JP2010523644A5 - - Google Patents
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- Publication number
- JP2010523644A5 JP2010523644A5 JP2010502609A JP2010502609A JP2010523644A5 JP 2010523644 A5 JP2010523644 A5 JP 2010523644A5 JP 2010502609 A JP2010502609 A JP 2010502609A JP 2010502609 A JP2010502609 A JP 2010502609A JP 2010523644 A5 JP2010523644 A5 JP 2010523644A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- dione
- trifluoromethyl
- methyl
- pyridyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CCC[C@](C)C(Cc1ncc(*)c*1C(F)(F)F)N(C(C(Br)=C1Br)=O)C1=O Chemical compound CCC[C@](C)C(Cc1ncc(*)c*1C(F)(F)F)N(C(C(Br)=C1Br)=O)C1=O 0.000 description 16
- ORIDHTHFLIVCEP-UHFFFAOYSA-N CC(C(CC1CNc2cc(Cl)c(ccc3c4cccc3)c4n2)=O)=C(C)C1=O Chemical compound CC(C(CC1CNc2cc(Cl)c(ccc3c4cccc3)c4n2)=O)=C(C)C1=O ORIDHTHFLIVCEP-UHFFFAOYSA-N 0.000 description 1
- XDTSESNHCPGWRH-UHFFFAOYSA-N CC(C(CCC1CNc2cc(Cl)c(ccc(Br)c3)c3n2)=O)=C(C)C1=O Chemical compound CC(C(CCC1CNc2cc(Cl)c(ccc(Br)c3)c3n2)=O)=C(C)C1=O XDTSESNHCPGWRH-UHFFFAOYSA-N 0.000 description 1
- UTLKHLBMVYBHDN-UHFFFAOYSA-N CC(O)OCC1=CC(NC(C)(CC(C(C)=C2C)O)C2O)NC2=C1CCC(Br)=C2 Chemical compound CC(O)OCC1=CC(NC(C)(CC(C(C)=C2C)O)C2O)NC2=C1CCC(Br)=C2 UTLKHLBMVYBHDN-UHFFFAOYSA-N 0.000 description 1
- HFBOMJUKXJADCC-AQHIEDMUSA-N CCBC1=CC(C(F)(F)F)=CC(C(C)N(/C(/C(C(C)C)=C2C3CNCC3)=C\CC)C2=O)=C(C)C1 Chemical compound CCBC1=CC(C(F)(F)F)=CC(C(C)N(/C(/C(C(C)C)=C2C3CNCC3)=C\CC)C2=O)=C(C)C1 HFBOMJUKXJADCC-AQHIEDMUSA-N 0.000 description 1
- HVFNUJBEIHOLQX-UHFFFAOYSA-N CCC(CCC(C(N1Nc2nc(Cl)c(C(F)(F)I)cc2)=O)=C(C)C1=O)O Chemical compound CCC(CCC(C(N1Nc2nc(Cl)c(C(F)(F)I)cc2)=O)=C(C)C1=O)O HVFNUJBEIHOLQX-UHFFFAOYSA-N 0.000 description 1
- RFPNKBGFFAGOCP-UHFFFAOYSA-N CCSC(C(C=O)N1Cc2ccccc2O)=C(C)C1=O Chemical compound CCSC(C(C=O)N1Cc2ccccc2O)=C(C)C1=O RFPNKBGFFAGOCP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91125807P | 2007-04-11 | 2007-04-11 | |
| US60/911,258 | 2007-04-11 | ||
| PCT/IB2008/003036 WO2009031040A2 (en) | 2007-04-11 | 2008-04-11 | Compounds with anti-cancer activity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013176324A Division JP2014012706A (ja) | 2007-04-11 | 2013-08-28 | 抗がん活性を有する化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010523644A JP2010523644A (ja) | 2010-07-15 |
| JP2010523644A5 true JP2010523644A5 (https=) | 2011-05-12 |
| JP5635396B2 JP5635396B2 (ja) | 2014-12-03 |
Family
ID=39939984
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010502609A Active JP5635396B2 (ja) | 2007-04-11 | 2008-04-11 | 抗がん活性を有する化合物 |
| JP2013176324A Withdrawn JP2014012706A (ja) | 2007-04-11 | 2013-08-28 | 抗がん活性を有する化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013176324A Withdrawn JP2014012706A (ja) | 2007-04-11 | 2013-08-28 | 抗がん活性を有する化合物 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US8084454B2 (https=) |
| EP (4) | EP3088397B1 (https=) |
| JP (2) | JP5635396B2 (https=) |
| KR (1) | KR101475311B1 (https=) |
| CN (2) | CN105175394B (https=) |
| AU (1) | AU2008294410B2 (https=) |
| BR (2) | BRPI0810911B1 (https=) |
| CA (4) | CA3188320A1 (https=) |
| DK (2) | DK2152692T3 (https=) |
| ES (3) | ES2927954T3 (https=) |
| HU (2) | HUE029370T2 (https=) |
| IL (4) | IL289165B2 (https=) |
| MX (3) | MX391154B (https=) |
| NZ (1) | NZ580237A (https=) |
| RU (1) | RU2482111C2 (https=) |
| WO (1) | WO2009031040A2 (https=) |
| ZA (1) | ZA200906960B (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3088397B1 (en) * | 2007-04-11 | 2019-04-10 | Canbas Co. Ltd. | Compounds that abrogate the cell cycle g2 checkpoint for use in the treatment of cancer |
| EP2304436A1 (en) | 2008-07-10 | 2011-04-06 | Nodality, Inc. | Methods for diagnosis, prognosis and treatment |
| EP2393488B1 (en) * | 2009-02-06 | 2019-06-19 | University Of Southern California | Therapeutic compositions comprising monoterpenes |
| US20100215644A1 (en) * | 2009-02-25 | 2010-08-26 | Nodality, Inc. A Delaware Corporation | Analysis of nodes in cellular pathways |
| EP2542082B8 (en) | 2010-03-03 | 2020-06-17 | Neonc Technologies Inc. | PHARMACEUTICAL COMPOSITIONS COMPRISING (S)-perillyl alcohol |
| US20160038600A1 (en) | 2012-08-03 | 2016-02-11 | Neonc Technologies Inc. | Pharmaceutical compositions comprising poh derivatives |
| DK3685835T3 (da) | 2010-08-27 | 2025-07-21 | Univ Southern California | Farmaceutiske sammensætninger, der omfatter derivater af perillylalkohol |
| ES3056006T3 (en) | 2010-12-17 | 2026-02-17 | Univ Southern California | Methods and devices for using isoperillyl alcohol |
| WO2013020024A2 (en) * | 2011-08-03 | 2013-02-07 | Karyopharm Therapeutics, Inc. | Maleimide compounds and methods of treatment |
| US9814693B2 (en) | 2012-05-09 | 2017-11-14 | Delmar Pharmaceuticals, Inc. | Veterinary use of dianhydrogalactitol, diacetyldianhydrogalactitol, and dibromodulcitol to treat malignancies |
| IN2014MN02512A (https=) | 2012-06-14 | 2015-07-17 | Daiichi Sankyo Co Ltd | |
| WO2014118186A1 (en) * | 2013-01-30 | 2014-08-07 | Bayer Pharma Aktiengesellschaft | Amino-substituted isothiazoles |
| US9540462B2 (en) | 2014-12-05 | 2017-01-10 | Massachusetts Institute Of Technology | Catechol-rich polymers from N-substituted maleimides |
| FI3250550T3 (fi) | 2015-01-26 | 2023-07-17 | Ottawa Hospital Res Inst | Koostumuksia ja menetelmiä virusherkistymiseen |
| JP6674957B2 (ja) | 2015-02-12 | 2020-04-01 | ネオンク テクノロジーズ インク． | ペリリルアルコール誘導体を含む医薬組成物 |
| CN109071444A (zh) | 2016-03-16 | 2018-12-21 | 拜耳作物科学股份公司 | 作为农药和植物保护剂的n-(氰苄基)-6-(环丙基-羰基氨基)-4-(苯基)-吡啶-2-羧酰胺衍生物及相关化合物 |
| USD801721S1 (en) | 2016-03-31 | 2017-11-07 | Patricia Grayson Briden | Spooled item holding device |
| USD915100S1 (en) | 2016-03-31 | 2021-04-06 | Ocean 22, Llc | Spooled item holding device |
| TW201811766A (zh) | 2016-08-29 | 2018-04-01 | 瑞士商諾華公司 | N-(吡啶-2-基)吡啶-磺醯胺衍生物及其用於疾病治療之用途 |
| JP2021512165A (ja) | 2018-01-29 | 2021-05-13 | コグノス・セラピューティクス・インコーポレイテッド | ボルテゾミブの腫瘍内送達 |
| MX2020007994A (es) | 2018-02-02 | 2020-09-09 | Boehringer Ingelheim Int | Derivados de triazolopirimidina para usar como inhibidores de ghrelin o-aciltransferasa (goat). |
| WO2019149657A1 (en) | 2018-02-02 | 2019-08-08 | Boehringer Ingelheim International Gmbh | Benzyl-, (pyridin-3-yl)methyl- or (pyridin-4-yl)methyl-substituted oxadiazolopyridine derivatives as ghrelin o-acyl transferase (goat) inhibitors |
| CN111936125B (zh) | 2018-02-08 | 2025-03-04 | 南加州大学 | 穿透血脑屏障的方法 |
| DK4153599T3 (da) | 2020-05-22 | 2024-06-17 | Boehringer Ingelheim Int | Fremgangsmåde til at fremstille alkyl 7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridin-carboxylat |
| ES2991340T3 (es) | 2020-05-22 | 2024-12-03 | Boehringer Ingelheim Int | Procedimiento continuo de fabricación de 7-amino-5-metil-[1,2,5]oxadiazolo[3,4-b]piridín-carboxilato de alquilo |
| EP4415700A4 (en) * | 2021-10-15 | 2025-12-24 | Univ Missouri | P1B TYPE ATPASES INHIBITORS |
| CN114425054A (zh) * | 2022-01-20 | 2022-05-03 | 中国人民解放军军事科学院军事医学研究院 | 一种蛋白酶体抑制剂Bortezomib在抗辐射损伤中的用途 |
| CN120247782B (zh) * | 2025-06-04 | 2025-08-19 | 北京颖泰嘉和生物科技股份有限公司 | 氟吡菌酰胺类化合物及其制备方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5564557A (en) * | 1978-11-08 | 1980-05-15 | Mitsui Toatsu Chem Inc | Diphenyl ether compound and herbicide containing the same |
| IL81307A0 (en) * | 1986-01-23 | 1987-08-31 | Union Carbide Agricult | Method for reducing moisture loss from plants and increasing crop yield utilizing nitrogen containing heterocyclic compounds and some novel polysubstituted pyridine derivatives |
| US5635966A (en) * | 1994-01-11 | 1997-06-03 | Hewlett-Packard Company | Edge feed ink delivery thermal inkjet printhead structure and method of fabrication |
| JPH07224032A (ja) | 1994-02-09 | 1995-08-22 | Mitsui Petrochem Ind Ltd | Ｎ−アリールオキシフタルイミド誘導体、その製造方 法及びそれを有効成分として含有する除草剤 |
| JPH07244032A (ja) * | 1994-03-01 | 1995-09-19 | Ishikawajima Harima Heavy Ind Co Ltd | 溶接部検査装置 |
| CA2230896A1 (en) * | 1995-09-01 | 1997-03-13 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
| US5935966A (en) * | 1995-09-01 | 1999-08-10 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
| CA2245029A1 (en) * | 1998-03-13 | 1999-09-13 | University Of British Columbia | Granulatimide compounds as g2 checkpoint inhibitors |
| US6205557B1 (en) | 1998-06-09 | 2001-03-20 | At&T Corp. | Redundant call processing |
| AU2093400A (en) * | 1998-11-24 | 2000-06-13 | Basf Aktiengesellschaft | Fungicides containing pyrrolidones as their active agents |
| JP4610828B2 (ja) | 1999-09-22 | 2011-01-12 | 株式会社 キャンバス | Ｇ２期細胞周期停止の阻害、およびｄｎａ損傷剤に対する細胞感作のための組成物および方法 |
| EP1257172B1 (de) | 2000-02-26 | 2004-10-13 | Basf Aktiengesellschaft | Fungizide mittel enthaltend als wirkstoffe pyrrolidone und deren verwendung bei der behandlung von pflanzen |
| JP2002318434A (ja) * | 2001-04-23 | 2002-10-31 | Konica Corp | ハロゲン化銀写真感光材料、処理方法、および画像形成方法 |
| FR2826653B1 (fr) * | 2001-06-29 | 2005-10-14 | Servier Lab | Nouveaux derives de pyrido-pyrido-pyrrolo[3,2-g]pyrrolo [3,4-e]-indole et pyrido-pyrrolo[2,3-a]pyrrolo[3,4-c] carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2003104181A2 (en) * | 2002-06-06 | 2003-12-18 | Canbas Co. Ltd. | Compounds that abrogate dna-damage-induced cell cycle g2 checkpoint and/or augment the anti-cancer activity of dna-damaging treatments |
| WO2005024755A2 (en) * | 2002-12-31 | 2005-03-17 | Deciphera Pharmaceuticals, Llc. | Medicaments for the treatment of neurodegenerative disorders or diabetes |
| US7572816B2 (en) * | 2003-08-01 | 2009-08-11 | Auspex Pharmaceuticals, Inc. | Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders |
| US7932281B2 (en) * | 2004-03-10 | 2011-04-26 | Kureha Corporation | Amine-based compound and use thereof |
| EP1730128A1 (en) * | 2004-03-31 | 2006-12-13 | Exelixis, Inc. | Anaplastic lymphoma kinase modulators and methods of use |
| AU2006212951A1 (en) * | 2005-02-08 | 2006-08-17 | Merck & Co., Inc. | Inhibitors of checkpoint kinases |
| JP4976394B2 (ja) * | 2005-08-17 | 2012-07-18 | シェーリング コーポレイション | 新規な高親和性のキノリンベースのキナーゼリガンド |
| CA2627910A1 (en) * | 2005-11-01 | 2007-05-10 | Janssen Pharmaceutica N.V. | Substituted cycloalkylpyrrolones as allosteric modulators of glucokinase |
| WO2007114338A1 (ja) * | 2006-03-31 | 2007-10-11 | Takeda Pharmaceutical Company Limited | 酸分泌抑制薬 |
| WO2008110891A2 (en) | 2007-03-09 | 2008-09-18 | Orchid Research Laboratories Limited, | New heterocyclic compounds |
| EP3088397B1 (en) | 2007-04-11 | 2019-04-10 | Canbas Co. Ltd. | Compounds that abrogate the cell cycle g2 checkpoint for use in the treatment of cancer |
-
2008
- 2008-04-11 EP EP16165912.3A patent/EP3088397B1/en active Active
- 2008-04-11 CA CA3188320A patent/CA3188320A1/en active Pending
- 2008-04-11 RU RU2009141619/04A patent/RU2482111C2/ru active
- 2008-04-11 CA CA2684037A patent/CA2684037C/en active Active
- 2008-04-11 BR BRPI0810911-7A patent/BRPI0810911B1/pt active IP Right Grant
- 2008-04-11 IL IL289165A patent/IL289165B2/en unknown
- 2008-04-11 JP JP2010502609A patent/JP5635396B2/ja active Active
- 2008-04-11 ES ES19167943T patent/ES2927954T3/es active Active
- 2008-04-11 NZ NZ580237A patent/NZ580237A/en unknown
- 2008-04-11 CA CA3030510A patent/CA3030510C/en active Active
- 2008-04-11 DK DK08829410.3T patent/DK2152692T3/en active
- 2008-04-11 CA CA2913840A patent/CA2913840C/en active Active
- 2008-04-11 MX MX2020009403A patent/MX391154B/es unknown
- 2008-04-11 EP EP22176177.8A patent/EP4074704A1/en not_active Withdrawn
- 2008-04-11 CN CN201510578313.XA patent/CN105175394B/zh active Active
- 2008-04-11 DK DK19167943.0T patent/DK3567035T3/da active
- 2008-04-11 AU AU2008294410A patent/AU2008294410B2/en active Active
- 2008-04-11 ES ES16165912T patent/ES2732230T3/es active Active
- 2008-04-11 HU HUE08829410A patent/HUE029370T2/hu unknown
- 2008-04-11 IL IL309201A patent/IL309201A/en unknown
- 2008-04-11 EP EP19167943.0A patent/EP3567035B1/en active Active
- 2008-04-11 BR BR122022005149-9A patent/BR122022005149B1/pt active IP Right Grant
- 2008-04-11 ES ES08829410.3T patent/ES2594704T3/es active Active
- 2008-04-11 US US12/082,643 patent/US8084454B2/en active Active
- 2008-04-11 WO PCT/IB2008/003036 patent/WO2009031040A2/en not_active Ceased
- 2008-04-11 CN CN200880019414A patent/CN101720323A/zh active Pending
- 2008-04-11 MX MX2015016591A patent/MX374896B/es unknown
- 2008-04-11 EP EP08829410.3A patent/EP2152692B9/en active Active
- 2008-04-11 KR KR1020097023566A patent/KR101475311B1/ko active Active
- 2008-04-11 MX MX2009011025A patent/MX2009011025A/es unknown
- 2008-04-11 HU HUE19167943A patent/HUE059861T2/hu unknown
-
2009
- 2009-10-06 ZA ZA2009/06960A patent/ZA200906960B/en unknown
- 2009-10-11 IL IL201380A patent/IL201380A0/en active IP Right Grant
-
2010
- 2010-11-19 US US12/950,297 patent/US8415357B2/en active Active
-
2013
- 2013-08-28 JP JP2013176324A patent/JP2014012706A/ja not_active Withdrawn
-
2015
- 2015-12-02 IL IL242883A patent/IL242883B/en unknown
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