JPWO2021191684A5 - - Google Patents
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- Publication number
- JPWO2021191684A5 JPWO2021191684A5 JP2022558519A JP2022558519A JPWO2021191684A5 JP WO2021191684 A5 JPWO2021191684 A5 JP WO2021191684A5 JP 2022558519 A JP2022558519 A JP 2022558519A JP 2022558519 A JP2022558519 A JP 2022558519A JP WO2021191684 A5 JPWO2021191684 A5 JP WO2021191684A5
- Authority
- JP
- Japan
- Prior art keywords
- kappa light
- antibody
- kma
- composition
- chains
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 13
- 239000011534 wash buffer Substances 0.000 claims 11
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 6
- 239000012562 protein A resin Substances 0.000 claims 6
- 238000005406 washing Methods 0.000 claims 6
- 230000002378 acidificating effect Effects 0.000 claims 5
- 238000001042 affinity chromatography Methods 0.000 claims 4
- 238000003556 assay Methods 0.000 claims 4
- 239000012149 elution buffer Substances 0.000 claims 4
- 230000007935 neutral effect Effects 0.000 claims 4
- 238000003998 size exclusion chromatography high performance liquid chromatography Methods 0.000 claims 4
- 238000004113 cell culture Methods 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 241000699802 Cricetulus griseus Species 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims 2
- 210000001672 ovary Anatomy 0.000 claims 2
- 239000001488 sodium phosphate Substances 0.000 claims 2
- 229910000162 sodium phosphate Inorganic materials 0.000 claims 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims 2
- 238000005277 cation exchange chromatography Methods 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000012930 cell culture fluid Substances 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 239000013628 high molecular weight specie Substances 0.000 claims 1
- 230000002779 inactivation Effects 0.000 claims 1
- 229910000029 sodium carbonate Inorganic materials 0.000 claims 1
- 238000011100 viral filtration Methods 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2020900948A AU2020900948A0 (en) | 2020-03-27 | Composition and method | |
| AU2020900948 | 2020-03-27 | ||
| US202163200752P | 2021-03-25 | 2021-03-25 | |
| US63/200,752 | 2021-03-25 | ||
| PCT/IB2021/000171 WO2021191684A1 (fr) | 2020-03-27 | 2021-03-26 | Composition et procédé |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023518905A JP2023518905A (ja) | 2023-05-08 |
| JPWO2021191684A5 true JPWO2021191684A5 (fr) | 2024-04-04 |
Family
ID=77890984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022558519A Pending JP2023518905A (ja) | 2020-03-27 | 2021-03-26 | 組成物および方法 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP4126900A4 (fr) |
| JP (1) | JP2023518905A (fr) |
| KR (1) | KR20230004543A (fr) |
| CN (1) | CN115551877A (fr) |
| AU (1) | AU2021244846A1 (fr) |
| BR (1) | BR112022019076A2 (fr) |
| CA (1) | CA3176109A1 (fr) |
| WO (1) | WO2021191684A1 (fr) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2513134T3 (en) * | 2009-12-18 | 2017-12-18 | Novartis Ag | Washing solution and process for affinity chromatography |
| WO2016031932A1 (fr) * | 2014-08-27 | 2016-03-03 | 田辺三菱製薬株式会社 | PROCÉDÉ DE PRODUCTION D'UNE PROTÉINE PORTANT UNE RÉGION Fc PAR LAVAGE ALCALIN |
| AU2016233557B2 (en) * | 2015-03-13 | 2021-06-24 | Bristol-Myers Squibb Company | Use of alkaline washes during chromatography to remove impurities |
| JP7229768B2 (ja) * | 2015-04-23 | 2023-02-28 | ヒーマロジックス プロプライエタリー リミテッド | カッパ骨髄腫抗原キメラ抗原受容体およびその使用 |
-
2021
- 2021-03-26 CA CA3176109A patent/CA3176109A1/fr active Pending
- 2021-03-26 KR KR1020227037511A patent/KR20230004543A/ko unknown
- 2021-03-26 BR BR112022019076A patent/BR112022019076A2/pt unknown
- 2021-03-26 EP EP21774251.9A patent/EP4126900A4/fr active Pending
- 2021-03-26 WO PCT/IB2021/000171 patent/WO2021191684A1/fr active Application Filing
- 2021-03-26 CN CN202180023593.1A patent/CN115551877A/zh active Pending
- 2021-03-26 JP JP2022558519A patent/JP2023518905A/ja active Pending
- 2021-03-26 AU AU2021244846A patent/AU2021244846A1/en active Pending
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