KR100491106B1 - health functional food with black fruits and vegetables, Manufacturing method thereof - Google Patents

Abstract

The present invention relates to a health functional food based on black fruit vegetables and a method of manufacturing the same. More specifically, the effects of cancer and aging prevention, ophthalmic disease prevention, and anti-oxidation improvement of black fruit vegetables are effective in preventing immunity, heart disease, and stroke. The present invention relates to a method for producing a food and health functional food, which is made from black fruits and vegetables as a main ingredient, and is added with grain powder and a thickener to improve nutrition and palatability.

The present invention is added to the black powdery vegetables, such as buckwheat, black rice, black soybeans, black sesame seeds and thickeners to the black fruit extracts obtained by hot water extraction of walnuts, stone parsley, 톳, mulberry, watermelon seeds, blueberry fruit, eggplant, etc. as black fruit The purpose of the present invention is to provide a health functional food and its manufacturing method that are easily portable and ingested by processing into various and uniform dosage forms.

The present invention comprises the steps of (1) extracting the harvested black fruit vegetables with hot water or ethanol at 90 ℃ or less, and then filtering and concentrating the extract,

(2) steaming and drying the grains and pulverizing them,

(3) mixing 45 to 55% by weight of the black fruit and vegetable extract concentrate of step (1), 52 to 44.5% by weight of grain powder of step (2) and 0.5 to 3% by weight of thickener.

Description

Health functional food with black fruits and vegetables, manufacturing method

The present invention relates to a health functional food based on black fruit vegetables and a method of manufacturing the same. More specifically, the effects of cancer and aging prevention, ophthalmic disease prevention, and anti-oxidation improvement of black fruit vegetables are effective in preventing immunity, heart disease, and stroke. The present invention relates to a dietary supplement and a method for producing the same, which are mainly composed of black fruits and vegetables, and the addition of grain powders and thickeners to improve nutritional properties and palatability.

Generally, fruits, edible fruits, fruit seeds, vegetables, vegetables, and seaweeds each have a unique color inside or outside thereof (hereinafter, fruit, edible fruits, fruit seeds, vegetables, vegetables, and seaweeds are collectively referred to as fruit and vegetable). .).

The present invention adds grain powder and thickener such as buckwheat, black rice, black bean, black sesame to black fruit vegetable extracts obtained by extracting hot water directly from scallop, stone parsley, 톳, mulberry, watermelon seed, blueberry fruit and eggplant as black fruit. The purpose of the present invention is to provide a health functional food and its manufacturing method that are easy to carry and consume by processing into a dosage form.

Black soybean, which is used as a healthy diet, is popular in almost all processed foods. Black soybeans have been used as a recipe from home and sansa since ancient times. Black soybean is known as a protein source as well as eye protection. have.

Black anthocyanins, such as black sesame seeds, black shiitake mushrooms, raisins, black seaweed, squid ink, eggplant, grapes and cherries, are known to be powerful antioxidants, reducing the risk of heart disease, stroke and enhancing immunity to cancer, adult diseases, It is known to prevent aging. Anthocyanins also have a pigment (rhodoxin) that senses light in the retina of the eye and delivers it to the brain, which is known to help regenerate it. Dr. Muraledaran Nair, of the University of Michigan, USA, found that anthocyanins in cherries are 10 times more anti-inflammatory than aspirin. Herbal black food is a food that protects the kidneys, warming the stomach and blood vessels, digestion, blood well, and stimulate the kidneys are known to have the effect of quickly discharging waste products in the body. Black beans help women with ovarian cancer, breast cancer, osteoporosis, hot flashes prevention and female hormones (estrogen). Black watermelon seed lowers cholesterol levels, dietary mushrooms and sour mushrooms improve energy and face color, and are good for preventing dysentery, diarrhea, high blood pressure, colitis and diabetes. Protein, fat, calcium, phosphorus, iron, sugar and vitamins are essential for the human body. It is known to contain blood evenly, and it is known to relieve anemia.

Among fruits and vegetables like apples, watermelons and grapes, the outside is red, but the inside is not red, there are also vegetables, such as tomatoes, peppers, bell peppers, strawberries, pomegranates, etc. As such, red fruits and vegetables have various functional components in themselves, and are known to have anti-cancer effects, cancer prevention such as colorectal cancer and breast cancer, arteriosclerosis, suppression of heart disease, delaying aging, and maintaining skin elasticity.

Among fruits and vegetables, carrots, pumpkins, tangerines, citron, lemons, sweet potatoes, peaches, apricots and persimmons are known as carotenoids. Carotenoids are yellow, orange, pigments widely distributed in animal or plant species. Carotenoids are carotene without oxygen in the molecule, β-carotene, carrot root, green leaves, egg yolk, blood and lycopene , Watermelon, strawberry, etc. There is also lutein as a carotene that does not contain oxygen in the molecule, which is distributed in egg yolks, green leaves, petals, etc., and zeaxanthin in yellow corn, egg yolks, etc. These substances play a similar but different role, and β-carotene is a source of vitamin A, which is converted to vitamin A in the human body, making sperm in men, boosting immunity, and boosting appetite and promoting growth.

Therefore, it is healthful to consume such fruit or vegetables frequently such as red or yellow. However, these red fruits and vegetables are usually consumed in small amounts as a dessert after meals, and are not easy to be stored, so there is a problem that it is difficult to easily carry and consume. In addition, the red fruits and yellow fruits and vegetables are said to be good for the body when the intake of only red fruits, there is a problem that the human body lacks a variety of nutrients required.

On the other hand, the prior art related to the present invention, there is a "wire type with black grains as a main raw material and a method of manufacturing thereof" in Korean Patent Laid-Open No. 2000-0073830, but the technical configuration is different from the present invention with fruit vegetables as the main raw material.

The present invention is to process the black fruit vegetables in the form of extracts for easy and easy ingestion of geriatric disease prevention ingredients contained in the black fruit vegetables, and by adding a grain powder and a thickener to the black fruit vegetables processed products in various and uniform forms The purpose of the present invention is to provide a dietary supplement with excellent nutritional properties and palatability and its manufacturing method.

In order to achieve the above-mentioned object, the method for producing a health functional food based on the black fruit vegetables of the present invention is a conventional functional food preparation,

(1) extracting the black fruit vegetable with hot water or ethanol at 90 ° C. or lower, and then filtering and concentrating the black fruit vegetable,

(2) steaming and drying the grains and pulverizing them,

(3) mixing 45 to 55% by weight of the black fruit and vegetable extract concentrate of step (1), 52 to 44.5% by weight of grain powder of step (2) and 0.5 to 3% by weight of thickener.

Hereinafter, the present invention will be described in more detail in the above steps.

Step 1: Processing Black Fruits

In the processing of black fruits and vegetables, for the convenience of carrying or taking them, tablets, capsules, or pills are supplied as hot water extracts from fruits and vegetables, and processed into extracts so that cereals and thickeners can be mixed.

<Extract>

Black fruits and vegetables are any one or more selected from the groupings, dulcis, parsley, 톳, mulberry, watermelon seeds, blueberry fruit, eggplant or two or more commercially available. Grind the fruit vegetable finely, extract the active ingredient of fruit vegetable at 10 ~ 10 times water or ethanol with extraction temperature at 70 ~ 90 ℃, and then concentrate the extract to 1/10 volume in a reduced pressure concentrator and filter to extract raw material. use.

Meanwhile, in the extraction of the fruit vegetable, the fruit vegetable may be a mixture of two or more kinds. For example, when mixing two fruits and vegetables, the mixing ratio may be mixed in a ratio of 1: 9 to 9: 1, and when mixing three or more fruits and vegetables, 1: 1: 8 to 1: 8: 1 to 8: 1: It can mix in 1 ratio, Preferably, the mixture mixed in the ratio of the weight of each can be used.

Step 2: Steaming and Powdering Grains

Grain in the present invention may also be used black grains, but not necessarily limited to black grains may use general grains. As an example of the black grain in the present invention, any one selected from buckwheat, black rice, black beans, black sesame seeds, or two or more may be used. In addition, the general grain may be any one or more selected from brown rice, glutinous rice, non-rice, buckwheat, barley, corn, crude, blood, sorghum, millet, soybean, red beans, green beans, peas, or a mixture of two or more. Meanwhile, a mixture of black grains and regular grains can be used. In using the grains in the present invention, when mixing two grains, the mixing ratio may be mixed in a ratio of 1: 9 to 9: 1, and when mixing three or more grains, 1: 1: 8 to 1: 8. It can mix in ratio of 1: 1-8: 1: 1.

In order to taste and take a feeling when ingesting the health functional food of the present invention, it is preferable to wash the powder before powdering to remove impurities and then steam. In the present invention, the steaming of the grains may steam the grains under conditions conventionally performed in the art. In the present invention, as an example of conditions for steaming grains, grains may be steamed for 20 to 40 minutes at 100 to 120 ° C.

On the other hand, as mentioned above, in the health functional food of the present invention, the grains may be used alone after being powdered or a mixture of several grains mixed in a predetermined ratio. Steaming is different from each other, so it is preferable to steam each separately.

If the steamed grains are immediately powdered with a grinder, the state of the grinder may be deteriorated by the moisture contained in the grains, so the steamed grains are dried and then powdered with a grinder. At this time, the drying may be carried out using a natural drying, drying using hot air, using a dryer. This drying can be carried out by the person skilled in the art appropriately selected details will be omitted below.

Grain powder in the present invention is preferably powdered into 200 to 400 mesh (mesh) in order to easily mix with the black fruit and vegetable extract concentrate of the first step.

Step 3: Mixing Fruit Extract, Grain Powder and Thickener

A thickener is added to the fruit vegetable concentrate and grain powder obtained from the first and second steps, and mixed. The thickener plays a role of evenly mixing the fruit vegetable powder and the grain powder. In the present invention, the thickener may be used as long as it is a food additive that is food acceptable. As an example of such a thickener, any one selected from carrageenan, locust gum, guar gum, xanthan gum, tamarind gum, gum arabic, glucomannan, or a mixture of two or more thereof may be used. In this case, when the two thickeners are mixed, the mixing ratio may be mixed in a ratio of 1: 9 to 9: 1. When three or more thickeners are mixed, the mixing ratio is 1: 1: 8 to 1: 8: 1 to 8: 1: 1. It can mix in ratio of 1.

The present invention can be mixed with 45 to 55% by weight of the black fruit and vegetable extract concentrate, 52 to 44.5% by weight and 0.5 to 3% by weight thickener obtained from the first and second steps.

In the present invention, black fruit and vegetable extract concentrates, grain powders and thickeners of various contents are applied. In order to obtain the desired health functional food of the present invention, it is preferable to use black fruit and vegetable extract concentrates, grain powders and thickeners of the aforementioned numerical range. good.

<Pills, tablets, capsules>

When the product of the present invention is a powder, tablets, capsules in a highly concentrated formulation, not in powder form, the above-mentioned grain powder, thickener and excipients are used in fruit and vegetable concentrates by a method known in the art. The formulation of the dietary supplement of the invention can be pilled, tableted or encapsulated. Excipients that can be added to change the formulation of the nutraceutical in the present invention can be used in one or two or more mixtures of food or pharmaceutical acceptable. In the present invention, such excipients are not an essential component of the present invention, and are also well known in the art, so that those skilled in the art can appropriately select and apply them in predetermined amounts.

On the other hand, the present invention includes a health functional food based on black fruits and vegetables by the above-mentioned method.

Hereinafter, the content of the present invention will be described in detail through examples and test examples. However, these are intended to explain the present invention in more detail, and the scope of the present invention is not limited thereto.

<Example 1>

(1) As black fruits and vegetables, 70L of purified water was added to 7 kg of finely ground pulverum, stone parsley, 톳, mulberry, watermelon seed, blueberry fruit and eggplant in the same proportions, and extracted at 90 ° C. for 5 hours, filtered and concentrated under reduced pressure. Concentrated to 1/10 with.

2) Brown rice and glutinous rice were selected as grains, and these were washed to remove impurities. After that, steamed brown rice and glutinous rice were steamed at 100 to 120 ° C. for 20 to 40 minutes, and dried by hot air drying. The dried grains were powdered into 200 to 400 meshes using a mill including a ball mill, and brown rice powder and glutinous rice powder were mixed at a ratio of 1: 1.

(3) 95% by weight of the mixture of each powdered black fruit vegetable of step (1) in the same ratio, 4.5% of the mixture of brown rice powder and glutinous rice powder in the ratio of 1: 1 in the step (2) % And 0.5% by weight of gum arabic as a thickener to prepare a health functional food mainly composed of red fruits and vegetables.

<Example 2>

As black fruits and vegetables, 3.5 liters of finely pulverized fruit vegetables were put into 3.5 kg of finely pulverized fruits and vegetables, and the extracts were extracted at 80 ° C. for 8 hours. Concentrated to 1/10 with. 50% by weight of black fruit concentrate, 47% by weight of brown rice powder and glutinous rice powder in a ratio of 1: 1, and 3% by weight of gum arabic as a thickener, followed by a known method to add an excipient to form a cyclic form. Health functional food was prepared.

<Example 3>

In Example 2, except for extracting the black fruit and vegetables at 70 ℃ hot water for 8 hours to prepare a health functional food in the form of tablets using the same composition and method as in Example 2.

<Example 4>

A dietary supplement was prepared using the same composition and method as in Example 2, except that the extract was extracted at 80 ° C. for 3 hours using ethanol as the extractant of black fruit.

Test Example 1 In Vitro Immune Activity Test

Immune cell line Raji was inoculated in the medium (RPM1-1640) targeting the concentrates of the extracts of the black fruit vegetables, rock mulberry, 톳, mulberry, watermelon, blueberry, eggplant, and extracts of these used in the present invention 1 After reaching the normal cell growth period for one week, 96-well plates (100 μl / well of the medium adjusted to 5 × 10 ⁴ Cells / ml) were incubated at 37 ° C. in a 5% CO ₂ state for 24 hours. 100 μl of the extract concentrates of each of the black fruits and vegetables and the mixed extract concentrates thereof at concentrations of 0.5 mg / ml, 1.0 mg / ml, 1.5 mg / ml, and 2.0 mg / ml were treated with 5% CO ₂ at 37 ° C. Incubated for 48 hours.

100 μl of cooled 10% (w / v) TCA (trichloroacetic acid) was added to the culture medium from which the supernatant was removed, and the mixture was left at 4 ° C. for 1 hour, washed 4 to 5 times with distilled water to remove TCA, and the plate was dried at room temperature. 100 μl of 0.4% (w / v) SRB solution dissolved in 1% (v / v) acetic acid was added to each well and stained at room temperature for 30 minutes.

Unbound SRB dye solution was washed 4-5 times with 1% acetic acid and dried, and then 100 mL of 10mM Tris buffer was added to dissolve the dye solution. The absorbance was measured at 540 nm using a microplate reader. After cancer cell growth (test / control × 100) was calculated.

Immune activity of the extracts of the extracts of black vinegar, rock mulberry, 톳, mulberry, watermelon, blueberry fruit, eggplant and mixed extracts of black fruits and vegetables are shown in Table 1. 168 (% / mg / ml) at 1.5mg / ml concentration of the extract from black fruit, 152 (% / mg / ml) at 1.0mg / ml stone extract, and 134 (% / ml) at 1.5mg / ml audio extract mg / ml), Audi extract 134 (% / mg / ml) at 1.5 mg / ml, watermelon seed extract 134 (% / mg / ml) at 0.5 mg / ml, blueberry fruit extract at 120 mg / ml (% / mg / ml), eggplant extract was found to be 126 (% / mg / ml) at a concentration of 1.5mg / ml. Among them, the most effective immunity was black fruit and vegetable extract, which showed an increase in activity of about 175-182 (% / mg / ml) at 0.5mg / ml concentration.

Table 1 Immune Activity Capacity of Black Fruit and Vegetable Extracts (% / mg / ml)

division Concentration 0.5mg / ml 1.0mg / ml 1.5mg / ml 2.0mg / ml Cornflower Extract 152 166 168 162 Stone Buttercup Extract 148 152 150 149 톳 Extract 136 140 142 139 Audi extract 128 132 134 130 Watermelon Seed Extract 134 132 128 130 Blueberry Fruit Extract 114 118 120 119 Eggplant Extract 112 124 126 121 Mixed Extract 180 182 181 175 Effect criteria 50% less than Black method SRB assay

<Test Example 2> Ex Vivo immune function search

The black fruit and vegetable extracts obtained in Examples 1 to 4 were administered to BALB / c mice at concentrations of 50 mg / kg bw and 500 mg / kg bw at 0.2 ml / day every other day for 4 weeks, and the control group (control ), The same amount of physiological saline was used. As an indicator for measuring mouse immunity, splenocytes were isolated to measure the proliferation of splenocytes. Peritoneal macrophages were isolated to secrete cytokine (IL-1β, IL-6, TNF-α) secreted by activated peritoneal macrophages. Measured.

Effect of Black Fruit Extracts on Mouse Splenocyte Proliferation

The spleens sacrificed by cervical vertebrae (female balb / c mouse, 5 weeks) were aseptically removed, and then centrifuged twice with RPMI medium 1640 solution. Cell concentration was 5.0 × 10 ⁶ cells / ml, and then divided into 96-well plate, experimental group without mitogen in cultivation, and 1 mcg / ml Concanavalin A (conA) were added. (LPS) 5mcg / ml was added to the experimental group, and then measured for proliferation at 24 hours and 48 hours using the MTT assay.

The effect on splenocyte proliferation is shown in FIG. 1. Figure 1 (a) is a result of splenocyte cell proliferation of mice fed the black fruit vegetable extract of Example 1, Figure 1 (b) is a result of splenocyte cell proliferation of mice fed the black fruit vegetable extract of Example 2, Figure 1 (c) is a splenocyte cell proliferation result of the mouse fed the black fruit vegetable extract of Example 3, Figure 1 (d) is a splenocyte cell proliferation capacity of the mouse fed the black fruit vegetable extract of Example 4.

1 (a) to 1 (d) showed a significantly higher proliferative capacity in the 50 mg / kg b.w concentration group of the experimental group added conA in the splenocyte proliferation capacity of the mice fed the black fruit and vegetable extract. In the experimental group to which LPS was added, the 50 mg / kg b.w. group and the 500 mg / kg b.w. The administration group showed significantly higher proliferative capacity than the experimental group without the addition of mitogen.

Effect of Black Food Extracts on the Proliferation of Mouse Peritoneal Macrophages

2 ml of 4% thioglycollate is injected into the mouse abdominal cavity to allow macrophages to accumulate in the abdominal cavity for 3 days and then sacrificed by cervical dislocation. After the incision of the epidermis of the mouse abdomen, the abdominal cavity was washed with 10 ml of RPMI medium 1640 solution, macrophages were taken, and the cells were cultured by centrifuging for 10 minutes at 4 ° C. and 3000 rpm. The concentration of cytokines secreted when activated was measured in the culture medium using the EILSA kit. First, disperse at 1 × 10 ⁶ cell / mL cell concentration in RPMI medium 1640 solution containing inactivated 10% FBS, and dispense 1000 μl into each well of a 24-well plate for 2 hours in an incubator. Incubated. After the supernatant for medium exchange, 900 μl of RPMI 1640 and 100 μl of extract (10ug / ml) containing inactivated RBS were added to each well, followed by culturing for 48 hours in an incubator to obtain a culture solution. The production amounts of (IL-1β, IL-6, and TNF-α) were measured and shown in FIGS. 2 to 4, respectively.

(1) IL-1β (FIG. 2)

As shown in FIG. 2, the IL-1β production amount of the peritoneal macrophages by the administration of the black fruit vegetable extracts obtained in Examples 1 to 4 secreted a large amount of IL-1β in the 50 mg / kg bw group. In LPS stimulation, the 50 mg / kg bw and 500 mg / kg bw groups showed significantly higher secretion capacity than the control group. In the LPS-stimulated experimental group (C), IL-1β secretion was significantly elevated, and oral administration of dietary supplements containing black fruit extracts is thought to stimulate IL-1β production and promote immune responses. .

2 (a) is the IL-1β production results of mice fed the black fruit vegetable extract of Example 1, Figure 2 (b) is IL- of mice fed the black fruit vegetable extract of Example 2 1β production result, Figure 2 (c) is the IL-1β production result of the mice fed the black fruit vegetable extract of Example 3, Figure 2 (d) of the mice fed the black fruit vegetable extract of Example 4 IL-1β production result.

(2) IL-6 (FIG. 3)

As a result of administering the black fruit vegetable extracts obtained in Examples 1 to 4 (see FIG. 3), IL-6 secretion was significantly increased in the 50 mg / kg b.w. group. IL-6 secretion was significantly increased in 50 mg / kg b.w. and 500 mg / kg b.w. groups of the LPS group compared to the control group.

Without LPS treatment, IL-6 secretion was significantly elevated in the 50 mg / kg b.w. concentration group, suggesting that administration of black fruit extract stimulates IL-6 production and promotes immune response. The IL-6 secretion was decreased in the 500 mg / kg b.w. group, which may be a result of high concentrations. However, LPS treatment showed significant IL-6 production in all experimental groups at concentrations of 50 mg / kg b.w. and 500 mg / kg b.w., suggesting that black fruit and vegetable extracts have the potential to activate immune cells.

3 (a) is a result of IL-6 production of mice fed the black fruit vegetable extract of Example 1, Figure 3 (b) is IL- of mice fed the black fruit vegetable extract of Example 2 6 production result, Figure 3 (c) is the IL-6 production result of the mice fed the black fruit vegetable extract of Example 3, Figure 3 (d) is a mouse of the black fruit vegetable extract of Example 4 IL-6 production result.

(3) TNF-α (FIG. 4)

As a result of administering the black fruit vegetable extracts obtained in Examples 1 to 4 (see FIG. 4), the TNF-α secretion was significantly higher in the 50 mg / kg b.w. group and the 500 mg / kg b.w. group compared to the control group.

LPS treatment showed significantly higher TNF-α secretion in the 50 mg / kg b.w. group. 50 mg / kg b.w. concentration group and LPS-stimulated 50 mg / kg b.w. The concentration-administered group showed higher TNF-α secretion ability than the control group. Concentration 500 mg / kg b.w. The administration group showed higher TNF-α secretion tendency than the control group, but decreased compared to the 50 mg / kg b.w.

  4 (a) is the TNF-α secretion results of the mice fed the black fruit vegetable extract of Example 1, Figure 4 (b) is TNF- of mice fed the black fruit vegetable extract of Example 2 α secretion results, Figure 4 (c) is the TNF-α secretion results of the mice fed the black fruit vegetable extract of Example 3, Figure 4 (d) of the mice fed the black fruit vegetable extract of Example 4 TNF-α secretion results.

Health functional foods based on black fruits and vegetables of the present invention are effective in improving immunity, heart disease, and stroke by preventing cancer and aging, preventing eye diseases, and also have functional and nutritional ingredients. It is possible to provide a health functional food and its preparation method that are easy to carry and consume.

As described above, although described with reference to a preferred embodiment of the present invention, those skilled in the art will be variously modified and modified within the scope of the present invention without departing from the spirit and scope of the present invention described in the claims below. It will be appreciated that it can be changed.

Figure 1 (a) to Figure 1 (d) shows the splenocyte proliferation capacity of the mouse in the Ex vivo immune function screening for black fruit vegetables of the present invention.

Figure 2 (a) to Figure 2 (d) shows the amount of mouse peritoneal macrophage Cytokine (IL-1β) secretion in the Ex vivo immune function screening for black fruit vegetables of the present invention.

Figure 3 (a) to Figure 3 (d) shows the amount of secretion of the peritoneal macrophage Cytokine (IL-6) of the mouse in the Ex vivo immune function screening for black fruit vegetables of the present invention.

Figure 4 (a) to Figure 4 (d) shows the amount of celiac macrophage Cytokine (TNF-α) secretion of mice in the Ex vivo immune function screening for black fruit vegetables of the present invention.

Claims (9)

 (1) extracting black fruit vegetables of any one selected from 톳, mulberry, watermelon seeds, blueberry fruit or two or more mixtures with a solvent at 90 ° C. or lower, and then filtering and concentrating the extract; (2) steaming and drying the grains and pulverizing them, (3) 45 to 55% by weight of the black fruit and vegetable extract concentrate of step (1), 52 to 44.5% by weight of grain powder of step (2) and 0.5 to 3% by weight of thickener, characterized in that it comprises the step of mixing Manufacturing method of health functional food based on black fruits and vegetables. delete The black fruit and vegetable according to claim 1, wherein the grain is at least one selected from brown rice, glutinous rice, buckwheat, barley, corn, crude, blood, sorghum, millet, soybean, red beans, mung beans, and peas, or a mixture of two or more. Method of manufacturing a health functional food containing the main ingredient. The method for producing a health functional food containing black fruits and vegetables as a main ingredient according to claim 1, wherein the grains are steamed at 100 to 120 ° C. for 20 to 40 minutes. The health functional food based on black fruits and vegetables according to claim 1, wherein the thickener is any one selected from carrageenan, locust gum, guar gum, xanthan gum, tamarind gum, gum arabic, glucomannan, or a mixture of two or more thereof. Manufacturing method. The method of producing a health functional food containing black fruit and vegetable as a main ingredient according to claim 1, wherein the grains are powdered into 200 to 400 mesh. The method of claim 1, wherein the formulation of the health functional food is a powder, a pill, a tablet, and a capsule.        The method of claim 1, wherein the solvent of the black fruit vegetable extract is a concentrate obtained by extracting and concentrating at 90 ° C. or less with hot water or ethanol. A health functional food prepared by the method of any one of claims 1 to 8.