KR100638536B1 - Preparation for hair and/or scalp - Google Patents

Abstract

The present invention provides a preparation for hair and/or scalp which is effective in growing hair and preventing hair removal and has an excellent skin-care effect on the scalp and high safety. The preparation comprises, as active ingredients, either oxidized coenzyme Q and reduced coenzyme Q or reduced coenzyme Q alone, the total content of oxidized coenzyme Q and reduced coenzyme Q being 0.0001 to 99% by weight based on the whole of the preparation.

Description

Composition for Hair and / or Scalp {PREPARATION FOR HAIR AND / OR SCALP}

The present invention relates to a composition for hair and / or scalp.

In the past, numerous hair cosmetics, medicines and quasi-drugs have been created which are used for the purpose of hair growth and / or wool. The general hair growth tonic composition is a hair growth ingredient that penetrates into the hair roots, expands blood vessels, promotes blood circulation, and stimulates hair papilla to promote hair growth, feeling of freshness. And a component that exhibits a bactericidal action, and a component that prevents dandruff and itching. More specifically, numerous hair growth tonics include minoxidil, female hormones, vitamin E, pantothenic acid, capsicum tincture, ginger tuncture, sialid extract, and separan as hair growth ingredients. Tin and photosensitive elements; Ethanol as a component that provides a refreshing feeling and has a bactericidal action; As resorcin, salicylic acid and zinc pyrithione as ingredients to prevent dandruff; And antihistamine as a component for preventing itching.

However, sufficient hair growth effects cannot be obtained by the conventional hair growth components described above, and in some cases, these components have an unwanted effect on the user. Therefore, the method of use must be strictly controlled.

Coenzyme Q is an essential component distributed in a wide range of living organisms, from bacteria to mammals, and is known as a component of the electron transport system of cellular mitochondria in vivo. Coenzyme Q is also known to perform an oxidation / reduction cycle in the mitochondria and to function as an electron carrier in the electron transport system, with reduced coenzyme Q mainly having antioxidant activity. Human coenzyme Q mainly consists of coenzyme Q ₁₀ having 10 repeating structures in the side chain, and about 40% to 90% of the coenzyme Q present in vivo is generally in reduced form. Examples of physiological functions of coenzyme Q include activation of energy production through activating the action of mitochondria, activation of cardiopulmonary function, stabilization of cell membranes, protection of cells through antioxidant activity, and the like.

Because coenzyme Q exhibits a variety of these physiological actions and is highly stable as a biological component, its use in a variety of applications is known. For example, oxidized coenzyme Q ₁₀ is being used as a drug for congestive heart failure. In addition to medicinal uses, coenzyme Q increases mitochondrial activity, so it has been used as a nutritional supplement or nutritional supplement such as vitamins. However, its activity as a hair growth tonic is not yet known. Although Japanese Laid-Open Patent Publication No. 59-13710 discloses the effect of preventing hair loss by the oxidized coenzyme Q ₁₀ , this effect is unclear due to the absence of examples of practical use. Further, the reduction is Q ₁₀ Coen characters being Although compounds exhibiting antioxidant activity an important function of the Q _10, action on the hairs of the reduced form coenzyme Q ₁₀ is not known.

Summary of the Invention

An object of the present invention is to provide a composition having high stability that is excellent for hair growth, wool, hair loss prevention, and scalp skin care.

As a result of research to overcome the above problems, the present inventors have found that oxidized coenzyme Q ₁₀ and reduced coenzyme Q ₁₀ have activity on hair growth, wool, hair loss prevention and two skin care.

The composition for hair and / or scalp of the present invention includes, as an active ingredient, an oxidized coenzyme Q represented by the following Chemical Formula 1 and a reduced coenzyme Q represented by the following Chemical Formula 2, or a reduced coenzyme Q represented by the following Chemical Formula 2; Contains:

Wherein n is an integer from 1 to 12

Wherein n is an integer from 1 to 12.

Here, the total content of oxidized coenzyme Q and reduced coenzyme Q is 0.0001 wt% to 99 wt% with respect to the whole composition.

In the present invention, "hair and / or scalp composition" means a composition used for the prescription of hair and / or scalp. In particular, the composition can be used for hair growth, wool, hair loss prevention, and scalp skincare.

The present invention also provides a method of prescribing hair and / or scalp comprising applying the hair and / or scalp composition to the hair and / or scalp. The prescription method may be performed for hair growth, wool, hair loss prevention and / or scalp skin care. This method can be applied to humans or animals.

Detailed description of the invention

The invention will be explained in detail below.

The compound represented by Formula 1 is an oxidized coenzyme Q, and the compound represented by Formula 2 is a reduced coenzyme Q.

The method of obtaining the oxidized coenzyme Q and the reduced coenzyme Q is not limited, but for example, coenzyme Q is obtained by conventionally known methods such as synthesis, fermentation, extraction from natural raw materials, and then oxidized coenzyme Q A method comprising concentrating the fraction or reduced coenzyme Q fraction from the chromatography eluate can be used. When the oxidized coenzyme Q is obtained, it can be obtained by a known method. In order to obtain reduced coenzyme Q, if necessary, to reduce the oxidized coenzyme Q contained in the coenzyme Q to the reduced coenzyme Q by conventional methods, a general reducing agent such as sodium borohydride, sodium dithionite (sodium Hydrosulfite) and the like can be added to coenzyme Q, and the reduced coenzyme Q obtained can then be concentrated by chromatography. In addition, reduced coenzyme Q can be obtained by applying a reducing agent to the high purity coenzyme Q present.

Although the method for obtaining the composition of the present invention is not limited, for example, the composition may be prepared by mixing the obtained reduced coenzyme Q with commercially available or known oxidation coenzyme Q obtained, or It can be obtained by dissolving the reduced coenzyme Q and the oxidized coenzyme Q separately in a suitable substrate. As a base material, the base material generally used for a medicine, cosmetics, etc. can be used as needed in the range which does not cause the deterioration of the effect of this invention.

As the oxidized coenzyme Q and the reduced coenzyme Q used in the present invention, coenzyme Q having 1 to 12 side chain repeating units (n in each formula) may be used, as shown in formulas (1) and (2). In particular, coenzyme Q having 10 side chain repeating units, that is, oxidized coenzyme Q ₁₀ and reduced coenzyme Q ₁₀ can be preferably used.

In the present invention, the above-mentioned necessary components and optional components of the composition are mixed according to a conventional method to tonics, lotions, treatments, creams, ointments, gels, shampoos, sprays (aerosols or mists), conditioners and the like. To form the same pharmaceutical or cosmetic formulation. Examples of application of the compositions include hair growth agents, wool agents, scalp preparations, hair dyes, shampoos, rinses, treatments, cosmetic ingredients, eyebrow pencils and the like. However, the application is not limited only to these formulations.

In addition to the oxidized coenzyme Q represented by the formula (1) and the reduced coenzyme Q represented by the formula (2), the composition of the present invention is a hair growth and / or wool active ingredient, for example minoxidil, pentadecanoic acid, pentadecanoic acid derivatives, hyaluronic acid Hair growth ingredients, such as chondroitin sulfate, proanthocyanidins, sphingoglycolipids, plant extracts, natural herbs or extracts thereof; Blood circulation promoters such as sialid extract, garlic extract, ceparantin, capronium chloride, acetylcholine and the like; Local stimulants such as pepper tincture, cantharis tincture, ginger tincture, nonyl acid vanylamide and the like; Keratolytic such as salicylic acid, resorcin, lactic acid, and the like; Metabolic activators such as placental extract, pentadecanoic acid glycerides, pantothenic acid, pantothenyl ethyl ether, biotin, hinokthiol, allantoin and the like; Anti-inflammatory agents such as glycyrrhizinic acid, glycyrrhetinic acid and the like; Fungicides such as isopropyl methyl phenol, triclosan, zinc pyrithione, hinokithiol and the like; And refreshing agents such as menthol, camphor and the like; And female hormones.

Among these ingredients, preferred hair growth and / or wool active ingredients are minoxidil, pentadecanoic acid, pentadecanoic acid derivatives, female hormones, pantothenic acid, capsicum tincture, ginger tincture, sialid extract, separanthin, hyaluronic acid, chondroitin sulfonate Pate, proanthocyanidins, sphingoglycolipids, capronium chloride, plant extracts, natural medicines and extracts thereof, and mixtures of these components.

The compositions of the present invention can be used for the purpose of hair and / or wool as well as for the purpose of makeup or scalp skincare. In this case, the composition of the present invention is preferably a cosmetic compound and / or raw material, or a skincare compound and / or raw material, in addition to the oxidized coenzyme Q represented by the formula (1) and the reduced coenzyme Q represented by the formula (2). It contains. The compound and / or raw material is not limited. Examples of the compounds and / or raw materials include alcohols, polyhydric alcohols, water soluble polymers, antioxidants, pH adjusters, sunscreen agents, metal ion blocking agents, thickeners, surfactants, purified water, flavorings, sterilizers, fungicides, higher fatty acids, fatty acids Cosmetic ingredients such as esters, fresheners, preservatives, antifoams, colorants, pigments with coloring action, emulsifiers, softeners, humectants and / or humectants, oils, waxes, and foam stabilizers, electrolytes, organic solvents, silicone derivatives, and the like, Animal and plant extracts such as natural drugs such as hormones, vitamins, amino acids, astringents and placental extracts, elastin, collagen, mucopolysaccharides, aloe extracts, gourd water, royal jelly, homegrown Tree, Carrot Extract, Chamomile Extract, Glycyrrhiza Extract, Salvia Extract, Althea Extract, Nosebleed Extract And the like.

The compositions of the present invention can be applied to humans or animals such as pets, farm animals, birds and the like. As pets, dogs and / or cats are preferred.

In the composition of the present invention, the total content of oxidized coenzyme Q and reduced coenzyme Q (when the composition contains only reduced coenzyme Q only, the content of reduced coenzyme Q relative to the whole composition) is 0.0001 with respect to the whole composition. Wt% to 99 wt%, preferably 0.05 wt% to 50 wt%, more preferably 0.01 wt% to 30 wt%.

 When the composition of the present invention contains both the oxidized coenzyme Q and the reduced coenzyme Q, the content of the reduced coenzyme Q is preferably greater than 20% by weight relative to the total of the oxidized coenzyme Q and the reduced coenzyme Q, More preferably, it is 40 weight% or more. The upper limit of the content may be 100% by weight or less, preferably less than 100% by weight, more preferably 98% by weight or less.

Although the present invention will be described in more detail with reference to Examples and Preparation Examples, the present invention is not limited to these Examples and Preparation Examples.

(Example 1)

Carefully shaved each back of 7-week-old male C3H mice whose hair growth cycle was the telogen period, and then tested a group of seven mice each having no back wound. In the control group, only polyethylene glycol 1000 (PEG1000) used as a substrate was applied to each mouse, whereas in the evaluation group, 10% oxidized coenzyme Q ₁₀ or 10% reduced coenzyme Q ₁₀ (reduced Q ₁₀ : oxidized Q ₁₀ = 95). : 5) was applied to shaved area once a day (total 14 times). After application, the back of each mouse was evaluated based on the following score for assessing the hair growth activity of the compound.

Score:

One; The skin was pink.

2; Less than 30% of the shaved area became gray.

3; Less than 60% of the shaved area was discolored in gray or hair growth was observed in less than 30% of the shaved area.

4; More than 60% of the shaved area was discolored in gray or hair growth was observed in less than 60% of the shaved area.

5. Hair growth was observed in at least 60% of the shaved area.

The results are shown in Table 1 below.

Wool Score in C3H Mice (n = 7) Before application After application Control 1.0 ± 0.00 1.4 ± 0.19 Oxidized coenzyme Q ₁₀ group 1.0 ± 0.00 2.7 ± 0.35 Reduced coenzyme Q ₁₀ group 1.0 ± 0.00 3.2 ± 0.64  Mean ± S.D.

The score was increased by applying oxidized coenzyme Q ₁₀ , and hair growth activity was observed. Higher hair growth activity was also observed in reduced coenzyme Q ₁₀ . These results indicate that coenzyme Q ₁₀ has hair growth activity.

(Example 2)

To assess hair loss prevention activity, 4 week old male hairless rats of the pilose period were used. The same sample as used in Example 1 was used. In each group of four hairless rats, each sample was applied to the back of each rat once a day for 12 days, then the application was terminated and the hair loss status was observed. The hair loss state was observed based on the following score.

Score:

One; Hair loss was not observed.

2; The hair shortened in 30% or less of the application area.

3; Hair shortened in up to 60% of the area of application and hair loss was observed in up to 30% of the area of application.

4; Hair shortened in at least 60% of the area of application and hair loss was observed in at least 30% of the area of application.

5; Hair loss was observed in at least 60% of the area of application.

Table 2 shows the results on day 71 after the completion of the application.

Hair Loss Score for Hairless Rats (n = 5) Before application 71 days later Control 1.0 ± 0.00 4.6 ± 0.55 Oxidized coenzyme Q ₁₀ group 1.0 ± 0.00 3.6 ± 0.24 Reduced coenzyme Q ₁₀ group 1.0 ± 0.00 3.0 ± 0.71   Mean ± S.D.

It has been confirmed that oxidized coenzyme Q ₁₀ or reduced coenzyme Q ₁₀ has hair loss prevention activity. The activity, as compared with oxidized coenzyme Q _10, was remarkable from the reduced form coenzyme Q _10. In addition, drying was observed in the control group at the time of observing the skin condition of each hairless rat. In the group to which coenzyme Q was applied to rats, the skin remained in a less dry good condition, and a health care effect on the skin was observed.

(Manufacture example 1)

According to a known method, hair tonics containing coenzyme Q ₁₀ were prepared using the following composition.

Olive oil 5.0 wt%

Isopropyl myristate 2.0 wt%

Isopropyl methyl phenol 0.1 wt%

Ethanol 55.0 wt%

Glycerin 5.0 wt%

Methyl Paraben 0.1 wt%

1.0 wt% coenzyme Q ₁₀ (reduced form, 95 wt%; oxidized form, 5 wt%)

100.0 wt% of purified water                 

(Manufacture example 2)

According to the known method, oily hair tonic containing coenzyme Q ₁₀ was prepared using the following composition.

Olive oil 5.0 wt%

Isopropyl myristate 2.0 wt%

Isopropyl methyl phenol 0.1 wt%

60.0% by weight of polyoxyethylene nonylphenol

0.1% by weight of ethanol

Glycerin 5.0 wt%

Methyl Paraben 0.1 wt%

1.0 wt% coenzyme Q ₁₀ (reduced form, 95 wt%; oxidized form, 5 wt%)

100.0 wt% of purified water

(Manufacture example 3)

According to a known method, a hair cream containing coenzyme Q ₁₀ was prepared using the following composition.

Glyceryl Monostearate 1.5% by weight

10.0% by weight of liquid parabens

1.5% by weight of solid parabens

Dimethyl Silicone 3.0 wt%                 

Cetyl Palmitate 2.0 wt%

Cetostearyl alcohol 4.0 wt%

Glycerin 12.0 wt%

1,3-butylene glycol 2.0% by weight

Carboxyvinyl Polymer 0.1 wt%

Xanthan Gum 0.1 wt%

Propyl Paraben 0.1 wt%

Methyl Paraben 0.4 wt%

1.0 wt% coenzyme Q ₁₀ (reduced form, 95 wt%; oxidized form, 5 wt%)

100.0 wt% of purified water

(Manufacture example 4)

According to a known method, hair growth tonics containing coenzyme Q ₁₀ were prepared using the following composition.

Pentadecanoic acid monoglycerides 2.5% by weight

Sorbitan monolaurate 3.0 wt%

Ethyl oleate 2.5 wt%

Yukaformer 201 0.1 wt%

Ethanol 10.0 wt%

1.0 wt% coenzyme Q ₁₀ (reduced form, 95 wt%; oxidized form 5, wt%)

100.0 wt% of purified water

(Manufacture example 5)

According to a known method, a shampoo containing coenzyme Q ₁₀ was prepared using the following composition.

Triethanolamine lauryl sulfate 8.0% by weight

Palm oil fatty acid diethanolamide 3.0 wt%

Ethylene Glycol Monostearate 2.0 wt%

1.0 wt% coenzyme Q ₁₀ (reduced form, 95 wt%; oxidized form, 5 wt%)

100.0 wt% of purified water

(Manufacture example 6)

According to a known method, a rinse containing coenzyme Q ₁₀ was prepared using the following composition.

Isostearyl myristate 1.0 wt%

Stearyl Trimethylammonium Chloride 1.0 wt%

Stearyl Alcohol 3.0 wt%

1.0% by weight of polyoxyethylene cured castor oil

Propylene Glycol 5.0 wt%

1.0 wt% coenzyme Q ₁₀ (reduced form, 95 wt%; oxidized form, 5 wt%)

100.0 wt% of purified water

The composition of the present invention having the above-described composition has excellent activity on the prevention of wool and hair loss, and has an excellent effect on health care of the scalp.

Claims (11)

As an active ingredient, it contains the oxidized coenzyme Q represented by the following formula (1) and the reduced coenzyme Q represented by the following formula (2), or the reduced coenzyme Q represented by the following formula (2), for hair, scalp, or hair and scalp Composition for: [Formula 1]

(Wherein n is an integer from 1 to 12); [Formula 2]

(Wherein n is an integer from 1 to 12); [Herein, the total content of oxidized coenzyme Q and reduced coenzyme Q is 0.0001% to 99% by weight based on the whole composition, and when the composition contains oxidized coenzyme Q and reduced coenzyme Q as an active ingredient, The amount of reduced coenzyme Q relative to the total coenzyme Q is greater than 20% by weight, or when the composition contains only reduced coenzyme Q as the active ingredient, the content of reduced coenzyme Q is 0.0001% to 99% by weight based on the total composition. % to be]. 2. Hair, scalp, or hair and scalp according to claim 1, wherein the oxidized coenzyme Q represented by the formula (1) is an oxidized coenzyme Q ₁₀ and the reduced coenzyme Q represented by the formula (2) is a reduced coenzyme Q ₁₀ . Composition. delete delete The hair, scalp, or hair and scalp composition according to claim 1 or 2, wherein the composition is used for the purpose of cosmetic or scalp skincare. delete The composition of claim 1 or 2, wherein the formulation of the composition is a lotion, spray, hair tonic, cream, shampoo, rinse, hair conditioner, hair dye or eyebrow pencil. The composition for hair, scalp, or hair and scalp according to claim 1 or 2, which is applied to humans. The composition for hair, scalp, or hair and scalp according to claim 1 or 2, which is applied to an animal. 10. Hair, scalp, or hair and scalp compositions according to claim 9, applied to dogs, cats, or dogs and cats. delete