JPWO2022149610A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2022149610A5 JPWO2022149610A5 JP2022574078A JP2022574078A JPWO2022149610A5 JP WO2022149610 A5 JPWO2022149610 A5 JP WO2022149610A5 JP 2022574078 A JP2022574078 A JP 2022574078A JP 2022574078 A JP2022574078 A JP 2022574078A JP WO2022149610 A5 JPWO2022149610 A5 JP WO2022149610A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- hydrogen atom
- pharmaceutically acceptable
- represented
- sulfonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 heterocyclic amine Chemical class 0.000 claims 25
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 24
- 150000001875 compounds Chemical class 0.000 claims 14
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 13
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 12
- 239000012453 solvate Substances 0.000 claims 12
- 125000004455 (C1-C3) alkylthio group Chemical group 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 10
- 125000001188 haloalkyl group Chemical group 0.000 claims 10
- 125000001424 substituent group Chemical group 0.000 claims 10
- 125000003277 amino group Chemical group 0.000 claims 8
- 125000005843 halogen group Chemical group 0.000 claims 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 8
- 125000006239 protecting group Chemical group 0.000 claims 8
- 150000001413 amino acids Chemical class 0.000 claims 7
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 7
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 6
- 125000004430 oxygen atom Chemical group O* 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 claims 4
- 125000002947 alkylene group Chemical group 0.000 claims 4
- 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 claims 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 125000006832 (C1-C10) alkylene group Chemical group 0.000 claims 2
- 125000006585 (C6-C10) arylene group Chemical group 0.000 claims 2
- 125000001989 1,3-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([H])C([*:2])=C1[H] 0.000 claims 2
- 125000000732 arylene group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 2
- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 claims 2
- 235000019260 propionic acid Nutrition 0.000 claims 2
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims 2
- 239000004475 Arginine Substances 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025191313A JP2026027427A (ja) | 2021-01-07 | 2025-11-11 | 新規グアニジン誘導体及びその製造方法 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021001758 | 2021-01-07 | ||
| PCT/JP2022/000356 WO2022149610A1 (ja) | 2021-01-07 | 2022-01-07 | 新規グアニジン誘導体及びその製造方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025191313A Division JP2026027427A (ja) | 2021-01-07 | 2025-11-11 | 新規グアニジン誘導体及びその製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2022149610A1 JPWO2022149610A1 (https=) | 2022-07-14 |
| JPWO2022149610A5 true JPWO2022149610A5 (https=) | 2023-12-28 |
Family
ID=82357978
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022574078A Pending JPWO2022149610A1 (https=) | 2021-01-07 | 2022-01-07 | |
| JP2025191313A Pending JP2026027427A (ja) | 2021-01-07 | 2025-11-11 | 新規グアニジン誘導体及びその製造方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025191313A Pending JP2026027427A (ja) | 2021-01-07 | 2025-11-11 | 新規グアニジン誘導体及びその製造方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20240010627A1 (https=) |
| EP (1) | EP4276096A4 (https=) |
| JP (2) | JPWO2022149610A1 (https=) |
| WO (1) | WO2022149610A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118978459B (zh) * | 2024-10-21 | 2025-01-28 | 安徽昊帆生物有限公司 | Fmoc-L-Lys(ivDde)-OH的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9309321D0 (en) * | 1993-05-06 | 1993-06-16 | Wellcome Found | Process for the preparation of ng-monoalkyl-l-arginine derivatives |
| CN101993475A (zh) * | 2009-08-21 | 2011-03-30 | 杭州诺泰制药技术有限公司 | 一种全液相依替巴肽(Eptifibatide)的合成方法 |
| CN102040652A (zh) * | 2009-10-12 | 2011-05-04 | 杭州诺泰制药技术有限公司 | 一种固液相结合依替巴肽(Eptifibatide)的合成方法 |
| US20150197500A1 (en) * | 2014-01-14 | 2015-07-16 | Euclises Pharmaceuticals, Inc. | No-releasing guanidine-chromene conjugates |
-
2022
- 2022-01-07 US US18/271,200 patent/US20240010627A1/en active Pending
- 2022-01-07 JP JP2022574078A patent/JPWO2022149610A1/ja active Pending
- 2022-01-07 WO PCT/JP2022/000356 patent/WO2022149610A1/ja not_active Ceased
- 2022-01-07 EP EP22736778.6A patent/EP4276096A4/en active Pending
-
2025
- 2025-11-11 JP JP2025191313A patent/JP2026027427A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK169333B1 (da) | Fremgangsmåde til fremstilling af optisk aktive S(-)-carbazolderivater, nye S(-)-carbazolderivater, samt lægemidler, der indeholder disse forbindelser | |
| JP2002533326A5 (https=) | ||
| JPH10279578A5 (https=) | ||
| JP2006501295A5 (https=) | ||
| DK3053576T3 (en) | ESTER PRO-DRUGS OF [3- (1- (1H-IMIDAZOL-4-YL) ETHYL) -2-METHYLPHENYL] METHANOL TO REDUCE INTRAOCULAR PRESSURE | |
| CA2436526A1 (en) | Heterocyclic sulfonamide inhibitors of beta amyloid production | |
| JP2003514786A5 (https=) | ||
| JP2004518725A5 (https=) | ||
| RU2003136097A (ru) | Производные фенилпиридинкарбонилпиперазина | |
| JP2002513793A5 (https=) | ||
| JP2007502806A5 (https=) | ||
| JP2004507501A5 (https=) | ||
| DK2888239T3 (en) | REDUCED CENTRAL CORCHET THICKENING USING HYDROFILE ESTER PRODUGS OF BETA-CHLORCYCLOPENTANE | |
| KR880000180B1 (ko) | 디하이드로 피리딘의 제조방법 | |
| CN1271354A (zh) | 具有神经原活性的化合物 | |
| JP2010510232A (ja) | 眼圧降下剤であるプロスタグランジンプロドラッグ | |
| JP2024508526A5 (https=) | ||
| JP2023538524A5 (https=) | ||
| JPWO2022149610A5 (https=) | ||
| JP2010526801A5 (https=) | ||
| JPH10203986A (ja) | 眼疾患用薬剤 | |
| RU2006128445A (ru) | Ацетилиновые пиперазиновые соединения и их применение в качестве антагонистов метаботропных глутаматных рецепторов | |
| JP2003514893A5 (https=) | ||
| SU990761A1 (ru) | Гидрохлориды производных 4-дифенилметилен-1-гидроксибензилпиперидина,обладающие свойством улучшать кровообращение | |
| JPS5840552B2 (ja) | １，４− ベンゾジオキサンノ アミンユウドウタイノセイホウ |