JPWO2022190016A5 - - Google Patents

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Publication number
JPWO2022190016A5
JPWO2022190016A5 JP2023554922A JP2023554922A JPWO2022190016A5 JP WO2022190016 A5 JPWO2022190016 A5 JP WO2022190016A5 JP 2023554922 A JP2023554922 A JP 2023554922A JP 2023554922 A JP2023554922 A JP 2023554922A JP WO2022190016 A5 JPWO2022190016 A5 JP WO2022190016A5
Authority
JP
Japan
Prior art keywords
recombinant protein
binding agent
binding
amino acid
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023554922A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024509904A (ja
JP2024509904A5 (https=
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2022/052126 external-priority patent/WO2022190016A1/en
Publication of JP2024509904A publication Critical patent/JP2024509904A/ja
Publication of JPWO2022190016A5 publication Critical patent/JPWO2022190016A5/ja
Publication of JP2024509904A5 publication Critical patent/JP2024509904A5/ja
Pending legal-status Critical Current

Links

JP2023554922A 2021-03-09 2022-03-09 新規なDARPinに基づく多重特異性T細胞エンゲージャ Pending JP2024509904A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202163158539P 2021-03-09 2021-03-09
US63/158,539 2021-03-09
US202163172973P 2021-04-09 2021-04-09
US63/172,973 2021-04-09
US202163265184P 2021-12-09 2021-12-09
US63/265,184 2021-12-09
PCT/IB2022/052126 WO2022190016A1 (en) 2021-03-09 2022-03-09 Novel darpin based multi-specific t-cell engagers

Publications (3)

Publication Number Publication Date
JP2024509904A JP2024509904A (ja) 2024-03-05
JPWO2022190016A5 true JPWO2022190016A5 (https=) 2025-03-18
JP2024509904A5 JP2024509904A5 (https=) 2025-03-18

Family

ID=81327872

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023554922A Pending JP2024509904A (ja) 2021-03-09 2022-03-09 新規なDARPinに基づく多重特異性T細胞エンゲージャ

Country Status (11)

Country Link
US (2) US11834504B2 (https=)
EP (1) EP4304731A1 (https=)
JP (1) JP2024509904A (https=)
KR (1) KR20230155464A (https=)
AU (1) AU2022234894A1 (https=)
BR (1) BR112023018293A2 (https=)
CA (1) CA3211381A1 (https=)
CO (1) CO2023012681A2 (https=)
IL (1) IL305677A (https=)
MX (1) MX2023010543A (https=)
WO (1) WO2022190016A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL305677A (en) * 2021-03-09 2023-11-01 Molecular Partners Ag Novel darpin based multi-specific t-cell engagers
EP4724486A1 (en) * 2023-06-06 2026-04-15 Molecular Partners AG Recombinant cd2 binding proteins and their use
WO2025163082A1 (en) * 2024-01-31 2025-08-07 Molecular Partners Ag Dll3-specific binding constructs and their use in radiotherapy
WO2025181039A1 (en) 2024-03-01 2025-09-04 Molecular Partners Ag Therapeutic combinations comprising a multi-specific t cell engager

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* Cited by examiner, † Cited by third party
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CA2877584A1 (en) 2012-06-28 2014-01-03 Molecular Partners Ag Designed ankyrin repeat proteins binding to platelet-derived growth factor
CA2883264A1 (en) 2012-10-15 2014-04-24 Universitat Zurich Prorektorat Mnw Bispecific her2 ligands for cancer therapy
EP2738180A1 (en) 2012-11-30 2014-06-04 Molecular Partners AG Binding proteins comprising at least two binding domains against HER2.
EP2789630A1 (en) 2013-04-09 2014-10-15 EngMab AG Bispecific antibodies against CD3e and ROR1
US11453708B2 (en) 2013-05-31 2022-09-27 Molecular Partners Ag Designed ankyrin repeat proteins binding to hepatocyte growth factor
EP2839842A1 (en) 2013-08-23 2015-02-25 MacroGenics, Inc. Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof
AU2016240220B2 (en) 2015-04-02 2019-11-21 Molecular Partners Ag Designed ankyrin repeat domains with binding specificity for serum albumin
WO2017040855A1 (en) * 2015-09-02 2017-03-09 Dose Medical Corporation Drug delivery implants as intraocular drug depots and methods of using same
WO2017165464A1 (en) * 2016-03-21 2017-09-28 Elstar Therapeutics, Inc. Multispecific and multifunctional molecules and uses thereof
US10717772B2 (en) 2016-09-22 2020-07-21 Molecular Partners Ag Recombinant binding proteins targeting HER2 and serum albumin, and their uses
RU2020135920A (ru) 2018-04-05 2022-05-05 Новартис Аг Триспецифические связывающие молекулы против форм рака и пути их применения
BR112020020604A2 (pt) * 2018-04-11 2021-01-12 Inhibrx, Inc. Construções de polipeptídeo multiespecífico tendo ligação restrita de cd3 e métodos e usos relacionados
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US12441772B2 (en) 2019-06-04 2025-10-14 Molecular Partners Ag Designed ankyrin repeat domain with improved stability
SG11202112925PA (en) 2019-06-04 2021-12-30 Molecular Partners Ag Recombinant fap binding proteins and their use
EP3980452A1 (en) 2019-06-04 2022-04-13 Molecular Partners AG Recombinant 4-1bb binding proteins and their use
CN114206943A (zh) * 2019-06-04 2022-03-18 分子伴侣公司 多特异性蛋白质
CA3161319A1 (en) 2019-12-11 2021-06-17 Victor LEVITSKY Recombinant peptide-mhc complex binding proteins and their generation and use
KR20220113492A (ko) 2019-12-11 2022-08-12 몰리큘라 파트너스 아게 변경된 표면 잔기를 갖는 설계된 안키린 반복 도메인
KR20230006558A (ko) 2020-05-06 2023-01-10 몰리큘라 파트너스 아게 신규한 안키린 반복 결합 단백질 및 그의 용도
IL298168A (en) 2020-05-14 2023-01-01 Molecular Partners Ag Multispecific proteins
US20240279309A1 (en) 2020-05-14 2024-08-22 Molecular Partners Ag Recombinant cd40 binding proteins and their use
US20240052033A1 (en) 2020-12-16 2024-02-15 Molecular Partners Ag Recombinant cd3 binding proteins and their use
CA3202358A1 (en) 2020-12-16 2022-06-23 Andreas BOSSHART Novel slow-release prodrugs
AU2022233791A1 (en) 2021-03-09 2023-09-28 Molecular Partners Ag Novel darpin based cd123 engagers
WO2022190010A1 (en) 2021-03-09 2022-09-15 Molecular Partners Ag Novel darpin based cd33 engagers
IL305677A (en) * 2021-03-09 2023-11-01 Molecular Partners Ag Novel darpin based multi-specific t-cell engagers
JP2024509890A (ja) 2021-03-09 2024-03-05 モレキュラー パートナーズ アクチェンゲゼルシャフト プロテアーゼ切断可能なプロドラッグ
EP4319883A1 (en) 2021-04-09 2024-02-14 Molecular Partners AG Novel darpin based cd70 engagers

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