JPWO2022225934A5 - - Google Patents
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- Publication number
- JPWO2022225934A5 JPWO2022225934A5 JP2023563990A JP2023563990A JPWO2022225934A5 JP WO2022225934 A5 JPWO2022225934 A5 JP WO2022225934A5 JP 2023563990 A JP2023563990 A JP 2023563990A JP 2023563990 A JP2023563990 A JP 2023563990A JP WO2022225934 A5 JPWO2022225934 A5 JP WO2022225934A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- pharma
- stereoisomer
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163176610P | 2021-04-19 | 2021-04-19 | |
| US63/176,610 | 2021-04-19 | ||
| US202163183563P | 2021-05-03 | 2021-05-03 | |
| US63/183,563 | 2021-05-03 | ||
| US202163254832P | 2021-10-12 | 2021-10-12 | |
| US63/254,832 | 2021-10-12 | ||
| PCT/US2022/025357 WO2022225934A1 (en) | 2021-04-19 | 2022-04-19 | Parp1 inhibitors and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024514223A JP2024514223A (ja) | 2024-03-28 |
| JPWO2022225934A5 true JPWO2022225934A5 (https=) | 2025-04-28 |
| JP2024514223A5 JP2024514223A5 (https=) | 2025-04-28 |
Family
ID=83723349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023563990A Pending JP2024514223A (ja) | 2021-04-19 | 2022-04-19 | Ｐａｒｐ１阻害薬及びその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11591331B2 (https=) |
| EP (1) | EP4326720A4 (https=) |
| JP (1) | JP2024514223A (https=) |
| KR (1) | KR20230172550A (https=) |
| AU (1) | AU2022260495A1 (https=) |
| CA (1) | CA3216373A1 (https=) |
| TW (1) | TW202309025A (https=) |
| WO (1) | WO2022225934A1 (https=) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202309025A (zh) | 2021-04-19 | 2023-03-01 | 美商辛瑟拉股份有限公司 | Parp1抑制劑及其用途 |
| CA3213029A1 (en) * | 2021-04-22 | 2022-10-27 | Yuli Xie | Parp inhibitor containing piperazine structure, preparation method therefor and pharmaceutical use thereof |
| WO2022223025A1 (zh) * | 2021-04-23 | 2022-10-27 | 上海翰森生物医药科技有限公司 | 杂环类衍生物抑制剂、其制备方法和应用 |
| EP4349836A4 (en) * | 2021-05-24 | 2024-10-30 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, ITS PREPARATION METHOD AND ITS APPLICATION IN DRUGS |
| AU2022334408A1 (en) * | 2021-08-27 | 2024-02-15 | Impact Therapeutics (Shanghai), Inc. | Substituted tricyclic compounds as parp inhibitors and use thereof |
| WO2023046034A1 (zh) * | 2021-09-22 | 2023-03-30 | 明慧医药（杭州）有限公司 | 一种含氮杂环化合物、其制备方法、其中间体及其应用 |
| WO2023046158A1 (zh) * | 2021-09-26 | 2023-03-30 | 张文燕 | 氮杂喹啉酮类化合物及其医药用途 |
| WO2023051812A1 (zh) * | 2021-09-30 | 2023-04-06 | 海思科医药集团股份有限公司 | 含氮杂环衍生物parp抑制剂及其用途 |
| US20230159525A1 (en) * | 2021-10-01 | 2023-05-25 | Xinthera, Inc. | Azetidine and pyrrolidine parp1 inhibitors and uses thereof |
| JP7762306B2 (ja) * | 2021-11-19 | 2025-10-29 | 康百達（四川）生物医薬科技有限公司 | 選択的ｐａｒｐ１阻害剤およびその用途 |
| CA3241338A1 (en) * | 2021-12-17 | 2023-06-22 | Yongqi Deng | Parp inhibitor, pharmaceutical composition comprising same, and use thereof |
| WO2023133413A1 (en) * | 2022-01-07 | 2023-07-13 | Slap Pharmaceuticals Llc | Multicyclic compounds |
| WO2023134647A1 (zh) * | 2022-01-13 | 2023-07-20 | 优领医药科技(香港)有限公司 | 含哌嗪并环类衍生物、其药学上可接受的盐及其制备方法和应用 |
| WO2023138541A1 (zh) * | 2022-01-20 | 2023-07-27 | 微境生物医药科技(上海)有限公司 | 吡啶酰胺类parp抑制剂、及其制备方法和医药用途 |
| AU2023209820B2 (en) | 2022-01-21 | 2024-10-10 | Xinthera, Inc. | Parp1 inhibitors and uses thereof |
| US20260098024A1 (en) * | 2022-01-27 | 2026-04-09 | Xinthera, Inc. | Parp1 inhibitors and uses thereof |
| WO2023146960A1 (en) * | 2022-01-28 | 2023-08-03 | Xinthera, Inc. | Parp1 inhibitors and uses thereof |
| IL315586A (en) * | 2022-03-11 | 2024-11-01 | Impact Therapeutics Shanghai Inc | Substituted tricyclic compounds as parp inhibitors and the use thereof |
| KR20240161147A (ko) | 2022-03-14 | 2024-11-12 | 슬랩 파마슈티컬스 엘엘씨 | 다중 사이클릭 화합물 |
| EP4514795A4 (en) * | 2022-04-28 | 2025-12-31 | Ningbo Newbay Tech Development Co Ltd | COMPOUNDS USED AS PARP1 INHIBITORS |
| FI4497438T3 (fi) | 2022-04-28 | 2025-10-20 | Xinthera Inc | Trisyklisiä parp1:n estäjiä ja niiden käyttötapoja |
| US20250346573A1 (en) * | 2022-06-02 | 2025-11-13 | Chengdu Easton Biopharmaceuticals Co., Ltd. | Azaquinolinone derivative, preparation method therefor and use thereof |
| CN115919859B (zh) * | 2022-07-14 | 2024-01-05 | 四川海思科制药有限公司 | 一种杂芳基衍生物的药物组合物及其在医药上的应用 |
| CN115232129B (zh) * | 2022-08-18 | 2023-12-01 | 上海闻耐医药科技有限公司 | 一种parp1选择性抑制剂及其制备方法和用途 |
| WO2024041605A1 (zh) * | 2022-08-24 | 2024-02-29 | 四川海思科制药有限公司 | 一种杂芳基衍生物parp抑制剂药学上可接受的盐及其用途 |
| WO2024041608A1 (zh) * | 2022-08-24 | 2024-02-29 | 四川海思科制药有限公司 | 一种杂芳基衍生物parp抑制剂的晶体形式及其用途 |
| TW202415658A (zh) * | 2022-09-30 | 2024-04-16 | 大陸商中國醫藥研究開發中心有限公司 | 含氮雜環類化合物及其醫藥用途 |
| US20240174669A1 (en) | 2022-10-06 | 2024-05-30 | Xinthera, Inc. | Crystalline forms of a parp1 inhibitor |
| WO2024083218A1 (zh) * | 2022-10-20 | 2024-04-25 | 成都赜灵生物医药科技有限公司 | 取代四氢吡啶类化合物及其用途 |
| CN120035592A (zh) * | 2022-10-20 | 2025-05-23 | 成都赜灵生物医药科技有限公司 | 并杂环类氘代化合物及其用途 |
| WO2024083201A1 (zh) * | 2022-10-20 | 2024-04-25 | 成都赜灵生物医药科技有限公司 | 并杂环类化合物及其用途 |
| JP2025538192A (ja) * | 2022-11-10 | 2025-11-26 | 上海海和薬物研究開発股▲ふん▼有限公司 | 縮合三環式ｐａｒｐ１阻害剤、その調製方法、および使用 |
| CN121698877A (zh) * | 2022-11-10 | 2026-03-20 | 正大天晴药业集团股份有限公司 | 稠合双环化合物 |
| EP4620956A1 (en) * | 2022-12-23 | 2025-09-24 | Zhejiang Yangli Pharmaceutical Technology Co., Ltd. | Parp1 inhibitors |
| WO2024158878A1 (en) * | 2023-01-25 | 2024-08-02 | Enliven Inc. | Fused tetracyclic selective parp1 inhibitors |
| WO2024178125A1 (en) * | 2023-02-21 | 2024-08-29 | 1Cbio, Inc. | Heterocyclic compounds and methods of use thereof |
| TW202502341A (zh) * | 2023-03-13 | 2025-01-16 | 大陸商江蘇豪森藥業集團有限公司 | 哌啶烯類化合物在製備治療癌症的藥物中的應用 |
| CN120882710A (zh) * | 2023-03-24 | 2025-10-31 | 新特拉有限公司 | 氮杂环丁烷parp1抑制剂的结晶形式 |
| WO2024227026A1 (en) * | 2023-04-28 | 2024-10-31 | Synnovation Therapeutics, Inc. | Heterocyclic compounds as parp1 inhibitors |
| CN120917007A (zh) * | 2023-05-19 | 2025-11-07 | 上海海和药物研究开发股份有限公司 | 一种芳基脲类parp1抑制剂、其制备方法及用途 |
| CN120677162A (zh) * | 2023-06-13 | 2025-09-19 | 中国医药研究开发中心有限公司 | 含氮杂环类化合物及其医药用途 |
| CN121464135A (zh) * | 2023-07-07 | 2026-02-03 | 优领医药科技(香港)有限公司 | 含哌嗪并环类衍生物的晶型、其盐型、其制备方法及应用 |
| CN119462669A (zh) * | 2023-08-11 | 2025-02-18 | 上海海和药物研究开发股份有限公司 | 稠合三环类化合物、其药物组合物和用途 |
| WO2025092973A1 (zh) * | 2023-11-03 | 2025-05-08 | 成都赜灵生物医药科技有限公司 | Parp1靶向化合物及其用途 |
| WO2025168048A1 (zh) * | 2024-02-08 | 2025-08-14 | 上海璎黎药业有限公司 | 一种三键结构化合物、其药物组合物及其应用 |
| WO2025261449A1 (zh) * | 2024-06-19 | 2025-12-26 | 浙江扬厉医药技术有限公司 | 一种parp1抑制剂吡啶酰胺类化合物、中间体及其制备方法 |
| WO2025261448A1 (zh) * | 2024-06-19 | 2025-12-26 | 浙江扬厉医药技术有限公司 | 一类吡啶酰胺化合物的盐型、晶型及其制备方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPS137402A0 (en) | 2002-03-26 | 2002-05-09 | Fujisawa Pharmaceutical Co., Ltd. | Novel tricyclic compounds |
| US8404713B2 (en) | 2007-10-26 | 2013-03-26 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP inhibitors |
| KR101779137B1 (ko) * | 2009-01-23 | 2017-09-18 | 다케다 야쿠힌 고교 가부시키가이샤 | 폴리(ａｄｐ-리보스)폴리머라제(ｐａｒｐ) 억제제 |
| EP2459561A1 (en) * | 2009-07-30 | 2012-06-06 | Takeda Pharmaceutical Company Limited | Poly (adp-ribose) polymerase (parp) inhibitors |
| HUE051078T2 (hu) | 2012-10-26 | 2021-03-01 | Nerviano Medical Sciences Srl | 4-karboxamido-izoindolinone származék mint szelektív parp-1 inhibitor |
| PH12017502228B1 (en) | 2015-06-09 | 2022-08-03 | Onconic Therapeutics Inc | Tricyclic derivative compound, method for preparing same, and pharmaceutical composition comprising same |
| MX2022000711A (es) | 2019-07-19 | 2022-02-23 | Astrazeneca Ab | Inhibidores de parp1. |
| US11795158B2 (en) | 2020-06-25 | 2023-10-24 | Astrazeneca Ab | Chemical compounds |
| IL301921A (en) * | 2020-10-09 | 2023-06-01 | Daiichi Sankyo Co Ltd | Combining an antibody-drug conjugate and a selective 1PARP inhibitor |
| TW202309025A (zh) * | 2021-04-19 | 2023-03-01 | 美商辛瑟拉股份有限公司 | Parp1抑制劑及其用途 |
| CA3213029A1 (en) * | 2021-04-22 | 2022-10-27 | Yuli Xie | Parp inhibitor containing piperazine structure, preparation method therefor and pharmaceutical use thereof |
| WO2022222966A1 (zh) | 2021-04-23 | 2022-10-27 | 成都百裕制药股份有限公司 | 一种选择性parp1抑制剂及其应用 |
| TW202304911A (zh) | 2021-04-23 | 2023-02-01 | 大陸商南京明德新藥研發有限公司 | 吡啶醯胺類化合物 |
| WO2022223025A1 (zh) | 2021-04-23 | 2022-10-27 | 上海翰森生物医药科技有限公司 | 杂环类衍生物抑制剂、其制备方法和应用 |
| WO2022222965A1 (zh) * | 2021-04-23 | 2022-10-27 | 成都百裕制药股份有限公司 | 吡啶衍生物及其在医药上的应用 |
| WO2022228387A1 (en) | 2021-04-26 | 2022-11-03 | Fochon Biosciences, Ltd. | Compounds as parp inhibitors |
| WO2023046034A1 (zh) * | 2021-09-22 | 2023-03-30 | 明慧医药（杭州）有限公司 | 一种含氮杂环化合物、其制备方法、其中间体及其应用 |
| US20240391937A1 (en) * | 2021-09-30 | 2024-11-28 | Xizang Haisco Pharmaceutical Co., Ltd. | Bicyclic derivative parp inhibitor and use thereof |
| CA3241338A1 (en) * | 2021-12-17 | 2023-06-22 | Yongqi Deng | Parp inhibitor, pharmaceutical composition comprising same, and use thereof |
| WO2023134647A1 (zh) * | 2022-01-13 | 2023-07-20 | 优领医药科技(香港)有限公司 | 含哌嗪并环类衍生物、其药学上可接受的盐及其制备方法和应用 |
| WO2023138541A1 (zh) * | 2022-01-20 | 2023-07-27 | 微境生物医药科技(上海)有限公司 | 吡啶酰胺类parp抑制剂、及其制备方法和医药用途 |
| CN115232129B (zh) | 2022-08-18 | 2023-12-01 | 上海闻耐医药科技有限公司 | 一种parp1选择性抑制剂及其制备方法和用途 |
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2022
- 2022-04-19 TW TW111114905A patent/TW202309025A/zh unknown
- 2022-04-19 US US17/723,929 patent/US11591331B2/en active Active
- 2022-04-19 EP EP22792317.4A patent/EP4326720A4/en active Pending
- 2022-04-19 JP JP2023563990A patent/JP2024514223A/ja active Pending
- 2022-04-19 CA CA3216373A patent/CA3216373A1/en active Pending
- 2022-04-19 AU AU2022260495A patent/AU2022260495A1/en active Pending
- 2022-04-19 KR KR1020237039422A patent/KR20230172550A/ko active Pending
- 2022-04-19 WO PCT/US2022/025357 patent/WO2022225934A1/en not_active Ceased
- 2022-09-19 US US17/933,326 patent/US20230128041A1/en not_active Abandoned