JP2017031160A5 - - Google Patents
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- JP2017031160A5 JP2017031160A5 JP2016163087A JP2016163087A JP2017031160A5 JP 2017031160 A5 JP2017031160 A5 JP 2017031160A5 JP 2016163087 A JP2016163087 A JP 2016163087A JP 2016163087 A JP2016163087 A JP 2016163087A JP 2017031160 A5 JP2017031160 A5 JP 2017031160A5
- Authority
- JP
- Japan
- Prior art keywords
- history
- months
- subject
- vegf antibody
- capecitabine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000306 recurrent effect Effects 0.000 claims description 12
- 206010007559 Cardiac failure congestive Diseases 0.000 claims description 10
- 206010019280 Heart failures Diseases 0.000 claims description 10
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims description 7
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims description 7
- 238000002512 chemotherapy Methods 0.000 claims description 6
- 238000011282 treatment Methods 0.000 claims description 6
- 206010002388 Angina unstable Diseases 0.000 claims description 5
- 206010053567 Coagulopathies Diseases 0.000 claims description 5
- 206010016717 Fistula Diseases 0.000 claims description 5
- 206010027476 Metastases Diseases 0.000 claims description 5
- 206010028980 Neoplasm Diseases 0.000 claims description 5
- 208000018262 Peripheral vascular disease Diseases 0.000 claims description 5
- 208000007814 Unstable Angina Diseases 0.000 claims description 5
- 206010052428 Wound Diseases 0.000 claims description 5
- 208000027418 Wounds and injury Diseases 0.000 claims description 5
- 230000003187 abdominal effect Effects 0.000 claims description 5
- 208000003455 anaphylaxis Diseases 0.000 claims description 5
- 208000015294 blood coagulation disease Diseases 0.000 claims description 5
- 230000036772 blood pressure Effects 0.000 claims description 5
- 201000010099 disease Diseases 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 230000003890 fistula Effects 0.000 claims description 5
- 230000002008 hemorrhagic effect Effects 0.000 claims description 5
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims description 5
- 230000036210 malignancy Effects 0.000 claims description 5
- 238000002625 monoclonal antibody therapy Methods 0.000 claims description 5
- 238000002560 therapeutic procedure Methods 0.000 claims description 5
- 206010034649 Peritoneal abscess Diseases 0.000 claims description 4
- 210000000056 organ Anatomy 0.000 claims description 4
- 238000002271 resection Methods 0.000 claims description 4
- 230000002496 gastric effect Effects 0.000 claims description 3
- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 claims 15
- GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 claims 15
- 229960004117 capecitabine Drugs 0.000 claims 15
- 239000003814 drug Substances 0.000 claims 11
- 206010055113 Breast cancer metastatic Diseases 0.000 claims 8
- 229960000397 bevacizumab Drugs 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 206010038111 Recurrent cancer Diseases 0.000 claims 7
- 230000004083 survival effect Effects 0.000 claims 7
- 239000002246 antineoplastic agent Substances 0.000 claims 5
- 229940127089 cytotoxic agent Drugs 0.000 claims 5
- 238000011226 adjuvant chemotherapy Methods 0.000 claims 4
- 210000003169 central nervous system Anatomy 0.000 claims 4
- 230000009852 coagulant defect Effects 0.000 claims 4
- 230000000302 ischemic effect Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 208000010125 myocardial infarction Diseases 0.000 claims 4
- 238000011227 neoadjuvant chemotherapy Methods 0.000 claims 4
- 230000001052 transient effect Effects 0.000 claims 4
- 206010002198 Anaphylactic reaction Diseases 0.000 claims 3
- 230000002490 cerebral effect Effects 0.000 claims 3
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 3
- 238000011269 treatment regimen Methods 0.000 claims 2
- 206010060921 Abdominal abscess Diseases 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000012325 curative resection Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000035876 healing Effects 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940045799 anthracyclines and related substance Drugs 0.000 description 2
- 229960000575 trastuzumab Drugs 0.000 description 2
- 206010061216 Infarction Diseases 0.000 description 1
- 208000032109 Transient ischaemic attack Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 238000009098 adjuvant therapy Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 238000009099 neoadjuvant therapy Methods 0.000 description 1
- 238000009101 premedication Methods 0.000 description 1
- 201000010875 transient cerebral ischemia Diseases 0.000 description 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11710208P | 2008-11-22 | 2008-11-22 | |
| US61/117,102 | 2008-11-22 | ||
| US17800909P | 2009-05-13 | 2009-05-13 | |
| US61/178,009 | 2009-05-13 | ||
| US17930709P | 2009-05-18 | 2009-05-18 | |
| US61/179,307 | 2009-05-18 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537663A Division JP6041489B2 (ja) | 2008-11-22 | 2009-11-20 | 乳癌の治療のための化学療法と併用した抗ｖｅｇｆ抗体の使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018080848A Division JP2018138583A (ja) | 2008-11-22 | 2018-04-19 | 乳癌の治療のための化学療法と併用した抗ｖｅｇｆ抗体の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017031160A JP2017031160A (ja) | 2017-02-09 |
| JP2017031160A5 true JP2017031160A5 (https=) | 2020-02-27 |
| JP6850562B2 JP6850562B2 (ja) | 2021-03-31 |
Family
ID=42154236
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537663A Active JP6041489B2 (ja) | 2008-11-22 | 2009-11-20 | 乳癌の治療のための化学療法と併用した抗ｖｅｇｆ抗体の使用 |
| JP2016163087A Active JP6850562B2 (ja) | 2008-11-22 | 2016-08-23 | 乳癌の治療のための化学療法と併用した抗ｖｅｇｆ抗体の使用 |
| JP2018080848A Withdrawn JP2018138583A (ja) | 2008-11-22 | 2018-04-19 | 乳癌の治療のための化学療法と併用した抗ｖｅｇｆ抗体の使用 |
| JP2020076277A Pending JP2020128389A (ja) | 2008-11-22 | 2020-04-22 | 乳癌の治療のための化学療法と併用した抗ｖｅｇｆ抗体の使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537663A Active JP6041489B2 (ja) | 2008-11-22 | 2009-11-20 | 乳癌の治療のための化学療法と併用した抗ｖｅｇｆ抗体の使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018080848A Withdrawn JP2018138583A (ja) | 2008-11-22 | 2018-04-19 | 乳癌の治療のための化学療法と併用した抗ｖｅｇｆ抗体の使用 |
| JP2020076277A Pending JP2020128389A (ja) | 2008-11-22 | 2020-04-22 | 乳癌の治療のための化学療法と併用した抗ｖｅｇｆ抗体の使用 |
Country Status (28)
| Country | Link |
|---|---|
| US (5) | US20100143351A1 (https=) |
| EP (3) | EP2752189B1 (https=) |
| JP (4) | JP6041489B2 (https=) |
| KR (3) | KR101807319B1 (https=) |
| CN (2) | CN102223897B (https=) |
| AR (1) | AR074203A1 (https=) |
| AU (1) | AU2009316409A1 (https=) |
| BR (1) | BRPI0916138A2 (https=) |
| CA (1) | CA2744158A1 (https=) |
| CL (1) | CL2011001186A1 (https=) |
| CY (1) | CY1118549T1 (https=) |
| DK (2) | DK2752189T3 (https=) |
| ES (2) | ES2611337T3 (https=) |
| HR (1) | HRP20170059T1 (https=) |
| HU (2) | HUE024872T2 (https=) |
| IL (2) | IL212998A (https=) |
| LT (1) | LT2752189T (https=) |
| MX (2) | MX340724B (https=) |
| PH (1) | PH12014502507A1 (https=) |
| PL (2) | PL2361085T5 (https=) |
| PT (1) | PT2752189T (https=) |
| RU (1) | RU2531948C2 (https=) |
| SG (1) | SG171780A1 (https=) |
| SI (2) | SI2361085T2 (https=) |
| SM (1) | SMT201700173T1 (https=) |
| TW (2) | TWI612971B (https=) |
| WO (1) | WO2010059969A2 (https=) |
| ZA (1) | ZA201103321B (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3782612B1 (en) | 2008-05-15 | 2023-11-08 | Celgene Corporation | Oral formulations of cytidine analogs and methods of use thereof |
| KR101807319B1 (ko) * | 2008-11-22 | 2017-12-11 | 제넨테크, 인크. | 유방암의 치료를 위한, 화학요법과 조합된 항-ｖｅｇｆ 항체의 용도 |
| KR102104197B1 (ko) | 2010-02-23 | 2020-04-24 | 제넨테크, 인크. | 난소암의 치료를 위한 항혈관신생 요법 |
| WO2013055874A2 (en) * | 2011-10-14 | 2013-04-18 | Genentech, Inc. | Uses for and article of manufacture including her2 dimerization inhibitor pertuzumab |
| US9125884B2 (en) * | 2011-11-01 | 2015-09-08 | Celgene Corporation | Methods for treating cancers using oral formulations of cytidine analogs |
| WO2013135602A2 (en) | 2012-03-13 | 2013-09-19 | F. Hoffmann-La Roche Ag | Combination therapy for the treatment of ovarian cancer |
| DK3038654T3 (da) | 2013-08-26 | 2020-02-03 | Novartis Ag | Ny anvendelse |
| MX2021012208A (es) | 2013-10-04 | 2023-01-19 | Infinity Pharmaceuticals Inc | Compuestos heterocíclicos y usos de los mismos. |
| NZ724368A (en) * | 2014-03-19 | 2023-07-28 | Infinity Pharmaceuticals Inc | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| MX2016017396A (es) * | 2014-07-03 | 2017-05-01 | Imclone Llc | Terapia de combinacion. |
| EP3169374B1 (en) | 2014-07-14 | 2022-01-05 | University of Utah Research Foundation | In situ solidifying complex coacervates and methods of making and using thereof |
| CN104991065B (zh) * | 2015-07-07 | 2017-01-11 | 复旦大学附属金山医院 | 一种用于诊断乳腺癌的三联标志物及其应用 |
| EP4585268A3 (en) | 2015-09-14 | 2025-10-15 | Twelve Therapeutics, Inc. | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
| KR102799807B1 (ko) | 2015-12-30 | 2025-04-24 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
| US11077189B2 (en) | 2017-03-02 | 2021-08-03 | Genentech Inc. | Adjuvant treatment of HER2-positive breast cancer |
| WO2019084548A1 (en) * | 2017-10-27 | 2019-05-02 | University Of Utah Research Foundation | COMPLEX LIQUID IN SITU SOLIDIFICATION COASTALITIES FOR LOCAL ADMINISTRATION OF ANTI-ANGIOGENIC AGENTS OR CHEMOTHERAPEUTIC AGENTS |
| CA3089480C (en) | 2018-01-26 | 2025-05-27 | Fluidx Medical Technology, Inc. | APPARATUS AND METHOD FOR USING COMPLEX COACERVATES WITH IN SITU SOLIDIFICATION FOR VASCULAR OCLUSION |
| MX2020009152A (es) | 2018-03-02 | 2020-11-09 | Kodiak Sciences Inc | Anticuerpos de il-6 y constructos de fusion y conjugados de los mismos. |
| CN112262157A (zh) * | 2018-03-09 | 2021-01-22 | 加利福尼亚大学董事会 | 化药抗性癌症的组合治疗 |
| CA3157509A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| CN111710425A (zh) * | 2020-06-19 | 2020-09-25 | 复旦大学附属中山医院 | 一种免疫检查点抑制剂心脏毒性评估方法，系统及装置 |
| CN120344271A (zh) * | 2023-01-19 | 2025-07-18 | 江苏恒瑞医药股份有限公司 | 抗her2抗体药物偶联物治疗乳腺癌 |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| WO1989006692A1 (en) | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| ATE300615T1 (de) | 1990-08-29 | 2005-08-15 | Genpharm Int | Transgene mäuse fähig zur produktion heterologer antikörper |
| CA2405246A1 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with alterred binding properties |
| US6582959B2 (en) | 1991-03-29 | 2003-06-24 | Genentech, Inc. | Antibodies to vascular endothelial cell growth factor |
| US20030206899A1 (en) | 1991-03-29 | 2003-11-06 | Genentech, Inc. | Vascular endothelial cell growth factor antagonists |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
| DE69232137T2 (de) | 1991-11-25 | 2002-05-29 | Enzon Inc | Multivalente antigen-bindende proteine |
| AU675929B2 (en) | 1992-02-06 | 1997-02-27 | Curis, Inc. | Biosynthetic binding protein for cancer marker |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| BR9207175A (pt) | 1992-10-28 | 1995-12-12 | Genentech Inc | Composição contendo antagonista de fator de crescimento de célula endotelial vascular sequência aminoácida de anticorpo monoclonal polipeptídeo e método de tratamento de tumor em mamífero |
| MD1367C2 (ro) | 1992-11-13 | 2000-11-30 | Idec Pharmaceuticals Corporation | Metode de tratament al limfomului celulelor B, anticorpi anti-CD20, hibridom. |
| US5635388A (en) | 1994-04-04 | 1997-06-03 | Genentech, Inc. | Agonist antibodies against the flk2/flt3 receptor and uses thereof |
| IL117645A (en) | 1995-03-30 | 2005-08-31 | Genentech Inc | Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| CA2226575C (en) | 1995-07-27 | 2011-10-18 | Genentech, Inc. | Stabile isotonic lyophilized protein formulation |
| US5730977A (en) | 1995-08-21 | 1998-03-24 | Mitsui Toatsu Chemicals, Inc. | Anti-VEGF human monoclonal antibody |
| GB9603256D0 (en) | 1996-02-16 | 1996-04-17 | Wellcome Found | Antibodies |
| US6100071A (en) | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
| JP3957765B2 (ja) | 1997-04-07 | 2007-08-15 | ジェネンテク・インコーポレイテッド | 抗ｖｅｇｆ抗体 |
| US6884879B1 (en) | 1997-04-07 | 2005-04-26 | Genentech, Inc. | Anti-VEGF antibodies |
| EP2338915A3 (en) | 1997-04-07 | 2011-10-12 | Genentech, Inc. | Anti-VEGF antibodies |
| US20020032315A1 (en) | 1997-08-06 | 2002-03-14 | Manuel Baca | Anti-vegf antibodies |
| ATE296315T1 (de) | 1997-06-24 | 2005-06-15 | Genentech Inc | Galactosylierte glykoproteine enthaltende zusammensetzungen und verfahren zur deren herstellung |
| WO1999022764A1 (en) | 1997-10-31 | 1999-05-14 | Genentech, Inc. | Methods and compositions comprising glycoprotein glycoforms |
| ZA9811162B (en) | 1997-12-12 | 2000-06-07 | Genentech Inc | Treatment with anti-ERBB2 antibodies. |
| ES2292236T3 (es) | 1998-04-02 | 2008-03-01 | Genentech, Inc. | Variantes de anticuerpos y sus fragmentos. |
| US6528624B1 (en) | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| US6242195B1 (en) | 1998-04-02 | 2001-06-05 | Genentech, Inc. | Methods for determining binding of an analyte to a receptor |
| ES2434961T5 (es) | 1998-04-20 | 2018-01-18 | Roche Glycart Ag | Ingeniería de glicosilación de anticuerpos para mejorar la citotoxicidad celular dependiente del anticuerpo |
| HU230769B1 (hu) | 1999-01-15 | 2018-03-28 | Genentech Inc. | Módosított effektor-funkciójú polipeptid-változatok |
| US6703020B1 (en) | 1999-04-28 | 2004-03-09 | Board Of Regents, The University Of Texas System | Antibody conjugate methods for selectively inhibiting VEGF |
| EP2180054A1 (en) | 1999-12-24 | 2010-04-28 | Genentech, Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
| CN101289511A (zh) | 2000-04-11 | 2008-10-22 | 杰南技术公司 | 多价抗体及其应用 |
| PT1355919E (pt) | 2000-12-12 | 2011-03-02 | Medimmune Llc | Moléculas com semivida longa, composições que as contêm e suas utilizações |
| EP2180044A1 (en) | 2001-08-03 | 2010-04-28 | GlycArt Biotechnology AG | Antibody glycosylation variants having increased anti-body-dependent cellular cytotoxicity |
| HUP0600342A3 (en) | 2001-10-25 | 2011-03-28 | Genentech Inc | Glycoprotein compositions |
| US20040093621A1 (en) | 2001-12-25 | 2004-05-13 | Kyowa Hakko Kogyo Co., Ltd | Antibody composition which specifically binds to CD20 |
| US7361740B2 (en) | 2002-10-15 | 2008-04-22 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| MXPA05012723A (es) * | 2003-05-30 | 2006-02-08 | Genentech Inc | Tratamiento con anticuerpos anti-vgf. |
| WO2005044853A2 (en) | 2003-11-01 | 2005-05-19 | Genentech, Inc. | Anti-vegf antibodies |
| US20050106667A1 (en) * | 2003-08-01 | 2005-05-19 | Genentech, Inc | Binding polypeptides with restricted diversity sequences |
| US20060009360A1 (en) | 2004-06-25 | 2006-01-12 | Robert Pifer | New adjuvant composition |
| KR20070036130A (ko) | 2004-07-16 | 2007-04-02 | 화이자 프로덕츠 인코포레이티드 | 항-아이지에프-1알 항체를 사용하는 비-혈액학적악성종양에 대한 조합 치료 |
| WO2006014729A2 (en) | 2004-07-20 | 2006-02-09 | Genentech, Inc. | Inhibitors of angiopoietin-like 4 protein, combinations, and their use |
| US8367805B2 (en) * | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| TWI577695B (zh) * | 2006-12-19 | 2017-04-11 | 建南德克公司 | 用於輔助及先導性輔助療法之血管內皮生長因子（ｖｅｇｆ）-特異性拮抗劑及早期腫瘤之治療 |
| MX2009008132A (es) * | 2007-02-01 | 2009-08-12 | Genentech Inc | Terapia de combinacion con inhibidores de angiogenesis. |
| KR101807319B1 (ko) * | 2008-11-22 | 2017-12-11 | 제넨테크, 인크. | 유방암의 치료를 위한, 화학요법과 조합된 항-ｖｅｇｆ 항체의 용도 |
| US11379945B2 (en) | 2019-02-27 | 2022-07-05 | Google Llc | Grayscale histogram generation |
-
2009
- 2009-11-20 KR KR1020117014272A patent/KR101807319B1/ko not_active Expired - Fee Related
- 2009-11-20 SM SM20170173T patent/SMT201700173T1/it unknown
- 2009-11-20 MX MX2014002003A patent/MX340724B/es unknown
- 2009-11-20 ES ES13189711.8T patent/ES2611337T3/es active Active
- 2009-11-20 BR BRPI0916138A patent/BRPI0916138A2/pt not_active Application Discontinuation
- 2009-11-20 TW TW104125142A patent/TWI612971B/zh not_active IP Right Cessation
- 2009-11-20 HU HUE09764134A patent/HUE024872T2/en unknown
- 2009-11-20 WO PCT/US2009/065381 patent/WO2010059969A2/en not_active Ceased
- 2009-11-20 SI SI200931187T patent/SI2361085T2/sl unknown
- 2009-11-20 RU RU2011125518/15A patent/RU2531948C2/ru active
- 2009-11-20 CA CA2744158A patent/CA2744158A1/en not_active Abandoned
- 2009-11-20 PL PL09764134T patent/PL2361085T5/pl unknown
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