JPWO2022140221A5 - - Google Patents
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- Publication number
- JPWO2022140221A5 JPWO2022140221A5 JP2023537555A JP2023537555A JPWO2022140221A5 JP WO2022140221 A5 JPWO2022140221 A5 JP WO2022140221A5 JP 2023537555 A JP2023537555 A JP 2023537555A JP 2023537555 A JP2023537555 A JP 2023537555A JP WO2022140221 A5 JPWO2022140221 A5 JP WO2022140221A5
- Authority
- JP
- Japan
- Prior art keywords
- rodent
- gene
- il7ra
- humanized
- tslpr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000283984 Rodentia Species 0.000 claims description 434
- 150000007523 nucleic acids Chemical group 0.000 claims description 119
- 101150050722 Crlf2 gene Proteins 0.000 claims description 105
- 108090000623 proteins and genes Proteins 0.000 claims description 103
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 86
- 210000004027 cell Anatomy 0.000 claims description 73
- 101100371162 Mus musculus Tslp gene Proteins 0.000 claims description 56
- 102000004169 proteins and genes Human genes 0.000 claims description 54
- 101000845170 Homo sapiens Thymic stromal lymphopoietin Proteins 0.000 claims description 52
- 101150072278 Tslp gene Proteins 0.000 claims description 49
- 101001043809 Homo sapiens Interleukin-7 receptor subunit alpha Proteins 0.000 claims description 47
- 101000956427 Homo sapiens Cytokine receptor-like factor 2 Proteins 0.000 claims description 46
- 102000045535 human TSLP Human genes 0.000 claims description 44
- 102100021593 Interleukin-7 receptor subunit alpha Human genes 0.000 claims description 40
- 102000048388 human CRLF2 Human genes 0.000 claims description 39
- 108020004707 nucleic acids Proteins 0.000 claims description 36
- 102000039446 nucleic acids Human genes 0.000 claims description 36
- 108020004705 Codon Proteins 0.000 claims description 33
- 108020004414 DNA Proteins 0.000 claims description 33
- 150000001413 amino acids Chemical class 0.000 claims description 33
- 238000000034 method Methods 0.000 claims description 32
- 108010076504 Protein Sorting Signals Proteins 0.000 claims description 31
- 229920001184 polypeptide Polymers 0.000 claims description 31
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 31
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 31
- 230000001086 cytosolic effect Effects 0.000 claims description 20
- 210000001671 embryonic stem cell Anatomy 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 11
- 101100441090 Mus musculus Crlf2 gene Proteins 0.000 claims description 9
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 201000011510 cancer Diseases 0.000 claims description 7
- 206010027654 Allergic conditions Diseases 0.000 claims description 6
- 210000001161 mammalian embryo Anatomy 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 108020005345 3' Untranslated Regions Proteins 0.000 claims description 4
- 108020003589 5' Untranslated Regions Proteins 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- -1 small molecule compound Chemical class 0.000 claims description 3
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims description 2
- 108010002386 Interleukin-3 Proteins 0.000 claims description 2
- 101150077103 TPO gene Proteins 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 230000035755 proliferation Effects 0.000 claims description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 36
- 230000008685 targeting Effects 0.000 description 5
- 238000000338 in vitro Methods 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 230000002685 pulmonary effect Effects 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 1
- 108700024394 Exon Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 229940037003 alum Drugs 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 210000003979 eosinophil Anatomy 0.000 description 1
- 238000010195 expression analysis Methods 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000011808 rodent model Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063128258P | 2020-12-21 | 2020-12-21 | |
| US63/128,258 | 2020-12-21 | ||
| PCT/US2021/064270 WO2022140221A1 (en) | 2020-12-21 | 2021-12-20 | Non-human animals having a humanized tslp gene, a humanized tslp receptor gene, and/or a humanized il7ra gene |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024500153A JP2024500153A (ja) | 2024-01-04 |
| JPWO2022140221A5 true JPWO2022140221A5 (enExample) | 2024-12-27 |
Family
ID=80050757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023537555A Pending JP2024500153A (ja) | 2020-12-21 | 2021-12-20 | ヒト化ｔｓｌｐ遺伝子、ヒト化ｔｓｌｐ受容体遺伝子、及び／又はヒト化ｉｌ７ｒａ遺伝子を有する非ヒト動物 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20220192165A1 (enExample) |
| EP (1) | EP4262374A1 (enExample) |
| JP (1) | JP2024500153A (enExample) |
| KR (1) | KR20230124973A (enExample) |
| CN (1) | CN116802200A (enExample) |
| AU (1) | AU2021409632A1 (enExample) |
| CA (1) | CA3171455A1 (enExample) |
| IL (1) | IL303724A (enExample) |
| WO (1) | WO2022140221A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023046201A1 (en) * | 2021-09-27 | 2023-03-30 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric genes |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| PL2767161T3 (pl) | 2004-10-19 | 2018-09-28 | Regeneron Pharmaceuticals, Inc. | Sposób wytwarzania zwierzęcia homozygotycznego pod względem modyfikacji genetycznej |
| ES3010323T3 (en) | 2009-10-06 | 2025-04-02 | Regeneron Pharma | Genetically modified mice and engraftment |
| US8962913B2 (en) * | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
| CN109913495B (zh) | 2013-02-20 | 2022-11-25 | 瑞泽恩制药公司 | 大鼠的遗传修饰 |
| SG10201808935WA (en) | 2013-04-16 | 2018-11-29 | Regeneron Pharma | Targeted modification of rat genome |
| PT4269430T (pt) | 2013-09-23 | 2025-08-06 | Regeneron Pharma | Animais não-humanos com um gene humanizado de proteína reguladora de sinal |
| NO2785538T3 (enExample) * | 2014-05-07 | 2018-08-04 | ||
| RU2731644C2 (ru) * | 2015-09-09 | 2020-09-07 | Новартис Аг | Молекулы, связывающиеся с тимусным стромальным лимфопоэтином (tslp), и способы применения таких молекул |
| WO2018177441A1 (en) | 2017-03-31 | 2018-10-04 | Beijing Biocytogen Co., Ltd | GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPα |
| WO2020008066A1 (en) * | 2018-07-06 | 2020-01-09 | Institut Pasteur | Human immune system mouse model |
| CN109678957B (zh) * | 2018-12-06 | 2021-04-06 | 浙江工业大学 | 一种抗人tslp单克隆抗体及其制备与应用 |
| CN111808882B (zh) | 2020-09-01 | 2020-12-29 | 北京百奥赛图基因生物技术有限公司 | Il7r基因人源化改造的动物模型的构建方法及其应用 |
-
2021
- 2021-12-20 CA CA3171455A patent/CA3171455A1/en active Pending
- 2021-12-20 CN CN202180086511.8A patent/CN116802200A/zh active Pending
- 2021-12-20 IL IL303724A patent/IL303724A/en unknown
- 2021-12-20 JP JP2023537555A patent/JP2024500153A/ja active Pending
- 2021-12-20 AU AU2021409632A patent/AU2021409632A1/en active Pending
- 2021-12-20 EP EP21848364.2A patent/EP4262374A1/en active Pending
- 2021-12-20 KR KR1020237024353A patent/KR20230124973A/ko active Pending
- 2021-12-20 US US17/555,550 patent/US20220192165A1/en not_active Abandoned
- 2021-12-20 WO PCT/US2021/064270 patent/WO2022140221A1/en not_active Ceased
-
2025
- 2025-04-25 US US19/189,370 patent/US20250248377A1/en active Pending
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