KR100565883B1 - 응고 및 종양 치료용 조직 인자 방법 및 조성물 - Google Patents

응고 및 종양 치료용 조직 인자 방법 및 조성물 Download PDF

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KR100565883B1
KR100565883B1 KR1019997006622A KR19997006622A KR100565883B1 KR 100565883 B1 KR100565883 B1 KR 100565883B1 KR 1019997006622 A KR1019997006622 A KR 1019997006622A KR 19997006622 A KR19997006622 A KR 19997006622A KR 100565883 B1 KR100565883 B1 KR 100565883B1
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coagulation
tumor
tissue factor
composition
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KR1019997006622A
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Korean (ko)
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KR20000070389A (ko
Inventor
쏘프필립이
킹스티븐더블유
가오보닝
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보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6435—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a connective tissue peptide, e.g. collagen, fibronectin or gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
KR1019997006622A 1997-01-22 1998-01-20 응고 및 종양 치료용 조직 인자 방법 및 조성물 Expired - Fee Related KR100565883B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US3592097P 1997-01-22 1997-01-22
US3620597P 1997-01-27 1997-01-27
US4242797P 1997-03-27 1997-03-27
US60/035,920 1997-03-27
US60/036,205 1997-03-27
US60/042,427 1997-03-27
PCT/US1998/001012 WO1998031394A2 (en) 1997-01-22 1998-01-20 Tissue factor methods and compositions for coagulation and tumor treatment

Publications (2)

Publication Number Publication Date
KR20000070389A KR20000070389A (ko) 2000-11-25
KR100565883B1 true KR100565883B1 (ko) 2006-03-31

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KR1019997006622A Expired - Fee Related KR100565883B1 (ko) 1997-01-22 1998-01-20 응고 및 종양 치료용 조직 인자 방법 및 조성물

Country Status (17)

Country Link
US (5) US6132730A (enExample)
EP (1) EP0988056B1 (enExample)
JP (1) JP2002514201A (enExample)
KR (1) KR100565883B1 (enExample)
CN (1) CN100333796C (enExample)
AT (1) ATE244579T1 (enExample)
AU (1) AU735187C (enExample)
BR (1) BR9806793A (enExample)
CA (1) CA2278106C (enExample)
CY (1) CY2416B1 (enExample)
DE (1) DE69816297T9 (enExample)
ES (1) ES2197458T3 (enExample)
IL (1) IL130908A0 (enExample)
NO (1) NO323702B1 (enExample)
NZ (1) NZ336720A (enExample)
PT (1) PT988056E (enExample)
WO (1) WO1998031394A2 (enExample)

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AU735187B2 (en) 2001-07-05
CA2278106A1 (en) 1998-07-23
NO323702B1 (no) 2007-06-25
AU735187C (en) 2002-04-18
ES2197458T3 (es) 2004-01-01
NO993567L (no) 1999-09-21
US6132729A (en) 2000-10-17
PT988056E (pt) 2003-09-30
US6156321A (en) 2000-12-05
DE69816297T2 (de) 2003-12-24
EP0988056A2 (en) 2000-03-29
IL130908A0 (en) 2001-01-28
BR9806793A (pt) 2000-05-16
CY2416B1 (en) 2004-11-12
WO1998031394A3 (en) 1998-09-17
EP0988056B1 (en) 2003-07-09
US6132730A (en) 2000-10-17
WO1998031394A2 (en) 1998-07-23
DE69816297T9 (de) 2004-09-09
CN1251532A (zh) 2000-04-26
AU5924398A (en) 1998-08-07
ATE244579T1 (de) 2003-07-15
US20030232753A1 (en) 2003-12-18
US7101557B2 (en) 2006-09-05
NO993567D0 (no) 1999-07-21
KR20000070389A (ko) 2000-11-25
CN100333796C (zh) 2007-08-29
US7951356B1 (en) 2011-05-31
DE69816297D1 (de) 2003-08-14
CA2278106C (en) 2005-04-12
JP2002514201A (ja) 2002-05-14

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