JPWO2021226597A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2021226597A5
JPWO2021226597A5 JP2022567617A JP2022567617A JPWO2021226597A5 JP WO2021226597 A5 JPWO2021226597 A5 JP WO2021226597A5 JP 2022567617 A JP2022567617 A JP 2022567617A JP 2022567617 A JP2022567617 A JP 2022567617A JP WO2021226597 A5 JPWO2021226597 A5 JP WO2021226597A5
Authority
JP
Japan
Prior art keywords
pharmaceutical composition
virus
present
human
thio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022567617A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023525270A5 (https=
JP2023525270A (ja
Publication date
Priority claimed from PCT/US2020/063494 external-priority patent/WO2021113777A2/en
Application filed filed Critical
Priority claimed from PCT/US2021/031629 external-priority patent/WO2021226597A2/en
Publication of JP2023525270A publication Critical patent/JP2023525270A/ja
Publication of JP2023525270A5 publication Critical patent/JP2023525270A5/ja
Publication of JPWO2021226597A5 publication Critical patent/JPWO2021226597A5/ja
Pending legal-status Critical Current

Links

JP2022567617A 2020-05-08 2021-05-10 環状rna組成物及び方法 Pending JP2023525270A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202063022248P 2020-05-08 2020-05-08
US63/022,248 2020-05-08
US202063087582P 2020-10-05 2020-10-05
US63/087,582 2020-10-05
PCT/US2020/063494 WO2021113777A2 (en) 2019-12-04 2020-12-04 Circular rna compositions and methods
USPCT/US2020/063494 2020-12-04
PCT/US2021/031629 WO2021226597A2 (en) 2020-05-08 2021-05-10 Circular rna compositions and methods

Publications (3)

Publication Number Publication Date
JP2023525270A JP2023525270A (ja) 2023-06-15
JP2023525270A5 JP2023525270A5 (https=) 2024-05-10
JPWO2021226597A5 true JPWO2021226597A5 (https=) 2024-05-10

Family

ID=78468564

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022567617A Pending JP2023525270A (ja) 2020-05-08 2021-05-10 環状rna組成物及び方法

Country Status (8)

Country Link
US (1) US20230226096A1 (https=)
EP (1) EP4146285A2 (https=)
JP (1) JP2023525270A (https=)
CN (1) CN116113419A (https=)
AU (1) AU2021269137A1 (https=)
CA (1) CA3178111A1 (https=)
MX (1) MX2022014070A (https=)
WO (1) WO2021226597A2 (https=)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3100276A1 (en) 2018-06-06 2019-12-12 Massachusetts Institute Of Technology Circular rna for translation in eukaryotic cells
MX2023007137A (es) * 2020-12-21 2023-08-28 Beam Therapeutics Inc Nanomateriales que comprenden acetales unidos a ésteres.
CN115997018A (zh) 2021-03-10 2023-04-21 尔知渃米斯股份有限公司 自身环化rna构建体
CA3211623A1 (en) 2021-05-24 2022-12-01 Bo YING Lipid compounds and lipid nanoparticle compositions
CN113264842B (zh) * 2021-07-21 2022-03-01 苏州科锐迈德生物医药科技有限公司 一种脂质化合物及包含其的脂质载体、核酸脂质纳米粒组合物和药物制剂
TW202328067A (zh) 2021-09-14 2023-07-16 美商雷納嘉德醫療管理公司 環狀脂質及其使用方法
CN118317944A (zh) 2021-09-14 2024-07-09 雷纳嘉德医疗管理公司 非环状脂质及其使用方法
MX2024006440A (es) 2021-11-24 2024-08-19 Flagship Pioneering Innovations Vi Llc Composiciones inmunogenicas y sus usos.
EP4436984A1 (en) 2021-11-24 2024-10-02 Flagship Pioneering Innovations VI, LLC Coronavirus immunogen compositions and their uses
AU2022397292A1 (en) 2021-11-24 2024-05-30 Flagship Pioneering Innovations Vi, Llc Varicella-zoster virus immunogen compositions and their uses
JP2024543272A (ja) * 2021-11-29 2024-11-20 ザ ガバニング カウンシル オブ ザ ユニバーシティ オブ トロント マルチモチーフデンドロン及びその超分子構造ならびにその使用
WO2023126053A1 (en) * 2021-12-28 2023-07-06 BioNTech SE Lipid-based formulations for administration of rna
CN114349811A (zh) * 2022-01-05 2022-04-15 上海交通大学 阳离子胆固醇衍生物、纳米复合物及其制备方法和应用
WO2023138666A1 (en) * 2022-01-19 2023-07-27 Utc Therapeutics (Shanghai) Co., Ltd. Circular rna and use thereof
EP4482819A2 (en) * 2022-02-24 2025-01-01 Vivasor, Inc. Novel ionizable cationic lipids
US20250188028A1 (en) * 2022-03-14 2025-06-12 Nanovation Therapeutics Inc. Synthetic Method for Producing Ionizable Amino Lipids
CN118871134A (zh) * 2022-03-21 2024-10-29 生物探险有限公司 用于增强蛋白质表达的内部核糖体进入位点(IRES)、质粒载体和环状mRNA
KR102560772B1 (ko) * 2022-03-21 2023-07-28 주식회사 메디치바이오 신규한 이온화지질 및 이를 이용한 지질나노입자 조성물
TW202408542A (zh) * 2022-05-20 2024-03-01 大陸商浙江健新原力製藥有限公司 製備環狀rna的方法
US12297285B2 (en) 2022-06-24 2025-05-13 Orna Therapeutics, Inc. Circular RNA encoding chimeric antigen receptors targeting BCMA
CN119343454A (zh) * 2022-09-13 2025-01-21 苏州艾博生物科技有限公司 用于合成环状rna的一步法
EP4596605A4 (en) * 2022-09-30 2026-01-14 Xiamen Sinopeg Biotech Co Ltd PEGYLATED LIPID CONTAINING A LYSIN NUCLEUS
CN117917398A (zh) * 2022-10-21 2024-04-23 华中师范大学 一种可离子化脂质化合物、核酸药物分子递送系统及应用
CN120390656A (zh) 2022-11-08 2025-07-29 欧纳医疗公司 环状rna组合物
CN120225500A (zh) * 2022-11-18 2025-06-27 韩国生命工学研究院 用于活性物质递送的脂质化合物及组合物
AU2023398825A1 (en) 2022-12-15 2025-06-26 Orna Therapeutics, Inc. Circular rna compositions and methods
CN120390801A (zh) * 2022-12-20 2025-07-29 杭州明德生物医药技术有限公司 环状rna分离和纯化方法
EP4642434A2 (en) * 2022-12-29 2025-11-05 Life Technologies Corporation Lipid compositions on the basis of ionizable lipids, use for delivery to immune cells
WO2024151583A2 (en) 2023-01-09 2024-07-18 Flagship Pioneering Innovations Vii, Llc Vaccines and related methods
WO2024167885A1 (en) 2023-02-06 2024-08-15 Flagship Pioneering Innovations Vii, Llc Immunomodulatory compositions and related methods
WO2024192420A1 (en) 2023-03-15 2024-09-19 Flagship Pioneering Innovations Vi, Llc Compositions comprising polyribonucleotides and uses thereof
WO2024192291A1 (en) 2023-03-15 2024-09-19 Renagade Therapeutics Management Inc. Delivery of gene editing systems and methods of use thereof
EP4680595A2 (en) 2023-03-15 2026-01-21 Renagade Therapeutics Management Inc. Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents
EP4680276A1 (en) 2023-03-15 2026-01-21 Flagship Pioneering Innovations VI, LLC Immunogenic compositions and uses thereof
KR20240159310A (ko) * 2023-04-28 2024-11-05 주식회사 메디치바이오 신규한 이온화지질을 이용한 지질나노입자 조성물
EP4698150A1 (en) 2023-04-19 2026-02-25 Sail Biomedicines, Inc. Delivery of polynucleotides from lipid nanoparticles comprising rna and ionizable lipids
WO2024220752A2 (en) * 2023-04-19 2024-10-24 Sail Biomedicines, Inc. Rna therapeutic compositions
WO2024233308A2 (en) 2023-05-05 2024-11-14 Orna Therapeutics, Inc. Circular rna compositions and methods
US12311033B2 (en) 2023-05-31 2025-05-27 Capstan Therapeutics, Inc. Lipid nanoparticle formulations and compositions
WO2025007148A1 (en) 2023-06-30 2025-01-02 Orna Therapeutics, Inc. Polymer lipid nanoparticle compositions for delivering circular polynucleotides
WO2025011502A1 (zh) * 2023-07-07 2025-01-16 仁景(苏州)生物科技有限公司 制备环状rna方法及用于所述方法的核酸序列
WO2025042786A1 (en) 2023-08-18 2025-02-27 Flagship Pioneering Innovations Vi, Llc Compositions comprising circular polyribonucleotides and uses thereof
WO2025049690A1 (en) 2023-08-29 2025-03-06 Orna Therapeutics, Inc. Circular polyethylene glycol lipids
AU2024335327A1 (en) 2023-09-01 2026-03-26 Renagade Therapeutics Management Inc. Gene editing systems, compositions, and methods for treatment of vexas syndrome
WO2025081042A1 (en) 2023-10-12 2025-04-17 Renagade Therapeutics Management Inc. Nickase-retron template-based precision editing system and methods of use
WO2025085695A1 (en) * 2023-10-18 2025-04-24 Trustees Of Dartmouth College Lipid nanoparticle formulations for delivery of nucleic acids to primary human b-cells
WO2025101501A1 (en) 2023-11-07 2025-05-15 Orna Therapeutics, Inc. Circular rna compositions
EP4559898A1 (en) * 2023-11-24 2025-05-28 AldexChem Kft. Novel ionizable cationic lipids containing thioether linkage
WO2025117969A1 (en) 2023-12-01 2025-06-05 Orna Therapeutics, Inc. Process for manufacturing lipid nanoparticles
WO2025120230A1 (en) 2023-12-07 2025-06-12 T-Curx Gmbh Method of producing leukocytes expressing artificial antigen receptors
WO2025128871A2 (en) 2023-12-13 2025-06-19 Renagade Therapeutics Management Inc. Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents
WO2025155753A2 (en) 2024-01-17 2025-07-24 Renagade Therapeutics Management Inc. Improved gene editing system, guides, and methods
TW202545974A (zh) 2024-01-26 2025-12-01 美商旗艦先鋒創新有限責任(Vii)公司 免疫受體抑制蛋白及相關方法
WO2025174765A1 (en) 2024-02-12 2025-08-21 Renagade Therapeutics Management Inc. Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents
WO2025240680A1 (en) 2024-05-16 2025-11-20 Flagship Pioneering Innovations Vii, Llc Immunoreceptor inhibitory proteins and related methods
WO2025245111A1 (en) 2024-05-22 2025-11-27 Flagship Pioneering Innovations Vii, Llc Immunoreceptor targeting proteins and related methods
WO2025250751A1 (en) 2024-05-31 2025-12-04 Orna Therapeutics, Inc. Circular rna compositions and methods
WO2026003582A2 (en) 2024-06-27 2026-01-02 Axelyf ehf. Lipids and lipid nanoparticles
WO2026006687A1 (en) * 2024-06-28 2026-01-02 Orbital Therapeutics, Inc. Circular rna compositions and uses thereof for diseases caused by varicella-zoster virus
WO2026006593A1 (en) 2024-06-28 2026-01-02 Orna Therapeutics, Inc. Synthetic internal ribosome entry sites
WO2026072709A1 (en) 2024-09-25 2026-04-02 Orna Therapeutics, Inc. Chimeric antigen receptors targeting bcma

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100305197A1 (en) * 2009-02-05 2010-12-02 Massachusetts Institute Of Technology Conditionally Active Ribozymes And Uses Thereof
ES2895651T3 (es) * 2013-12-19 2022-02-22 Novartis Ag Lípidos y composiciones lipídicas para la administración de agentes activos
EP4286012A3 (en) * 2015-09-17 2024-05-29 ModernaTX, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
EP3668834B1 (en) * 2017-08-17 2024-10-02 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
CA3100276A1 (en) * 2018-06-06 2019-12-12 Massachusetts Institute Of Technology Circular rna for translation in eukaryotic cells
US12263248B2 (en) * 2018-09-19 2025-04-01 Modernatx, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
WO2020237227A1 (en) * 2019-05-22 2020-11-26 Massachusetts Institute Of Technology Circular rna compositions and methods

Similar Documents

Publication Publication Date Title
JPWO2021226597A5 (https=)
US12570996B2 (en) Circular RNA for translation in eukaryotic cells
JP7618577B2 (ja) 修飾環状ポリリボヌクレオチドを含む組成物及びその使用
US20240100145A1 (en) Vlp enteroviral vaccines
JP4804467B2 (ja) 多重rnaポリメラーゼiiiプロモーター発現構築物
US20240209068A1 (en) Mucosal expression of antibody structures and isotypes by mrna
JPWO2021113777A5 (https=)
JP2025041835A (ja) 呼吸器合胞体ウイルスワクチン
EP4554617A1 (en) Norovirus mrna vaccines
JP2005506087A (ja) プラス鎖rnaウイルスによる感染症を処置するための2本鎖リボ核酸の使用
JP5383186B2 (ja) H19をダウンレギュレートする核酸薬剤、及びそれを使用する方法
CN117295819A (zh) 用于抑制补体组分3表达的组合物和方法
TW202321451A (zh) 工程化的 adar 招募 rnas 及其使用方法
WO2022138929A1 (ja) 標的rnaのポリアデニル化シグナル配列を編集するためのガイドrna
WO2025102504A1 (zh) 基于i型内含子的环状rna制备方法及其应用
JP2025542215A (ja) 自己環状化rnaの製造方法
JP7807019B2 (ja) 新規なレプリカーゼサイクリング反応(rcr)
US20260117252A1 (en) Circular RNA For Translation In Eukaryotic Cells
WO2025011502A1 (zh) 制备环状rna方法及用于所述方法的核酸序列
TW202540418A (zh) 新穎rna構建體及使用其製備環狀rna的方法
TW202339775A (zh) 工程化的 adar 募集 rna 及其使用方法