JPWO2021163170A5 - - Google Patents

Info

Publication number

JPWO2021163170A5

JPWO2021163170A5 JP2022548596A JP2022548596A JPWO2021163170A5 JP WO2021163170 A5 JPWO2021163170 A5 JP WO2021163170A5 JP 2022548596 A JP2022548596 A JP 2022548596A JP 2022548596 A JP2022548596 A JP 2022548596A JP WO2021163170 A5 JPWO2021163170 A5 JP WO2021163170A5

Authority

JP

Japan

Prior art keywords

antigen

antibody

seq

binding fragment

acvr1

Prior art date

2024-02-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 239000012634 fragment Substances 0.000 claims 41
• 239000000427 antigen Substances 0.000 claims 39
• 108091007433 antigens Proteins 0.000 claims 39
• 102000036639 antigens Human genes 0.000 claims 39
• 101000799140 Homo sapiens Activin receptor type-1 Proteins 0.000 claims 31
• 125000003275 alpha amino acid group Chemical group 0.000 claims 29
• 102100034111 Activin receptor type-1 Human genes 0.000 claims 20
• 239000008194 pharmaceutical composition Substances 0.000 claims 12
• 102000054953 human ACVR1 Human genes 0.000 claims 11
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 9
• 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims 6
• 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims 6
• 238000003556 assay Methods 0.000 claims 6
• 229940112869 bone morphogenetic protein Drugs 0.000 claims 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
• 102000040430 polynucleotide Human genes 0.000 claims 6
• 108091033319 polynucleotide Proteins 0.000 claims 6
• 239000002157 polynucleotide Substances 0.000 claims 6
• 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 6
• 102000004169 proteins and genes Human genes 0.000 claims 5
• 108090000623 proteins and genes Proteins 0.000 claims 5
• 101100490443 Mus musculus Acvr1 gene Proteins 0.000 claims 4
• 230000001404 mediated effect Effects 0.000 claims 4
• 238000000034 method Methods 0.000 claims 4
• 108700028369 Alleles Proteins 0.000 claims 3
• 241000699666 Mus <mouse, genus> Species 0.000 claims 3
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• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 208000034970 Heterotopic Ossification Diseases 0.000 claims 2
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• XJOTXKZIRSHZQV-RXHOOSIZSA-N (3S)-3-amino-4-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S,3S)-1-[[(1R,6R,12R,17R,20S,23S,26R,31R,34R,39R,42S,45S,48S,51S,59S)-51-(4-aminobutyl)-31-[[(2S)-6-amino-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-1-oxohexan-2-yl]carbamoyl]-20-benzyl-23-[(2S)-butan-2-yl]-45-(3-carbamimidamidopropyl)-48-(hydroxymethyl)-42-(1H-imidazol-4-ylmethyl)-59-(2-methylsulfanylethyl)-7,10,19,22,25,33,40,43,46,49,52,54,57,60,63,64-hexadecaoxo-3,4,14,15,28,29,36,37-octathia-8,11,18,21,24,32,41,44,47,50,53,55,58,61,62,65-hexadecazatetracyclo[32.19.8.26,17.212,39]pentahexacontan-26-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-oxobutanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](Cc5ccccc5)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1cnc[nH]1)NC3=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N2)C(=O)NCC(=O)N4)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O XJOTXKZIRSHZQV-RXHOOSIZSA-N 0.000 claims 1
• 229940122361 Bisphosphonate Drugs 0.000 claims 1
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• 239000000488 activin Substances 0.000 claims 1
• 108010023082 activin A Proteins 0.000 claims 1
• 239000000556 agonist Substances 0.000 claims 1
• 208000007502 anemia Diseases 0.000 claims 1
• 229940124599 anti-inflammatory drug Drugs 0.000 claims 1
• 150000004663 bisphosphonates Chemical class 0.000 claims 1
• 235000015872 dietary supplement Nutrition 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 102000018511 hepcidin Human genes 0.000 claims 1
• 108060003558 hepcidin Proteins 0.000 claims 1
• 229940066919 hepcidin Drugs 0.000 claims 1
• 230000007941 heterotopic ossification Effects 0.000 claims 1
• 102000046107 human BMP7 Human genes 0.000 claims 1
• 102000053342 human STK36 Human genes 0.000 claims 1
• 239000003112 inhibitor Substances 0.000 claims 1
• 229910052742 iron Inorganic materials 0.000 claims 1
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• 150000003431 steroids Chemical class 0.000 claims 1