KR100365070B1 - 토코페롤 유도체 및 그의 제조방법 - Google Patents

토코페롤 유도체 및 그의 제조방법 Download PDF

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Publication number
KR100365070B1
KR100365070B1 KR1020000050330A KR20000050330A KR100365070B1 KR 100365070 B1 KR100365070 B1 KR 100365070B1 KR 1020000050330 A KR1020000050330 A KR 1020000050330A KR 20000050330 A KR20000050330 A KR 20000050330A KR 100365070 B1 KR100365070 B1 KR 100365070B1
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KR
South Korea
Prior art keywords
tocopherol
organic solvent
reacting
derivatives
present
Prior art date
Application number
KR1020000050330A
Other languages
English (en)
Korean (ko)
Other versions
KR20020029443A (ko
Inventor
김길중
김덕희
노호식
유재원
남춘자
홍종언
강학희
장이섭
Original Assignee
주식회사 태평양
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 주식회사 태평양 filed Critical 주식회사 태평양
Priority to KR1020000050330A priority Critical patent/KR100365070B1/ko
Priority to US09/756,179 priority patent/US6410752B1/en
Priority to JP2001003665A priority patent/JP4330279B2/ja
Priority to FR0100389A priority patent/FR2813191B1/fr
Publication of KR20020029443A publication Critical patent/KR20020029443A/ko
Application granted granted Critical
Publication of KR100365070B1 publication Critical patent/KR100365070B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
KR1020000050330A 2000-08-29 2000-08-29 토코페롤 유도체 및 그의 제조방법 KR100365070B1 (ko)

Priority Applications (4)

Application Number Priority Date Filing Date Title
KR1020000050330A KR100365070B1 (ko) 2000-08-29 2000-08-29 토코페롤 유도체 및 그의 제조방법
US09/756,179 US6410752B1 (en) 2000-08-29 2001-01-09 Tocopherol derivatives and method for preparation thereof
JP2001003665A JP4330279B2 (ja) 2000-08-29 2001-01-11 トコフェロール誘導体及びその製造方法
FR0100389A FR2813191B1 (fr) 2000-08-29 2001-01-12 Derives du tocopherol et procede de preparation de ceux-ci

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020000050330A KR100365070B1 (ko) 2000-08-29 2000-08-29 토코페롤 유도체 및 그의 제조방법

Publications (2)

Publication Number Publication Date
KR20020029443A KR20020029443A (ko) 2002-04-19
KR100365070B1 true KR100365070B1 (ko) 2002-12-16

Family

ID=19685777

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020000050330A KR100365070B1 (ko) 2000-08-29 2000-08-29 토코페롤 유도체 및 그의 제조방법

Country Status (4)

Country Link
US (1) US6410752B1 (US20020045765A1-20020418-C00004.png)
JP (1) JP4330279B2 (US20020045765A1-20020418-C00004.png)
KR (1) KR100365070B1 (US20020045765A1-20020418-C00004.png)
FR (1) FR2813191B1 (US20020045765A1-20020418-C00004.png)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100394770B1 (ko) * 2001-06-05 2003-08-14 주식회사 태평양 토코페롤 유도체를 이용하여 나노유화입자를 안정화시키는방법 및 나노유화입자를 함유하는 피부 외용제 조성물
KR100401959B1 (ko) * 2001-06-02 2003-10-17 주식회사 태평양 토코페롤 유도체를 사용하여 레시틴을 안정화하는 방법

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPR549901A0 (en) * 2001-06-06 2001-07-12 Vital Health Sciences Pty Ltd Topical formulation containing tocopheryl phosphates
CN1262274C (zh) * 2000-11-14 2006-07-05 生命健康科学有限公司 磷酸盐衍生物复合物
KR100376088B1 (ko) * 2001-03-09 2003-03-28 주식회사 태평양 3-아미노프로필코질포스페이트 및 그의 염을 함유한미백화장료 조성물
BR0211673A (pt) 2001-07-27 2004-07-13 Vital Health Sciences Pty Ltd Terapia dermal utilizando derivados de fosfato de agentes de transferência de elétrons
WO2003049774A1 (en) * 2001-12-13 2003-06-19 Vital Health Sciences Pty Ltd Transdermal transport of compounds
KR100456427B1 (ko) * 2001-12-14 2004-11-10 주식회사 태평양 3-아미노프로필토코페릴 포스페이트를 함유한나노유화입자 및 그의 제조방법, 및 이를 함유하는피부외용제 조성물
AU2002950713A0 (en) 2002-08-09 2002-09-12 Vital Health Sciences Pty Ltd Carrier
KR20050086954A (ko) * 2003-01-17 2005-08-30 바이탈 헬스 사이언시즈 피티와이 리미티드 항증식성 화합물
WO2005084678A1 (en) * 2004-03-03 2005-09-15 Vital Health Sciences Pty Ltd Alkaloid formulations
KR101238703B1 (ko) * 2004-08-03 2013-03-04 바이탈 헬스 사이언시즈 피티와이 리미티드 경구 투여용 담체
US20090239827A1 (en) * 2005-03-03 2009-09-24 Esra Ogru Compounds having lipid lowering properties
KR101056879B1 (ko) * 2005-06-08 2011-08-12 (주)아모레퍼시픽 세사몰 유도체 또는 그의 염, 그의 제조방법, 및 이를함유하는 피부외용제 조성물
KR20080019228A (ko) 2005-06-17 2008-03-03 바이탈 헬스 사이언시즈 피티와이 리미티드 하나 이상의 디 및/또는 모노-(전자전달제) 인산염 유도체또는 그의 착염을 함유하는 담체
AU2011213557B2 (en) 2010-02-05 2015-05-07 Phosphagenics Limited Carrier comprising non-neutralised tocopheryl phosphate
CN102821791B (zh) 2010-03-30 2015-06-17 磷肌酸有限公司 透皮递送贴剂
EP2685992A4 (en) 2011-03-15 2014-09-10 Phosphagenics Ltd AMINO-QUINOLINES AS KINASE INHIBITORS
US10434204B2 (en) 2011-07-15 2019-10-08 Soclean, Inc. Technologies for sanitizing mist humidifiers
KR20160068776A (ko) 2013-09-13 2016-06-15 더 보드 오브 트러스티스 오브 더 유니버시티 오브 아칸소 방사선 효과의 완화 및 예방을 위한 조성물의 제조 및 용도
US20160324914A1 (en) 2015-05-05 2016-11-10 Tocol Pharmaceuticals, Llc Use of rice bran oil distillate extract for prevention and mitigation of the effects of radiation
CA3007587C (en) 2015-12-09 2023-12-05 Phosphagenics Limited Pharmaceutical formulation
BR112019012946A2 (pt) 2016-12-21 2019-11-26 Avecho Biotechnology Ltd processo

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4564686A (en) * 1983-05-30 1986-01-14 Senju Pharmaceutical Co., Ltd. Phosphoric acid diesters or their salts and process for producing the same
US4977282A (en) * 1984-04-17 1990-12-11 Henkel Corporation Production of d-alpha-tocopherol from natural plant sources
US5603949A (en) * 1991-08-01 1997-02-18 Lvmh Recherche Use of a tocopherol phosphate or one of its derivatives, for the preparation of cosmetic or pharmaceutical compositions and compositions so obtained
JPH1045783A (ja) * 1996-07-29 1998-02-17 Showa Denko Kk ヒドロキシクロマン誘導体リン酸エステルの製造方法
US5965750A (en) * 1995-10-17 1999-10-12 Showa Denko K.K. High- purity tocopherol phosphates, process for the preparation thereof, methods for analysis thereof, and cosmetics

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4564686A (en) * 1983-05-30 1986-01-14 Senju Pharmaceutical Co., Ltd. Phosphoric acid diesters or their salts and process for producing the same
US4977282A (en) * 1984-04-17 1990-12-11 Henkel Corporation Production of d-alpha-tocopherol from natural plant sources
US5603949A (en) * 1991-08-01 1997-02-18 Lvmh Recherche Use of a tocopherol phosphate or one of its derivatives, for the preparation of cosmetic or pharmaceutical compositions and compositions so obtained
US5965750A (en) * 1995-10-17 1999-10-12 Showa Denko K.K. High- purity tocopherol phosphates, process for the preparation thereof, methods for analysis thereof, and cosmetics
JPH1045783A (ja) * 1996-07-29 1998-02-17 Showa Denko Kk ヒドロキシクロマン誘導体リン酸エステルの製造方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100401959B1 (ko) * 2001-06-02 2003-10-17 주식회사 태평양 토코페롤 유도체를 사용하여 레시틴을 안정화하는 방법
KR100394770B1 (ko) * 2001-06-05 2003-08-14 주식회사 태평양 토코페롤 유도체를 이용하여 나노유화입자를 안정화시키는방법 및 나노유화입자를 함유하는 피부 외용제 조성물

Also Published As

Publication number Publication date
US20020045765A1 (en) 2002-04-18
JP2002088091A (ja) 2002-03-27
FR2813191B1 (fr) 2003-06-20
US6410752B1 (en) 2002-06-25
FR2813191A1 (fr) 2002-03-01
KR20020029443A (ko) 2002-04-19
JP4330279B2 (ja) 2009-09-16

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