KR100517090B1 - 서방형 제약 조성물 및 제약 활성제의 방출 방법 - Google Patents
서방형 제약 조성물 및 제약 활성제의 방출 방법 Download PDFInfo
- Publication number
- KR100517090B1 KR100517090B1 KR10-2001-7004708A KR20017004708A KR100517090B1 KR 100517090 B1 KR100517090 B1 KR 100517090B1 KR 20017004708 A KR20017004708 A KR 20017004708A KR 100517090 B1 KR100517090 B1 KR 100517090B1
- Authority
- KR
- South Korea
- Prior art keywords
- pharmaceutical composition
- hydrophilic polymer
- weight
- nonionic hydrophilic
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 44
- 239000012730 sustained-release form Substances 0.000 title claims abstract description 15
- 238000013268 sustained release Methods 0.000 title claims abstract description 14
- 238000000034 method Methods 0.000 title claims description 14
- 239000013543 active substance Substances 0.000 title description 26
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract description 56
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- 229920001477 hydrophilic polymer Polymers 0.000 claims abstract description 29
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- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims abstract description 22
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims abstract description 22
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- ZGGHKIMDNBDHJB-NRFPMOEYSA-M (3R,5S)-fluvastatin sodium Chemical compound [Na+].C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C1C1=CC=C(F)C=C1 ZGGHKIMDNBDHJB-NRFPMOEYSA-M 0.000 claims description 23
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 20
- 229920003091 Methocel™ Polymers 0.000 claims description 17
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- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 11
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- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
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- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 2
- 101100504379 Mus musculus Gfral gene Proteins 0.000 description 2
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
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- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
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- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US17249198A | 1998-10-14 | 1998-10-14 | |
| US09/172,491 | 1998-10-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20010080156A KR20010080156A (ko) | 2001-08-22 |
| KR100517090B1 true KR100517090B1 (ko) | 2005-09-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP (2) | JP2002527388A (enExample) |
| KR (1) | KR100517090B1 (enExample) |
| CN (1) | CN1196481C (enExample) |
| AR (2) | AR020780A1 (enExample) |
| AT (1) | ATE382345T1 (enExample) |
| AU (1) | AU765475B2 (enExample) |
| BR (1) | BR9911648A (enExample) |
| CA (1) | CA2346868C (enExample) |
| CO (1) | CO5140079A1 (enExample) |
| CY (1) | CY1107874T1 (enExample) |
| DE (1) | DE69937891T2 (enExample) |
| DK (1) | DK1121116T3 (enExample) |
| ES (1) | ES2297936T3 (enExample) |
| HK (1) | HK1040920B (enExample) |
| HU (1) | HUP0104268A3 (enExample) |
| ID (1) | ID29350A (enExample) |
| IL (2) | IL142375A0 (enExample) |
| MY (1) | MY121105A (enExample) |
| NO (1) | NO327285B1 (enExample) |
| NZ (1) | NZ511010A (enExample) |
| PE (1) | PE20001110A1 (enExample) |
| PL (1) | PL198850B1 (enExample) |
| PT (1) | PT1121116E (enExample) |
| RU (1) | RU2259826C2 (enExample) |
| SK (2) | SK286596B6 (enExample) |
| TR (1) | TR200101088T2 (enExample) |
| TW (1) | TW577738B (enExample) |
| WO (1) | WO2000021525A2 (enExample) |
| ZA (1) | ZA200103001B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6569461B1 (en) | 1999-03-08 | 2003-05-27 | Merck & Co., Inc. | Dihydroxy open-acid and salts of HMG-CoA reductase inhibitors |
| US6242003B1 (en) * | 2000-04-13 | 2001-06-05 | Novartis Ag | Organic compounds |
| DE60041281D1 (de) | 2000-06-09 | 2009-02-12 | Lek Pharmaceuticals | Stabilisiertes arzneimittel und arzneizubereitung |
| NZ524641A (en) * | 2000-09-29 | 2004-09-24 | Solvay Pharmaceuticals B | A pharmaceutical hydrophilic gel forming matrix formulation having prolonged release which is ion strength independent |
| US20060127474A1 (en) | 2001-04-11 | 2006-06-15 | Oskar Kalb | Pharmaceutical compositions comprising fluvastatin |
| EP1537880A4 (en) * | 2002-09-11 | 2009-07-01 | Takeda Pharmaceutical | Sustained release preparation |
| US20070042143A1 (en) | 2003-04-23 | 2007-02-22 | Ferring B.V. | Sachet for a pharmaceutical composition |
| US8987322B2 (en) | 2003-11-04 | 2015-03-24 | Circ Pharma Research And Development Limited | Pharmaceutical formulations for carrier-mediated transport statins and uses thereof |
| DE102004062475A1 (de) * | 2004-12-24 | 2006-07-06 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung |
| KR100582347B1 (ko) * | 2004-12-30 | 2006-05-22 | 한미약품 주식회사 | 3-하이드록시-3-메틸글루타릴 조효소 ａ 환원효소 억제제및 고혈압 치료제의 복합제제 및 그의 제조방법 |
| EP1940391A4 (en) * | 2005-08-05 | 2010-01-20 | Orbus Pharma Inc | STABILIZED PHARMACEUTICAL COMPOSITIONS WITH EXTENDED RELEASE WITH AN HMG COA REDUCTASE INHIBITOR |
| WO2007100822A2 (en) * | 2006-02-24 | 2007-09-07 | Teva Pharmaceutical Industries Ltd. | Fluvastatin sodium pharmaceutical compositions |
| RU2342144C1 (ru) * | 2007-04-05 | 2008-12-27 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Фармацевтический состав, обладающий противосудорожным и психотропным действием |
| RU2356532C2 (ru) * | 2007-06-01 | 2009-05-27 | Открытое Акционерное Общество "Отечественные Лекарства" | Фармацевтическая композиция проксодолола с контролируемым высвобождением |
| CN102805739B (zh) * | 2012-04-10 | 2013-08-14 | 宋芸 | 氟伐他汀钠缓释包衣滴丸及其制备方法 |
| RU2015128914A (ru) * | 2013-01-09 | 2017-02-14 | Эджмонт Фармасьютикалз Ллс | Составы лоразепама с контролируемым высвобождением |
| CN106344535B (zh) * | 2016-08-29 | 2019-09-20 | 济南康和医药科技有限公司 | 一种氟伐他汀钠微孔渗透泵控释片及其制备方法 |
| CN112236138B (zh) | 2017-12-05 | 2024-05-31 | 赛诺维信制药公司 | 晶体形式及其制备方法 |
| JP7268026B2 (ja) | 2017-12-05 | 2023-05-02 | サノビオン ファーマシューティカルズ インク | 非ラセミ混合物およびその使用 |
| JP7499259B2 (ja) | 2018-09-25 | 2024-06-13 | ポンス デ レオン ヘルス デジグネイテッド アクティビティ カンパニー | αケトグルタル酸カルシウムを製造するためのプロセス |
| EP3980009A4 (en) | 2019-06-04 | 2023-07-05 | Sunovion Pharmaceuticals Inc. | MODIFIED RELEASE FORMULATIONS AND ASSOCIATED USES |
| EP3980001B1 (en) * | 2019-06-10 | 2025-08-27 | Ponce de Leon Health Designated Activity Company | Sustained-release compositions of alpha-ketoglutarate |
Citations (1)
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| WO1998015264A1 (en) * | 1996-10-08 | 1998-04-16 | Astra Aktiebolag | PHARMACEUTICAL COMPOSITIONS FOR SUSTAINED RELEASE OF THE HMG-CoA REDUCTASE INHIBITOR FLUVASTATIN |
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|---|---|---|---|---|
| US4915954A (en) * | 1987-09-03 | 1990-04-10 | Alza Corporation | Dosage form for delivering a drug at two different rates |
| EP0465096A1 (en) * | 1990-06-26 | 1992-01-08 | Merck & Co. Inc. | Plasma cholesterol level lowering composition |
| ZA959221B (en) * | 1994-11-02 | 1997-04-30 | Janssen Pharmaceutica Nv | Cisapride extended release |
| IL118778A (en) * | 1995-07-03 | 1999-07-14 | Sankyo Co | Pharmaceutical compositions for the treatment of arteriosclerosis and xanthoma containing an hmg-coa reductase inhibitor |
| GB9523752D0 (en) * | 1995-11-21 | 1996-01-24 | Pfizer Ltd | Pharmaceutical formulations |
| HU227798B1 (en) * | 1995-12-22 | 2012-03-28 | Kowa Co | Pharmaceutical composition stabilized with a basic agent |
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1999
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- 1999-10-12 ID IDW20010807A patent/ID29350A/id unknown
- 1999-10-12 AR ARP990105146A patent/AR020780A1/es not_active Application Discontinuation
- 1999-10-12 DE DE69937891T patent/DE69937891T2/de not_active Expired - Lifetime
- 1999-10-12 AT AT99947489T patent/ATE382345T1/de active
- 1999-10-12 CN CNB998120812A patent/CN1196481C/zh not_active Expired - Lifetime
- 1999-10-12 SK SK509-2001A patent/SK286595B6/sk not_active IP Right Cessation
- 1999-10-12 WO PCT/EP1999/007627 patent/WO2000021525A2/en not_active Ceased
- 1999-10-12 HU HU0104268A patent/HUP0104268A3/hu not_active Application Discontinuation
- 1999-10-12 PT PT99947489T patent/PT1121116E/pt unknown
- 1999-10-12 RU RU2001111882/15A patent/RU2259826C2/ru active
- 1999-10-12 ES ES99947489T patent/ES2297936T3/es not_active Expired - Lifetime
- 1999-10-12 DK DK99947489T patent/DK1121116T3/da active
- 1999-10-12 PE PE1999001027A patent/PE20001110A1/es not_active IP Right Cessation
- 1999-10-12 CA CA002346868A patent/CA2346868C/en not_active Expired - Lifetime
- 1999-10-12 PL PL348109A patent/PL198850B1/pl unknown
- 1999-10-12 TR TR2001/01088T patent/TR200101088T2/xx unknown
- 1999-10-12 BR BR9911648-0A patent/BR9911648A/pt not_active Application Discontinuation
- 1999-10-12 EP EP99947489A patent/EP1121116B1/en not_active Revoked
- 1999-10-13 MY MYPI99004430A patent/MY121105A/en unknown
- 1999-10-14 TW TW088117692A patent/TW577738B/zh not_active IP Right Cessation
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2001
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- 2001-04-11 ZA ZA200103001A patent/ZA200103001B/en unknown
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2006
- 2006-08-14 JP JP2006221194A patent/JP4938383B2/ja not_active Expired - Fee Related
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2008
- 2008-02-04 CY CY20081100134T patent/CY1107874T1/el unknown
- 2008-11-11 AR ARP080104921A patent/AR069281A2/es not_active Application Discontinuation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998015264A1 (en) * | 1996-10-08 | 1998-04-16 | Astra Aktiebolag | PHARMACEUTICAL COMPOSITIONS FOR SUSTAINED RELEASE OF THE HMG-CoA REDUCTASE INHIBITOR FLUVASTATIN |
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