONS FOR GASTRIC ULCER TREATMENT}

1 is a graph showing the antacid test results of Mori to show the pH change with time when the moist was added to the artificial gastric juice.

Figure 2a is a picture of gastric ulcers of the ethanol-induced rats, 2b is a photograph showing the ulcers healed after the administration of the composition containing powder and red coal and optionally moor.

Figure 3a is a cross-sectional picture of the gastric ulcer tissue of the ethanol-induced rats, 3b is a cross-sectional picture of the gastric tissue showing a state of healing of the ulcer after administration of the composition containing powder and red coal and optionally moor.

Figure 4a is a picture of gastric ulcer in rats induced by cysteamine (control), 4b shows the healing effect of the gastric ulcer after two administrations of the powder, red paper and the mixed solution.

FIG. 5a is a duodenal ulcer photograph of a rat induced by cysteamine (control), and 5b shows a duodenal ulcer healing effect after administration of a powder, red tallow and a mixed mixture.

The present invention relates to a composition for treating peptic ulcer, which contains a powder, red coal paper and, optionally, a pill.

More specifically, the present invention relates to a composition containing about 5 to 50 parts by weight of acid, 1 to 25 parts by weight of red paper, and optionally 1 to 25 parts by weight, wherein the composition of the present invention promotes the healing of peptic ulcers and It has the effect of rapidly removing excess secretion of gastric acid in the gastrointestinal tract, which can be usefully used as a gastrointestinal protective agent and gastroduodenal ulcer treatment.

Peptic ulcers are known to be caused by a variety of factors, including mental and physical stress, drugs (mostly anti-inflammatory painkillers), and traumas that break down the homeostasis between attackers and defenders on the gastrointestinal mucosa.

Peptic ulcers are diseases in which circular, elliptical, or linear ulcers occur in part of the mucous membrane of the digestive tract. This is called peptic ulcer because the ulcer is called on the site where strong gastric gastric fluid comes into contact, namely the lower esophagus, gastric antrum, proximal part of the duodenum, Mckel diverticulum and gastrointestinal suture. Most cases occur in the stomach and duodenum, so it is generally called stomach or duodenal ulcer.

Pathologically, the presence of ulcers on the mucous membranes of the stomach and intestine is called hemorrhagic erosion or acute superficial ulcer. Superficial ulcers reach the mucous mucosa and pass through the submucosa to the muscularis. In severe cases, the damaged area reaches the serosa and gastric fluid leaks into the abdominal cavity, causing severe pain and requiring surgical intervention. Peptic ulcers can cure naturally without any symptoms, but most ulcer patients complain of heartburn or sintrim.

Korean people have many digestive diseases such as gastritis and gastric ulcer due to eating habits, and these diseases have high recurrence rate after initial treatment. Antacids, H₂antagonists, proton pump inhibitors, and cytoprotective agents have been developed, but problems such as side effects and accumulation effects for long-term use have been raised. Therefore, the need for more effective and safe drug development is increasing by improving this. Recently, the domestic pharmaceutical industry is a drug applied in private or oriental medicine, which has a relatively lower development cost and shorter development time than new drug development. Efforts are underway to develop therapeutics.

The inventors of the present invention have developed a suspension in which powdered red pepper powder and seed powder are added to a powder of extracts to develop medicines for the treatment of digestive ulcers caused by long-term and repeated stimulation as well as the loss of all symptoms of digestive diseases such as heartburn, bloating and pain. The present invention was completed by confirming that the ulcer induced rats had a significant ulcer healing effect.

It is an object of the present invention to provide a novel peptic ulcer composition for treating a peptic ulcer that exhibits high physiological activity in the treatment of peptic ulcers.

In order to achieve the above object, the present invention provides a composition for treating peptic ulcer containing acid powder and red paper.

In another aspect, the present invention provides a composition for treating peptic ulcers containing a seed in addition to powder and red ash.

The present invention also provides an oral preparation for treating peptic ulcer containing the composition and comprising a pharmaceutically acceptable excipient. At this time, the oral preparation is preferably in the form of tablets, capsules, soft capsules, pills, granules, gels, suspensions or solutions.

Hereinafter, the present invention will be described in detail.

The present invention provides a composition for treating peptic ulcer containing powder and red coal paper.

Dioscoreae rhizoma is used to remove the skin of the rhizome of the rhizomes (Dioscorea batatas Decaisne) and yam (Dioscorea japonica Thunberg) belonging to the family Dioscoreaceae and dried or steamed. Known ingredients include mucilage, steroidal saponin (dioscin), starch (16%), vitamin C, 3,4-dihydroxyphenylethylamine (dopamine), and phytic acid in the rhizome. acid), polyphenol oxidase and the like. In Chinese medicine, the ear canal is strong in the lungs, the nasal cavity, and the nerves. This fragile I am used for the treatment of diarrhea, long dysentery, seawater, oil wells, hypocalcemia and urine bins.

Haloysitum rubrum is a red mass formed by decomposing kaolin feldspar from heat and infiltration of carbonic acid-containing water.The main components are 42.93% silicon, 36.58% aluminum, 4.85% magnesium oxide and magnesium oxide with aluminum silicate hydrate and iron oxide. It consists of 0.94% calcium and 14.75% moisture. In oriental medicine, the ear canal is known as nasal, gastric, and large intestine, has astringent action, toxic adsorption, and hemostatic action in ulcer tissue and is known to give birth to granulation tissue.

"Natural products" such as acid powder, red paper and the like included in the composition of the present invention are not limited to the forms in which the natural products are present.

The composition for treating peptic ulcer containing powder and red powder according to the present invention contains 5 to 50 parts by weight of powder and 1 to 50 parts by weight of red paper as active ingredients.

Specifically, the powder may be dried and powdered raw material itself, but it is preferable to use an extract. The extract may be soaked in a solvent, an organic solvent or a mixed solvent for a predetermined time, and sometimes heated to obtain an active ingredient of a natural product. Obtained by extraction and then filtered or, if desired, concentrated. In the present invention, the extract powder was dried and used in the form of a powder.

In addition, red pepper paper may be used as an extract. In the present invention, since the raw material is present as a powder, it was used as it is.

In the present invention, in order to confirm the physiological activity of the composition containing the acid and red ash, administration of the composition according to the present invention to artificially induced gastric ulcer and observed the regeneration effect of damaged gastrointestinal epithelial cells as a result It was found that the composition of the present invention had a significant gastric ulcer healing effect.

Specifically, in the rats artificially induced ulcers by the administration of anhydrous ethanol for about 3 days the administration of the composition of the powder and red paper containing the composition according to the present invention and the stomach was extracted by measuring the length of the ulcers 80% or more compared to the negative control group The treatment rate was shown.

The present invention provides a composition for treating peptic ulcer, which contains a seed in addition to the powder and red ash. Specifically, it is preferably contained in about 5 to 50 parts by weight, 1 to 25 parts by weight of red paper and 1 to 25 parts by weight.

In addition, the extract may be used as an extract, and in the present invention, since the raw material is present as a powder, it is added to the composition of the present invention as it is.

Ostreae testa is a shell of Ostridae oyster (Ostrea gigas Thunberg), which is composed of 80-95% calcium carbonate, calcium phosphate, magnesium, aluminum, silicon and iron oxide. In oriental medicine, the ear is the liver and nerves. Its effect is to soothe the liver's yang, and it is used in the chest and abdomen and other mental anxiety, insomnia and dimming. It is known that there is a local acid action. If this is interpreted in a modern sense, it can be said that not only the function of antacid (除 酸 劑) but also the suppression of gastric acid secretion due to stress.

In the present invention, by using the fact that the moles have a fatty acid action to prevent the recurrence of peptic ulcer by promoting gastric acid secretion by repetitive stress by adding the moles to the composition of the present invention.

In addition, in the present invention, it was confirmed that the ulcer healing effect was increased in the case of adding the seed to the powder of the powdered / red paper mixture compared with the administration of the powder / red paper. Therefore, it was confirmed that the acidic action of the hull has an effect of promoting the healing effect of peptic ulcer. This supports that there are synergistic and additive actions in ulceration of antacids and red sediments.

The composition according to the present invention should be adjusted according to the age, sex and condition of the patient, but in general, it is preferable to administer three times a day at 0.1 to 30 g per 60 kg body weight, and more preferably 1 to 10 g.

The present invention relates to oral preparations such as tablets, capsules, soft capsules, granules, pills, liquids for the treatment of peptic ulcers, which comprise a composition containing a powder, red coal paper and, optionally, a pill and a pharmaceutically acceptable excipient. To provide.

At this time, the oral preparation can be prepared by conventional pharmaceutical methods.

The present invention will be described in detail with reference to the following Examples, but the scope of the present invention is not limited to these Examples, and various modifications and variations are possible within the protection scope of the present invention described in the claims. It will be apparent to those of ordinary skill in the art.

Example 1 Preparation of Acid Extract

After purchasing the medicine from the Chinese medicine company (Cheongju, Wonchang Pharmacy), put it in an Erlenmeyer flask, pour enough distilled water and methanol 1: 1 mixture to immerse it and leave it at room temperature for 1 day, shaking it occasionally to extract the active ingredient, and then put it in an ultrasonic cleaner again. After sonication at 60 ° C. for 5 hours to allow the remaining active ingredient to be extracted better, the supernatant was taken and concentrated using a rotary evaporator.

Example 2 Preparation of Extract

In addition to Example 1 was prepared using a conventional herbal extract method. That is, decoction was performed for 2 hours and 30 minutes using an electronic bath (Daewoong Drug Bath DWP-3800T), the supernatant was taken into a centrifuge tube, and centrifuged at 5,000 rpm for 15 minutes to separate the supernatant from the lower layer.

The supernatant was concentrated using a rotary vacuum distillation, frozen in a freezer (deep freezer, -70 ℃) and dried using a lyophilizer. The lower layer was collected separately and evenly spread on a glass plate and dried using a vacuum dryer. These powders were each powdered using a motor grinder (Germany, Retsch), and then samples having a particle size of 75 μm or less were collected by using a chemical substance.

Test Example 1 Induction of Anhydrous Ethanol Ulcer

Acute gastric ulcer animal testing model was used to measure the damaged gastrointestinal epithelial regeneration effect of the composition including powder and red coal (Shay M., et al., Gastroenterology 26 , 906-913 (1954)).

The experimental animals were supplied with Sprague-Dawley male rats weighing 220 ± 5g from Samtaco (Gyeonggi-do, Osan), and were used for 3 days in an animal room that maintained constant temperature, humidity, and light. . During this period, feed and purified water were freely consumed, and the number of experimental animals was 6 per group.

One day before the start of the test, the diet and water supply were stopped and ulcers were induced by administering 1 ml / 250 g of absolute ethanol to the control and test groups. Ulcer index was measured by anesthetizing rats with ether, then removing stomach, injecting saline to remove gastric contents, and fixing the stomach by injecting 10% formalin.

Since the drug was administered for 3 days in this test (see Test Example 2), the test was started after establishing the suitability of the experimental animal model by confirming the presence of the ulcer 3 days after the ethanol administration in the control group (see FIG. 2A). .

<Test Example 2> Confirming the healing effect of peptic ulcer

To the composition according to the invention in the composition of Table 1 below.

Specifically, the powdered extract was prepared by mixing the powdered powder of the powdered extract prepared in accordance with the method of Example 1 and the red paper or shaved powder in the composition ratio of Table 1.

Gastric Ulcer Healing Effect after Pesticide, Red Paper, and Moist Mixture in Ethanol-induced Gastric Ulcer Administration group                                              Dose / Rat (250 g)  Ulcer Length (mm)  Treatment rate (%)  Control 68.00 ± 5.86  More + red earth  50mg + 50mg 46.88 ± 4.55 31.06  Potion + More  500mg + 50mg 25.50 ± 3.73 62.50  Potion + red earth  500mg + 50mg 11.67 ± 3.07 82.84  Potion + Redwood + More  500mg + 50mg + 50mg  5.25 ± 0.43 92.28

The composition was administered to test group rats inducing ulceration in Test Example 1 for 3 days (twice a day, 9 am and 6 pm).

The test result was measured and summed up the length of gastric ulcer site, and the treatment rate was calculated by the following equation.

Treatment Rate (%) = [(Control Ulcer Length-Test Ulcer Length) / Control Ulcer Length] x 100

As a result, as shown in Table 1, the treatment rate was generally high when the drug is put in the four administration groups, and when there is no powder, the treatment rate was 31.06%. In addition, when the medicinal herb was basically used and red paper was used, the treatment rate tended to increase. Therefore, in the case of the present invention, it was found that the powder and red rock are essential elements for ulcer fusion.

On the other hand, when the medicinal herb and red sediment were combined with antacid and local acidic treatment, the treatment rate was 92.28%, which was a fairly good treatment rate, which was about 10% higher than that without the combination. Reference).

In addition, these union states did not open the ulcer surface during visual observation, and when observed through the tissue cross-sectional view, it was observed that the tissue became more dense than before administration (see FIG. 3B).

<Test Example 3> Confirming the healing effect of peptic ulcer

In the present invention, in consideration of the fact that Chinese medicine is usually taken in the form of a decoction, using the same method as in Example 2, after extracting the conventional medicine to examine the healing effect of the gastric ulcer of the powder prepared by drying the supernatant and the lower layer.

At this time, the water-soluble fraction and the water-insoluble fraction were obtained in 1: 3 to prepare a composition with the composition as shown in Table 2 and then confirmed the healing effect of peptic ulcer by the same method as in Test Example 2.

Gastric Ulcer Healing Effect after Ethanol-Induced Gastric Ulcer Mixture Administration group                                              Dose / Rat (250 g)  Ulcer Length (mm)  Treatment rate (%)  Control 68.00 ± 5.86  Upper layer + red ground  50mg + 50mg 0.975 ± 0.67 98.57  Lower layer + red earth  150mg + 50mg 0.750 ± 0.17 98.89

As a result, as shown in Table 2, in the case of the upper layer administration, 50 mg, which is a dose of 1/10 of Example 1, was administered, but the treatment rate was rather high, and the lower layer also showed a high treatment rate. However, in this case, the treatment rate was high in both cases, so there was no discrimination on whether the active ingredient was ubiquitous in the upper and lower layers, but it is considered that the active ingredient contained in both the water-soluble and water-insoluble components.

Test Example 4 In vitro Antacid Test

This experiment is an in vitro test to see how much acid can be removed per unit time. In this case, 50 ml of 0.1 N-HCl is added 0.5 g or 1.0 g and 2 ml of 1 N-HCl is added every 10 minutes. While measuring the pH will show the change in pH over time. The addition of 2 ml of 1N-HCl added twice the amount of HCl secreted continuously by the stomach. This process was performed until the pH reached 1.8.

The results are shown in FIG. 1, and when 1 g of fertilizer was added, the pH was maintained for 5 hours or more. Therefore, the antacid's antacid ability was found to be extremely good.

Test Example 5 Inhibition of Gastric Acid Secretion in Vivo

This experiment is a modification of the Shay method, and the ligation of the pyloric part of Sprague-Dawley rats is used to measure the inhibitory effect of basal gastric acid secretion by the test substance (Shay M., et al., Gastroenterology 26 , 906-913 (1954).

To collect gastric juice, 6 rats fasted for 24 hours were grouped into 1 group, and then opened under ether anesthesia and ligation of the pyloric glands. (50 mg dose in 250 g rats) orally administered, positive control (omeprazole) was injected into the duodenum at a dose of 20 mg / kg (5 mg dose in 250 g rats) and the abdomen was closed again.

Fasting after ligation, anesthetized with ether after 5 hours in a state of saving water, and lethal. The abdominal cavity was excised to remove the stomach, and the gastric juice was collected and centrifuged at 5,000 rpm for 10 minutes at 4 ° C. to remove precipitates, and then the amount of supernatant, pH, total acidity, and pepsin activity were measured.

The total acidity was measured by neutralizing titration with 1 ml of gastric juice and neutralizing with 0.01 N-NaOH solution, and the total acidity (μEq / ml) was measured. The relative value was calculated by the following Equation 2.

Inhibition degree = (control value-test substance value) / (control value-omeprazole value)

Pepsin activity in gastric juice was measured by the method of Okabe (Okabe S., et al., J. Dig. Dis ., 22, 671-684 (1977)), wherein the activity of pepsin was determined by tyrosine liberated in 30 min culture. (tyrosine) concentration. First, 0.9 ml of saline was added to 0.1 ml of gastric juice, and 1 ml of 1% bovine serum albumine (BSA, Sigma) solution dissolved in Sorensen buffer was added and reacted at 37 ° C. for 30 minutes. . Next, 1 ml of 0.4 M trichloroacetic acid was added to stop the reaction, and then centrifuged at 5000 rpm for 10 minutes. 1 ml of this supernatant was added, and 5 ml of 0.5 M Na ₂ CO ₃ and 0.5 ml of a 3-fold dilution of Folin reagent (Solinyo, Japan) were observed for color reaction at 660 nm. The standard curve was prepared by dissolving tyrosine in 0.4M TCA by concentration and measuring the absorbance in the same manner as described above.

In this experiment, the weight of 250g ± 5g rats suspended in distilled water at a concentration of 50mg / ml to administer 0.5ml and the pH, total acidity and pepsin activity of gastric juice after 5 hours was measured as shown in Table 3.

Measurement of gastric acid secretion inhibitory effect Aid Dosage Gastric juice volume (ml) pH Total acidity (μEq / hr) Pepsin Activity (mM / hrml) Control  Distilled water 1.78 ± 0.30  3.42 ± 0.43  31.78 ± 6.94  11.61 ± 1.77 More  25 mg / horse 1.33 ± 0.15  5.39 ± 0.24  14.09 ± 2.20  12.49 ± 2.19 Omeprazole  5 mg / horse 1.52 ± 0.16  5.44 ± 0.27  14.72 ± 2.33  12.58 ± 0.51

In other words, the amount of gastric juice secretion was slightly decreased compared to the control group by administration of 25 mg, pH was increased by 1.9, and total acidity was decreased by 44.34%, whereas pepsin activity was maintained. It showed the potential as an ideal antacid and acid antacid. In addition, these results showed a similar tendency as the administration of omeprazole 5mg, showing an inhibition degree of 1.04.

Experimental Example 6 Induction of Hydrochloric Acid-Anhydrous Ethanol Ulcer

This experiment is an animal model using the Okabe method (Hara N., et al., Folia . Pharmacol . Jap . 85, 443-1446 (1985)), which causes damage to the stomach wall by the direct administration of free hydrochloric acid. Experimental methods can be used to estimate the increase in mucus secretion and the presence of defensive factors for hydrochloric acid. That is, it may be a method for evaluating the antacid and fatty acid efficacy of the seed or the gastric mucosa protective effect of the mucus component in the powder.

The experimental animals were supplied from Samtaco (Gyeonggi-do and Osan) with Sprag-Dauri male rats weighing 220 ± 5g and used for three days in an animal room that maintained constant temperature, humidity, and light. And purified water. The number of test animals was 6 per group. First, oral administration of the sample, and after 30 minutes oral administration of 1 ml of hydrochloric acid-ethanol solution (containing 150 mM HCl in 60% ethanol), the rats were anesthetized with ether after 1 day. After the extraction, 10% formalin injection, the stomach was fixed, and the Taiwanese section was dissected to confirm the presence of ulcers in the control group.

In this experiment, the ethanol-induced ulcers of Test Example 1 showed good ulcer healing effect when co-administered with red paper and powder, and in addition, the anti-acid effect was excellent in in vitro test and the gastric acid secretion inhibitory effect was also excellent in in vivo test. Since 25 mg of red tide and palm were used in combination with 25 mg of the upper part of the powdered powder prepared in Example 2, that is, ulcer after administration twice a day, that is, 9 hours 1 hour before the incidence of ulceration and 6 hours after 8 hours of induction. The healing effect was measured. As described above, the reason why the ulcer induction was 1 hour before the administration time was expected from the test example 5, and the anti-gastric mucosa protective effect as the anti-acid agent was expected. And it was set to expect the gastrointestinal epithelial cell regeneration effect of red tide paper.

The results are shown in Table 4 below.

Gastric Ulcer Healing Effect after Pesticide, Red Paper, and Moist Mixture in Ethanol-induced Gastric Ulcer Administration group Dose / Marine Ulcer Length (mm) Treatment rate (%) Control Purified water 51.20 ± 10.44 Pesticide + Red Rock + Morning 25mg each 10.89 ± 2.45 78.73 Cimetidine 5mg 27.97 ± 4.57 45.37

The ulcer index was 10.89 ± 2.45 mm with 78.73% ulcer healing rate. In addition, it showed a 1.74 times higher healing rate than the positive control cimetidine (1/5 administration).

<Test Example 7> Induction of ulcer by cysteamine and confirmation of ulcer healing effect

This experiment was conducted 1 hour prior to the administration of cysteamine in rats fasted for 24 hours in a duodenal ulcer-induced animal test model by the method of Selye H. and Szabo S. Nature 244, 458-459 (1973). (See Table 5) was orally administered, followed by subcutaneous injection of 400 μl (16 mg / 100 g) of 10% aqueous solution of cysteamine. After 4 hours, the same dose of cysteamine was injected subcutaneously, and after 4 hours, the test drug was administered once more.

24 hours after the first administration of cysteamine, rats were anesthetized with ether, lethal, abdominal incisions were taken out of the stomach and duodenum, and then fixed with 5% injection of 10% formalin for 5 minutes. It was. The stomach was incision along the Taiwan site and the duodenum was incision along the anterior wall.

The experimental results were measured by using Scion (Scion Image for Windows, Release Beta 4.0.2), a computer software developed by the National Institutes of Health, USA (Khan HA, J. Pharmacol . & Toxicol . Methods 49, 89-95 (2004)). This method scans the gastrointestinal tract directly with a scanner, computerizes the ulcer area, converts it into pixels, calculates the area, and scans a known area to create a calibration curve and convert it to the actual ulcer area. The advantage of measuring the area of ulceration using this program is that it is convenient for calculating the area of ulcers in the form of ulcers spread around, rather than simple linear ulcers, such as those caused by hydrochloric acid-filled ulcers or indomethacin. There is this.

Figures 4a and 5a is a picture of the stomach and duodenum of the control group scanned with a direct scanner (HP L-6000) of the rat gastric and duodenum induced by cysteamine, Figures 4b and 5b are powder, red tallow and Photographs of the drug group when gastric and duodenal ulcers were healed by molar administration. At this time, the scan condition of the stomach was 120 for brightness and 130 for contrast, and 120 and 150 for duodenum, respectively, so as to be optimal for calculating the ulcer area using Scion. In addition, when using Scion, the subtract for subtracting parts other than the ulcer was 125 for both gastric and duodenal ulcers.

Gastric Ulcer Index Induced by Cysteamine and Healing Effect of Gastric Ulcer, Red Chloride and Moist Mixture Administration group                                              Dose / Marine Ulcer length (mm ² )  Treatment rate (%)  Control  Purified water 54.15 ± 10.94  Potion + Redwood + Mortar  25mg each 9.72 ± 4.13 82.05%

Hepatic Duodenal Ulcer Index Induced by Cysteamine and Healing Effect of Duodenal Ulcer after Administration of Pesticide, Red Paper, and Shaft Administration group                                              Dose / Marine Ulcer length (mm ² )  Treatment rate (%)  Control 27.47 ± 11.71  Potion + Redwood + Mortar  25mg each 15.91 ± 3.92 42.08%

Tables 5 and 6 show values of the ulcer areas of FIGS. 4 and 5 using Scion. In the case of 2 mg / day of each dose of powder, red tide and seed, the treatment rate of gastric ulcer was 82.05% higher than that of the control group. In the case of duodenal ulcer, the treatment rate was 42.08%.

As described above, the composition according to the present invention has the effect of reducing the area of peptic ulcer by containing red paper in addition to the acid and optionally having more moles, thereby quickly removing excess acid in the gastrointestinal tract. It can be usefully used as a gastrointestinal protector and gastroduodenal ulcer drug.

Claims (6)

Composition for the treatment of peptic ulcer containing 5 to 50 parts by weight of the extract powder and 1 to 50 parts by weight of red coal paper. A composition for treating peptic ulcer containing 5 to 50 parts by weight of an extract of powder, 1 to 25 parts by weight of red paper, and 1 to 25 parts by weight. The method according to claim 1 or 2, The acid extract is a composition for treating peptic ulcer, characterized in that extracted with water, C1 ~ C4 lower alcohol or a mixed solvent thereof. An oral preparation for treating peptic ulcer, comprising a composition for treating peptic ulcer containing 5 to 50 parts by weight of a powder of a powder of the extract and 1 to 50 parts by weight of red coal paper, and comprising a pharmaceutically acceptable excipient. An oral preparation for treating peptic ulcers, comprising a composition for treating peptic ulcers containing 5 to 50 parts by weight of a powder extract, 1 to 50 parts by weight of red paper and 1 to 25 parts by weight, and a pharmaceutically acceptable excipient. The oral preparation according to claim 4 or 5 in the form of tablets, capsules, soft capsules, pills, granules, gels, suspensions or solutions.

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