JPWO2021212097A5 - - Google Patents

Info

Publication number

JPWO2021212097A5

JPWO2021212097A5 JP2022563191A JP2022563191A JPWO2021212097A5 JP WO2021212097 A5 JPWO2021212097 A5 JP WO2021212097A5 JP 2022563191 A JP2022563191 A JP 2022563191A JP 2022563191 A JP2022563191 A JP 2022563191A JP WO2021212097 A5 JPWO2021212097 A5 JP WO2021212097A5

Authority

JP

Japan

Prior art keywords

fraction

composition

hyaluronic acid

subject

composition according

Prior art date

2024-04-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 239000000203 mixture Substances 0.000 claims 17
• 229920002674 hyaluronan Polymers 0.000 claims 14
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 13
• 229960003160 hyaluronic acid Drugs 0.000 claims 13
• 239000012736 aqueous medium Substances 0.000 claims 2
• 210000004207 dermis Anatomy 0.000 claims 2
• 239000011859 microparticle Substances 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 210000002615 epidermis Anatomy 0.000 claims 1
• 238000002347 injection Methods 0.000 claims 1
• 239000007924 injection Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000002245 particle Substances 0.000 claims 1
• 230000004962 physiological condition Effects 0.000 claims 1
• 210000003491 skin Anatomy 0.000 claims 1
• 230000007928 solubilization Effects 0.000 claims 1
• 238000005063 solubilization Methods 0.000 claims 1
• 239000000243 solution Substances 0.000 claims 1
• 238000007920 subcutaneous administration Methods 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 230000008961 swelling Effects 0.000 claims 1
• 210000001179 synovial fluid Anatomy 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1
• 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
• 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1