JPWO2022190018A5 - - Google Patents
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- Publication number
- JPWO2022190018A5 JPWO2022190018A5 JP2023554813A JP2023554813A JPWO2022190018A5 JP WO2022190018 A5 JPWO2022190018 A5 JP WO2022190018A5 JP 2023554813 A JP2023554813 A JP 2023554813A JP 2023554813 A JP2023554813 A JP 2023554813A JP WO2022190018 A5 JPWO2022190018 A5 JP WO2022190018A5
- Authority
- JP
- Japan
- Prior art keywords
- repeat domain
- ankyrin repeat
- human
- binding
- binding protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000008102 Ankyrins Human genes 0.000 claims 13
- 108010049777 Ankyrins Proteins 0.000 claims 13
- 108091008324 binding proteins Proteins 0.000 claims 13
- 102000023732 binding proteins Human genes 0.000 claims 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 210000002865 immune cell Anatomy 0.000 claims 6
- 101000998120 Homo sapiens Interleukin-3 receptor subunit alpha Proteins 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 102000052088 human IL3RA Human genes 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 102000008100 Human Serum Albumin Human genes 0.000 claims 3
- 108091006905 Human Serum Albumin Proteins 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 239000004473 Threonine Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163158539P | 2021-03-09 | 2021-03-09 | |
| US63/158,539 | 2021-03-09 | ||
| US202163173227P | 2021-04-09 | 2021-04-09 | |
| US63/173,227 | 2021-04-09 | ||
| US202163265187P | 2021-12-09 | 2021-12-09 | |
| US63/265,187 | 2021-12-09 | ||
| PCT/IB2022/052128 WO2022190018A1 (en) | 2021-03-09 | 2022-03-09 | Novel darpin based cd123 engagers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024509241A JP2024509241A (ja) | 2024-02-29 |
| JPWO2022190018A5 true JPWO2022190018A5 (https=) | 2025-03-18 |
| JP2024509241A5 JP2024509241A5 (https=) | 2025-03-18 |
Family
ID=80820043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023554813A Pending JP2024509241A (ja) | 2021-03-09 | 2022-03-09 | 新規のＤＡＲＰｉｎに基づくＣＤ１２３エンゲージャ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20240150475A1 (https=) |
| EP (1) | EP4304729A1 (https=) |
| JP (1) | JP2024509241A (https=) |
| AU (1) | AU2022233791A1 (https=) |
| CA (1) | CA3211368A1 (https=) |
| WO (1) | WO2022190018A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL298168A (en) | 2020-05-14 | 2023-01-01 | Molecular Partners Ag | Multispecific proteins |
| IL305677A (en) | 2021-03-09 | 2023-11-01 | Molecular Partners Ag | Novel darpin based multi-specific t-cell engagers |
| EP4673159A1 (en) * | 2023-02-27 | 2026-01-07 | Molecular Partners AG | Darpins for use in reducing renal accumulation of drugs |
| WO2024251628A1 (en) * | 2023-06-06 | 2024-12-12 | Molecular Partners Ag | Recombinant cd16a binding proteins and their use |
| WO2025163082A1 (en) * | 2024-01-31 | 2025-08-07 | Molecular Partners Ag | Dll3-specific binding constructs and their use in radiotherapy |
| WO2025181039A1 (en) | 2024-03-01 | 2025-09-04 | Molecular Partners Ag | Therapeutic combinations comprising a multi-specific t cell engager |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9400088D0 (sv) | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
| US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| DE60140474D1 (de) | 2000-09-08 | 2009-12-24 | Univ Zuerich | Sammlung von proteinen mit sich wiederholenden sequenzen (repeat proteins), die repetitive sequenzmodule enthalten |
| US20050053973A1 (en) | 2001-04-26 | 2005-03-10 | Avidia Research Institute | Novel proteins with targeted binding |
| US20050048512A1 (en) | 2001-04-26 | 2005-03-03 | Avidia Research Institute | Combinatorial libraries of monomer domains |
| US20040175756A1 (en) | 2001-04-26 | 2004-09-09 | Avidia Research Institute | Methods for using combinatorial libraries of monomer domains |
| WO2005063815A2 (en) | 2003-11-12 | 2005-07-14 | Biogen Idec Ma Inc. | Fcϝ receptor-binding polypeptide variants and methods related thereto |
| US20060008844A1 (en) | 2004-06-17 | 2006-01-12 | Avidia Research Institute | c-Met kinase binding proteins |
| CA2700391A1 (en) | 2007-09-24 | 2009-04-02 | University Of Zuerich | Designed armadillo repeat proteins |
| EP3785735A1 (en) | 2008-11-03 | 2021-03-03 | Molecular Partners AG | Binding proteins inhibiting the vegf-a receptor interaction |
| TWI510246B (zh) | 2010-04-30 | 2015-12-01 | Molecular Partners Ag | 抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質 |
| DK2643349T3 (da) | 2010-11-26 | 2019-11-25 | Molecular Partners Ag | Designede repeat-proteiner, der binder til serumalbumin |
| CA2877584A1 (en) | 2012-06-28 | 2014-01-03 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to platelet-derived growth factor |
| EP2738180A1 (en) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Binding proteins comprising at least two binding domains against HER2. |
| EP2789630A1 (en) | 2013-04-09 | 2014-10-15 | EngMab AG | Bispecific antibodies against CD3e and ROR1 |
| US11453708B2 (en) | 2013-05-31 | 2022-09-27 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to hepatocyte growth factor |
| EP2839842A1 (en) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof |
| AU2016240220B2 (en) | 2015-04-02 | 2019-11-21 | Molecular Partners Ag | Designed ankyrin repeat domains with binding specificity for serum albumin |
| US10717772B2 (en) | 2016-09-22 | 2020-07-21 | Molecular Partners Ag | Recombinant binding proteins targeting HER2 and serum albumin, and their uses |
| CN121499810A (zh) * | 2018-09-28 | 2026-02-10 | 剑桥企业有限公司 | 疫苗和方法 |
| EP3980452A1 (en) * | 2019-06-04 | 2022-04-13 | Molecular Partners AG | Recombinant 4-1bb binding proteins and their use |
| SG11202112925PA (en) * | 2019-06-04 | 2021-12-30 | Molecular Partners Ag | Recombinant fap binding proteins and their use |
| US12441772B2 (en) * | 2019-06-04 | 2025-10-14 | Molecular Partners Ag | Designed ankyrin repeat domain with improved stability |
-
2022
- 2022-03-09 AU AU2022233791A patent/AU2022233791A1/en not_active Abandoned
- 2022-03-09 CA CA3211368A patent/CA3211368A1/en active Pending
- 2022-03-09 JP JP2023554813A patent/JP2024509241A/ja active Pending
- 2022-03-09 EP EP22711618.3A patent/EP4304729A1/en active Pending
- 2022-03-09 US US18/281,161 patent/US20240150475A1/en active Pending
- 2022-03-09 WO PCT/IB2022/052128 patent/WO2022190018A1/en not_active Ceased