JPWO2022125904A5 - - Google Patents

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Publication number
JPWO2022125904A5
JPWO2022125904A5 JP2023534650A JP2023534650A JPWO2022125904A5 JP WO2022125904 A5 JPWO2022125904 A5 JP WO2022125904A5 JP 2023534650 A JP2023534650 A JP 2023534650A JP 2023534650 A JP2023534650 A JP 2023534650A JP WO2022125904 A5 JPWO2022125904 A5 JP WO2022125904A5
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JP
Japan
Prior art keywords
alkyldiyl
peg
alkyl
immunoconjugate
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023534650A
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English (en)
Japanese (ja)
Other versions
JP2023552792A5 (https=
JP2023552792A (ja
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/062816 external-priority patent/WO2022125904A1/en
Publication of JP2023552792A publication Critical patent/JP2023552792A/ja
Publication of JP2023552792A5 publication Critical patent/JP2023552792A5/ja
Publication of JPWO2022125904A5 publication Critical patent/JPWO2022125904A5/ja
Pending legal-status Critical Current

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JP2023534650A 2020-12-11 2021-12-10 抗her2免疫複合体、及びその使用 Pending JP2023552792A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063124367P 2020-12-11 2020-12-11
US63/124,367 2020-12-11
PCT/US2021/062816 WO2022125904A1 (en) 2020-12-11 2021-12-10 Anti-her2 immunoconjugates, and uses thereof

Publications (3)

Publication Number Publication Date
JP2023552792A JP2023552792A (ja) 2023-12-19
JP2023552792A5 JP2023552792A5 (https=) 2024-12-10
JPWO2022125904A5 true JPWO2022125904A5 (https=) 2024-12-10

Family

ID=79686820

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023534650A Pending JP2023552792A (ja) 2020-12-11 2021-12-10 抗her2免疫複合体、及びその使用

Country Status (6)

Country Link
US (1) US20240091370A1 (https=)
EP (1) EP4259212A1 (https=)
JP (1) JP2023552792A (https=)
CN (1) CN116744978A (https=)
CA (1) CA3200056A1 (https=)
WO (1) WO2022125904A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220195066A1 (en) * 2020-12-11 2022-06-23 Bolt Biotherapeutics, Inc. Anti-cea immunoconjugates, and uses thereof
CN118475372A (zh) * 2021-10-29 2024-08-09 博尔特生物治疗药物有限公司 具有半胱氨酸突变抗体的tlr激动剂免疫缀合物及其用途
WO2024173387A1 (en) 2023-02-14 2024-08-22 Bolt Biotherapeutics, Inc. Aza-benzazepine immunoconjugates, and uses thereof

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988007089A1 (en) 1987-03-18 1988-09-22 Medical Research Council Altered antibodies
WO1989006692A1 (en) 1988-01-12 1989-07-27 Genentech, Inc. Method of treating tumor cells by inhibiting growth factor receptor function
EP1400536A1 (en) 1991-06-14 2004-03-24 Genentech Inc. Method for making humanized antibodies
US6800738B1 (en) 1991-06-14 2004-10-05 Genentech, Inc. Method for making humanized antibodies
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
PT1308456E (pt) 1998-05-06 2007-12-03 Genentech Inc Purificação de anticorpos por cromatografia de permuta iónica
US6949245B1 (en) 1999-06-25 2005-09-27 Genentech, Inc. Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
CA2399940A1 (en) 2000-04-13 2001-10-25 The Rockefeller University Enhancement of antibody-mediated immune responses
KR101270829B1 (ko) 2004-09-23 2013-06-07 제넨테크, 인크. 시스테인 유전자조작 항체 및 접합체
WO2006073921A2 (en) 2004-12-30 2006-07-13 The Rockefeller University Compositions and methods for enhanced dendritic cell maturation and function
US20080286819A1 (en) 2005-11-07 2008-11-20 Ravetch Jeffrey V Reagents, Methods and Systems for Selecting a Cytotoxic Antibody or Variant Thereof
EP2144628B1 (en) 2007-05-08 2012-10-17 Genentech, Inc. Cysteine engineered anti-muc16 antibodies and antibody drug conjugates
MX2010003718A (es) 2007-10-19 2010-04-21 Genentech Inc Anticuerpos anti-tenb2 producidos por ingenieria de cisteina y conjugados de farmaco y anticuerpo.
JP5889912B2 (ja) 2010-11-17 2016-03-22 ジェネンテック, インコーポレイテッド アラニニルメイタンシノール抗体コンジュゲート
MY189836A (en) 2014-11-21 2022-03-11 Bristol Myers Squibb Co Antibodies against cd73 and uses thereof
AU2017259654B2 (en) * 2016-05-06 2020-02-27 Shanghai De Novo Pharmatech Co., Ltd. Benzazepine derivative, preparation method, pharmaceutical composition and use thereof
US20200113912A1 (en) * 2018-09-12 2020-04-16 Silverback Therapeutics, Inc. Methods and Compositions for the Treatment of Disease with Immune Stimulatory Conjugates
AU2020291014B2 (en) * 2019-06-13 2025-06-05 Bolt Biotherapeutics, Inc. Aminobenzazepine compounds, immunoconjugates, and uses thereof
WO2020252254A1 (en) * 2019-06-13 2020-12-17 Bolt Biotherapeutics, Inc. Macromolecule-supported aminobenzazepine compounds
CN115996756A (zh) * 2020-05-08 2023-04-21 博尔特生物治疗药物有限公司 弹性蛋白酶底物肽连接子免疫缀合物及其用途
US20220195066A1 (en) * 2020-12-11 2022-06-23 Bolt Biotherapeutics, Inc. Anti-cea immunoconjugates, and uses thereof
CN118475372A (zh) * 2021-10-29 2024-08-09 博尔特生物治疗药物有限公司 具有半胱氨酸突变抗体的tlr激动剂免疫缀合物及其用途

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