JPWO2021224501A5 - - Google Patents

Info

Publication number

JPWO2021224501A5

JPWO2021224501A5 JP2022567655A JP2022567655A JPWO2021224501A5 JP WO2021224501 A5 JPWO2021224501 A5 JP WO2021224501A5 JP 2022567655 A JP2022567655 A JP 2022567655A JP 2022567655 A JP2022567655 A JP 2022567655A JP WO2021224501 A5 JPWO2021224501 A5 JP WO2021224501A5

Authority

JP

Japan

Prior art keywords

thiazolo

oxo

cyclopropyl

pyridine

cyclobuta

Prior art date

2024-05-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 150000001875 compounds Chemical class 0.000 claims 17
• 150000003839 salts Chemical class 0.000 claims 15
• 125000001153 fluoro group Chemical group F* 0.000 claims 14
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 10
• 125000001424 substituent group Chemical group 0.000 claims 10
• 125000001309 chloro group Chemical group Cl* 0.000 claims 9
• -1 1-naphthyloxy, 9-anthryl Chemical group 0.000 claims 8
• 125000004093 cyano group Chemical group *C#N 0.000 claims 8
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 6
• 208000019206 urinary tract infection Diseases 0.000 claims 6
• 201000010099 disease Diseases 0.000 claims 5
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
• 239000008194 pharmaceutical composition Substances 0.000 claims 5
• 206010011409 Cross infection Diseases 0.000 claims 4
• 125000001246 bromo group Chemical group Br* 0.000 claims 4
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 4
• 241000192125 Firmicutes Species 0.000 claims 3
• 125000000623 heterocyclic group Chemical group 0.000 claims 3
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
• 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims 2
• 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims 2
• 206010014666 Endocarditis bacterial Diseases 0.000 claims 2
• 206010035664 Pneumonia Diseases 0.000 claims 2
• 206010040047 Sepsis Diseases 0.000 claims 2
• 208000031650 Surgical Wound Infection Diseases 0.000 claims 2
• 206010043376 Tetanus Diseases 0.000 claims 2
• 206010052428 Wound Diseases 0.000 claims 2
• 208000027418 Wounds and injury Diseases 0.000 claims 2
• 125000000217 alkyl group Chemical group 0.000 claims 2
• 208000009361 bacterial endocarditis Diseases 0.000 claims 2
• 208000037815 bloodstream infection Diseases 0.000 claims 2
• 125000000000 cycloalkoxy group Chemical group 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 2
• 229910052739 hydrogen Inorganic materials 0.000 claims 2
• 208000015181 infectious disease Diseases 0.000 claims 2
• 201000007119 infective endocarditis Diseases 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 230000002265 prevention Effects 0.000 claims 2
• 229920006395 saturated elastomer Polymers 0.000 claims 2
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 2
• 125000003831 tetrazolyl group Chemical group 0.000 claims 2
• QSLPNSWXUQHVLP-UHFFFAOYSA-N $l^{1}-sulfanylmethane Chemical compound [S]C QSLPNSWXUQHVLP-UHFFFAOYSA-N 0.000 claims 1
• 125000000027 (C1-C10) alkoxy group Chemical group 0.000 claims 1
• 125000006727 (C1-C6) alkenyl group Chemical group 0.000 claims 1
• MNCMBBIFTVWHIP-UHFFFAOYSA-N 1-anthracen-9-yl-2,2,2-trifluoroethanone Chemical group C1=CC=C2C(C(=O)C(F)(F)F)=C(C=CC=C3)C3=CC2=C1 MNCMBBIFTVWHIP-UHFFFAOYSA-N 0.000 claims 1
• HHLHGWWYDQLQIK-WSEDSVFCSA-N CN([C@H](C1SC2=C(C3CC3)C(CC3=CC=CC4=CC=CC=C34)=C3)C4=CC(Cl)=CC(Cl)=C4)C1(C(O)=O)N2C3=O Chemical compound CN([C@H](C1SC2=C(C3CC3)C(CC3=CC=CC4=CC=CC=C34)=C3)C4=CC(Cl)=CC(Cl)=C4)C1(C(O)=O)N2C3=O HHLHGWWYDQLQIK-WSEDSVFCSA-N 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• 241001465754 Metazoa Species 0.000 claims 1
• DFYRPWRVWNCIKC-OIOREYSGSA-N OC(C(C1SC2=C(C3CC3)C(CC3=CC=CC4=CC=CC=C34)=C3)(N[C@H]1C1=CC(Cl)=CC(Cl)=C1)N2C3=O)=O Chemical compound OC(C(C1SC2=C(C3CC3)C(CC3=CC=CC4=CC=CC=C34)=C3)(N[C@H]1C1=CC(Cl)=CC(Cl)=C1)N2C3=O)=O DFYRPWRVWNCIKC-OIOREYSGSA-N 0.000 claims 1
• 239000002671 adjuvant Substances 0.000 claims 1
• 125000003545 alkoxy group Chemical group 0.000 claims 1
• 125000003118 aryl group Chemical group 0.000 claims 1
• ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims 1
• 125000000753 cycloalkyl group Chemical group 0.000 claims 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
• 239000001257 hydrogen Substances 0.000 claims 1
• 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
• CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 claims 1
• 125000004552 isoquinolin-4-yl group Chemical group C1=NC=C(C2=CC=CC=C12)* 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 125000001639 phenylmethylene group Chemical group [H]C(=*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1