KR100202771B1 - 미생물감염에대한숙주의예방적치료용백신 - Google Patents
미생물감염에대한숙주의예방적치료용백신 Download PDFInfo
- Publication number
- KR100202771B1 KR100202771B1 KR1019920702407A KR920702407A KR100202771B1 KR 100202771 B1 KR100202771 B1 KR 100202771B1 KR 1019920702407 A KR1019920702407 A KR 1019920702407A KR 920702407 A KR920702407 A KR 920702407A KR 100202771 B1 KR100202771 B1 KR 100202771B1
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- South Korea
- Prior art keywords
- bacterium
- gene
- salmonella
- vaccine
- mutation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0275—Salmonella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/255—Salmonella (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/826—Bacterial vaccine for avian species, e.g. poultry or other birds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9007194.5 | 1990-03-30 | ||
| GB9007194,5 | 1990-03-30 | ||
| GB909007194A GB9007194D0 (en) | 1990-03-30 | 1990-03-30 | Live vaccines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR937000640A KR937000640A (ko) | 1993-03-15 |
| KR100202771B1 true KR100202771B1 (ko) | 1999-06-15 |
Family
ID=10673583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019920702407A Expired - Lifetime KR100202771B1 (ko) | 1990-03-30 | 1991-03-28 | 미생물감염에대한숙주의예방적치료용백신 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US5804194A (enExample) |
| EP (1) | EP0524205B1 (enExample) |
| JP (1) | JP3054440B2 (enExample) |
| KR (1) | KR100202771B1 (enExample) |
| AT (1) | ATE157397T1 (enExample) |
| CA (1) | CA2079463C (enExample) |
| DE (1) | DE69127440T2 (enExample) |
| DK (1) | DK0524205T3 (enExample) |
| ES (1) | ES2106776T3 (enExample) |
| GB (1) | GB9007194D0 (enExample) |
| GR (1) | GR3025258T3 (enExample) |
| HU (1) | HU217776B (enExample) |
| IE (1) | IE911037A1 (enExample) |
| IL (1) | IL97720A (enExample) |
| MY (1) | MY130001A (enExample) |
| NZ (1) | NZ237616A (enExample) |
| TW (1) | TW205567B (enExample) |
| WO (1) | WO1991015572A1 (enExample) |
| ZA (1) | ZA912397B (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5662908A (en) * | 1985-07-31 | 1997-09-02 | The Board Of Trustees Of The Leland Stanford Jr. University | Invasive microorganisms |
| CA2099841C (en) * | 1991-03-05 | 2003-02-25 | Ian G. Charles | Expression of recombinant proteins in attenuated bacteria |
| AU675940B2 (en) * | 1992-03-02 | 1997-02-27 | Board Of Trustees Of The Leland Stanford Junior University | Microorganisms having attenuated invasiveness |
| DE69322092T2 (de) * | 1992-09-04 | 1999-07-15 | University Of Saskatchewan, Saskatoon | Neue bakterielle impfstoffe unter verwendung von impfstämmen von pathogenen bakterien |
| ES2171454T3 (es) | 1993-06-04 | 2002-09-16 | Whitehead Biomedical Inst | Proteinas de estres y sus usos. |
| US5997873A (en) * | 1994-01-13 | 1999-12-07 | Mount Sinai School Of Medicine Of The City University Of New York | Method of preparation of heat shock protein 70-peptide complexes |
| US5750119A (en) | 1994-01-13 | 1998-05-12 | Mount Sinai School Of Medicine Of The City University Of New York | Immunotherapeutic stress protein-peptide complexes against cancer |
| GB9401795D0 (en) * | 1994-01-31 | 1994-03-23 | Medeva Holdings Bv | Vaccines |
| US5961979A (en) * | 1994-03-16 | 1999-10-05 | Mount Sinai School Of Medicine Of The City University Of New York | Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens |
| US5985270A (en) * | 1995-09-13 | 1999-11-16 | Fordham University | Adoptive immunotherapy using macrophages sensitized with heat shock protein-epitope complexes |
| US5935576A (en) | 1995-09-13 | 1999-08-10 | Fordham University | Compositions and methods for the treatment and prevention of neoplastic diseases using heat shock proteins complexed with exogenous antigens |
| US5837251A (en) * | 1995-09-13 | 1998-11-17 | Fordham University | Compositions and methods using complexes of heat shock proteins and antigenic molecules for the treatment and prevention of neoplastic diseases |
| US5796671A (en) | 1996-03-01 | 1998-08-18 | Wahlstrom; Sven E. | Dynamic random access memory |
| US7157089B1 (en) | 1996-11-26 | 2007-01-02 | Stressgen Biotechnologies Corporation | Immune responses using compositions containing stress proteins |
| US5830464A (en) * | 1997-02-07 | 1998-11-03 | Fordham University | Compositions and methods for the treatment and growth inhibition of cancer using heat shock/stress protein-peptide complexes in combination with adoptive immunotherapy |
| US6017540A (en) | 1997-02-07 | 2000-01-25 | Fordham University | Prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases with heat shock/stress protein-peptide complexes |
| HUP0003601A3 (en) | 1997-08-05 | 2003-03-28 | Stressgen Biotechnologies Corp | Immune responses against hpv antigens elicited by compositions comprising an hpv antigen and a stress protein or an expression vector capable of expression of these proteins |
| US6905691B1 (en) | 1997-12-11 | 2005-06-14 | Celltech Pharma Europe Limited | Vaccines containing attenuated bacteria |
| US5948646A (en) | 1997-12-11 | 1999-09-07 | Fordham University | Methods for preparation of vaccines against cancer comprising heat shock protein-peptide complexes |
| CU22661A1 (es) * | 1997-12-30 | 2001-04-27 | Cnic Ct Nac Investigaciones | Nuevos candidatos vacunales de vibrio cholerae y método de obtención |
| EP1054683B1 (en) | 1998-02-20 | 2007-04-11 | University Of Miami | Modified heat shock protein-antigenic peptide complex |
| GB9806449D0 (en) * | 1998-03-25 | 1998-05-27 | Peptide Therapeutics Ltd | Attenuated bacteria useful in vaccines |
| US8076130B2 (en) | 1998-12-02 | 2011-12-13 | University Of Maryland, Baltimore | Plasmid maintenance system for antigen delivery |
| CZ20011538A3 (cs) | 1998-12-02 | 2001-11-14 | University Of Maryland, Baltimore | Nezávisle fungující expresní kazeta, amplifikovatelný plazmidový replikon, bakteriální buňka, vakcinační vektor, podmíněně nestabilní plazmid, způsob vyvolání imunitní odpovědi, DNA a expresní plazmid |
| US6413768B1 (en) | 1998-12-02 | 2002-07-02 | University Of Maryland | Expression plasmids |
| US6497880B1 (en) | 1998-12-08 | 2002-12-24 | Stressgen Biotechnologies Corporation | Heat shock genes and proteins from Neisseria meningitidis, Candida glabrata and Aspergillus fumigatus |
| FR2787810B1 (fr) * | 1998-12-24 | 2002-10-31 | Inst Nat De La Rech Agronomique Inra | Bacteries a gram positif depourvues d'activite proteasique htra, et leurs utilisations |
| EP1196772A2 (en) | 1999-07-08 | 2002-04-17 | Stressgen Biotechnologies Corporation | Induction of a th1-like response in vitro |
| AU1814101A (en) | 2000-01-14 | 2001-07-24 | Massachusetts Institute Of Technology | In vivo CTL elicitation by heat shock protein fusion proteins maps to a discrete ATP binding domain and is CD4+ cell-independent |
| WO2001091787A1 (en) | 2000-06-02 | 2001-12-06 | University Of Connecticut Health Center | Complexes of alpha (2) macroglobulin and antigenic molecules for immunotherapy |
| SK18362002A3 (sk) | 2000-06-26 | 2004-02-03 | Stressgen Biotechnologies Corporation | Použitie prostriedku s obsahom fúzneho proteínu |
| US6872547B1 (en) | 2000-10-11 | 2005-03-29 | Washington University | Functional balanced-lethal host-vector systems |
| KR20030074787A (ko) | 2001-02-05 | 2003-09-19 | 스트레스젠 바이오테크놀러지스 코포레이션 | Ｂ형 간염 바이러스 치료 |
| ITRM20010295A1 (it) * | 2001-05-30 | 2002-12-02 | Stresstech S R L | Metodo per ottenere microrganismi patogeni non virulenti attraverso una modificazione dello stato fisico e/o dinamico delle loro membrane bi |
| WO2003015712A2 (en) | 2001-08-20 | 2003-02-27 | University Of Connecticut Health Center | Methods for preparing compositions comprising heat shock proteins or alpha-2-macroglobulin |
| GB0121998D0 (en) | 2001-09-11 | 2001-10-31 | Acambis Res Ltd | Attenuated bacteria useful in vaccines |
| US7541043B2 (en) | 2002-01-16 | 2009-06-02 | The United States Of America As Represented By The Department Of Health And Human Services | Vaccine for protection against Shigella sonnei disease |
| UA100370C2 (uk) | 2006-12-11 | 2012-12-25 | Мериал Лимитед | Спосіб вакцинації птахів проти salmonella |
| EP2752193B1 (en) | 2008-03-03 | 2017-01-11 | The University of Miami | Allogeneic cancer cell-based immunotherapy |
| WO2009117116A2 (en) | 2008-03-20 | 2009-09-24 | University Of Miami | Heat shock protein gp96 vaccination and methods of using same |
| IL214246B (en) * | 2011-07-21 | 2018-08-30 | Shafferman Avigdor | Vaccines produced from htra-defective Bacillus anthraxis |
| MX392514B (es) | 2014-04-15 | 2025-03-24 | Univ Griffith | Vacuna para estreptococo del grupo a. |
| BR112017016681A2 (pt) | 2015-02-06 | 2018-04-10 | Heat Biologics Inc | vetor de coexpressão de vacina e moléculas coestimulatórias |
| CA3040123A1 (en) | 2016-10-11 | 2018-04-19 | University Of Miami | Vectors and vaccine cells for immunity against zika virus |
| US11548930B2 (en) | 2017-04-04 | 2023-01-10 | Heat Biologics, Inc. | Intratumoral vaccination |
| KR20220152402A (ko) | 2019-11-25 | 2022-11-15 | 그리피스 유니버시티 | 임균 감염에 대한 면역원성 단백질 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4337314A (en) * | 1979-05-23 | 1982-06-29 | Research Corporation | Genetically attenuated bacterial vaccines with multiple mutations of the same phenotype |
| US4735801A (en) * | 1982-09-07 | 1988-04-05 | Board Of Trustees Of Leland Stanford Jr. University | Novel non-reverting salmonella live vaccines |
| GB8314645D0 (en) * | 1983-05-26 | 1983-06-29 | Wellcome Found | Bivalent vaccines |
| WO1988005821A1 (en) * | 1987-01-30 | 1988-08-11 | President And Fellows Of Harvard College | Periplasmic protease mutants of escherichia coli |
| US4895717A (en) * | 1987-07-10 | 1990-01-23 | The United States Of America As Represented By The Secretary Of Agriculture | Revertant serotype 1 Marek's disease vaccine |
| GB8730037D0 (en) * | 1987-12-23 | 1988-02-03 | Wellcome Found | Vaccines |
| US5114844A (en) * | 1989-03-14 | 1992-05-19 | Yeda Research And Development Co., Ltd. | Diagnosis and treatment of insulin dependent diabetes mellitus |
| GB8912330D0 (en) * | 1989-05-30 | 1989-07-12 | Wellcome Found | Live vaccines |
-
1990
- 1990-03-30 GB GB909007194A patent/GB9007194D0/en active Pending
-
1991
- 1991-03-28 DE DE69127440T patent/DE69127440T2/de not_active Expired - Lifetime
- 1991-03-28 KR KR1019920702407A patent/KR100202771B1/ko not_active Expired - Lifetime
- 1991-03-28 EP EP91906493A patent/EP0524205B1/en not_active Expired - Lifetime
- 1991-03-28 CA CA002079463A patent/CA2079463C/en not_active Expired - Lifetime
- 1991-03-28 WO PCT/GB1991/000484 patent/WO1991015572A1/en not_active Ceased
- 1991-03-28 ES ES91906493T patent/ES2106776T3/es not_active Expired - Lifetime
- 1991-03-28 IL IL9772091A patent/IL97720A/en not_active IP Right Cessation
- 1991-03-28 NZ NZ237616A patent/NZ237616A/en unknown
- 1991-03-28 MY MYPI91000506A patent/MY130001A/en unknown
- 1991-03-28 AT AT91906493T patent/ATE157397T1/de not_active IP Right Cessation
- 1991-03-28 DK DK91906493.1T patent/DK0524205T3/da active
- 1991-03-28 TW TW080102452A patent/TW205567B/zh active
- 1991-03-28 HU HU9203098A patent/HU217776B/hu unknown
- 1991-03-28 JP JP3506347A patent/JP3054440B2/ja not_active Expired - Lifetime
- 1991-03-28 IE IE103791A patent/IE911037A1/en not_active IP Right Cessation
- 1991-03-28 ZA ZA912397A patent/ZA912397B/xx unknown
-
1994
- 1994-12-07 US US08/350,741 patent/US5804194A/en not_active Expired - Lifetime
-
1995
- 1995-06-05 US US08/463,875 patent/US5980907A/en not_active Expired - Fee Related
-
1997
- 1997-11-05 GR GR970402896T patent/GR3025258T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0524205A1 (en) | 1993-01-27 |
| HU217776B (hu) | 2000-04-28 |
| JPH05507842A (ja) | 1993-11-11 |
| DK0524205T3 (da) | 1997-10-27 |
| JP3054440B2 (ja) | 2000-06-19 |
| NZ237616A (en) | 1994-03-25 |
| GB9007194D0 (en) | 1990-05-30 |
| CA2079463C (en) | 2002-03-05 |
| TW205567B (enExample) | 1993-05-11 |
| WO1991015572A1 (en) | 1991-10-17 |
| DE69127440D1 (de) | 1997-10-02 |
| AU7541791A (en) | 1991-10-30 |
| ATE157397T1 (de) | 1997-09-15 |
| IL97720A0 (en) | 1992-06-21 |
| AU659995B2 (en) | 1995-06-08 |
| CA2079463A1 (en) | 1991-10-01 |
| ZA912397B (en) | 1992-11-25 |
| GR3025258T3 (en) | 1998-02-27 |
| HU9203098D0 (en) | 1992-12-28 |
| US5804194A (en) | 1998-09-08 |
| MY130001A (en) | 2007-05-31 |
| IE911037A1 (en) | 1991-10-09 |
| HUT65496A (en) | 1994-06-28 |
| DE69127440T2 (de) | 1998-01-02 |
| ES2106776T3 (es) | 1997-11-16 |
| IL97720A (en) | 1999-06-20 |
| US5980907A (en) | 1999-11-09 |
| EP0524205B1 (en) | 1997-08-27 |
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