JPWO2021174170A5 - - Google Patents
Info
- Publication number
- JPWO2021174170A5 JPWO2021174170A5 JP2022552203A JP2022552203A JPWO2021174170A5 JP WO2021174170 A5 JPWO2021174170 A5 JP WO2021174170A5 JP 2022552203 A JP2022552203 A JP 2022552203A JP 2022552203 A JP2022552203 A JP 2022552203A JP WO2021174170 A5 JPWO2021174170 A5 JP WO2021174170A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- alkyl
- disease
- heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062983537P | 2020-02-28 | 2020-02-28 | |
| US62/983,537 | 2020-02-28 | ||
| US202063007134P | 2020-04-08 | 2020-04-08 | |
| US63/007,134 | 2020-04-08 | ||
| US202063040474P | 2020-06-17 | 2020-06-17 | |
| US63/040,474 | 2020-06-17 | ||
| US202063072781P | 2020-08-31 | 2020-08-31 | |
| US63/072,781 | 2020-08-31 | ||
| US202063126491P | 2020-12-16 | 2020-12-16 | |
| US63/126,491 | 2020-12-16 | ||
| PCT/US2021/020160 WO2021174170A1 (en) | 2020-02-28 | 2021-02-28 | Pyridazine dervatives for modulating nucleic acid splicing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023515617A JP2023515617A (ja) | 2023-04-13 |
| JPWO2021174170A5 true JPWO2021174170A5 (enExample) | 2025-08-06 |
Family
ID=75278334
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022552206A Pending JP2023515618A (ja) | 2020-02-28 | 2021-02-28 | 核酸スプライシングを調節するためのピリダジン誘導体 |
| JP2022552203A Pending JP2023515617A (ja) | 2020-02-28 | 2021-02-28 | 核酸スプライシングを調節するためのピリダジン誘導体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022552206A Pending JP2023515618A (ja) | 2020-02-28 | 2021-02-28 | 核酸スプライシングを調節するためのピリダジン誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20230140983A1 (enExample) |
| EP (2) | EP4110771A1 (enExample) |
| JP (2) | JP2023515618A (enExample) |
| KR (2) | KR20220158236A (enExample) |
| CN (2) | CN115551847A (enExample) |
| AU (3) | AU2021228286A1 (enExample) |
| BR (2) | BR112022017107A2 (enExample) |
| CA (2) | CA3169667A1 (enExample) |
| IL (2) | IL295954A (enExample) |
| MX (2) | MX2022010634A (enExample) |
| WO (2) | WO2021174176A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2020105929A (ru) | 2017-08-04 | 2021-09-06 | Скайхоук Терапьютикс, Инк. | Способы и композиции для модулирования сплайсинга |
| EP3920926A4 (en) | 2019-02-05 | 2022-10-19 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
| JP7603592B2 (ja) * | 2019-02-05 | 2024-12-20 | スカイホーク・セラピューティクス・インコーポレーテッド | スプライシングを調節するための方法および組成物 |
| CN119638696A (zh) | 2019-02-06 | 2025-03-18 | 斯基霍克疗法公司 | 用于调节剪接的方法和组合物 |
| WO2020163544A1 (en) | 2019-02-06 | 2020-08-13 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
| CN116997548A (zh) | 2020-05-13 | 2023-11-03 | Chdi基金会股份有限公司 | 用于治疗亨廷顿病的htt调节剂 |
| US20240368163A1 (en) | 2021-08-30 | 2024-11-07 | Remix Therapeutics Inc. | Compounds and methods for modulating splicing |
| WO2023034836A1 (en) * | 2021-08-30 | 2023-03-09 | Remix Therapeutics Inc. | Compounds and methods for modulating splicing |
| WO2023081857A1 (en) * | 2021-11-04 | 2023-05-11 | Skyhawk Therapeutics, Inc. | Condensed pyridazine amine derivatives treating sca3 |
| US12281116B2 (en) | 2021-11-17 | 2025-04-22 | Chdi Foundation, Inc. | HTT modulators for treating Huntington's disease |
| TW202332434A (zh) * | 2022-01-31 | 2023-08-16 | 瑞士商諾華公司 | 可用作抗癌劑的吡唑基衍生物之合成方法 |
| AU2023246405A1 (en) * | 2022-04-01 | 2024-07-11 | Tyk Medicines (Zhengzhou), Inc. | Compound used as kinase inhibitor and use thereof |
| IL318791A (en) * | 2022-08-22 | 2025-04-01 | Redx Pharma Ltd | Pyridopyrazoles as DDR'S inhibitors for the treatment of lipid disorders and cancer |
| WO2024182747A2 (en) * | 2023-03-01 | 2024-09-06 | Remix Therapeutics Inc. | Compounds and methods for modulating splicing |
| TW202547501A (zh) * | 2024-04-05 | 2025-12-16 | 日商日本新藥股份有限公司 | Ｃｕｇ重複ｒｎａ與ｍｂｎｌ蛋白質之結合阻礙化合物及醫藥 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7160876B2 (en) * | 2003-12-22 | 2007-01-09 | Abbott Laboratories | Fused bicycloheterocycle substituted quinuclidine derivatives |
| JP6092897B2 (ja) | 2012-02-10 | 2017-03-08 | ピーティーシー セラピューティクス， インコーポレイテッド | 脊髄性筋萎縮症を治療するための化合物 |
| US8729263B2 (en) | 2012-08-13 | 2014-05-20 | Novartis Ag | 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions |
| CN105492432B (zh) * | 2013-07-31 | 2019-06-14 | 住友化学株式会社 | 四唑啉酮化合物及其用途 |
| JP6672296B2 (ja) * | 2014-10-31 | 2020-03-25 | ザ ジェネラル ホスピタル コーポレイション | 強力なγ−セクレターゼモジュレータ |
| WO2016128343A1 (en) | 2015-02-09 | 2016-08-18 | F. Hoffmann-La Roche Ag | Compounds for the treatment of cancer |
| EP4249472A3 (en) | 2015-05-30 | 2023-12-13 | PTC Therapeutics, Inc. | Methods for modulating rna splicing |
| CN110946865B (zh) * | 2015-12-10 | 2024-01-26 | Ptc医疗公司 | 用于治疗亨廷顿病的方法 |
| WO2018098446A1 (en) | 2016-11-28 | 2018-05-31 | Ptc Therapeutics, Inc | Methods for modulating rna splicing |
| WO2018140578A1 (en) * | 2017-01-25 | 2018-08-02 | President And Fellows Of Harvard College | Non-fullerene solar panel acceptor compounds |
| BR112019026508A2 (pt) * | 2017-06-14 | 2020-07-14 | Ptc Therapeutics, Inc. | métodos para modificar o splicing do rna |
| RU2020105929A (ru) * | 2017-08-04 | 2021-09-06 | Скайхоук Терапьютикс, Инк. | Способы и композиции для модулирования сплайсинга |
| EP3688187A4 (en) | 2017-09-25 | 2021-09-29 | Skyhawk Therapeutics, Inc. | PROCEDURES AND COMPOSITIONS FOR SCREENING AND IDENTIFYING SPICE MODULATORS |
| US11299481B2 (en) * | 2017-10-20 | 2022-04-12 | Vanderbilt University | Antagonists of the muscarinic acetylcholine receptor M4 |
| JP7352294B2 (ja) * | 2018-02-02 | 2023-09-28 | ヴァンダービルト ユニバーシティー | ムスカリン性アセチルコリン受容体ｍ４のアンタゴニスト |
| US11530207B2 (en) | 2018-04-10 | 2022-12-20 | Skyhawk Therapeutics, Inc. | Compounds for the treatment of cancer |
| TWI823932B (zh) * | 2018-05-11 | 2023-12-01 | 中國大陸商迪哲（江蘇）醫藥有限公司 | 三唑并嘧啶化合物及其在治療癌症中之用途 |
-
2021
- 2021-02-28 CA CA3169667A patent/CA3169667A1/en active Pending
- 2021-02-28 MX MX2022010634A patent/MX2022010634A/es unknown
- 2021-02-28 US US17/802,702 patent/US20230140983A1/en active Pending
- 2021-02-28 WO PCT/US2021/020173 patent/WO2021174176A1/en not_active Ceased
- 2021-02-28 AU AU2021228286A patent/AU2021228286A1/en not_active Abandoned
- 2021-02-28 EP EP21713826.2A patent/EP4110771A1/en active Pending
- 2021-02-28 JP JP2022552206A patent/JP2023515618A/ja active Pending
- 2021-02-28 CA CA3169643A patent/CA3169643A1/en active Pending
- 2021-02-28 CN CN202180030690.3A patent/CN115551847A/zh active Pending
- 2021-02-28 WO PCT/US2021/020160 patent/WO2021174170A1/en not_active Ceased
- 2021-02-28 CN CN202180031321.6A patent/CN115551843A/zh active Pending
- 2021-02-28 AU AU2021228288A patent/AU2021228288A1/en active Pending
- 2021-02-28 BR BR112022017107A patent/BR112022017107A2/pt unknown
- 2021-02-28 JP JP2022552203A patent/JP2023515617A/ja active Pending
- 2021-02-28 US US17/802,747 patent/US20230365526A1/en active Pending
- 2021-02-28 KR KR1020227033654A patent/KR20220158236A/ko active Pending
- 2021-02-28 IL IL295954A patent/IL295954A/en unknown
- 2021-02-28 IL IL295953A patent/IL295953A/en unknown
- 2021-02-28 KR KR1020227033652A patent/KR20220157407A/ko active Pending
- 2021-02-28 EP EP21715355.0A patent/EP4110774A1/en active Pending
- 2021-02-28 MX MX2022010637A patent/MX2022010637A/es unknown
- 2021-02-28 BR BR112022017089A patent/BR112022017089A2/pt unknown
-
2024
- 2024-03-08 AU AU2024201568A patent/AU2024201568A1/en active Pending
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