JPWO2022101303A5 - - Google Patents
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- Publication number
- JPWO2022101303A5 JPWO2022101303A5 JP2023528189A JP2023528189A JPWO2022101303A5 JP WO2022101303 A5 JPWO2022101303 A5 JP WO2022101303A5 JP 2023528189 A JP2023528189 A JP 2023528189A JP 2023528189 A JP2023528189 A JP 2023528189A JP WO2022101303 A5 JPWO2022101303 A5 JP WO2022101303A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitor
- combination
- oral
- methoxyurea
- tetrahydrothieno
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102100033350 ATP-dependent translocase ABCB1 Human genes 0.000 claims 24
- 101001017818 Homo sapiens ATP-dependent translocase ABCB1 Proteins 0.000 claims 24
- 239000003112 inhibitor Substances 0.000 claims 23
- AOMXMOCNKJTRQP-UHFFFAOYSA-N 1-[4-[1-[(2,6-difluorophenyl)methyl]-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea Chemical compound C1=CC(NC(=O)NOC)=CC=C1C1=C(CN(C)C)C(C(=O)N(C=2N=NC(OC)=CC=2)C(=O)N2CC=3C(=CC=CC=3F)F)=C2S1 AOMXMOCNKJTRQP-UHFFFAOYSA-N 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 14
- 208000009011 Cytochrome P-450 CYP3A Inhibitors Diseases 0.000 claims 11
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 6
- 229960005309 estradiol Drugs 0.000 claims 6
- 229930182833 estradiol Natural products 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 238000009472 formulation Methods 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 208000005641 Adenomyosis Diseases 0.000 claims 4
- 201000009273 Endometriosis Diseases 0.000 claims 4
- 206010060862 Prostate cancer Diseases 0.000 claims 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 4
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims 4
- 206010046798 Uterine leiomyoma Diseases 0.000 claims 4
- 201000009274 endometriosis of uterus Diseases 0.000 claims 4
- 201000010260 leiomyoma Diseases 0.000 claims 4
- 208000002193 Pain Diseases 0.000 claims 3
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims 3
- 239000000583 progesterone congener Substances 0.000 claims 3
- 238000012423 maintenance Methods 0.000 claims 2
- 208000007106 menorrhagia Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000000144 pharmacologic effect Effects 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 229960003604 testosterone Drugs 0.000 claims 2
- 208000005171 Dysmenorrhea Diseases 0.000 claims 1
- 206010013935 Dysmenorrhoea Diseases 0.000 claims 1
- 208000000450 Pelvic Pain Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063112523P | 2020-11-11 | 2020-11-11 | |
| US63/112,523 | 2020-11-11 | ||
| US202163151423P | 2021-02-19 | 2021-02-19 | |
| US63/151,423 | 2021-02-19 | ||
| PCT/EP2021/081304 WO2022101303A1 (en) | 2020-11-11 | 2021-11-10 | Methods of administering relugolix |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023549196A JP2023549196A (ja) | 2023-11-22 |
| JPWO2022101303A5 true JPWO2022101303A5 (https=) | 2024-11-15 |
| JP2023549196A5 JP2023549196A5 (https=) | 2024-11-15 |
Family
ID=78709420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023528189A Pending JP2023549196A (ja) | 2020-11-11 | 2021-11-10 | レルゴリクスの投与方法 |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP4243829A1 (https=) |
| JP (1) | JP2023549196A (https=) |
| WO (1) | WO2022101303A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2912929T5 (en) | 2016-09-30 | 2025-05-09 | Sumitomo Pharma Switzerland Gmbh | Methods of treating uterine fibroids and endometriosis |
| JP2022551316A (ja) | 2019-10-10 | 2022-12-08 | ミオバント サイエンシズ ゲーエムベーハー | Ｎ－（４－（１－（２，６－ジフルオロベンジル）－５－（（ジメチルアミノ）メチル）－３－（６－メトキシ－３－ピリダジニル）－２，４－ジオキソ－１，２，３，４－テトラヒドロチエノ［２，３－ｄ］ピリミジン－６－イル）フェニル）－Ｎ’－メトキシ尿素の結晶形 |
| CA3185151A1 (en) | 2020-05-29 | 2021-12-02 | Myovant Sciences Gmbh | Combination solid oral dosage forms of gonadotropin-releasing hormone antagonists |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7300935B2 (en) | 2003-01-29 | 2007-11-27 | Takeda Pharmaceutical Company | Thienopyrimidine compounds and use thereof |
| AR092707A1 (es) | 2012-09-28 | 2015-04-29 | Takeda Pharmaceuticals Co | Metodo de produccion de derivado de tienopirimidina |
| TWI744224B (zh) | 2015-02-26 | 2021-11-01 | 日商武田藥品工業股份有限公司 | 固形製劑 |
| AU2016317955B2 (en) * | 2015-09-01 | 2021-05-20 | Abbvie Inc. | Methods of administering Elagolix |
| ES2912929T5 (en) | 2016-09-30 | 2025-05-09 | Sumitomo Pharma Switzerland Gmbh | Methods of treating uterine fibroids and endometriosis |
| MA46361A (fr) * | 2016-09-30 | 2021-03-31 | Myovant Sciences Gmbh | Traitement du cancer de la prostate |
| EA201992612A1 (ru) * | 2017-06-05 | 2020-05-20 | Обсева С.А. | Схемы применения антагониста гонадотропин-высвобождающего гормона для лечения эндометриоза |
| US20190054088A1 (en) * | 2017-08-18 | 2019-02-21 | Abbvie Inc. | Pharmaceutical Formulations for Treating Endometriosis, Uterine Fibroids, Polycystic Ovary Syndrome or Adenomyosis |
| WO2021069700A1 (en) | 2019-10-10 | 2021-04-15 | Myovant Sciences Gmbh | Crystalline solvated forms of n-(4-(1-(2,6-difluorobenzyl)-5- ((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4- tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-n'-methoxyurea |
| JP2022551316A (ja) | 2019-10-10 | 2022-12-08 | ミオバント サイエンシズ ゲーエムベーハー | Ｎ－（４－（１－（２，６－ジフルオロベンジル）－５－（（ジメチルアミノ）メチル）－３－（６－メトキシ－３－ピリダジニル）－２，４－ジオキソ－１，２，３，４－テトラヒドロチエノ［２，３－ｄ］ピリミジン－６－イル）フェニル）－Ｎ’－メトキシ尿素の結晶形 |
-
2021
- 2021-11-10 WO PCT/EP2021/081304 patent/WO2022101303A1/en not_active Ceased
- 2021-11-10 EP EP21810968.4A patent/EP4243829A1/en not_active Withdrawn
- 2021-11-10 JP JP2023528189A patent/JP2023549196A/ja active Pending
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