JP2010512326A5 - - Google Patents
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- Publication number
- JP2010512326A5 JP2010512326A5 JP2009540329A JP2009540329A JP2010512326A5 JP 2010512326 A5 JP2010512326 A5 JP 2010512326A5 JP 2009540329 A JP2009540329 A JP 2009540329A JP 2009540329 A JP2009540329 A JP 2009540329A JP 2010512326 A5 JP2010512326 A5 JP 2010512326A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- stable
- sequence
- seq
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 101000914195 Homo sapiens Cerberus Proteins 0.000 claims 1
- 102000004472 Myostatin Human genes 0.000 claims 1
- 108010056852 Myostatin Proteins 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87393306P | 2006-12-08 | 2006-12-08 | |
| PCT/US2007/025180 WO2008073351A2 (en) | 2006-12-08 | 2007-12-10 | Uses of cerberus, coco and derivatives thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010512326A JP2010512326A (ja) | 2010-04-22 |
| JP2010512326A5 true JP2010512326A5 (https=) | 2011-03-10 |
Family
ID=39183158
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009540329A Pending JP2010512326A (ja) | 2006-12-08 | 2007-12-10 | Ｃｅｒｂｅｒｕｓ、Ｃｏｃｏおよびこれらの誘導体の使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7833971B2 (https=) |
| EP (1) | EP2099471A2 (https=) |
| JP (1) | JP2010512326A (https=) |
| AU (1) | AU2007332819A1 (https=) |
| CA (1) | CA2671983A1 (https=) |
| WO (1) | WO2008073351A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9045553B2 (en) * | 2004-05-27 | 2015-06-02 | Acceleron Pharma, Inc. | Cerberus/Coco derivatives and uses thereof |
| MA41920B1 (fr) | 2015-04-06 | 2021-05-31 | Acceleron Pharma Inc | Protéines de fusion de récepteur type i et type ii à bras unique et leurs utilisations |
| MA41919A (fr) | 2015-04-06 | 2018-02-13 | Acceleron Pharma Inc | Hétéromultimères alk4:actriib et leurs utilisations |
| WO2017177013A1 (en) | 2016-04-06 | 2017-10-12 | Acceleron Pharma Inc. | Alk7 antagonists and uses thereof |
| DK3496739T3 (da) | 2016-07-15 | 2021-05-10 | Acceleron Pharma Inc | Sammensætninger omfattende actriia-polypeptider til brug i behandlingen af pulmonal hypertension |
| CA3039573A1 (en) | 2016-10-05 | 2018-04-12 | Acceleron Pharma Inc. | Alk4:actriib heteromultimers and uses thereof |
| US20230174620A1 (en) | 2020-04-28 | 2023-06-08 | Acceleron Pharma Inc. | Actrii proteins and use in treating post-capillary pulmonary hypertension |
| US12508262B2 (en) | 2020-04-30 | 2025-12-30 | Keros Therapeutics, Inc. | Methods of using ALK2 inhibitors |
| WO2022098812A1 (en) | 2020-11-04 | 2022-05-12 | Keros Therapeutics, Inc. | Methods of treating iron overload |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6133232A (en) | 1996-06-20 | 2000-10-17 | The Regents Of The University Of California | Endoderm, cardiac and neural inducing factors |
| WO1998034951A1 (en) | 1997-02-11 | 1998-08-13 | Amrad Operations Pty. Ltd. | A new cytokine family and uses thereof |
| US6610510B1 (en) * | 1997-04-29 | 2003-08-26 | Regeneron Pharmaceuticals, Inc. | Morphogenic proteins |
| US5935852A (en) * | 1997-07-03 | 1999-08-10 | Genetics Institute, Inc. | DNA molecules encoding mammalian cerberus-like proteins |
| US6656475B1 (en) | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
| CA2319703C (en) | 1998-02-05 | 2005-09-20 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-8 |
| US20040009535A1 (en) | 1998-11-27 | 2004-01-15 | Celltech R&D, Inc. | Compositions and methods for increasing bone mineralization |
| WO2000055193A2 (en) | 1999-03-12 | 2000-09-21 | Regeneron Pharmaceuticals, Inc. | Human dan/cerberus related protein 6 (dcr6) |
| AU2002227172A1 (en) | 2000-10-19 | 2002-04-29 | Genaissance Pharmaceuticals, Inc. | Haplotypes of the cer1 gene |
| WO2002054940A2 (en) | 2001-01-12 | 2002-07-18 | University Of Medicine & Dentistry Of New Jersey | Bone morphogenetic protein-2 in the treatment and diagnosis of cancer |
| EP1383867A2 (en) | 2001-03-23 | 2004-01-28 | Axordia Limited | Stem cell differentiation |
| WO2002078516A2 (en) | 2001-03-30 | 2002-10-10 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of cancer |
| GB0111004D0 (en) | 2001-05-04 | 2001-06-27 | Univ Sheffield | Screening method |
| GB0118223D0 (en) | 2001-07-26 | 2001-09-19 | Univ Sheffield | Stem loop RNA |
| KR100996226B1 (ko) | 2001-10-31 | 2010-11-24 | 유니버시티 오브 노스 텍사스 헬스 사이언스 센터 | 뼈 형태발생 단백질(ｂｍｐ), ｂｍｐ 수용체 및 ｂｍｐ결합 단백질 및 녹내장 진단 및 치료에서 그의 용도 |
| GB0130738D0 (en) * | 2001-12-21 | 2002-02-06 | Serono Internat S A | Protein |
| US20030134790A1 (en) * | 2002-01-11 | 2003-07-17 | University Of Medicine And Dentistry Of New Jersey | Bone Morphogenetic Protein-2 And Bone Morphogenetic Protein-4 In The Treatment And Diagnosis Of Cancer |
| BR0307871A (pt) | 2002-02-21 | 2005-04-12 | Wyeth Corp | Proteìnas contendo domìnio de folistatina |
| US7193069B2 (en) | 2002-03-22 | 2007-03-20 | Research Association For Biotechnology | Full-length cDNA |
| US20030194704A1 (en) * | 2002-04-03 | 2003-10-16 | Penn Sharron Gaynor | Human genome-derived single exon nucleic acid probes useful for gene expression analysis two |
| US20040023356A1 (en) | 2002-06-14 | 2004-02-05 | Robb Krumlauf | Wise/Sost nucleic acid sequences and amino acid sequences |
| BR0317538A (pt) * | 2002-12-20 | 2005-11-29 | Amgen Inc | Agente ligante, sequência de polinucleotìdeo, vetor de expressão, célula hospedeira, composição farmacêutica, e, métodos de inibir a atividade de miostatina, de aumentar a massa muscular magra e a razão de massa muscular magra para gordura, de tratar uma doença de emaciação muscular e um distúrbio metabólico relacionado com miostatina em um indivìduo, de detectar e medir miostatina em uma amostra, e, de diagnosticar um distúrbio relacionado com miostatina em um indivìduo |
| WO2004074460A2 (en) | 2003-02-19 | 2004-09-02 | The Rockefeller University | Nucleotide and protein sequences of coc genes and methods based thereon |
| KR100543937B1 (ko) * | 2003-10-31 | 2006-01-23 | 주식회사 하이닉스반도체 | 데이터 출력제어회로 |
| JP2008500373A (ja) * | 2004-05-27 | 2008-01-10 | アクセルロン ファーマ インコーポレーテッド | ケルベロス（Ｃｅｒｂｅｒｕｓ）／ココ（Ｃｏｃｏ）誘導体およびそれらの使用 |
-
2007
- 2007-12-10 CA CA002671983A patent/CA2671983A1/en not_active Abandoned
- 2007-12-10 JP JP2009540329A patent/JP2010512326A/ja active Pending
- 2007-12-10 EP EP07862679A patent/EP2099471A2/en not_active Withdrawn
- 2007-12-10 AU AU2007332819A patent/AU2007332819A1/en not_active Abandoned
- 2007-12-10 US US12/001,494 patent/US7833971B2/en active Active
- 2007-12-10 WO PCT/US2007/025180 patent/WO2008073351A2/en not_active Ceased
-
2010
- 2010-11-05 US US12/940,740 patent/US8796199B2/en active Active
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