WO2021035527A1 - 一种多脑区记录电极、制作方法及植入方法 - Google Patents

一种多脑区记录电极、制作方法及植入方法 Download PDF

Info

Publication number
WO2021035527A1
WO2021035527A1 PCT/CN2019/102810 CN2019102810W WO2021035527A1 WO 2021035527 A1 WO2021035527 A1 WO 2021035527A1 CN 2019102810 W CN2019102810 W CN 2019102810W WO 2021035527 A1 WO2021035527 A1 WO 2021035527A1
Authority
WO
WIPO (PCT)
Prior art keywords
brain
brain area
electrode
electrodes
recording electrode
Prior art date
Application number
PCT/CN2019/102810
Other languages
English (en)
French (fr)
Inventor
王璐璐
鲁艺
钟成
曹燚
潘苏婉
王立平
Original Assignee
中国科学院深圳先进技术研究院
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 中国科学院深圳先进技术研究院 filed Critical 中国科学院深圳先进技术研究院
Priority to PCT/CN2019/102810 priority Critical patent/WO2021035527A1/zh
Publication of WO2021035527A1 publication Critical patent/WO2021035527A1/zh

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
    • A61B5/293—Invasive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4058—Detecting, measuring or recording for evaluating the nervous system for evaluating the central nervous system
    • A61B5/4064—Evaluating the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/685—Microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/686—Permanently implanted devices, e.g. pacemakers, other stimulators, biochips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
    • A61B5/6868—Brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04—Arrangements of multiple sensors of the same type
    • A61B2562/043—Arrangements of multiple sensors of the same type in a linear array
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04—Arrangements of multiple sensors of the same type
    • A61B2562/046—Arrangements of multiple sensors of the same type in a matrix array
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
    • A61B2562/125—Manufacturing methods specially adapted for producing sensors for in-vivo measurements characterised by the manufacture of electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/107—Measuring physical dimensions, e.g. size of the entire body or parts thereof
    • A61B5/1072—Measuring physical dimensions, e.g. size of the entire body or parts thereof measuring distances on the body, e.g. measuring length, height or thickness

Definitions

  • the present invention relates to the technical field of medical equipment, in particular to a multi-brain area recording electrode, a manufacturing method and an implantation method.
  • the brain area recording electrode is used to realize the simultaneous recording of action potentials and local field potentials in multiple brain areas of the experimental animals, so as to solve the problem of simultaneous multiple brain area electrical activities on freely moving animals under a specific behavioral paradigm
  • the problem of function recording to analyze the related loop functions under this behavior is very helpful for the analysis of neural loop functions.
  • the single brain area electrodes on the market are used for signal recording of a single brain area.
  • the purpose of the present invention is to provide a multi-brain area recording electrode, which can be implanted into multiple different target brain areas at one time.
  • Another object of the present invention is to provide a method for manufacturing a multi-brain recording electrode, which can produce a multi-brain recording electrode that can be implanted into multiple different target brain regions at one time.
  • Another object of the present invention is to provide a method for implanting recording electrodes in multiple brain regions, which can be implanted into multiple different target brain regions at one time.
  • a multi-brain area recording electrode comprising a row of needles and a plurality of single brain area electrodes connected in parallel with each other, wherein the plurality of single brain area electrodes respectively have oppositely arranged connection ends and implant ends, and a plurality of single brain areas
  • the connecting ends of the electrodes are respectively electrically connected to the pin headers, a plurality of the single brain area electrodes all extend in the same direction, and the implantation ends of any two single brain area electrodes are located between the single brain area electrodes
  • the electrodes are arranged at intervals in the extension direction, and the implanted ends of the plurality of single brain area electrodes are used for inserting into different target brain areas respectively.
  • a plurality of the single brain area electrodes are arranged in a stack in sequence.
  • the multi-brain area recording electrode further includes a glue layer, and any two adjacent single brain area electrodes are connected by the glue layer.
  • the single brain region electrode includes a plurality of electrode units, the plurality of electrode units are arranged in a row, and the plurality of electrode units all extend in the same direction.
  • a plurality of the electrode units are sequentially connected in the arrangement direction.
  • the electrode unit includes a sleeve and an electrode wire, the sleeve is sleeved on the electrode wire, and the connecting end and the implanted end are respectively arranged at opposite ends of the electrode wire,
  • the implanted end passes through the sleeve, the sleeves of the two adjacent electrode units are arranged in a row and connected in sequence, and the sleeve is used to guide the electrode wire to make the implant The end is inserted into the target brain area.
  • the implanted ends of the multiple electrode wires in the same single brain area electrode are flush.
  • the connecting ends of the plurality of single brain area electrodes are flush.
  • the present invention also provides a method for manufacturing a multi-brain area recording electrode, which is used to make the multi-brain area recording electrode.
  • the multi-brain area electrode includes a pin header and a plurality of parallel-connected single brain area electrodes.
  • the single brain area electrodes respectively have oppositely arranged connecting ends and implanted ends.
  • the connecting ends of a plurality of single brain area electrodes are respectively electrically connected to the pin headers, and the plurality of single brain area electrodes are all along Extending in the same direction, the implanted ends of any two single brain area electrodes are arranged at intervals in the extending direction of the single brain area electrodes, and the implanted ends of a plurality of single brain area electrodes are used to respectively insert into Different target brain areas.
  • the manufacturing method of the multi-brain recording electrode includes:
  • connection ends of the multiple single brain area electrodes are electrically connected to the header pins.
  • the present invention also provides a method for implanting multi-brain area recording electrodes.
  • the multi-brain area recording electrode includes a pin header and a plurality of single brain area electrodes connected in parallel with each other.
  • the single brain area electrodes respectively have oppositely arranged connecting ends and implanted ends.
  • the connecting ends of a plurality of single brain area electrodes are respectively electrically connected to the pin headers, and the plurality of single brain area electrodes are all along Extending in the same direction, the implanted ends of any two single brain area electrodes are arranged at intervals in the extending direction of the single brain area electrodes, and the implanted ends of a plurality of single brain area electrodes are used to respectively insert into Different target brain areas.
  • the implantation method of the multi-brain area recording electrode includes:
  • the multi-brain recording electrode is fixed on the skull.
  • the multi-brain recording electrode provided by the present invention Compared with the prior art, in the multi-brain recording electrode provided by the present invention, a plurality of single brain regions are connected in parallel with each other and all extend in the same direction. The implanted ends of any two single brain region electrodes extend in the single brain region electrode. Set the interval in the direction.
  • multiple single brain area electrodes connected together are implanted at the same time, and the implantation can be completed until the implanted end of each single brain area electrode reaches its corresponding target brain area, which is convenient, fast and takes up a lot of space. Small space, not affected by the brain volume of the implanted object. Therefore, the beneficial effects of the multi-brain recording electrode provided by the present invention are that it can be implanted into multiple target brain regions at the same time, is convenient and quick, saves time and labor costs, and has wide applicability.
  • FIG. 1 is a schematic diagram of the structure of a multi-brain recording electrode provided by an embodiment of the present invention
  • FIG. 2 is a schematic diagram of the structure of the pin header in FIG. 1;
  • Fig. 3 is a schematic diagram of the structure of the single brain area electrode in Fig. 1;
  • FIG. 4 is a schematic block diagram of a process flow of a method for manufacturing a multi-brain recording electrode according to an embodiment of the present invention
  • FIG. 5 is a schematic block diagram of a flow of a method for implanting recording electrodes in multiple brain regions according to an embodiment of the present invention.
  • Icon 100-multiple brain area recording electrode; 110-pin header; 111-body part; 113-pin; 130-single brain area electrode; 131-connection end; 132-electrode unit; 1321-cannula; 1323-electrode wire ; 133-Implanted end; 150-Glue layer.
  • connection can be a fixed connection or an optional connection.
  • Detachable connection, or integral connection it can be mechanical connection or electrical connection; it can be direct connection or indirect connection through an intermediate medium, and it can be the internal communication between two components.
  • connection can be a fixed connection or an optional connection.
  • Detachable connection, or integral connection it can be mechanical connection or electrical connection; it can be direct connection or indirect connection through an intermediate medium, and it can be the internal communication between two components.
  • the multi-brain recording electrode 100 provided by the embodiment of the present invention is used to implant the brain of an experimental animal to realize the simultaneous recording of action potentials and local field potentials of multiple brain regions, thereby solving the problem of Under a specific behavioral paradigm, the problem of recording the activity of multiple brain areas on a freely moving animal at the same time, in order to analyze the related loop function under this behavior.
  • the multi-brain recording electrode 100 provided in this embodiment can be implanted into multiple target brain regions at the same time, which is convenient and quick, saves time and labor costs, and has wide applicability.
  • the multi-brain recording electrode 100 provided in this embodiment includes a header 110 and a plurality of single-brain electrodes 130 connected in parallel with each other.
  • the multiple single-brain electrodes 130 are used to be inserted into different target brain regions.
  • the brain area electrodes 130 respectively have a connecting end 131 and an implanted end 133 opposite to each other.
  • the connecting ends 131 of the multiple single brain area electrodes 130 are electrically connected to the header 110 respectively, and the implant end 133 of the multiple single brain area electrodes 130 is used for Insert it into the corresponding target brain area.
  • the multiple single brain area electrodes 130 all extend in the same direction. That is, the multiple single brain area electrodes 130 in the multi-brain area recording electrode 100 provided in this embodiment are all arranged in parallel.
  • multiple single brain area electrodes 130 are arranged in parallel.
  • the implantation direction angle of the zone electrode 130 is also the same.
  • the implanted ends 133 of any two single-brain electrodes 130 are arranged at intervals in the extending direction of the single-brain electrodes 130, that is, of any two single-brain electrodes 130, the implanted end 133 of one single-brain electrode 130 is in the The extension direction of the single brain area electrode 130 crosses the implantation end 133 of the other single brain area electrode 130.
  • the pin header 110 can be connected to the electrophysiological recording instrument.
  • the pin header 110 includes a main body 111 and a plurality of rows of pins 113 protruding from one side of the main body 111.
  • the specific number of the pins 113 and the number of distribution layers are determined according to the specific number of the single brain area electrodes 130.
  • a 16-channel pin header 110 is used, that is, the number of pins 113 is 16, and they are distributed in two layers, with 8 in each layer. Therefore, two single brain area electrodes 130 are correspondingly connected, that is, two brains are correspondingly inserted. Area.
  • matching pin headers 110 are selected according to the required number of target brain regions, and then corresponding single brain region electrodes 130 are manufactured. For example, when corresponding to three brain regions, a pin header 110 with three rows of pins 113 is selected, and each row of pins 113 is correspondingly connected to a single brain region electrode 130.
  • the 32-channel pin header 110 can be directly used.
  • the upper pins 113 are arranged in 4 layers, 8 in each layer, and the pins 113 in each layer are connected to a single brain area electrode 130. In addition, four single brain area electrodes 130 are sequentially stacked and connected.
  • the multiple single-brain electrodes 130 can stay in different brain regions of the experimental animal's brain when the external force of implantation stops.
  • the multi-brain recording electrode 100 is selected according to the location of the different brain regions of the experimental animal.
  • each single brain area electrode 130 stops when the respective implanted end 133 of each single brain area electrode 130 reaches the corresponding target brain area, that is, the implantation of the multi-brain area recording electrode 100 is completed, and multiple single brain area electrodes 130 are simultaneously Implantation of the corresponding target brain regions can realize the simultaneous recording of action potentials and local field potentials in multiple brain regions.
  • multiple single brain area electrodes 130 are stacked one after another.
  • multiple single brain areas 130 can also be arranged side by side and spaced apart, and the multiple single brain areas 130 can be separated by other middleware.
  • the areas 130 are connected together.
  • multiple single brain regions 130 may also be in multiple different planes, and the planes on which they are located intersect.
  • the multi-brain recording electrode 100 further includes a glue layer 150, and any two adjacent single brain area electrodes 130 are connected by the glue layer 150.
  • glue such as glue
  • two adjacent single-brain electrodes 130 are bonded by an adhesive such as glue to realize the sequential connection of the multiple single-brain electrodes 130.
  • the adhesive is stacked, the adhesive layer 150 is formed when the adhesive is solidified.
  • the two adjacent single brain area electrodes 130 may also be connected in other forms, such as binding by a binding member.
  • the single brain area electrode 130 includes multiple electrode units 132, the multiple electrode units 132 are arranged in rows, and the multiple electrode units 132 extend in the same direction, that is, multiple electrode units 132 are parallel to each other.
  • a plurality of electrode units 132 are sequentially connected in the arrangement direction, and two adjacent electrode units 132 are directly bonded sequentially by an adhesive such as glue.
  • the multiple electrode units 132 on the same single brain area electrode 130 may also be connected and fixed together in other forms, such as binding by a binding member.
  • the electrode unit 132 includes a sleeve 1321 and an electrode wire 1323.
  • the sleeve 1321 is sleeved on the electrode wire 1323.
  • the connecting end 131 and the implant end 133 are respectively arranged on opposite ends of the electrode wire 1323, and the implant end 133 passes through the sleeve.
  • Pipe 1321 In the actual manufacturing process, since the wire used in the electrode wire 1323 is often soft, it is difficult to insert into the corresponding target brain area during the implantation process. Therefore, the sleeve 1321 is sleeved on the electrode wire 1323 to guide the electrode. Wire 1323 so that the implanted end 133 is inserted into the target brain area.
  • the sleeve 1321 is a silicon tube. In other embodiments, the sleeve 1321 can also be made of other materials according to actual implantation requirements.
  • the multi-brain recording electrode 100 provided in this embodiment has 16 channels, and the wire electrode 1323 in each sleeve 1321 is composed of two wires twisted together, that is, each wire electrode 1323 That is, there are two channels, that is, the number of sleeves 1321 is 8.
  • a layer of 4 sleeves 1321 is sleeved on the 4 electrode wires 1323 to form 4 electrode units 132, and the 4 electrode units 132 are arranged to form a single brain area electrode 130.
  • Another layer of four sleeves 1321 is sleeved on the other four electrode wires 1323 to form four electrode units 132, and the four electrode units 132 are arranged to form another single brain electrode 130.
  • Two single brain area electrodes 130 are stacked and arranged, corresponding to the 16-channel pin header 110.
  • the pin header 110 is provided with 16 pins 113.
  • the 16 pins 113 are also arranged in two rows.
  • Two of the four electrode wires 1323 are respectively welded to a row of eight pins 113 in a one-to-one correspondence.
  • the wire electrode 1323 may also be electrically connected to the pin 113 on the pin header 110 in another form, such as a wire connection.
  • the number of channels can be changed, such as 32 channels, etc., and the corresponding pin 110 can be selected.
  • the implanted ends 133 of the multiple electrode wires 1323 in the same single brain area electrode 130 are flush. Taking into account the uncertain factors in actual processing, in other embodiments, the implanted ends 133 of the multiple electrode wires 1323 in the same single brain area electrode 130 may have a certain error, that is, they may be approximately flush. In addition, in this embodiment, the connecting ends 131 of the multiple electrode wires 1323 in the same single brain area electrode 130 are also flush.
  • the multiple single-brain electrodes 130 simultaneously move toward the respective target brain regions along the implantation direction to reach each single brain region.
  • the implantation end 133 of each brain area electrode 130 stops when it reaches the corresponding target brain area, that is, the implantation of the multi-brain area recording electrode 100 is completed, and multiple single brain area electrodes 130 are implanted in their respective target brain areas at the same time.
  • This enables simultaneous recording of action potentials and local field potentials in multiple brain regions.
  • the pattern of multi-brain signal recording electrodes and the corresponding electrode implantation method are simplified.
  • the implants occupy the surface of the brain.
  • the entry space is extremely small, the realization range is large, and the applicability is wide.
  • the multi-brain area recording electrode provided by the present invention has a simple structure, can be implanted into multiple target brain areas at the same time, is convenient and quick, saves time and labor costs, and has wide applicability.
  • the structure provided by the multi-brain recording electrode 100 provided by the present invention is not limited to multi-brain signal recording, and optical fibers can also be implanted in certain brain regions for optical stimulation.
  • the present invention also provides a method for manufacturing a multi-brain recording electrode for manufacturing the multi-brain recording electrode 100 provided in the embodiment, including:
  • Step S101 Measure the distances between multiple target brain regions to obtain multiple preset distance values.
  • the preset distance value is the distance between the implant ends 133 of any two single brain area electrodes 130 in the extending direction of the single brain area electrodes 130 in the embodiment.
  • the manufacturing method of the multi-brain recording electrode further includes:
  • step S102 a plurality of single brain area electrodes 130 are connected in parallel, and the extension directions of the plurality of single brain area electrodes 130 are consistent.
  • one electrode unit 132 is formed by passing one end of the electrode wire 1323 through the sleeve 1321, and then a plurality of electrode units 132 are arranged in rows and connected in sequence to form a single brain area electrode 130.
  • the extension direction of the single brain area electrode 130 is the extension direction of the sleeve 1321.
  • the manufacturing method of the multi-brain recording electrode further includes:
  • Step S103 cutting a plurality of single brain area electrodes 130 to obtain the implanted end 133 and the connecting end 131, and make the implanted ends 133 of any two single brain area electrodes 130 be separated by a predetermined distance in the extension direction of the single brain area electrodes 130 Value setting.
  • the ends of the multiple electrode wires 1323 that pass through the sleeve 1321 are cut, so that the electrode wires 1323 on any two single brain area electrodes 130 are in the extending direction of the sleeve 1321
  • the interval is equal to the preset distance value.
  • One end of the cut electrode wire 1323 is the implant end 133, and the other end opposite to the implant end 133 is the connection end 131.
  • the manufacturing method of the multi-brain recording electrode further includes:
  • step S104 the connection ends 131 of the multiple single brain area electrodes 130 are electrically connected to the header pins 110, respectively.
  • the multi-brain recording electrode 100 After the multi-brain recording electrode 100 is manufactured, it needs to be modified and tested. Through the manufacturing method of the multi-brain recording electrode provided by the present invention, the multi-brain electrode 100 as provided in the embodiment can be manufactured.
  • the present invention also provides a method for implanting multi-brain recording electrodes.
  • the multi-brain recording electrode 100 provided in the embodiment is used.
  • the implanting method for multi-brain recording electrodes includes:
  • step S201 multiple target brain regions are located.
  • Multiple target brain regions in the brain of the experimental subject are located by means of animal brain region positioning surgery, etc., and the implantation direction is determined.
  • the implantation method of the multi-brain area recording electrode further includes:
  • step S202 the multi-brain area recording electrode 100 is pushed so that the respective implant ends 133 of the multiple single-brain area electrodes 130 are simultaneously inserted into the respective target brain areas.
  • the multi-brain recording electrode 100 is implanted according to the implantation direction determined in step S201. During the implantation process, the multiple single brain area electrodes 130 on the multi-brain recording electrode 100 all move toward their respective target brain regions, to When each single brain area electrode 130 reaches its corresponding target brain area, it stops pushing, and the multi-brain area recording electrode 100 is fixed by dental cement or other fixing methods.
  • the implantation method of the multi-brain area recording electrode further includes:
  • step S203 the multi-brain recording electrode 100 is fixed on the skull.
  • the multi-brain recording electrode 100 is fixed on the corresponding skull of the implanted subject's brain to complete the implantation.
  • the multi-brain recording electrode implantation method provided by the present invention is used to implant the multi-brain recording electrode 100 provided in the embodiment into the experimental brain, and in actual use, the implanting method of the multi-brain recording electrode is the same as The multi-brain recording electrodes 100 provided in the embodiment do not necessarily need to be completely bound together.

Abstract

一种多脑区记录电极(100)包括排针(110)及多个相互并列连接的单脑区电极(130)。多个单脑区电极(130)分别具有相对设置的连接端(131)和植入端(133)。多个单脑区电极(130)的连接端(131)分别与排针(110)电连接。多个单脑区电极(130)均沿同一方向延伸。任意两个单脑区电极(130)的植入端(133)在单脑区电极(130)的延伸方向上间隔设置。多个单脑区电极(130)的植入端(133)用于分别插入至不同的目标脑区。多脑区记录电极(100)能够同时植入至多个目标脑区，方便快捷，节约时间及人力成本，且适用性广。

Description

一种多脑区记录电极、制作方法及植入方法 技术领域
本发明涉及医疗设备技术领域，具体而言，涉及一种多脑区记录电极、制作方法及植入方法。
背景技术
通过脑区记录电极来实现对试验动物的大脑多个脑区的动作电位以及局部场电位的同步记录，从而解决在特定的行为学范式下对自由活动的动物上同时进行多个脑区电活动功能记录的问题，以解析此行为学下相关的环路功能，对于神经环路功能解析很有帮助。
目前，市面上的单脑区电极用于单脑区的信号记录，在进行多脑区信号记录时，需要针对不同的目标脑区，分别依次植入多个单脑区电极，此过程将耗费较多的时间以及较大的成本，并且，多个单脑区电极植入不同的位置将需要较大空间，当植入对象的脑部体积较小时将无法进行。
发明内容
本发明的目的在于提供一种多脑区记录电极，其能够一次性植入至多个不同的目标脑区。
本发明的另一目的在于提供一种多脑区记录电极的制作方法，其能够制作得到一种能够一次性植入至多个不同的目标脑区的多脑区记录电极。
本发明的又一目的在于提供一种多脑区记录电极的植入方法，其能够一次性植入至多个不同的目标脑区。
本发明提供一种技术方案：
一种多脑区记录电极，包括排针及多个相互并列连接的单脑区电极，多个所述单脑区电极分别具有相对设置的连接端和植入端，多个所述单脑区电极的所述连接端分别与所述排针电连接，多个所述单脑区电极均沿同一方向延伸，任意两个所述单脑区电极的植入端在所述单脑区电极的延伸方向上间隔设置，多个所述单脑区电极的所述植入端用于分别插入至不同的目标脑区。
进一步地，多个所述单脑区电极依次层叠设置。
进一步地，所述多脑区记录电极还包括胶层，任意相邻两个所述单脑区电极通过所述胶层连接。
进一步地，所述单脑区电极包括多个电极单元，多个所述电极单元成排状排布，且多个所述电极单元均沿同一方向延伸。
进一步地，多个所述电极单元在排布方向上依次连接。
进一步地，所述电极单元包括套管和电极丝，所述套管套设于所述电极丝上，所述连接端与所述植入端分别设置于所述电极丝上相对的两端，所述植入端穿出所述套管，相邻的两个所述电极单元的套管成排状排布并依次连接，所述套管用于引导所述电极丝，以使所述植入端插入至所述目标脑区。
进一步地，同一个所述单脑区电极中的多个所述电极丝的所述植入端平齐。
进一步地，多个所述单脑区电极的所述连接端平齐。
本发明还提供一种多脑区记录电极的制作方法，用于制作所述的多脑区记录电极，所述多脑区电极包括排针及多个相互并列连接的单脑区电极，多个所述单脑区电极分别具有相对设置的连接端和植入端，多个所述单脑区电极的所述连接端分别与所述排针电连接，多个所述单脑区电极均沿同一方向延伸，任意两个所述单脑区电极的植入端在所述单脑区电极的延伸方向上间隔设置，多个所述单脑区电极的所述植入端用于分别插入至不同的目标脑区。所述多脑区记录电极的制作方法包括：
测量多个目标脑区相互间的距离，得到多个预设距离值；
并列连接多个单脑区电极，并使多个所述单脑区电极的延伸方向一致；
裁剪多个所述单脑区电极得到所述植入端及所述连接端，并使得任意两个所述单脑区电极的植入端在所述单脑区电极的延伸方向上间隔所述预设距离值设置；
将多个所述单脑区电极的连接端分别与排针电连接。
本发明还提供一种多脑区记录电极的植入方法，采用所述的多脑区记录电极，所述多脑区记录电极包括排针及多个相互并列连接的单脑区电极，多个所述单脑区电极分别具有相对设置的连接端和植入端，多个所述单脑区电极的所述连接端分别与所述排针电连接，多个所述单脑区电极均沿同一方向延伸，任意两个所述单脑区电极的植入端在所述单脑区电极的延伸方向上间隔设置，多个所述单脑区电极的所述植入端用于分别插入至不同的目标脑区。所述多脑区记录电极的植入方法包括：
对多个目标脑区进行定位；
推动所述多脑区记录电极，使得多个所述单脑区电极同时朝向各自对应的所述目标脑区运动，以使所述单脑区电极各自的所述植入端插入至各自对应的所述目标脑区；
将所述多脑区记录电极固定于颅骨上。
相比现有技术，本发明提供的多脑区记录电极，多个单脑区相互并列连接，且均沿同一方向延伸，任意两个单脑区电极的植入端在单脑区电极的延伸方向上间隔设置。在实际应用中，将连接在一起的多个单脑区电极同时植入，并直至各个单脑区电极的植入端到达各自对应的目标脑区，即可完成植入，方便快捷且占据较小空间，不受植入对象的脑部体积影响。因此，本发明提供的多脑区记录电极的有益效果是：能够同时植入至多个目标脑区，方便快捷，节约时间及人力成本，且适用性广。
附图说明
为了更清楚地说明本发明实施例的技术方案，下面将对实施例中所需要使用的附图作简单地介绍。应当理解，以下附图仅示出了本发明的某些实施例，因此不应被看作是对范围的限定。对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他相关的附图。
图1为本发明的实施例提供的多脑区记录电极的结构示意图；
图2为图1中的排针的结构示意图；
图3为图1中的单脑区电极的结构示意图；
图4为本发明的实施例提供的多脑区记录电极的制作方法的流程示意框图；
图5为本发明的实施例提供的多脑区记录电极的植入方法的流程示意框图。
图标：100-多脑区记录电极；110-排针；111-主体部；113-针脚；130-单脑区电极；131-连接端；132-电极单元；1321-套管；1323-电极丝；133-植入端；150-胶层。
具体实施方式
为使本发明实施例的目的、技术方案和优点更加清楚，下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述。显然，所描述的实施例是本发明一部分实施例，而不是全部的实施例。通常在此处附图中描述和示出的本发明实施例的组件可以以各种不同的配置来布置和设计。
因此，以下对在附图中提供的本发明的实施例的详细描述并非旨在限制要求保护的本发明的范围，而是仅仅表示本发明的选定实施例。基于本发明中的实施例，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
应注意到：相似的标号和字母在下面的附图中表示类似项，因此，一旦某一项在一个附图中被定义，则在随后的附图中不需要对其进行进一步定义和解释。
在本发明的描述中，需要理解的是，如“上”等指示方位或位置的关系为基于附图所示的方位或位置关系，或者是该发明产品使用时惯常摆放的方位或位置关系，或者是本领域技术人员惯常理解的方位或位置关系，仅是为了便于描述本发明和简化描述，而不是指示或暗示所指的设备或元件必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本发明的限制。
此外，术语“第一”、“第二”等仅用于区分描述，而不能理解为指示或暗示相对重要性。
在本发明的描述中，还需要说明的是，除非另有明确的规定和限定，“设置”、“连接”等术语应做广义理解，例如，“连接”可以是固定连接，也可以是可拆卸连接，或一体地连接；可以是机械连接，也可以是电连接；可以是直接连接，也可以通过中间媒介间接连接，可以是两个元件内部的连通。对于本领域的普通技术人员而言，可以根据具体情况理解上述术语在本发明中的具体含义。
下面结合附图，对本发明的具体实施方式进行详细说明。
请参照图1所示，本发明的实施例提供的多脑区记录电极100，用于植入实验动物大脑，以实现对多个脑区的动作电位以及局部场电位的同步记录，从而解决在特定的行为学范式下对自由活动的动物上同时进行多个脑区点活动功能记录的问题，以解析此行为学下相关的环路功能。本实施例提供的多脑区记录电极100，能够同时植入至多个目标脑区，方便快捷，节约时间及人力成本，且适用性广。
本实施例提供的多脑区记录电极100，包括排针110及多个相互并列连接的单脑区电极130，多个单脑区电极130用于分别插入至不同的目标脑区，多个单脑区电极130分别具有相对设置的连接端131和植入端133，多个单脑区电极130的连接端131分别与排针110电连接，多个单脑区电极130的植入端133用于插入至对应的目标脑区。多个单脑区电极130均沿同一方向延伸，即本实施例提供的多脑区记录电极100中的多个单脑区电极130均平行设置，在 实际的植入过程中，多个单脑区电极130的植入方向角度也相同。任意两个单脑区电极130的植入端133在单脑区电极130的延伸方向上间隔设置，即任意两个单脑区电极130中，其中一个单脑区电极130的植入端133在单脑区电极130的延伸方向上越过另一个单脑区电极130的植入端133。
请结合图1及图2所示，排针110能够与电生理记录仪器导通。排针110包括主体部111以及凸设于主体部111一侧的多排针脚113，针脚113的具体个数以及分布层数根据单脑区电极130的具体个数而定。本实施例中，采用16通道的排针110，即针脚113个数为16个，并且分两层分布，每层8个，因此，对应连接两个单脑区电极130，即对应插入双脑区。
在实际制作过程中，根据所需的目标脑区数量选用匹配的排针110，进而制作对应的单脑区电极130。例如，对应三脑区时，选用布置有三排针脚113的排针110，每排针脚113对应连接一个单脑区电极130。当实验多脑区为四脑区时，可以直接采用32通道的排针110，其上针脚113分4层布置，每层8个，每一层的针脚113对应连接一个单脑区电极130，并且4个单脑区电极130依次层叠设置并连接。
在本实施例提供的多脑区记录电极100的实际植入过程中，由于多个单脑区电极130的植入端133在单脑区电极130的延伸方向上间隔设置，则多个单脑区电极130的植入端133能够在停止植入的外力作用时，停留在实验动物大脑的不同脑区。则实际应用中，根据实验动物大脑的不同脑区定位选用多脑区记录电极100，外力作用下植入多脑区记录电极100时，多个单脑区电极130沿植入方向同时朝各自对应的目标脑区运动，至各个单脑区电极130各自的植入端133到达各自对应的目标脑区时停止，即完成对多脑区记录电极100的植入，多个单脑区电极130同时植入各自对应的目标脑区，从而能够实现对多个脑区的动作电位以及局部场电位的同步记录。
在本实施例中，多个单脑区电极130依次层叠设置，在其他实施例中，根据植入需求，多个单脑区130还可以并排间隔设置，并通过其他中间件将多个 单脑区130连接在一起。另外，多个单脑区130还可以处于多个不同的平面内，并且所处的平面相交。
多脑区记录电极100还包括胶层150，任意相邻两个单脑区电极130通过胶层150连接。本实施例提供的多脑区记录电极100在实际制备过程中，相邻的两个单脑区电极130之间通过如胶水等的粘结剂进行粘结实现多个单脑区电极130的依次层叠设置，粘结剂凝固即形成胶层150。在其他实施例中，相邻的两个单脑区电极130之间还可以通过其他形式进行连接，如通过捆绑件进行捆绑等。
请结合图1及图3所示，单脑区电极130包括多个电极单元132，多个电极单元132成排状排布，且多个电极单元132均沿同一方向延伸，即多个电极单元132相互平行。
本实施例中，多个电极单元132在排布方向上依次连接，相邻的两个电极单元132直接通过胶水等的粘结剂进行依次粘结。在其他实施例中，同一个单脑区电极130上的多个电极单元132还可以通过其他形式进行连接固定在一起，如通过捆绑件进行捆绑。
电极单元132包括套管1321和电极丝1323，套管1321套设于电极丝1323上，连接端131与植入端133分别设置于电极丝1323上相对的两端，植入端133穿出套管1321。在实际制作过程中，由于电极丝1323采用的金属丝往往较为柔软，在植入过程中难以插入至对应的目标脑区，因此，将套管1321套设于电极丝1323上，用于引导电极丝1323，以使植入端133插入至目标脑区。本实施例中，套管1321采用硅管，在其他实施例中，套管1321还可以根据实际植入需求选用其他材质的管。
请继续参照图1所示，本实施例提供的多脑区记录电极100为16通道，每一套管1321中的电极丝1323为两股金属丝拧合在一起组成，即每一电极丝1323即为两个通道，即套管1321的数量为8个。一层4个套管1321套设于4根电极丝1323上形成4个电极单元132，4个电极单元132排布形成一个单脑 区电极130。另一层4个套管1321套设于另外4根电极丝1323上形成4个电极单元132，4个电极单元132排布形成另一个单脑区电极130。两个单脑区电极130层叠设置，对应选用16通道的排针110，排针110上对应设置有16根针脚113，16根针脚113同样分为两排设置，一个单脑区电极130中的4个电极丝1323中的两根金属丝分别与一排8个针脚113一一对应焊接。在其他实施例中，电极丝1323还可以通过其他形式与排针110上的针脚113电连接，如通过导线连接。
在其他实施例中，根据实际目标脑区的实际数量等其它实验需求，可以改变通道数，如32通道等，选用对应排针110即可。
本实施例中。同一个单脑区电极130中的多个电极丝1323的植入端133平齐。考虑到实际加工中的不确定因素，其他实施例中，同一单脑区电极130中的多个电极丝1323的植入端133可以存在一定误差，即大致平齐即可。另外，本实施例中，同一单脑区电极130中的多个电极丝1323的连接端131也平齐。
本实施例提供的多脑区记录电极100，在外力作用下植入多脑区记录电极100时，多个单脑区电极130沿植入方向同时朝各自对应的目标脑区运动，至各个单脑区电极130各自的植入端133到达各自对应的目标脑区时停止，即完成对多脑区记录电极100的植入，多个单脑区电极130同时植入各自对应的目标脑区，从而能够实现对多个脑区的动作电位以及局部场电位的同步记录。由此，简化了多脑区信号记录电极样式及其对应的电极植入方法，在植入对象的大脑体积较小的情况下由于不用分区植入多个单脑区电极，占据大脑表面的植入空间极小，实现范围较大，适用性广。
因此，本发明提供的多脑区记录电极结构简单，能够同时植入至多个目标脑区，方便快捷，节约时间及人力成本，且适用性广。
本发明提供的多脑区记录电极100提供的结构形式，并不限于多脑区信号的记录，也可在某些脑区植入光纤进行光刺激。
请参照图4所示，本发明还提供一种多脑区记录电极的制作方法，用于制作如实施例提供的多脑区记录电极100，包括：
步骤S101，测量多个目标脑区相互间的距离，得到多个预设距离值。
此预设距离值即为实施例中任意两个单脑区电极130的植入端133在单脑区电极130的延伸方向上间隔设置的间隔距离。
进一步地，该多脑区记录电极的制作方法还包括：
步骤S102，并列连接多个单脑区电极130，并使多个单脑区电极130的延伸方向一致。
本实施例中，通过将电极丝1323的一端穿过套管1321的方式形成一个电极单元132，再将多个电极单元132成排状排布并依次连接，即组成单脑区电极130。单脑区电极130的延伸方向即为套管1321的延伸方向。
进一步地，该多脑区记录电极的制作方法还包括：
步骤S103，裁剪多个单脑区电极130得到植入端133及连接端131，并使得任意两个单脑区电极130的植入端133在单脑区电极130的延伸方向上间隔预设距离值设置。
根据步骤S101得到的多个预设距离值对多个电极丝1323的穿出套管1321的一端进行裁剪，使得任意两个单脑区电极130上的电极丝1323在套管1321的延伸方向上的间隔等于预设距离值。被裁剪的电极丝1323的一端即为植入端133，与植入端133相对的另一端即为连接端131。
进一步地，该多脑区记录电极的制作方法还包括：
步骤S104，将多个单脑区电极130的连接端131分别与排针110电连接。
在多脑区记录电极100制作完成后，还需要对其进行修饰及检测。经过本发明提供的多脑区记录电极的制作方法，能够制作得到如实施例提供的多脑区电极100。
请参照图5所示，本发明还提供一种多脑区记录电极的植入方法，采用如实施例提供的多脑区记录电极100，多脑区记录电极的植入方法包括：
步骤S201，对多个目标脑区进行定位。
通过动物脑区定位手术等方式对实验对象的大脑中的多个目标脑区进行定位，确定植入方向。
进一步地，该多脑区记录电极的植入方法还包括：
步骤S202，推动多脑区记录电极100，使得多个单脑区电极130各自的植入端133同时插入至各自对应的目标脑区。
根据步骤S201确定的植入方向植入多脑区记录电极100，在植入的过程中，多脑区记录电极100上的多个单脑区电极130均朝向各自对应的目标脑区运动，至各个单脑区电极130到达各自对应的目标脑区时，停止推动，并通过牙科水泥或其他固定方法将多脑区记录电极100进行固定。
进一步地，该多脑区记录电极的植入方法还包括：
步骤S203，将多脑区记录电极100固定于颅骨上。
将多脑区记录电极100固定于植入对象大脑的对应颅骨上，即完成植入。
本发明提供的多脑区记录电极的植入方法，用于将如实施例提供的多脑区记录电极100植入实验大脑，而在实际使用中，该多脑区记录电极的植入方法与实施例提供的多脑区记录电极100不一定要完全绑定在一起。
以上所述仅为本发明的优选实施例而已，并不用于限制本发明，对于本领域的技术人员来说，本发明可以有各种更改和变化。凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。

Claims (10)

  1. 一种多脑区记录电极，其特征在于，包括排针及多个相互并列连接的单脑区电极，多个所述单脑区电极分别具有相对设置的连接端和植入端，多个所述单脑区电极的所述连接端分别与所述排针电连接，多个所述单脑区电极均沿同一方向延伸，任意两个所述单脑区电极的植入端在所述单脑区电极的延伸方向上间隔设置，多个所述单脑区电极的所述植入端用于分别插入至不同的目标脑区。
  2. 根据权利要求1所述的多脑区记录电极，其特征在于，多个所述单脑区电极依次层叠设置。
  3. 根据权利要求1所述的多脑区记录电极，其特征在于，所述多脑区记录电极还包括胶层，任意相邻两个所述单脑区电极通过所述胶层连接。
  4. 根据权利要求1所述的多脑区记录电极，其特征在于，所述单脑区电极包括多个电极单元，多个所述电极单元成排状排布，且多个所述电极单元均沿同一方向延伸。
  5. 根据权利要求4所述的多脑区记录电极，其特征在于，多个所述电极单元在排布方向上依次连接。
  6. 根据权利要求4所述的多脑区记录电极，其特征在于，所述电极单元包括套管和电极丝，所述套管套设于所述电极丝上，所述连接端与所述植入端分别设置于所述电极丝上相对的两端，所述植入端穿出所述套管，相邻的两个所述电极单元的套管成排状排布并依次连接，所述套管用于引导所述电极丝，以使所述植入端插入至所述目标脑区。
  7. 根据权利要求6所述的多脑区记录电极，其特征在于，同一个所述单脑区电极中的多个所述电极丝的所述植入端平齐。
  8. 根据权利要求1所述的多脑区记录电极，其特征在于，多个所述单脑区电极的所述连接端平齐。
  9. 一种多脑区记录电极的制作方法，其特征在于，用于制作如权利要求1-8 任一项所述的多脑区记录电极，所述多脑区记录电极的制作方法包括：
    测量多个目标脑区相互间的距离，得到多个预设距离值；
    并列连接多个单脑区电极，并使多个所述单脑区电极的延伸方向一致；
    裁剪多个所述单脑区电极得到所述植入端及所述连接端，并使得任意两个所述单脑区电极的植入端在所述单脑区电极的延伸方向上间隔所述预设距离值设置；
    将多个所述单脑区电极的连接端分别与排针电连接。
  10. 一种多脑区记录电极的植入方法，其特征在于，采用如权利要求1-8任一项所述的多脑区记录电极，所述多脑区记录电极的植入方法包括：
    对多个目标脑区进行定位；
    推动所述多脑区记录电极，使得多个所述单脑区电极同时朝向各自对应的所述目标脑区运动，以使所述单脑区电极各自的所述植入端插入至各自对应的所述目标脑区；
    将所述多脑区记录电极固定于颅骨上。
PCT/CN2019/102810 2019-08-27 2019-08-27 一种多脑区记录电极、制作方法及植入方法 WO2021035527A1 (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2019/102810 WO2021035527A1 (zh) 2019-08-27 2019-08-27 一种多脑区记录电极、制作方法及植入方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2019/102810 WO2021035527A1 (zh) 2019-08-27 2019-08-27 一种多脑区记录电极、制作方法及植入方法

Publications (1)

Publication Number Publication Date
WO2021035527A1 true WO2021035527A1 (zh) 2021-03-04

Family

ID=74684974

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2019/102810 WO2021035527A1 (zh) 2019-08-27 2019-08-27 一种多脑区记录电极、制作方法及植入方法

Country Status (1)

Country Link
WO (1) WO2021035527A1 (zh)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1383372A (zh) * 2000-07-05 2002-12-04 松下电器产业株式会社 筛选仪器和方法,由筛选方法获得的嗅觉粘膜刺激化合物,治疗仪器和测量电极组
CN101316553A (zh) * 2005-10-06 2008-12-03 简斯·斯科恩博格 电极束
CN101543406A (zh) * 2008-03-26 2009-09-30 中国科学院半导体研究所 使用硅阵列孔装配微丝电极阵列的方法
CN101616630A (zh) * 2007-01-23 2009-12-30 神经毫微股份公司 电极阵列
US20110125001A1 (en) * 2009-11-25 2011-05-26 Weileun Fang 3d microelectrode structure and method for assembling the same
CN105852855A (zh) * 2016-04-15 2016-08-17 郑州科斗创客科技有限公司 用于鼠类大脑初级视觉皮层脑电测量的植入式脑电极
CN106562786A (zh) * 2016-11-07 2017-04-19 深圳先进技术研究院 一种多脑区场电位记录电极及植入方法
CN109171718A (zh) * 2018-08-03 2019-01-11 北京大学 微针电极阵列装置

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1383372A (zh) * 2000-07-05 2002-12-04 松下电器产业株式会社 筛选仪器和方法,由筛选方法获得的嗅觉粘膜刺激化合物,治疗仪器和测量电极组
CN101316553A (zh) * 2005-10-06 2008-12-03 简斯·斯科恩博格 电极束
CN101616630A (zh) * 2007-01-23 2009-12-30 神经毫微股份公司 电极阵列
CN101543406A (zh) * 2008-03-26 2009-09-30 中国科学院半导体研究所 使用硅阵列孔装配微丝电极阵列的方法
US20110125001A1 (en) * 2009-11-25 2011-05-26 Weileun Fang 3d microelectrode structure and method for assembling the same
CN105852855A (zh) * 2016-04-15 2016-08-17 郑州科斗创客科技有限公司 用于鼠类大脑初级视觉皮层脑电测量的植入式脑电极
CN106562786A (zh) * 2016-11-07 2017-04-19 深圳先进技术研究院 一种多脑区场电位记录电极及植入方法
CN109171718A (zh) * 2018-08-03 2019-01-11 北京大学 微针电极阵列装置

Similar Documents

Publication Publication Date Title
Steinmetz et al. Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings
US20200261713A1 (en) Structures and techniques for medical lead fabrication
US7603153B2 (en) Multi-element probe array
Barz et al. Versatile, modular 3D microelectrode arrays for neuronal ensemble recordings: from design to fabrication, assembly, and functional validation in non-human primates
Hetke et al. Silicon ribbon cables for chronically implantable microelectrode arrays
US9248269B2 (en) Neural device with modular electrode array
US10124160B2 (en) Charge steering high density electrode array
US9636028B2 (en) Three-dimensional neural probe microelectrode array and method of manufacture
Nguyen et al. Micro-drive array for chronic in vivo recording: tetrode assembly
US20200229704A1 (en) Optoelectronic device to write-in and read-out activity in brain circuits
CN102918370A (zh) 用于零热通量深部组织温度测量装置的构造
CN110786846B (zh) 一种柔性记录电极及其制备方法与植入方法
US20200085375A1 (en) Electrode fabrication and design
Chang et al. Construction of microdrive arrays for chronic neural recordings in awake behaving mice
Xie et al. 512-channel and 13-region simultaneous recordings coupled with optogenetic manipulation in freely behaving mice
CN104490385A (zh) 一种针式微电极阵列
WO2021035527A1 (zh) 一种多脑区记录电极、制作方法及植入方法
Tooker et al. Towards a large-scale recording system: Demonstration of polymer-based penetrating array for chronic neural recording
Lu et al. Extracellularly identifying motor neurons for a muscle motor pool in Aplysia californica
US20150216682A1 (en) Array of Microelectrodes for Interfacing to Neurons within Fascicles
Lu et al. Construction of an improved multi-tetrode hyperdrive for large-scale neural recording in behaving rats
CN105852855A (zh) 用于鼠类大脑初级视觉皮层脑电测量的植入式脑电极
US20120131233A1 (en) Method for assigning device addresses to sensors in a physiological measurement system, a physiological measurement system, and a connector element for a physiological measurement system
US8939774B2 (en) Methods and apparatus for three-dimensional microfabricated arrays
CN211066593U (zh) 一种多脑区记录电极

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 19943797

Country of ref document: EP

Kind code of ref document: A1