JPWO2021201029A1 - - Google Patents

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Publication number
JPWO2021201029A1
JPWO2021201029A1 JP2022512585A JP2022512585A JPWO2021201029A1 JP WO2021201029 A1 JPWO2021201029 A1 JP WO2021201029A1 JP 2022512585 A JP2022512585 A JP 2022512585A JP 2022512585 A JP2022512585 A JP 2022512585A JP WO2021201029 A1 JPWO2021201029 A1 JP WO2021201029A1
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2022512585A
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Japanese (ja)
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JP7328729B2 (ja
JPWO2021201029A5 (https=
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Publication of JPWO2021201029A1 publication Critical patent/JPWO2021201029A1/ja
Publication of JPWO2021201029A5 publication Critical patent/JPWO2021201029A5/ja
Priority to JP2023078055A priority Critical patent/JP7546968B2/ja
Application granted granted Critical
Publication of JP7328729B2 publication Critical patent/JP7328729B2/ja
Priority to JP2023176775A priority patent/JP7546976B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/16—Physical preservation processes
    • A01N1/162—Temperature processes, e.g. following predefined temperature changes over time
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/125—Freeze protecting agents, e.g. cryoprotectants or osmolarity regulators
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
    • A01N1/142—Apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M45/00—Means for pre-treatment of biological substances
    • C12M45/22—Means for packing or storing viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/04—Preserving or maintaining viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0665—Blood-borne mesenchymal stem cells, e.g. from umbilical cord blood
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/35—Polyols, e.g. glycerin, inositol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure
    • C12N2500/62—DMSO
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2523/00—Culture process characterised by temperature

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Sustainable Development (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicinal Preparation (AREA)
JP2022512585A 2020-03-31 2021-03-30 細胞の保存方法 Active JP7328729B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023078055A JP7546968B2 (ja) 2020-03-31 2023-05-10 細胞の保存方法
JP2023176775A JP7546976B2 (ja) 2020-03-31 2023-10-12 細胞の保存方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020063821 2020-03-31
JP2020063821 2020-03-31
PCT/JP2021/013685 WO2021201029A1 (ja) 2020-03-31 2021-03-30 細胞の保存方法

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023078055A Division JP7546968B2 (ja) 2020-03-31 2023-05-10 細胞の保存方法

Publications (3)

Publication Number Publication Date
JPWO2021201029A1 true JPWO2021201029A1 (https=) 2021-10-07
JPWO2021201029A5 JPWO2021201029A5 (https=) 2022-11-30
JP7328729B2 JP7328729B2 (ja) 2023-08-17

Family

ID=77930013

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2022512585A Active JP7328729B2 (ja) 2020-03-31 2021-03-30 細胞の保存方法
JP2023078055A Active JP7546968B2 (ja) 2020-03-31 2023-05-10 細胞の保存方法
JP2023176775A Active JP7546976B2 (ja) 2020-03-31 2023-10-12 細胞の保存方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2023078055A Active JP7546968B2 (ja) 2020-03-31 2023-05-10 細胞の保存方法
JP2023176775A Active JP7546976B2 (ja) 2020-03-31 2023-10-12 細胞の保存方法

Country Status (8)

Country Link
US (1) US20230132689A1 (https=)
EP (1) EP4130237A1 (https=)
JP (3) JP7328729B2 (https=)
CN (1) CN115244172A (https=)
AU (1) AU2021245671A1 (https=)
CA (1) CA3172745A1 (https=)
TW (1) TW202204600A (https=)
WO (1) WO2021201029A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120059933B (zh) * 2025-04-24 2025-10-28 阳信华胜清真肉类有限公司 一种配种用冻精解冻装置

Citations (8)

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JP2004073084A (ja) * 2002-08-19 2004-03-11 Olympus Corp 培養容器および培養装置
US20060212020A1 (en) * 2002-10-10 2006-09-21 Lynne Rainen Sample collection system with caspase inhibitor
US20080199900A1 (en) * 2004-08-04 2008-08-21 Universita' Degli Studi Di Roma "La Spienza" Disposable Device For One Or More Introductions, Treatment And Sampling Of Biological Material From At Least One Of The Separation Phases Present Within The Device, Under Sterility Conditions and Constant Pressure
JP2009511212A (ja) * 2005-10-13 2009-03-19 アルゴス・セラピューティクス・インコーポレーテッド 低温で貯蔵された液体薬剤の送達に適する装置、システム、および関連する方法
JP2012510299A (ja) * 2008-11-28 2012-05-10 テルモ株式会社 血液バッグシステム及びカセット
US20150140656A1 (en) * 2013-11-20 2015-05-21 Cellulis, S.L. Method of freezing cells
WO2016163444A1 (ja) * 2015-04-07 2016-10-13 日産化学工業株式会社 液状の培地組成物の製造方法、およびそのための製造装置とキット
WO2017073656A1 (ja) * 2015-10-27 2017-05-04 株式会社カネカ 間葉系幹細胞を含む細胞集団の製造方法、間葉系幹細胞、細胞集団、並びに医薬組成物

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CA2253872A1 (en) * 1997-03-07 1998-09-11 Thermogenesis Corp. Method and apparatus for altering the osmotic pressure of cryopreserved white stem cells
US6579219B2 (en) * 2001-04-09 2003-06-17 Medtronic, Inc. Centrifuge bag and methods of use
JP4310433B2 (ja) * 2003-11-28 2009-08-12 独立行政法人産業技術総合研究所 生体材料の前処理方法及び用途
EA018221B1 (ru) 2007-02-09 2013-06-28 Акселерон Фарма Инк. АНТАГОНИСТЫ АКТИВИНА-ActRIIa И ПРИМЕНЕНИЕ ДЛЯ СТИМУЛЯЦИИ РОСТА КОСТИ У БОЛЬНЫХ РАКОМ
EP3763376A1 (en) 2007-02-12 2021-01-13 Celularity, Inc. Treatment of inflammatory diseases using placental stem cells
AU2008298816B2 (en) 2007-09-11 2013-09-26 Sapporo Medical University Cell growth method and pharmaceutical preparation for tissue repair and regeneration
US8465733B2 (en) 2007-11-02 2013-06-18 Jcr Pharmaceuticals Co., Ltd. Pharmaceutical composition containing human mesenchymal stem cell
CA2795627C (en) 2010-04-09 2023-03-14 Fred Hutchinson Cancer Research Center Compositions and methods for providing hematopoietic function without hla matching
US8529883B2 (en) * 2010-05-07 2013-09-10 Fibrocell Technologies, Inc. Dosage unit formulations of autologous dermal fibroblasts
US9982238B2 (en) * 2011-02-09 2018-05-29 Organ Technologies, Inc. Method for producing regenerative organ primordium provided with guide for transplantation, composition containing regenerative organ primordium provided with guide for transplantation produced thereby, and method for transplanting regenerative organ primordium provided with guide for transplantation
CN103906496B (zh) * 2011-09-30 2018-03-06 贝克顿·迪金森公司 流体交换方法与装置
US20130129688A1 (en) * 2011-11-09 2013-05-23 Allocure, Inc. Assay for the Prediction of Therapeutic Effectiveness or Potency of Mesenchymal Stem Cells, and Methods of Using Same
JP5890222B2 (ja) * 2012-03-30 2016-03-22 株式会社ジーシー 培養軟骨組織材料
KR101523040B1 (ko) * 2012-06-26 2015-05-26 라정찬 고농도의 줄기세포 제조방법
JP5802298B2 (ja) * 2014-03-25 2015-10-28 テルモ株式会社 凍結保存細胞からの生細胞の回収方法およびシステム
KR101596581B1 (ko) 2014-06-18 2016-02-23 전세화 조직재생물질 방출 유도형 세포치료제 조성물 및 그의 제조방법
CN108925548A (zh) * 2017-05-24 2018-12-04 西比曼生物科技（香港）有限公司 一种冻存细胞制剂及细胞复苏方式
KR20210041578A (ko) * 2018-07-31 2021-04-15 제이씨알 파마 가부시키가이샤 치수 유래 세포의 제조 방법
CN109045282A (zh) 2018-08-14 2018-12-21 东营凤起生物科技发展有限公司 一种采用脐血干细胞输注联合自体外周血干细胞延缓卵巢早衰和治疗骨质疏松的方法

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004073084A (ja) * 2002-08-19 2004-03-11 Olympus Corp 培養容器および培養装置
US20060212020A1 (en) * 2002-10-10 2006-09-21 Lynne Rainen Sample collection system with caspase inhibitor
US20080199900A1 (en) * 2004-08-04 2008-08-21 Universita' Degli Studi Di Roma "La Spienza" Disposable Device For One Or More Introductions, Treatment And Sampling Of Biological Material From At Least One Of The Separation Phases Present Within The Device, Under Sterility Conditions and Constant Pressure
JP2009511212A (ja) * 2005-10-13 2009-03-19 アルゴス・セラピューティクス・インコーポレーテッド 低温で貯蔵された液体薬剤の送達に適する装置、システム、および関連する方法
JP2012510299A (ja) * 2008-11-28 2012-05-10 テルモ株式会社 血液バッグシステム及びカセット
US20150140656A1 (en) * 2013-11-20 2015-05-21 Cellulis, S.L. Method of freezing cells
WO2016163444A1 (ja) * 2015-04-07 2016-10-13 日産化学工業株式会社 液状の培地組成物の製造方法、およびそのための製造装置とキット
WO2017073656A1 (ja) * 2015-10-27 2017-05-04 株式会社カネカ 間葉系幹細胞を含む細胞集団の製造方法、間葉系幹細胞、細胞集団、並びに医薬組成物

Also Published As

Publication number Publication date
CN115244172A (zh) 2022-10-25
JP7328729B2 (ja) 2023-08-17
TW202204600A (zh) 2022-02-01
EP4130237A1 (en) 2023-02-08
JP7546976B2 (ja) 2024-09-09
JP2024009947A (ja) 2024-01-23
US20230132689A1 (en) 2023-05-04
AU2021245671A1 (en) 2022-10-20
JP7546968B2 (ja) 2024-09-09
WO2021201029A1 (ja) 2021-10-07
CA3172745A1 (en) 2021-10-07
JP2023109846A (ja) 2023-08-08

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