JPWO2022114164A5 - - Google Patents
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- Publication number
- JPWO2022114164A5 JPWO2022114164A5 JP2022565480A JP2022565480A JPWO2022114164A5 JP WO2022114164 A5 JPWO2022114164 A5 JP WO2022114164A5 JP 2022565480 A JP2022565480 A JP 2022565480A JP 2022565480 A JP2022565480 A JP 2022565480A JP WO2022114164 A5 JPWO2022114164 A5 JP WO2022114164A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- phenyl
- pyrazole
- alkyl
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020197899 | 2020-11-30 | ||
| JP2020197899 | 2020-11-30 | ||
| PCT/JP2021/043540 WO2022114164A1 (ja) | 2020-11-30 | 2021-11-29 | ヘテロアリールカルボキシアミド化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2022114164A1 JPWO2022114164A1 (https=) | 2022-06-02 |
| JPWO2022114164A5 true JPWO2022114164A5 (https=) | 2023-10-23 |
| JP7397452B2 JP7397452B2 (ja) | 2023-12-13 |
Family
ID=81754515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022565480A Active JP7397452B2 (ja) | 2020-11-30 | 2021-11-29 | ヘテロアリールカルボキシアミド化合物 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20240043403A1 (https=) |
| EP (1) | EP4253373A4 (https=) |
| JP (1) | JP7397452B2 (https=) |
| KR (1) | KR20230116838A (https=) |
| CN (1) | CN116528864A (https=) |
| AR (1) | AR124172A1 (https=) |
| AU (1) | AU2021389180A1 (https=) |
| CA (1) | CA3203285A1 (https=) |
| CL (1) | CL2023001534A1 (https=) |
| CO (1) | CO2023008271A2 (https=) |
| CR (1) | CR20230415A (https=) |
| DO (1) | DOP2023000107A (https=) |
| EC (1) | ECSP23048974A (https=) |
| IL (1) | IL303209A (https=) |
| JO (1) | JOP20230118A1 (https=) |
| MX (1) | MX2023006318A (https=) |
| PE (1) | PE20231986A1 (https=) |
| TW (1) | TWI911340B (https=) |
| WO (1) | WO2022114164A1 (https=) |
| ZA (1) | ZA202305845B (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202525813A (zh) | 2019-12-19 | 2025-07-01 | 比利時商健生藥品公司 | 經取代之直鏈螺環接衍生物 |
| AR120896A1 (es) | 2019-12-25 | 2022-03-30 | Astellas Pharma Inc | COMPUESTO DE PIRIDAZINIL-TIAZOLCARBOXAMIDA COMO INHIBIDORES DE DGKz |
| CR20230415A (es) * | 2020-11-30 | 2023-09-08 | Kotobuki Pharmaceutical Co Ltd | Compuesto de heteroarilcarboxamida |
| US20250312341A1 (en) | 2022-06-20 | 2025-10-09 | Astellas Pharma Inc. | Methods for treating patients with locally advanced and/or metastatic solid tumors using a dgk zeta inhibitor |
| US12600722B2 (en) | 2022-07-18 | 2026-04-14 | Incyte Corporation | Tetracyclic compounds as DGK inhibitors |
| US12600723B2 (en) | 2022-07-18 | 2026-04-14 | Incyte Corporation | Tetracyclic compounds as DGK inhibitors |
| US20240217989A1 (en) * | 2022-11-18 | 2024-07-04 | Incyte Corporation | Heteroaryl Fluoroalkenes As DGK Inhibitors |
| TW202428575A (zh) * | 2023-01-12 | 2024-07-16 | 美商英塞特公司 | 作為ｄｇｋ抑制劑之雜芳基氟代烯烴 |
| EP4661869A1 (en) | 2023-02-06 | 2025-12-17 | Bayer Aktiengesellschaft | Combinations of dgk (diacylglycerol kinase) inhibitors and immune checkpoint inhibitors and modulators |
| CN120826398A (zh) * | 2023-03-30 | 2025-10-21 | 微境生物医药科技(上海)有限公司 | 作为DGKζ抑制剂的化合物 |
| CN120826393A (zh) * | 2023-04-06 | 2025-10-21 | 微境生物医药科技(上海)有限公司 | 作为DGKζ抑制剂的噻唑类化合物 |
| WO2025067360A1 (zh) * | 2023-09-27 | 2025-04-03 | 海思科医药集团股份有限公司 | 一种DGKzeta拮抗剂及其在医药上的应用 |
| WO2025082460A1 (zh) * | 2023-10-20 | 2025-04-24 | 上海先祥医药科技有限公司 | 二酰基甘油激酶抑制剂化合物及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7381401B2 (en) | 2004-01-08 | 2008-06-03 | The University Of Chicago | T cell anergy is reversed by active Ras and regulated by diacylglycerol kinase |
| PL1848435T3 (pl) | 2005-01-25 | 2016-08-31 | Synta Pharmaceuticals Corp | Związki przeciwko zapaleniom i zastosowania związane z odpornością |
| US8455658B2 (en) * | 2006-01-25 | 2013-06-04 | Synta Pharmaceuticals Corp. | Thiazole and thiadiazole compounds for inflammation and immune-related uses |
| JP5182088B2 (ja) | 2006-04-19 | 2013-04-10 | アステラス製薬株式会社 | アゾールカルボキサミド誘導体 |
| WO2008054702A1 (en) | 2006-10-31 | 2008-05-08 | Schering Corporation | Anilinopiperazine derivatives and methods of use thereof |
| WO2019046944A1 (en) | 2017-09-06 | 2019-03-14 | Propellon Therapeutics Inc. | INHIBITORS OF PROTEIN BINDING WDR5-PROTEIN |
| KR102767739B1 (ko) * | 2018-06-27 | 2025-02-12 | 브리스톨-마이어스 스큅 컴퍼니 | T 세포 활성화제로서 유용한 치환된 나프티리디논 화합물 |
| AR120896A1 (es) | 2019-12-25 | 2022-03-30 | Astellas Pharma Inc | COMPUESTO DE PIRIDAZINIL-TIAZOLCARBOXAMIDA COMO INHIBIDORES DE DGKz |
| CN115697980B (zh) | 2020-04-24 | 2025-03-21 | 拜耳公司 | 作为dgkzeta抑制剂用于免疫活化的取代的氨基噻唑 |
| CR20230415A (es) | 2020-11-30 | 2023-09-08 | Kotobuki Pharmaceutical Co Ltd | Compuesto de heteroarilcarboxamida |
-
2021
- 2021-11-29 CR CR20230415A patent/CR20230415A/es unknown
- 2021-11-29 EP EP21898136.3A patent/EP4253373A4/en active Pending
- 2021-11-29 CA CA3203285A patent/CA3203285A1/en active Pending
- 2021-11-29 TW TW110144382A patent/TWI911340B/zh active
- 2021-11-29 PE PE2023001705A patent/PE20231986A1/es unknown
- 2021-11-29 KR KR1020237021502A patent/KR20230116838A/ko active Pending
- 2021-11-29 AU AU2021389180A patent/AU2021389180A1/en active Pending
- 2021-11-29 JP JP2022565480A patent/JP7397452B2/ja active Active
- 2021-11-29 US US18/254,829 patent/US20240043403A1/en active Pending
- 2021-11-29 AR ARP210103290A patent/AR124172A1/es unknown
- 2021-11-29 CN CN202180080083.8A patent/CN116528864A/zh active Pending
- 2021-11-29 MX MX2023006318A patent/MX2023006318A/es unknown
- 2021-11-29 WO PCT/JP2021/043540 patent/WO2022114164A1/ja not_active Ceased
- 2021-11-29 IL IL303209A patent/IL303209A/en unknown
-
2023
- 2023-05-29 CL CL2023001534A patent/CL2023001534A1/es unknown
- 2023-05-29 DO DO2023000107A patent/DOP2023000107A/es unknown
- 2023-05-30 JO JOJO/P/2023/0118A patent/JOP20230118A1/ar unknown
- 2023-05-31 ZA ZA2023/05845A patent/ZA202305845B/en unknown
- 2023-06-23 CO CONC2023/0008271A patent/CO2023008271A2/es unknown
- 2023-06-29 EC ECSENADI202348974A patent/ECSP23048974A/es unknown
- 2023-11-28 US US18/521,400 patent/US12077519B2/en active Active
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