JP2017031160A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017031160A5 JP2017031160A5 JP2016163087A JP2016163087A JP2017031160A5 JP 2017031160 A5 JP2017031160 A5 JP 2017031160A5 JP 2016163087 A JP2016163087 A JP 2016163087A JP 2016163087 A JP2016163087 A JP 2016163087A JP 2017031160 A5 JP2017031160 A5 JP 2017031160A5
- Authority
- JP
- Japan
- Prior art keywords
- history
- months
- subject
- vegf antibody
- capecitabine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000306 recurrent effect Effects 0.000 claims description 12
- 206010007559 Cardiac failure congestive Diseases 0.000 claims description 10
- 206010019280 Heart failures Diseases 0.000 claims description 10
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims description 7
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims description 7
- 238000002512 chemotherapy Methods 0.000 claims description 6
- 238000011282 treatment Methods 0.000 claims description 6
- 206010002388 Angina unstable Diseases 0.000 claims description 5
- 206010053567 Coagulopathies Diseases 0.000 claims description 5
- 206010016717 Fistula Diseases 0.000 claims description 5
- 206010027476 Metastases Diseases 0.000 claims description 5
- 206010028980 Neoplasm Diseases 0.000 claims description 5
- 208000018262 Peripheral vascular disease Diseases 0.000 claims description 5
- 208000007814 Unstable Angina Diseases 0.000 claims description 5
- 206010052428 Wound Diseases 0.000 claims description 5
- 208000027418 Wounds and injury Diseases 0.000 claims description 5
- 230000003187 abdominal effect Effects 0.000 claims description 5
- 208000003455 anaphylaxis Diseases 0.000 claims description 5
- 208000015294 blood coagulation disease Diseases 0.000 claims description 5
- 230000036772 blood pressure Effects 0.000 claims description 5
- 201000010099 disease Diseases 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 230000003890 fistula Effects 0.000 claims description 5
- 230000002008 hemorrhagic effect Effects 0.000 claims description 5
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims description 5
- 230000036210 malignancy Effects 0.000 claims description 5
- 238000002625 monoclonal antibody therapy Methods 0.000 claims description 5
- 238000002560 therapeutic procedure Methods 0.000 claims description 5
- 206010034649 Peritoneal abscess Diseases 0.000 claims description 4
- 210000000056 organ Anatomy 0.000 claims description 4
- 238000002271 resection Methods 0.000 claims description 4
- 230000002496 gastric effect Effects 0.000 claims description 3
- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 claims 15
- GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 claims 15
- 229960004117 capecitabine Drugs 0.000 claims 15
- 239000003814 drug Substances 0.000 claims 11
- 206010055113 Breast cancer metastatic Diseases 0.000 claims 8
- 229960000397 bevacizumab Drugs 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 206010038111 Recurrent cancer Diseases 0.000 claims 7
- 230000004083 survival effect Effects 0.000 claims 7
- 239000002246 antineoplastic agent Substances 0.000 claims 5
- 229940127089 cytotoxic agent Drugs 0.000 claims 5
- 238000011226 adjuvant chemotherapy Methods 0.000 claims 4
- 210000003169 central nervous system Anatomy 0.000 claims 4
- 230000009852 coagulant defect Effects 0.000 claims 4
- 230000000302 ischemic effect Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 208000010125 myocardial infarction Diseases 0.000 claims 4
- 238000011227 neoadjuvant chemotherapy Methods 0.000 claims 4
- 230000001052 transient effect Effects 0.000 claims 4
- 206010002198 Anaphylactic reaction Diseases 0.000 claims 3
- 230000002490 cerebral effect Effects 0.000 claims 3
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 3
- 238000011269 treatment regimen Methods 0.000 claims 2
- 206010060921 Abdominal abscess Diseases 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000012325 curative resection Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000035876 healing Effects 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940045799 anthracyclines and related substance Drugs 0.000 description 2
- 229960000575 trastuzumab Drugs 0.000 description 2
- 206010061216 Infarction Diseases 0.000 description 1
- 208000032109 Transient ischaemic attack Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 238000009098 adjuvant therapy Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 238000009099 neoadjuvant therapy Methods 0.000 description 1
- 238000009101 premedication Methods 0.000 description 1
- 201000010875 transient cerebral ischemia Diseases 0.000 description 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11710208P | 2008-11-22 | 2008-11-22 | |
| US61/117,102 | 2008-11-22 | ||
| US17800909P | 2009-05-13 | 2009-05-13 | |
| US61/178,009 | 2009-05-13 | ||
| US17930709P | 2009-05-18 | 2009-05-18 | |
| US61/179,307 | 2009-05-18 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537663A Division JP6041489B2 (ja) | 2008-11-22 | 2009-11-20 | 乳癌の治療のための化学療法と併用した抗ｖｅｇｆ抗体の使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018080848A Division JP2018138583A (ja) | 2008-11-22 | 2018-04-19 | 乳癌の治療のための化学療法と併用した抗ｖｅｇｆ抗体の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017031160A JP2017031160A (ja) | 2017-02-09 |
| JP2017031160A5 true JP2017031160A5 (https=) | 2020-02-27 |
| JP6850562B2 JP6850562B2 (ja) | 2021-03-31 |
Family
ID=42154236
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537663A Active JP6041489B2 (ja) | 2008-11-22 | 2009-11-20 | 乳癌の治療のための化学療法と併用した抗ｖｅｇｆ抗体の使用 |
| JP2016163087A Active JP6850562B2 (ja) | 2008-11-22 | 2016-08-23 | 乳癌の治療のための化学療法と併用した抗ｖｅｇｆ抗体の使用 |
| JP2018080848A Withdrawn JP2018138583A (ja) | 2008-11-22 | 2018-04-19 | 乳癌の治療のための化学療法と併用した抗ｖｅｇｆ抗体の使用 |
| JP2020076277A Pending JP2020128389A (ja) | 2008-11-22 | 2020-04-22 | 乳癌の治療のための化学療法と併用した抗ｖｅｇｆ抗体の使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537663A Active JP6041489B2 (ja) | 2008-11-22 | 2009-11-20 | 乳癌の治療のための化学療法と併用した抗ｖｅｇｆ抗体の使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018080848A Withdrawn JP2018138583A (ja) | 2008-11-22 | 2018-04-19 | 乳癌の治療のための化学療法と併用した抗ｖｅｇｆ抗体の使用 |
| JP2020076277A Pending JP2020128389A (ja) | 2008-11-22 | 2020-04-22 | 乳癌の治療のための化学療法と併用した抗ｖｅｇｆ抗体の使用 |
Country Status (28)
| Country | Link |
|---|---|
| US (5) | US20100143351A1 (https=) |
| EP (3) | EP2752189B1 (https=) |
| JP (4) | JP6041489B2 (https=) |
| KR (3) | KR101807319B1 (https=) |
| CN (2) | CN102223897B (https=) |
| AR (1) | AR074203A1 (https=) |
| AU (1) | AU2009316409A1 (https=) |
| BR (1) | BRPI0916138A2 (https=) |
| CA (1) | CA2744158A1 (https=) |
| CL (1) | CL2011001186A1 (https=) |
| CY (1) | CY1118549T1 (https=) |
| DK (2) | DK2361085T4 (https=) |
| ES (2) | ES2535404T5 (https=) |
| HR (1) | HRP20170059T1 (https=) |
| HU (2) | HUE024872T2 (https=) |
| IL (2) | IL212998A (https=) |
| LT (1) | LT2752189T (https=) |
| MX (2) | MX340724B (https=) |
| PH (1) | PH12014502507A1 (https=) |
| PL (2) | PL2752189T3 (https=) |
| PT (1) | PT2752189T (https=) |
| RU (1) | RU2531948C2 (https=) |
| SG (1) | SG171780A1 (https=) |
| SI (2) | SI2361085T2 (https=) |
| SM (1) | SMT201700173T1 (https=) |
| TW (2) | TWI612971B (https=) |
| WO (1) | WO2010059969A2 (https=) |
| ZA (1) | ZA201103321B (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3692983T3 (pl) | 2008-05-15 | 2021-12-27 | Celgene Corporation | Doustne formulacje analogów cytydyny i sposoby ich zastosowania |
| DK2361085T4 (en) * | 2008-11-22 | 2018-10-08 | Hoffmann La Roche | USE OF ANTI-VEGF ANTIBODY IN COMBINATION WITH CHEMOTHERY TO TREAT CANCER CANCER |
| TWI619509B (zh) | 2010-02-23 | 2018-04-01 | 建南德克公司 | 治療先前未經治療之ⅲ期或ⅳ期卵巢癌、輸卵管癌或原發性腹膜癌之卡鉑、太平洋紫杉醇與抗-vegf抗體之組合 |
| IL301603A (en) * | 2011-10-14 | 2023-05-01 | Genentech Inc | Pertuzumab, trastuzumab, docetaxel and carboplatin for use in the preoperative treatment of a patient |
| TW201700103A (zh) * | 2011-11-01 | 2017-01-01 | 西建公司 | 利用胞嘧啶核苷類似物之口服配方治療癌症的方法 |
| DK2825558T3 (da) | 2012-03-13 | 2019-07-22 | Hoffmann La Roche | Kombinationsterapi til behandling af ovariecancer |
| ES2968541T3 (es) | 2013-08-26 | 2024-05-10 | Novartis Ag | Tratamiento de enfermedades cardiovasculares |
| PT3052485T (pt) | 2013-10-04 | 2021-10-22 | Infinity Pharmaceuticals Inc | Compostos heterocíclicos e suas utilizações |
| MX382033B (es) | 2014-03-19 | 2025-03-13 | Infinity Pharmaceuticals Inc | Compuestos heterocíclicos para utilizarlos en el tratamiento de trastornos mediados por pi3k-gamma. |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| MA40367A (fr) * | 2014-07-03 | 2017-05-10 | Imclone Llc | Polythérapie |
| US9913927B2 (en) | 2014-07-14 | 2018-03-13 | University Of Utah Research Foundation | In situ solidifying complex coacervates and methods of making and using thereof |
| CN104991065B (zh) * | 2015-07-07 | 2017-01-11 | 复旦大学附属金山医院 | 一种用于诊断乳腺癌的三联标志物及其应用 |
| WO2017048702A1 (en) | 2015-09-14 | 2017-03-23 | Infinity Pharmaceuticals, Inc. | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
| KR20250057128A (ko) | 2015-12-30 | 2025-04-28 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
| PT3589661T (pt) | 2017-03-02 | 2024-01-29 | Genentech Inc | Tratamento com adjuvante de cancro da mama positivo para her2 |
| WO2019084548A1 (en) * | 2017-10-27 | 2019-05-02 | University Of Utah Research Foundation | COMPLEX LIQUID IN SITU SOLIDIFICATION COASTALITIES FOR LOCAL ADMINISTRATION OF ANTI-ANGIOGENIC AGENTS OR CHEMOTHERAPEUTIC AGENTS |
| AU2019212513B2 (en) | 2018-01-26 | 2024-10-31 | Fluidx Medical Technology, Llc | Apparatus and method of using in situ solidifying complex coacervates for vascular occlusion |
| EP3758737A4 (en) | 2018-03-02 | 2022-10-12 | Kodiak Sciences Inc. | IL-6 ANTIBODIES AND FUSION CONSTRUCTS AND CONJUGATES THEREOF |
| JP2021517135A (ja) * | 2018-03-09 | 2021-07-15 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | 化学療法抵抗性がんの組合せ処置 |
| CA3157509A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| CN111710425A (zh) * | 2020-06-19 | 2020-09-25 | 复旦大学附属中山医院 | 一种免疫检查点抑制剂心脏毒性评估方法，系统及装置 |
| AU2024210067A1 (en) * | 2023-01-19 | 2025-08-07 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Anti-her2 antibody-drug conjugate for treating breast cancer |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| JP3040121B2 (ja) | 1988-01-12 | 2000-05-08 | ジェネンテク，インコーポレイテッド | 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法 |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| ATE158021T1 (de) | 1990-08-29 | 1997-09-15 | Genpharm Int | Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| CA2095633C (en) | 1990-12-03 | 2003-02-04 | Lisa J. Garrard | Enrichment method for variant proteins with altered binding properties |
| US6582959B2 (en) | 1991-03-29 | 2003-06-24 | Genentech, Inc. | Antibodies to vascular endothelial cell growth factor |
| US20030206899A1 (en) | 1991-03-29 | 2003-11-06 | Genentech, Inc. | Vascular endothelial cell growth factor antagonists |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| ATE207080T1 (de) | 1991-11-25 | 2001-11-15 | Enzon Inc | Multivalente antigen-bindende proteine |
| CA2372813A1 (en) | 1992-02-06 | 1993-08-19 | L.L. Houston | Biosynthetic binding protein for cancer marker |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| AU687727B2 (en) | 1992-10-28 | 1998-03-05 | Genentech Inc. | Vascular endothelial cell growth factor antagonists |
| DK0752248T3 (da) | 1992-11-13 | 2000-11-13 | Idec Pharma Corp | Terapeutisk anvendelse af kimæriske og radioaktivt mærkede antistoffer mod humant B-lymfocytbegrænset differentieringsantig |
| US5635388A (en) | 1994-04-04 | 1997-06-03 | Genentech, Inc. | Agonist antibodies against the flk2/flt3 receptor and uses thereof |
| IL117645A (en) | 1995-03-30 | 2005-08-31 | Genentech Inc | Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| ES2434840T3 (es) | 1995-07-27 | 2013-12-17 | Genentech, Inc. | Formulación de proteína liofilizada isotónica estable |
| US5730977A (en) | 1995-08-21 | 1998-03-24 | Mitsui Toatsu Chemicals, Inc. | Anti-VEGF human monoclonal antibody |
| GB9603256D0 (en) | 1996-02-16 | 1996-04-17 | Wellcome Found | Antibodies |
| US6100071A (en) | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
| US6884879B1 (en) | 1997-04-07 | 2005-04-26 | Genentech, Inc. | Anti-VEGF antibodies |
| US20020032315A1 (en) | 1997-08-06 | 2002-03-14 | Manuel Baca | Anti-vegf antibodies |
| KR100816621B1 (ko) | 1997-04-07 | 2008-03-24 | 제넨테크, 인크. | 항-ｖｅｇｆ 항체 |
| PT971959E (pt) | 1997-04-07 | 2006-05-31 | Genentech Inc | Anticorpos humanizados e metodos para formar anticorpos humanizados |
| ES2244066T3 (es) | 1997-06-24 | 2005-12-01 | Genentech, Inc. | Procedimiento y composiciones de glicoproteinas galactosiladas. |
| AU759779B2 (en) | 1997-10-31 | 2003-05-01 | Genentech Inc. | Methods and compositions comprising glycoprotein glycoforms |
| ZA9811162B (en) | 1997-12-12 | 2000-06-07 | Genentech Inc | Treatment with anti-ERBB2 antibodies. |
| US6242195B1 (en) | 1998-04-02 | 2001-06-05 | Genentech, Inc. | Methods for determining binding of an analyte to a receptor |
| ATE375365T1 (de) | 1998-04-02 | 2007-10-15 | Genentech Inc | Antikörper varianten und fragmente davon |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| US6528624B1 (en) | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
| DK1071700T3 (da) | 1998-04-20 | 2010-06-07 | Glycart Biotechnology Ag | Glykosylerings-modifikation af antistoffer til forbedring af antistofafhængig cellulær cytotoksicitet |
| PL209392B1 (pl) | 1999-01-15 | 2011-08-31 | Genentech Inc | Przeciwciało, komórka gospodarza, sposób wytwarzania przeciwciała oraz zastosowanie przeciwciała |
| US6703020B1 (en) | 1999-04-28 | 2004-03-09 | Board Of Regents, The University Of Texas System | Antibody conjugate methods for selectively inhibiting VEGF |
| EP1240337B1 (en) | 1999-12-24 | 2006-08-23 | Genentech, Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
| JP2003531588A (ja) | 2000-04-11 | 2003-10-28 | ジェネンテック・インコーポレーテッド | 多価抗体とその用途 |
| US7083784B2 (en) | 2000-12-12 | 2006-08-01 | Medimmune, Inc. | Molecules with extended half-lives, compositions and uses thereof |
| NZ571596A (en) | 2001-08-03 | 2010-11-26 | Glycart Biotechnology Ag | Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity |
| CA2463879C (en) | 2001-10-25 | 2012-12-04 | Genentech, Inc. | Glycoprotein compositions |
| US20040093621A1 (en) | 2001-12-25 | 2004-05-13 | Kyowa Hakko Kogyo Co., Ltd | Antibody composition which specifically binds to CD20 |
| US7361740B2 (en) | 2002-10-15 | 2008-04-22 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| UA101945C2 (uk) * | 2003-05-30 | 2013-05-27 | Дженентек, Инк. | Лікування злоякісного новоутворення за допомогою бевацизумабу |
| US20050106667A1 (en) * | 2003-08-01 | 2005-05-19 | Genentech, Inc | Binding polypeptides with restricted diversity sequences |
| WO2005044853A2 (en) | 2003-11-01 | 2005-05-19 | Genentech, Inc. | Anti-vegf antibodies |
| US20060009360A1 (en) | 2004-06-25 | 2006-01-12 | Robert Pifer | New adjuvant composition |
| KR20080019733A (ko) | 2004-07-16 | 2008-03-04 | 화이자 프로덕츠 인코포레이티드 | 항-아이지에프-1알 항체를 사용하는 비-혈액학적악성종양에 대한 조합 치료 |
| SI1771474T1 (sl) | 2004-07-20 | 2010-06-30 | Genentech Inc | Inhibitorji angiopoetinu podobnega proteina kombinacije in njihova uporaba |
| US8367805B2 (en) * | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| HUE029445T2 (en) * | 2006-12-19 | 2017-02-28 | Genentech Inc | VEGF-specific antagonists for adjuvant and neoadjuvant therapy and treatment of early-stage tumors |
| BRPI0806414A2 (pt) * | 2007-02-01 | 2011-09-06 | Genentech Inc | método para tratamento de tumor |
| DK2361085T4 (en) * | 2008-11-22 | 2018-10-08 | Hoffmann La Roche | USE OF ANTI-VEGF ANTIBODY IN COMBINATION WITH CHEMOTHERY TO TREAT CANCER CANCER |
| WO2020176087A1 (en) | 2019-02-27 | 2020-09-03 | Google Llc | Grayscale histogram generation |
-
2009
- 2009-11-20 DK DK09764134.4T patent/DK2361085T4/en active
- 2009-11-20 SM SM20170173T patent/SMT201700173T1/it unknown
- 2009-11-20 HU HUE09764134A patent/HUE024872T2/en unknown
- 2009-11-20 ES ES09764134.4T patent/ES2535404T5/es active Active
- 2009-11-20 KR KR1020117014272A patent/KR101807319B1/ko not_active Expired - Fee Related
- 2009-11-20 AR ARP090104477A patent/AR074203A1/es unknown
- 2009-11-20 PL PL13189711T patent/PL2752189T3/pl unknown
- 2009-11-20 PL PL09764134T patent/PL2361085T5/pl unknown
- 2009-11-20 KR KR1020187030405A patent/KR20180117734A/ko not_active Ceased
- 2009-11-20 SI SI200931187T patent/SI2361085T2/sl unknown
- 2009-11-20 CN CN200980146589.3A patent/CN102223897B/zh not_active Expired - Fee Related
- 2009-11-20 MX MX2014002003A patent/MX340724B/es unknown
- 2009-11-20 EP EP13189711.8A patent/EP2752189B1/en not_active Revoked
- 2009-11-20 PT PT131897118T patent/PT2752189T/pt unknown
- 2009-11-20 CN CN201510520134.0A patent/CN105214086B/zh not_active Expired - Fee Related
- 2009-11-20 CA CA2744158A patent/CA2744158A1/en not_active Abandoned
- 2009-11-20 TW TW104125142A patent/TWI612971B/zh not_active IP Right Cessation
- 2009-11-20 MX MX2011005383A patent/MX2011005383A/es active IP Right Grant
- 2009-11-20 RU RU2011125518/15A patent/RU2531948C2/ru active
- 2009-11-20 AU AU2009316409A patent/AU2009316409A1/en not_active Abandoned
- 2009-11-20 ES ES13189711.8T patent/ES2611337T3/es active Active
- 2009-11-20 JP JP2011537663A patent/JP6041489B2/ja active Active
- 2009-11-20 BR BRPI0916138A patent/BRPI0916138A2/pt not_active Application Discontinuation
- 2009-11-20 EP EP16188246.9A patent/EP3178478A1/en not_active Withdrawn
- 2009-11-20 WO PCT/US2009/065381 patent/WO2010059969A2/en not_active Ceased
- 2009-11-20 EP EP09764134.4A patent/EP2361085B9/en not_active Not-in-force
- 2009-11-20 TW TW098139537A patent/TWI542359B/zh not_active IP Right Cessation
- 2009-11-20 SI SI200931591T patent/SI2752189T1/sl unknown
- 2009-11-20 HU HUE13189711A patent/HUE032693T2/en unknown
- 2009-11-20 KR KR1020177002172A patent/KR20170015525A/ko not_active Ceased
- 2009-11-20 SG SG2011036696A patent/SG171780A1/en unknown
- 2009-11-20 US US12/623,297 patent/US20100143351A1/en not_active Abandoned
- 2009-11-20 DK DK13189711.8T patent/DK2752189T3/en active
- 2009-11-20 LT LTEP13189711.8T patent/LT2752189T/lt unknown
-
2011
- 2011-05-06 ZA ZA2011/03321A patent/ZA201103321B/en unknown
- 2011-05-19 IL IL212998A patent/IL212998A/en active IP Right Grant
- 2011-05-20 CL CL2011001186A patent/CL2011001186A1/es unknown
-
2014
- 2014-11-10 PH PH12014502507A patent/PH12014502507A1/en unknown
-
2015
- 2015-05-15 US US14/714,177 patent/US20150246124A1/en not_active Abandoned
-
2016
- 2016-01-21 IL IL243741A patent/IL243741A0/en unknown
- 2016-05-13 US US15/154,797 patent/US20160243227A1/en not_active Abandoned
- 2016-08-23 JP JP2016163087A patent/JP6850562B2/ja active Active
- 2016-12-20 US US15/385,602 patent/US20170100478A1/en not_active Abandoned
-
2017
- 2017-01-16 HR HRP20170059TT patent/HRP20170059T1/hr unknown
- 2017-01-25 CY CY20171100116T patent/CY1118549T1/el unknown
-
2018
- 2018-04-19 JP JP2018080848A patent/JP2018138583A/ja not_active Withdrawn
-
2020
- 2020-04-22 JP JP2020076277A patent/JP2020128389A/ja active Pending
- 2020-05-15 US US16/874,936 patent/US20210093715A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017031160A5 (https=) | ||
| CN111065411B (zh) | Pd-1抗体和vegfr抑制剂联合治疗小细胞肺癌的用途 | |
| JP2012509889A5 (https=) | ||
| JP2013520442A5 (https=) | ||
| JP2022121594A5 (https=) | ||
| JP2013173775A5 (https=) | ||
| JP2023502929A5 (https=) | ||
| RU2011125518A (ru) | Антиангиогенная терапия, применяемая для лечения рака молочной железы | |
| JP2022511394A5 (https=) | ||
| JP2020521797A5 (https=) | ||
| JP2022512750A5 (https=) | ||
| JP2021512149A (ja) | プリナブリンの投与による血小板減少症を軽減するための組成物および方法 | |
| JP2022512851A5 (https=) | ||
| JPWO2020111018A5 (https=) | ||
| JP2025509510A5 (https=) | ||
| JP2019508476A5 (https=) | ||
| JP2023548055A5 (https=) | ||
| JP2019524820A5 (https=) | ||
| JP2016094450A5 (https=) | ||
| JP2024016209A5 (https=) | ||
| JP2024517085A5 (https=) | ||
| JP2021511344A5 (https=) | ||
| JP2013501801A5 (https=) | ||
| JP2022553041A5 (https=) | ||
| RU2012109932A (ru) | Антиангиогенная терапия для лечения ранее подвергавшегося лечению рака молочной железы |