JPWO2022239765A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2022239765A5 JPWO2022239765A5 JP2023521204A JP2023521204A JPWO2022239765A5 JP WO2022239765 A5 JPWO2022239765 A5 JP WO2022239765A5 JP 2023521204 A JP2023521204 A JP 2023521204A JP 2023521204 A JP2023521204 A JP 2023521204A JP WO2022239765 A5 JPWO2022239765 A5 JP WO2022239765A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- peptide
- acid sequence
- amyloid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 21
- 125000000539 amino acid group Chemical group 0.000 claims 15
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 230000006933 amyloid-beta aggregation Effects 0.000 claims 8
- 239000003112 inhibitor Substances 0.000 claims 8
- 230000002776 aggregation Effects 0.000 claims 5
- 238000004220 aggregation Methods 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000005145 Cerebral amyloid angiopathy Diseases 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 206010027175 memory impairment Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021080513 | 2021-05-11 | ||
| PCT/JP2022/019786 WO2022239765A1 (ja) | 2021-05-11 | 2022-05-10 | アミロイドβの凝集抑制剤、アミロイドβ凝集疾患用医薬組成物、およびその用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2022239765A1 JPWO2022239765A1 (https=) | 2022-11-17 |
| JPWO2022239765A5 true JPWO2022239765A5 (https=) | 2025-05-01 |
Family
ID=84029643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023521204A Pending JPWO2022239765A1 (https=) | 2021-05-11 | 2022-05-10 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20240238365A1 (https=) |
| EP (1) | EP4338748A4 (https=) |
| JP (1) | JPWO2022239765A1 (https=) |
| CN (1) | CN117295511A (https=) |
| WO (1) | WO2022239765A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2022239764A1 (https=) * | 2021-05-11 | 2022-11-17 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070021345A1 (en) * | 2003-06-30 | 2007-01-25 | Ehud Gazit | Peptides antibodies directed thereagainst and methods using same for diagnosing and treating amyloid-associated diseases |
| US7314974B2 (en) * | 2002-02-21 | 2008-01-01 | Monsanto Technology, Llc | Expression of microbial proteins in plants for production of plants with improved properties |
| US20040162236A1 (en) * | 2002-04-01 | 2004-08-19 | John Alsobrook | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| WO2017119511A1 (ja) * | 2016-01-06 | 2017-07-13 | 学校法人沖縄科学技術大学院大学学園 | 加水分解活性を示す新規ペプチドおよびその用途 |
| AU2017254477A1 (en) * | 2016-04-18 | 2018-11-01 | Jennifer G. ABELIN | Improved HLA epitope prediction |
| EP3773625A4 (en) * | 2018-03-29 | 2021-05-19 | Mayo Foundation for Medical Education and Research | METHODS AND MATERIALS FOR TREATMENT OF CANCER |
| JP7360155B2 (ja) | 2019-11-18 | 2023-10-12 | 奥野製薬工業株式会社 | 無電解ニッケルめっき皮膜及び該無電解ニッケルめっき皮膜形成のための前処理方法 |
-
2022
- 2022-05-10 EP EP22807465.4A patent/EP4338748A4/en active Pending
- 2022-05-10 CN CN202280034441.6A patent/CN117295511A/zh active Pending
- 2022-05-10 US US18/559,482 patent/US20240238365A1/en active Pending
- 2022-05-10 JP JP2023521204A patent/JPWO2022239765A1/ja active Pending
- 2022-05-10 WO PCT/JP2022/019786 patent/WO2022239765A1/ja not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008525033A5 (https=) | ||
| ITMI971523A1 (it) | Sali nitrati di ace-inibitori | |
| JP2008538183A5 (https=) | ||
| JPH0449545B2 (https=) | ||
| MXPA01010114A (es) | Inhibidores de peso molecular bajo de las proteasas complemento. | |
| JPWO2022239765A5 (https=) | ||
| MX2022003057A (es) | Nuevos peptidos. | |
| JP2024520234A5 (https=) | ||
| JP5410278B2 (ja) | βセクレターゼ阻害活性を有する新規化合物 | |
| US7585938B2 (en) | Gamma-secretase inhibitors | |
| JPWO2011126054A1 (ja) | 生理活性ペプチド | |
| JP2010512326A5 (https=) | ||
| JP2000511882A (ja) | Ａｃｅ阻害剤及び／またはｎｅｐ阻害剤として有用なｎ―ホルミルヒドロキシルアミン化合物 | |
| JP2006158399A5 (ja) | 細胞増殖抑制タンパク質並びにそれを用いる細胞増殖抑制剤、癌診断薬及び癌治療剤 | |
| MX2007006252A (es) | Nuevos peptidos utiles como inhibidores duales de caspasa-2/-6 y sus aplicaciones biologicas. | |
| JP2008517998A5 (https=) | ||
| CN104109189B (zh) | Thr-Pro-Pro-Thr四肽的液相合成方法 | |
| JP2012521346A5 (https=) | ||
| JP2012116851A (ja) | アミロイドβ線維化阻害ペプチド | |
| EP4427749A1 (en) | Use of apomorphine as therapeutic agent for necroptosis-related diseases | |
| JP2008508363A5 (https=) | ||
| JPWO2023058337A5 (https=) | ||
| JP2024516605A5 (https=) | ||
| HU181402B (en) | Process for preparing new peptides with psychopharmacological activity | |
| JP2007161696A (ja) | 新規なヘプタペプチド及びプロリルエンドペプチダーゼ阻害剤 |