JPWO2023204259A5 - - Google Patents

Info

Publication number

JPWO2023204259A5

JPWO2023204259A5 JP2024505170A JP2024505170A JPWO2023204259A5 JP WO2023204259 A5 JPWO2023204259 A5 JP WO2023204259A5 JP 2024505170 A JP2024505170 A JP 2024505170A JP 2024505170 A JP2024505170 A JP 2024505170A JP WO2023204259 A5 JPWO2023204259 A5 JP WO2023204259A5

Authority

JP

Japan

Prior art keywords

salt

formula

compound represented

solvate

medicament according

Prior art date

2023-04-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 150000001875 compounds Chemical class 0.000 claims 37
• 150000003839 salts Chemical class 0.000 claims 36
• 239000012453 solvate Substances 0.000 claims 30
• 239000003814 drug Substances 0.000 claims 29
• 239000003795 chemical substances by application Substances 0.000 claims 26
• 230000008685 targeting Effects 0.000 claims 21
• 159000000000 sodium salts Chemical group 0.000 claims 8
• 229940124639 Selective inhibitor Drugs 0.000 claims 5
• 102100033019 Tyrosine-protein phosphatase non-receptor type 11 Human genes 0.000 claims 5
• 101710116241 Tyrosine-protein phosphatase non-receptor type 11 Proteins 0.000 claims 5
• 239000005557 antagonist Substances 0.000 claims 5
• 239000003112 inhibitor Substances 0.000 claims 5
• 239000008194 pharmaceutical composition Substances 0.000 claims 5
• 102200006538 rs121913530 Human genes 0.000 claims 5
• 239000002525 vasculotropin inhibitor Substances 0.000 claims 5
• RGCGBFIARQENML-JOCHJYFZSA-N (3R)-1'-[3-(3,4-dihydro-2H-1,5-naphthyridin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]spiro[3H-1-benzofuran-2,4'-piperidine]-3-amine Chemical compound N[C@@H]1c2ccccc2OC11CCN(CC1)c1cnc2c(n[nH]c2n1)N1CCCc2ncccc12 RGCGBFIARQENML-JOCHJYFZSA-N 0.000 claims 3
• UCJZOKGUEJUNIO-IINYFYTJSA-N (3S,4S)-8-[6-amino-5-(2-amino-3-chloropyridin-4-yl)sulfanylpyrazin-2-yl]-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine Chemical compound C[C@@H]1OCC2(CCN(CC2)C2=CN=C(SC3=C(Cl)C(N)=NC=C3)C(N)=N2)[C@@H]1N UCJZOKGUEJUNIO-IINYFYTJSA-N 0.000 claims 3
• 206010028980 Neoplasm Diseases 0.000 claims 3
• 229940126002 RMC-4630 Drugs 0.000 claims 3
• 229940125811 TNO155 Drugs 0.000 claims 3
• HISJAYUQVHMWTA-BLLLJJGKSA-N [6-(2-amino-3-chloropyridin-4-yl)sulfanyl-3-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-5-methylpyrazin-2-yl]methanol Chemical compound NC1=NC=CC(=C1Cl)SC1=C(N=C(C(=N1)CO)N1CCC2([C@@H]([C@@H](OC2)C)N)CC1)C HISJAYUQVHMWTA-BLLLJJGKSA-N 0.000 claims 3
• 229960000397 bevacizumab Drugs 0.000 claims 3
• 229940079593 drug Drugs 0.000 claims 3
• NXQKSXLFSAEQCZ-SFHVURJKSA-N sotorasib Chemical compound FC1=CC2=C(N(C(N=C2N2[C@H](CN(CC2)C(C=C)=O)C)=O)C=2C(=NC=CC=2C)C(C)C)N=C1C1=C(C=CC=C1O)F NXQKSXLFSAEQCZ-SFHVURJKSA-N 0.000 claims 3
• 229940073531 sotorasib Drugs 0.000 claims 3
• PEMUGDMSUDYLHU-ZEQRLZLVSA-N 2-[(2S)-4-[7-(8-chloronaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoroprop-2-enoyl)piperazin-2-yl]acetonitrile Chemical group ClC=1C=CC=C2C=CC=C(C=12)N1CC=2N=C(N=C(C=2CC1)N1C[C@@H](N(CC1)C(C(=C)F)=O)CC#N)OC[C@H]1N(CCC1)C PEMUGDMSUDYLHU-ZEQRLZLVSA-N 0.000 claims 2
• 229940124988 adagrasib Drugs 0.000 claims 2
• 229960003852 atezolizumab Drugs 0.000 claims 2
• 201000011510 cancer Diseases 0.000 claims 2
• YGUFCDOEKKVKJK-UHFFFAOYSA-N 6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine Chemical compound NC1(CCN(CC1)C1=CN=C(C(=N1)N)C1=C(C(=CC=C1)Cl)Cl)C YGUFCDOEKKVKJK-UHFFFAOYSA-N 0.000 claims 1
• 206010005003 Bladder cancer Diseases 0.000 claims 1
• 206010009944 Colon cancer Diseases 0.000 claims 1
• 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
• 206010025323 Lymphomas Diseases 0.000 claims 1
• 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
• 206010033128 Ovarian cancer Diseases 0.000 claims 1
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
• 229940125999 RMC-4550 Drugs 0.000 claims 1
• 208000000453 Skin Neoplasms Diseases 0.000 claims 1
• 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
• 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
• 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
• IKUYEYLZXGGCRD-ORAYPTAESA-N [3-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-6-(2,3-dichlorophenyl)-5-methylpyrazin-2-yl]methanol Chemical compound N[C@@H]1[C@@H](OCC11CCN(CC1)C=1C(=NC(=C(N=1)C)C1=C(C(=CC=C1)Cl)Cl)CO)C IKUYEYLZXGGCRD-ORAYPTAESA-N 0.000 claims 1
• IFVGQKHFUZRWNA-ZPZFBZIMSA-L [Na+].[Na+].Oc1c(cc(c2cccnc12)S([O-])(=O)=O)\N=N\c1ccc2cc(ccc2c1)S([O-])(=O)=O Chemical compound [Na+].[Na+].Oc1c(cc(c2cccnc12)S([O-])(=O)=O)\N=N\c1ccc2cc(ccc2c1)S([O-])(=O)=O IFVGQKHFUZRWNA-ZPZFBZIMSA-L 0.000 claims 1
• 208000029742 colonic neoplasm Diseases 0.000 claims 1
• 229940000425 combination drug Drugs 0.000 claims 1
• 201000004101 esophageal cancer Diseases 0.000 claims 1
• 206010017758 gastric cancer Diseases 0.000 claims 1
• 201000010536 head and neck cancer Diseases 0.000 claims 1
• 208000014829 head and neck neoplasm Diseases 0.000 claims 1
• 208000032839 leukemia Diseases 0.000 claims 1
• 201000005202 lung cancer Diseases 0.000 claims 1
• 208000020816 lung neoplasm Diseases 0.000 claims 1
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
• 201000002528 pancreatic cancer Diseases 0.000 claims 1
• 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
• 201000000849 skin cancer Diseases 0.000 claims 1
• 201000011549 stomach cancer Diseases 0.000 claims 1
• 201000002510 thyroid cancer Diseases 0.000 claims 1
• 201000005112 urinary bladder cancer Diseases 0.000 claims 1
• 206010046766 uterine cancer Diseases 0.000 claims 1