KR100466954B1 - 스크리닝 장치 및 방법, 스크리닝 방법에 의해 얻어지는후점막 자극 화합물, 및, 치료 장치, 측정 전극부 - Google Patents
스크리닝 장치 및 방법, 스크리닝 방법에 의해 얻어지는후점막 자극 화합물, 및, 치료 장치, 측정 전극부 Download PDFInfo
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Abstract
Description
Claims (31)
- 실험 동물의 후점막을 향하여 후점막 자극 화합물을 투여하는 투여 수단과,상기 실험 동물의 후구에 매립되어, 후구에서 생기는 전기 신호를 측정하는 측정 전극부와,상기 실험 동물의 생체 내에 생기는 생리적 반응을 측정하는 생리적 반응 측정 수단과,상기 투여 수단에 의해 실험 동물에 후점막 자극 화합물이 투여된 경우, 상기 전기 신호와 상기 생리적 반응의 측정 결과를 대비하여 상기 후점막 자극 화합물의 유효성을 판정하는 처리 수단을 포함하는, 후점막 자극 화합물 스크리닝 장치.
- 제 1 항에 있어서,상기 처리 수단은 실험 동물로부터 생리적 반응에 관한 데이터를 직접 얻어 상기 측정 전극부에서 측정되는 전기 신호와의 상관 관계를 분석하는, 후점막 자극 화합물 스크리닝 장치.
- 제 1 항에 있어서,상기 처리 수단은 실험 동물에 생리적 반응을 유기시키는 후구에서의 전기 신호에 관한 데이터를 미리 갖고 있고, 그 데이터에 기초하여 상기 측정 전극부에서 측정되는 전기 신호와의 상관 관계를 분석하는, 후점막 자극 화합물 스크리닝 장치.
- 제 1 항 내지 제 3 항 중 어느 한 항에 있어서,상기 투여 수단은 후점막 자극 화합물을 수용하는 박스와 상기 박스 내에 수용된 후점막 자극 화합물을 실험 동물의 후점막 부근에 분무하는 노즐을 갖는, 후점막 자극 화합물 스크리닝 장치.
- 제 1 항에 있어서,상기 측정 전극부는 후구의 신경 세포로부터의 전기 신호를 검출하는 적어도 하나의 미소 전극을 갖는, 후점막 자극 화합물 스크리닝 장치.
- 제 5 항에 있어서,상기 미소 전극이 복수 설치되어 있고, 각 미소 전극은, 실험 동물의 후점막 에 대한 후점막 자극 화합물의 투여에 의해 후구에 발생하는 전기 신호 패턴이 복수의 점에서 얻어지도록 배치된, 후점막 자극 화합물 스크리닝 장치.
- 제 5 항에 있어서,상기 각 미소 전극에는, 실험 동물이 생리적 반응을 유기시키는 전기 신호가 각각 주어지는, 후점막 자극 화합물 스크리닝 장치.
- 실험 동물의 후점막을 향하여 후점막 자극 화합물을 투여하는 단계와,상기 실험 동물의 후점막에 후점막 자극 화합물이 투여된 경우, 실험 동물의 후구에 생기는 전기 신호를 측정하는 단계와,상기 실험 동물의 생체 내에 생기는 생리적 반응을 측정하는 단계와,상기 전기 신호와 상기 생리적 반응의 측정 결과를 대비하여 상기 후점막 자극 화합물의 유효성을 판정하는 단계를 포함하는, 후점막 자극 화합물 스크리닝 방법.
- (삭제)
- 생체의 후구에 매립되는 측정 전극부와,후점막 자극 화합물이 상기 생리적 반응을 야기한다고 판정된 경우에 기록된 전기 신호 패턴을 보존한 컴퓨터, 상기 신호를 증폭하는 신호 증폭 자극 장치 및 측정 전극부에 연결된 신호 증폭 장치를 포함하는, 치료 장치.
- 실험 동물의 후구에 매립되어, 후구에서 생기는 전기 신호의 측정 또는 후구에 전기 신호를 인가하기 위해 사용되는 측정 전극부로서,후구의 신경 세포로부터 전기 신호를 각각 검출하는 복수의 미소 전극이 설치되어 있고, 각 미소 전극이 매트릭스 형상 또는 전극열로서 배치된, 측정 전극부.
- 제 11 항에 있어서,상기 각 미소 전극이, 1μm2내지 100,000,000μm2의 면적인, 측정 전극부.
- 제 12 항에 있어서,상기 미소 전극이 매트릭스 형상으로 배치된, 측정 전극부.
- 제 13 항에 있어서,인접하는 미소 전극의 간격이, 10 내지 10,000μm로 된, 측정 전극부.
- 제 11 항에 있어서,상기 각 미소 전극은, 필름 형상의 기판 상에 배치된, 측정 전극부.
- 제 15 항에 있어서,상기 각 미소 전극은, 각각 링 형상을 하고 있고, 상기 기판에 설치된 관통 구멍의 주변 테두리부에 각각 배치된, 측정 전극부.
- 제 16 항에 있어서,상기 기판에 형성된 관통 구멍의 내경이 10,000μm 이하인, 측정 전극부.
- 제 11 항에 있어서,상기 미소 전극은, 상기 기판의 표면 및 뒷면의 동일 위치에 배치되어 있고, 상기 기판의 한쪽 면에 설치된 각 미소 전극은 실험 동물이 생리적 반응을 유기시키는 전기 신호 패턴을 검출하고, 다른 쪽은 검출한 신호와 동일한 또는 상이한 신호를 인가하는, 측정 전극부.
- 제 15 항에 있어서,상기 미소 전극이, 금, 백금, ITO, 질화티타늄, 구리, 은, 텅스텐 중 어느 하나로 형성된, 측정 전극부.
- 제 15 항에 있어서,상기 기판이, 생체 재료에 의해서 구성된, 측정 전극부.
- 제 15 항에 있어서,상기 기판이, 폴리에틸렌테레프탈레이트, 테플론, 실리콘 고무, 반도체 재료, 도전성 고무 중 어느 하나로 구성된, 측정 전극부.
- 제 13 항에 있어서,상기 미소 전극은, 바늘 형상 도선의 선단부에 각각 형성되어 있고, 소정 갯수의 바늘 형상 도선이 각 미소 전극이 각각 소정의 간격을 둔 상태로 묶여져 전극열을 구성함과 동시에, 복수의 전극열이 소정의 간격을 두고 평행하게 배치된, 측정 전극부.
- 제 22 항에 있어서,상기 바늘 형상 도선은, 직경 1μm 내지 1,000μm로 된, 측정 전극부.
- 제 22 항에 있어서,상기 바늘 형상 도선은 바늘 형상의 도전 재료를 선단부의 미소 전극을 제외하고 절연 피막에 의해 피복되어 구성된, 측정 전극부.
- 제 24 항에 있어서,상기 바늘 형상 도선의 도전 재료가, 금, 백금, ITO, 질화티타늄, 구리, 은, 텅스텐, 도전성 고무 중 어느 하나로 구성된, 측정 전극부.
- 제 24 항에 있어서,상기 바늘 형상 도선의 절연 피막이, 폴리스티렌, 아크릴, 폴리카보네이트, 폴리이미드 중 어느 하나로 구성된, 측정 전극부.
- 제 11 항에 있어서,상기 미소 전극은 생체 재료로 구성된 피막에 의해서 피복된, 측정 전극부.
- 제 22 항에 있어서,상기 바늘 형상 도전성 재료의 선단부가 생체 재료의 피막에 의해서 피복된, 측정 전극부.
- 실험 동물의 후점막을 향하여 후점막 자극 화합물을 투여하는 단계와,실험 동물의 후점막에 후점막 자극 화합물이 투여된 경우, 실험 동물의 후구에 생기는 전기 신호를 측정하는 단계와,측정되는 전기 신호의 패턴과, 상기 전기 신호의 패턴에 의해 실험 동물에 유기되는 생리적 반응의 종류 및 정도를 파악하는 단계와,목적의 생리적 반응을 일으키는 데 충분한 전기 신호 패턴을 자극 패턴으로서 상기 실험 동물의 후구에 공급하는 단계를 포함하고,상기 생리적 반응은 혈압 강하 또는 혈당치의 저하인, 치료 방법.
- 삭제
- 삭제
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KR101007558B1 (ko) | 2008-10-08 | 2011-01-14 | 한국과학기술연구원 | 실험용 동물 eeg 측정용 박막형 다채널 미세전극 및 미세전극을 이용한 실험용 동물 eeg 측정 방법 |
US8798707B2 (en) | 2008-10-08 | 2014-08-05 | Korea Institute Of Science And Technology | Flexible, multi-channel microelectrode for recording laboratory animal EEG and method for recording laboratory animal EEG using the same |
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US6994671B2 (en) | 2006-02-07 |
US20040229345A1 (en) | 2004-11-18 |
EP1234540B1 (en) | 2007-03-21 |
JP3705546B2 (ja) | 2005-10-12 |
CN1235543C (zh) | 2006-01-11 |
EP1234540A4 (en) | 2005-06-15 |
KR20020035130A (ko) | 2002-05-09 |
DE60127376T2 (de) | 2007-07-12 |
EP1234540A1 (en) | 2002-08-28 |
CN1383372A (zh) | 2002-12-04 |
AU2001274614A1 (en) | 2002-01-14 |
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