JPWO2023086815A5 - - Google Patents

Info

Publication number
JPWO2023086815A5
JPWO2023086815A5 JP2024527321A JP2024527321A JPWO2023086815A5 JP WO2023086815 A5 JPWO2023086815 A5 JP WO2023086815A5 JP 2024527321 A JP2024527321 A JP 2024527321A JP 2024527321 A JP2024527321 A JP 2024527321A JP WO2023086815 A5 JPWO2023086815 A5 JP WO2023086815A5
Authority
JP
Japan
Prior art keywords
feline
immunoglobulin
rodent
locus
variable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024527321A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024543248A5 (https=
JP2024543248A (ja
Publication date
Application filed filed Critical
Priority claimed from PCT/US2022/079533 external-priority patent/WO2023086815A1/en
Publication of JP2024543248A publication Critical patent/JP2024543248A/ja
Publication of JPWO2023086815A5 publication Critical patent/JPWO2023086815A5/ja
Publication of JP2024543248A5 publication Critical patent/JP2024543248A5/ja
Pending legal-status Critical Current

Links

JP2024527321A 2021-11-10 2022-11-09 トランスジェニック哺乳動物およびその使用方法 Pending JP2024543248A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163263855P 2021-11-10 2021-11-10
US63/263,855 2021-11-10
PCT/US2022/079533 WO2023086815A1 (en) 2021-11-10 2022-11-09 Transgenic mammals and methods of use thereof

Publications (3)

Publication Number Publication Date
JP2024543248A JP2024543248A (ja) 2024-11-20
JPWO2023086815A5 true JPWO2023086815A5 (https=) 2025-11-17
JP2024543248A5 JP2024543248A5 (https=) 2025-11-17

Family

ID=84519373

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024527321A Pending JP2024543248A (ja) 2021-11-10 2022-11-09 トランスジェニック哺乳動物およびその使用方法

Country Status (9)

Country Link
US (1) US20240423175A1 (https=)
EP (1) EP4429456A1 (https=)
JP (1) JP2024543248A (https=)
KR (1) KR20240110577A (https=)
CN (1) CN118265449A (https=)
AU (1) AU2022386319A1 (https=)
CA (1) CA3235395A1 (https=)
IL (1) IL312359A (https=)
WO (1) WO2023086815A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202209247D0 (en) * 2022-06-23 2022-08-10 Petmedix Ltd Animal models and therapeutic molecules

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1293460C (en) 1985-10-07 1991-12-24 Brian Lee Sauer Site-specific recombination of dna in yeast
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
GB8904009D0 (en) 1989-02-22 1989-04-05 Celltech Ltd Vector
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
US6689610B1 (en) 1989-08-22 2004-02-10 University Of Utah Research Foundation Cells and non-human organisms containing predetermined genomic modifications and positive-negative selection methods and vectors for making same
US6673986B1 (en) 1990-01-12 2004-01-06 Abgenix, Inc. Generation of xenogeneic antibodies
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US7041871B1 (en) 1995-10-10 2006-05-09 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
ATE352612T1 (de) 1990-08-29 2007-02-15 Pharming Intellectual Pty Bv Homologe rekombination in säugetier-zellen
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5874299A (en) 1990-08-29 1999-02-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
WO1992015694A1 (en) 1991-03-08 1992-09-17 The Salk Institute For Biological Studies Flp-mediated gene modification in mammalian cells, and compositions and cells useful therefor
DE4228162C1 (de) 1992-08-25 1994-01-13 Rajewsky Klaus Dr Verfahren zum Ersetzen homologer Genabschnitte aus Säugern in der Keimbahn von nicht-menschlichen Säugern
US5593598A (en) 1994-04-20 1997-01-14 Mcginness; Michael P. Method and apparatus for closed loop recycling of contaminated cleaning solution
US6130364A (en) 1995-03-29 2000-10-10 Abgenix, Inc. Production of antibodies using Cre-mediated site-specific recombination
US6091001A (en) 1995-03-29 2000-07-18 Abgenix, Inc. Production of antibodies using Cre-mediated site-specific recombination
EP1500329B1 (en) 1996-12-03 2012-03-21 Amgen Fremont Inc. Human antibodies that specifically bind human TNF alpha
US6774279B2 (en) 1997-05-30 2004-08-10 Carnegie Institution Of Washington Use of FLP recombinase in mice
FR2814642B1 (fr) 2000-10-03 2005-07-01 Ass Pour Le Dev De La Rech En Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US7422889B2 (en) 2004-10-29 2008-09-09 Stowers Institute For Medical Research Dre recombinase and recombinase systems employing Dre recombinase
US10662256B2 (en) * 2010-07-26 2020-05-26 Trianni, Inc. Transgenic mammals and methods of use thereof
US20170058052A1 (en) 2015-08-24 2017-03-02 Trianni, Inc. Enhanced production of immunoglobulins
WO2018128691A1 (en) * 2016-11-04 2018-07-12 Regeneron Pharmaceuticals, Inc. Non-human animals having an engineered immunoglobulin lambda light chain locus
GB2561352B (en) * 2017-04-10 2023-01-18 Genome Res Ltd Animal models and therapeutic molecules
GB2578867A (en) * 2018-10-09 2020-06-03 Genome Res Ltd Animal models and therapeutic molecules
CA3144956A1 (en) * 2019-07-01 2021-01-07 Trianni, Inc. Transgenic mammals and methods of use
WO2021003152A1 (en) * 2019-07-01 2021-01-07 Trianni, Inc. Transgenic mammals and methods of use thereof

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