JPWO2022067094A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2022067094A5 JPWO2022067094A5 JP2023518858A JP2023518858A JPWO2022067094A5 JP WO2022067094 A5 JPWO2022067094 A5 JP WO2022067094A5 JP 2023518858 A JP2023518858 A JP 2023518858A JP 2023518858 A JP2023518858 A JP 2023518858A JP WO2022067094 A5 JPWO2022067094 A5 JP WO2022067094A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- heterocyclyl
- aryl
- cycloalkyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 50
- 125000000623 heterocyclic group Chemical group 0.000 claims 30
- 125000003118 aryl group Chemical group 0.000 claims 29
- 125000000753 cycloalkyl group Chemical group 0.000 claims 27
- 125000000217 alkyl group Chemical group 0.000 claims 23
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 15
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 12
- 125000001072 heteroaryl group Chemical group 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 8
- 239000012453 solvate Substances 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
- 125000003282 alkyl amino group Chemical group 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 108091006027 G proteins Proteins 0.000 claims 2
- 102000030782 GTP binding Human genes 0.000 claims 2
- 108091000058 GTP-Binding Proteins 0.000 claims 2
- -1 -OR Chemical group 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000003251 Pruritus Diseases 0.000 claims 1
- 101100495923 Schizosaccharomyces pombe (strain 972 / ATCC 24843) chr2 gene Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063083638P | 2020-09-25 | 2020-09-25 | |
| US63/083,638 | 2020-09-25 | ||
| US202163145407P | 2021-02-03 | 2021-02-03 | |
| US63/145,407 | 2021-02-03 | ||
| US202163211987P | 2021-06-17 | 2021-06-17 | |
| US63/211,987 | 2021-06-17 | ||
| PCT/US2021/052044 WO2022067094A1 (en) | 2020-09-25 | 2021-09-24 | Modulators of mas-related g-protein receptor x2 and related products and methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023542541A JP2023542541A (ja) | 2023-10-10 |
| JPWO2022067094A5 true JPWO2022067094A5 (https=) | 2024-10-02 |
| JP2023542541A5 JP2023542541A5 (https=) | 2024-10-02 |
Family
ID=78302949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023518858A Pending JP2023542541A (ja) | 2020-09-25 | 2021-09-24 | Ｍａｓ関連ｇタンパク質受容体ｘ２のモジュレーター、並びに関連製品及び方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11919864B2 (https=) |
| EP (1) | EP4217345A1 (https=) |
| JP (1) | JP2023542541A (https=) |
| KR (1) | KR20230097015A (https=) |
| CN (1) | CN116406357A (https=) |
| AU (1) | AU2021347360A1 (https=) |
| CA (1) | CA3193207A1 (https=) |
| IL (1) | IL301575A (https=) |
| MX (1) | MX2023003476A (https=) |
| WO (1) | WO2022067094A1 (https=) |
| ZA (1) | ZA202304729B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023542541A (ja) * | 2020-09-25 | 2023-10-10 | エサイエント ファーマシューティカルズ，インコーポレイティド | Ｍａｓ関連ｇタンパク質受容体ｘ２のモジュレーター、並びに関連製品及び方法 |
| EP4232042A1 (en) * | 2020-10-21 | 2023-08-30 | Escient Pharmaceuticals, Inc. | Modulators of mas-related g-protein receptor x2 and related products and their use |
| CA3245969A1 (en) | 2022-03-30 | 2023-10-05 | Escient Pharmaceuticals, Inc. | QUINOLINE DERIVATIVES AS MRGPRX2 RECEIVER MODULATORS AND RELATED PRODUCTS |
| CN115850250B (zh) * | 2022-10-25 | 2025-12-23 | 南京师范大学 | 一种可控可视化的一氧化碳释放剂及其制备方法和应用 |
| CN121532382A (zh) * | 2023-07-13 | 2026-02-13 | 北京普祺医药科技股份有限公司 | Mas相关g蛋白受体x2的拮抗剂及其用途 |
| US20250084063A1 (en) | 2023-08-18 | 2025-03-13 | Incyte Corporation | Bicyclic heterocycles as mrgprx2 antagonists |
| CN119504738A (zh) * | 2023-08-25 | 2025-02-25 | 武汉人福创新药物研发中心有限公司 | 作为mrgprx2拮抗剂的化合物及其制备方法和应用 |
| WO2025119372A2 (zh) * | 2023-12-08 | 2025-06-12 | 武汉人福创新药物研发中心有限公司 | Mrgprx2拮抗剂及用途 |
| WO2025153014A1 (zh) * | 2024-01-17 | 2025-07-24 | 武汉人福创新药物研发中心有限公司 | Mas相关g蛋白受体x2拮抗剂及用途 |
| US20250243208A1 (en) | 2024-01-25 | 2025-07-31 | Incyte Corporation | Bicyclic heterocycles as mrgprx2 antagonists |
| WO2025222040A1 (en) | 2024-04-19 | 2025-10-23 | Escient Pharmaceuticals, Inc. | Mrgprx2 modulators for use in treating mrgprx2 dependent conditions in subjects with low ige |
| WO2025223036A1 (zh) * | 2024-04-23 | 2025-10-30 | 凯复(苏州)生物医药有限公司 | Mrgprx2拮抗剂、包含其的药物组合物及其用途 |
| WO2025264860A2 (en) | 2024-06-18 | 2025-12-26 | Yale University | Methods of treating post-covid airway disease |
| WO2026009854A1 (ja) * | 2024-07-01 | 2026-01-08 | 日本たばこ産業株式会社 | ピリダジノン化合物及びその医薬用途 |
| WO2026037254A1 (zh) * | 2024-08-10 | 2026-02-19 | 杭州英创医药科技有限公司 | 作为mrgprx2拮抗剂的化合物 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030085005A (ko) * | 2001-03-19 | 2003-11-01 | 니뽄 신야쿠 가부시키가이샤 | 진양제 |
| KR100955015B1 (ko) * | 2001-08-15 | 2010-04-28 | 이코스 코포레이션 | 2ｈ-프탈라진-1-온 및 이것의 사용 방법 |
| US7320989B2 (en) * | 2003-02-28 | 2008-01-22 | Encysive Pharmaceuticals, Inc. | Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-II receptor antagonists |
| EP1603884A4 (en) * | 2003-02-28 | 2008-05-28 | Encysive Pharmaceuticals Inc | PYRIDINE, PYRIMIDINE, QUINOLINE, QUINAZOLINE AND NAPHTHALENE UROTENSIN II RECEPTOR ANTAGONISTS |
| JP2007517868A (ja) * | 2004-01-07 | 2007-07-05 | アストラゼネカ アクチボラグ | 治療薬ｉ |
| JP2006124387A (ja) * | 2004-09-30 | 2006-05-18 | Taisho Pharmaceut Co Ltd | 新規なキノリン、テトラヒドロキナゾリン、及びピリミジン誘導体と、これらを使用することに関連した治療方法 |
| CN102625799A (zh) * | 2009-06-25 | 2012-08-01 | 安姆根有限公司 | 杂环化合物及其用途 |
| CA2853833A1 (en) * | 2011-11-08 | 2013-05-16 | Arena Pharmaceuticals, Inc. | Modulators of the g protein-coupled mas receptor and the treatment of disorders related thereto |
| DK2950649T3 (da) * | 2013-02-01 | 2020-05-04 | Wellstat Therapeutics Corp | Aminforbindelser med antiinflammations-, antisvampe-, antiparasit- og anticanceraktivitet |
| JP2023542541A (ja) * | 2020-09-25 | 2023-10-10 | エサイエント ファーマシューティカルズ，インコーポレイティド | Ｍａｓ関連ｇタンパク質受容体ｘ２のモジュレーター、並びに関連製品及び方法 |
-
2021
- 2021-09-24 JP JP2023518858A patent/JP2023542541A/ja active Pending
- 2021-09-24 CA CA3193207A patent/CA3193207A1/en active Pending
- 2021-09-24 US US17/484,993 patent/US11919864B2/en active Active
- 2021-09-24 CN CN202180075369.7A patent/CN116406357A/zh active Pending
- 2021-09-24 KR KR1020237013945A patent/KR20230097015A/ko not_active Ceased
- 2021-09-24 AU AU2021347360A patent/AU2021347360A1/en active Pending
- 2021-09-24 IL IL301575A patent/IL301575A/en unknown
- 2021-09-24 EP EP21795105.2A patent/EP4217345A1/en active Pending
- 2021-09-24 WO PCT/US2021/052044 patent/WO2022067094A1/en not_active Ceased
- 2021-09-24 MX MX2023003476A patent/MX2023003476A/es unknown
-
2023
- 2023-04-24 ZA ZA2023/04729A patent/ZA202304729B/en unknown
- 2023-11-30 US US18/525,253 patent/US12275707B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPWO2022067094A5 (https=) | ||
| JP2021523221A5 (https=) | ||
| JP2021534124A5 (https=) | ||
| SI2961736T1 (en) | Histone demethylase inhibitors | |
| JP2015503529A5 (https=) | ||
| RU2017145650A (ru) | Ингибиторы тирозинкиназы брутона | |
| EA035500B1 (ru) | Производные сульфамоилтиофенамида и их применение в качестве медикаментов для лечения гепатита b | |
| JP2004524301A5 (https=) | ||
| JP2008504266A5 (https=) | ||
| RU2004117545A (ru) | Аминопиримидины и пиридины | |
| JP2017504576A5 (https=) | ||
| JP2011503193A5 (https=) | ||
| RU2008112691A (ru) | Азотсодержащее гетероциклическое соединение и его фармацевтическое применение | |
| JP2012528166A5 (https=) | ||
| EP1240160A1 (en) | Substituted pyridazines having cytokine inhibitory activity | |
| JP2006507355A5 (https=) | ||
| RU2012116877A (ru) | Соединения 2-пиридона, применяемые в качестве ингибиторов нейтрофильной эластазы | |
| JP2013503139A5 (https=) | ||
| RU2010113358A (ru) | Гуанидинсодержащие соединения, применимые в качестве антагонистов мускариновых рецепторов | |
| JP2020511536A5 (https=) | ||
| JP2004525183A5 (https=) | ||
| JP2020111571A5 (https=) | ||
| JP2019535813A5 (https=) | ||
| JPWO2019241292A5 (https=) | ||
| RU2005133990A (ru) | 1, 3, 4-замещенные пиразолы в качкстве антагонистов 5-ht рецепторов для психозов и неврологических нарушений |