KR100406159B1 - β-뉴클레오시드아날로그화합물및그의염을제조하기위한방법 - Google Patents

β-뉴클레오시드아날로그화합물및그의염을제조하기위한방법 Download PDF

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Publication number
KR100406159B1
KR100406159B1 KR10-1998-0704473A KR19980704473A KR100406159B1 KR 100406159 B1 KR100406159 B1 KR 100406159B1 KR 19980704473 A KR19980704473 A KR 19980704473A KR 100406159 B1 KR100406159 B1 KR 100406159B1
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KR
South Korea
Prior art keywords
alkyl
rti
group
halogen
formula
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Expired - Fee Related
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KR10-1998-0704473A
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English (en)
Korean (ko)
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KR19990072141A (ko
Inventor
타렉 맨스워
알렉스 심포이아
크르지스즈토푸 베드나르스키
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샤이어 바이오켐 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR10-1998-0704473A 1995-12-14 1996-12-13 β-뉴클레오시드아날로그화합물및그의염을제조하기위한방법 Expired - Fee Related KR100406159B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9525606.1A GB9525606D0 (en) 1995-12-14 1995-12-14 Method and compositions for the synthesis of dioxolane nucleosides with › - configuration
GB9525606.1 1995-12-14

Publications (2)

Publication Number Publication Date
KR19990072141A KR19990072141A (ko) 1999-09-27
KR100406159B1 true KR100406159B1 (ko) 2004-11-16

Family

ID=10785435

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-1998-0704473A Expired - Fee Related KR100406159B1 (ko) 1995-12-14 1996-12-13 β-뉴클레오시드아날로그화합물및그의염을제조하기위한방법

Country Status (27)

Country Link
US (4) US5922867A (cg-RX-API-DMAC10.html)
EP (1) EP0970074B1 (cg-RX-API-DMAC10.html)
JP (1) JP3229990B2 (cg-RX-API-DMAC10.html)
KR (1) KR100406159B1 (cg-RX-API-DMAC10.html)
CN (1) CN1080263C (cg-RX-API-DMAC10.html)
AP (1) AP879A (cg-RX-API-DMAC10.html)
AT (1) ATE214699T1 (cg-RX-API-DMAC10.html)
AU (1) AU706328B2 (cg-RX-API-DMAC10.html)
BR (1) BR9612351A (cg-RX-API-DMAC10.html)
CA (1) CA2237730C (cg-RX-API-DMAC10.html)
DE (1) DE69620042T2 (cg-RX-API-DMAC10.html)
DK (1) DK0970074T3 (cg-RX-API-DMAC10.html)
EA (1) EA000844B1 (cg-RX-API-DMAC10.html)
ES (1) ES2172697T3 (cg-RX-API-DMAC10.html)
GB (1) GB9525606D0 (cg-RX-API-DMAC10.html)
HU (1) HU224076B1 (cg-RX-API-DMAC10.html)
IL (3) IL124663A (cg-RX-API-DMAC10.html)
IN (1) IN187349B (cg-RX-API-DMAC10.html)
MX (1) MX9804701A (cg-RX-API-DMAC10.html)
NO (1) NO309901B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ323855A (cg-RX-API-DMAC10.html)
OA (1) OA11094A (cg-RX-API-DMAC10.html)
PL (1) PL188447B1 (cg-RX-API-DMAC10.html)
PT (1) PT970074E (cg-RX-API-DMAC10.html)
TW (1) TW341574B (cg-RX-API-DMAC10.html)
WO (1) WO1997021706A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA9610544B (cg-RX-API-DMAC10.html)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001518899A (ja) 1997-04-07 2001-10-16 トライアングル ファーマシューティカルズ，インコーポレイティド 他の抗ウイルス剤との組合せにおけるｍｋｃ−４４２の使用
PT2322518E (pt) 1998-08-12 2015-06-08 Gilead Sciences Inc Métodos de fabrico de nucleosídeos de 1,3-dioxolano e 1,3 oxatiolano
US6979561B1 (en) 1998-10-09 2005-12-27 Gilead Sciences, Inc. Non-homogeneous systems for the resolution of enantiomeric mixtures
NZ513094A (en) 1998-12-23 2004-05-28 Shire Biochem Inc Antiviral nucleoside analogues
CA2362570A1 (en) * 1999-02-11 2000-08-17 Shire Biochem Inc. Stereoselective synthesis of nucleoside analogues
AU777869B2 (en) * 1999-09-24 2004-11-04 Shire Canada Inc. Method for the treatment or prevention of viral infection using nucleoside analogues
US6566365B1 (en) 1999-11-04 2003-05-20 Biochem Pharma Inc. Method for the treatment of Flaviviridea viral infection using nucleoside analogues
US7038039B2 (en) * 2000-02-10 2006-05-02 Mitsui Chemicals, Inc. Process for selectively producing 1-phosphorylated sugar derivative anomer and process for producing nucleoside
ES2284613T3 (es) 2000-02-11 2007-11-16 Shire Biochem Inc. Sintesis estereoselectiva de analogos de nucleosido.
WO2002051852A1 (fr) * 2000-12-27 2002-07-04 Mitsui Chemicals, Inc. Procede de production d'un derive de saccharide non naturel
ES2299950T3 (es) * 2001-03-01 2008-06-01 Abbott Laboratories Formas polimorficas y otras formas cristalinas cis-ftc.
AU2002329970A1 (en) * 2001-09-04 2003-03-18 Isis Pharmaceuticals, Inc. Pyrrolo(2,3-d)pyrimidines for inhibiting rna-dependent rna viral polymerase
WO2003037344A1 (en) * 2001-11-02 2003-05-08 Shire Biochem Inc. Pharmaceutical compositions for the treatment of leukemia comprising dioxolane nucleosides analogs
JP2005519916A (ja) * 2001-12-14 2005-07-07 フアーマセツト・リミテツド ウィルス感染治療用ｎ４−アシルシトシンヌクレオシド類
CA2473736C (en) * 2002-01-25 2011-10-11 Shire Biochem Inc. Process for producing dioxolane nucleoside analogues
DE60335805D1 (de) 2002-08-06 2011-03-03 Pharmasset Inc Verfahren zur herstellung von 1,3-dioxolan-nucleosiden
KR101113341B1 (ko) 2002-10-15 2012-09-27 엑손모빌 케미칼 패턴츠 인코포레이티드 올레핀 중합용 다중 촉매 시스템 및 이로부터 제조된중합체
DE10335061B4 (de) * 2003-07-31 2005-11-17 Wacker-Chemie Gmbh Verfahren zur Herstellung von OH-geschützten [4-(2,6-damino-9H-purin-9-yl)-1,3-dioxolan-2-yl]methanol-Derivaten
US7785839B2 (en) 2004-02-03 2010-08-31 Emory University Methods to manufacture 1,3-dioxolane nucleosides
US7749531B2 (en) * 2005-06-08 2010-07-06 Indicator Systems International Apparatus and method for detecting bacterial growth beneath a wound dressing
BRPI0813036A2 (pt) * 2007-07-30 2017-10-24 Rfs Pharma Llc processo estereosseletivo para preparar derivados do nucleosídeo dioxolana de purina.
CN101862676B (zh) * 2009-04-17 2012-01-25 中国石油化工股份有限公司 大孔径sba-15介孔材料-三氟甲磺酸铜复合催化剂、制备方法及应用
CN103288806A (zh) * 2013-07-02 2013-09-11 山东大学 一种曲沙他滨的合成方法
WO2018022263A1 (en) 2016-07-29 2018-02-01 Exxonmobil Chemical Patents Inc. Polymerization processes using high molecular weight polyhydric quenching agents
JP7337539B2 (ja) 2018-06-21 2023-09-04 メディヴィル・アクチエボラーグ 白血病療法のための塩基修飾シチジンヌクレオチド
WO2019245444A1 (en) 2018-06-21 2019-12-26 Medivir Ab Base-modified cytidine nucleotides for leukemia therapy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
IL106078A0 (en) * 1992-06-22 1993-10-20 Lilly Co Eli Stereoselective anion glycosylation process

Also Published As

Publication number Publication date
CN1208414A (zh) 1999-02-17
EA000844B1 (ru) 2000-06-26
EA199800555A1 (ru) 1999-02-25
PT970074E (pt) 2002-09-30
GB9525606D0 (en) 1996-02-14
DE69620042T2 (de) 2002-10-17
EP0970074A1 (en) 2000-01-12
OA11094A (en) 2003-03-13
HUP9901050A2 (hu) 2001-04-28
ZA9610544B (en) 1997-07-29
AP879A (en) 2000-10-02
IL144155A (en) 2003-07-06
TW341574B (en) 1998-10-01
PL327443A1 (en) 1998-12-07
US5922867A (en) 1999-07-13
US20030060476A1 (en) 2003-03-27
CN1080263C (zh) 2002-03-06
BR9612351A (pt) 1999-07-13
US20020058670A1 (en) 2002-05-16
US6069250A (en) 2000-05-30
IL124663A0 (en) 1998-12-06
IL124663A (en) 2001-10-31
ES2172697T3 (es) 2002-10-01
IL144155A0 (en) 2002-05-23
AP9801252A0 (en) 1998-06-30
EP0970074B1 (en) 2002-03-20
HUP9901050A3 (en) 2001-05-28
JP3229990B2 (ja) 2001-11-19
AU706328B2 (en) 1999-06-17
WO1997021706A1 (en) 1997-06-19
HU224076B1 (hu) 2005-05-30
NO982716L (no) 1998-06-12
NO982716D0 (no) 1998-06-12
CA2237730A1 (en) 1997-06-19
MX9804701A (es) 1998-10-31
IN187349B (cg-RX-API-DMAC10.html) 2002-03-30
AU1089397A (en) 1997-07-03
NO309901B1 (no) 2001-04-17
NZ323855A (en) 1999-11-29
HK1017886A1 (en) 1999-12-03
DE69620042D1 (de) 2002-04-25
PL188447B1 (pl) 2005-02-28
ATE214699T1 (de) 2002-04-15
DK0970074T3 (da) 2002-07-15
KR19990072141A (ko) 1999-09-27
JP2000501714A (ja) 2000-02-15
CA2237730C (en) 2001-12-04

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