JPWO2021158840A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2021158840A5 JPWO2021158840A5 JP2022547846A JP2022547846A JPWO2021158840A5 JP WO2021158840 A5 JPWO2021158840 A5 JP WO2021158840A5 JP 2022547846 A JP2022547846 A JP 2022547846A JP 2022547846 A JP2022547846 A JP 2022547846A JP WO2021158840 A5 JPWO2021158840 A5 JP WO2021158840A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- alkyl
- alkylene
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062970832P | 2020-02-06 | 2020-02-06 | |
| US62/970,832 | 2020-02-06 | ||
| PCT/US2021/016698 WO2021158840A1 (en) | 2020-02-06 | 2021-02-05 | Macrocyclic pad4 inhibitors useful as immunosuppressant |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2023512557A JP2023512557A (ja) | 2023-03-27 |
| JP2023512557A5 JP2023512557A5 (https=) | 2024-02-06 |
| JPWO2021158840A5 true JPWO2021158840A5 (https=) | 2024-02-06 |
| JP7711073B2 JP7711073B2 (ja) | 2025-07-22 |
Family
ID=74798090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022547846A Active JP7711073B2 (ja) | 2020-02-06 | 2021-02-05 | 免疫抑制剤として有用な大環状ｐａｄ４阻害剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12492202B2 (https=) |
| EP (1) | EP4100405A1 (https=) |
| JP (1) | JP7711073B2 (https=) |
| KR (1) | KR20220137694A (https=) |
| CN (1) | CN115298175B (https=) |
| WO (1) | WO2021158840A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4100405A1 (en) | 2020-02-06 | 2022-12-14 | Bristol-Myers Squibb Company | Macrocyclic pad4 inhibitors useful as immunosuppressant |
| TW202140477A (zh) | 2020-02-12 | 2021-11-01 | 美商必治妥美雅史谷比公司 | 雜環ｐａｄ４抑制劑 |
| EP4143189A1 (en) * | 2020-04-30 | 2023-03-08 | Gilead Sciences, Inc. | Macrocyclic inhibitors of peptidylarginine deiminases |
| TW202241884A (zh) | 2020-12-22 | 2022-11-01 | 美商基利科學股份有限公司 | 肽基精胺酸去亞胺酶之抑制劑 |
| WO2022140428A2 (en) | 2020-12-22 | 2022-06-30 | Gilead Sciences, Inc. | Inhibitors of peptidylarginine deiminases |
| WO2025024265A1 (en) | 2023-07-21 | 2025-01-30 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad4 modulators |
| WO2026020127A2 (en) | 2024-07-19 | 2026-01-22 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad2 modulators |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS55684B1 (sr) * | 2012-07-26 | 2017-07-31 | Glaxo Group Ltd | 2-(azaindol-2-il)benzimidazoli kao pad4 inhibitori |
| US10407407B2 (en) * | 2015-05-21 | 2019-09-10 | Glaxosmithkline Intellectual Property Development Limited | Benzoimidazole derivatives as PAD4 inhibitors |
| AR107030A1 (es) | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores aza-bencimidazol de pad4 |
| AR107032A1 (es) * | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores bicíclicos de pad4 |
| JP6926126B2 (ja) | 2016-02-23 | 2021-08-25 | パドロック・セラピューティクス・インコーポレイテッドＰａｄｌｏｃｋ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | Ｐａｄ４のヘテロアリール阻害剤 |
| KR102398941B1 (ko) * | 2016-07-27 | 2022-05-17 | 패들락 테라퓨틱스, 인코포레이티드 | Pad4의 공유결합성 억제제 |
| JP7118951B2 (ja) | 2016-09-12 | 2022-08-16 | パドロック・セラピューティクス・インコーポレイテッド | Ｐａｄ４のヘテロアリール阻害剤 |
| CN112789087B (zh) | 2018-08-08 | 2024-08-13 | 百时美施贵宝公司 | Pad酶的苯并咪唑抑制剂 |
| AU2019319835A1 (en) | 2018-08-08 | 2021-03-25 | Bristol-Myers Squibb Company | Indole and azaindole inhibitors of PAD enzymes |
| EP3833671B1 (en) | 2018-08-08 | 2022-08-24 | Bristol-Myers Squibb Company | Substituted thienopyrroles as pad4 inhibitors |
| WO2020033488A1 (en) | 2018-08-08 | 2020-02-13 | Bristol-Myers Squibb Company | Substituted benzimidazoles as pad4 inhibitors |
| EP4100405A1 (en) | 2020-02-06 | 2022-12-14 | Bristol-Myers Squibb Company | Macrocyclic pad4 inhibitors useful as immunosuppressant |
| TW202140477A (zh) | 2020-02-12 | 2021-11-01 | 美商必治妥美雅史谷比公司 | 雜環ｐａｄ４抑制劑 |
-
2021
- 2021-02-05 EP EP21708867.3A patent/EP4100405A1/en active Pending
- 2021-02-05 KR KR1020227030292A patent/KR20220137694A/ko active Pending
- 2021-02-05 CN CN202180022507.5A patent/CN115298175B/zh active Active
- 2021-02-05 WO PCT/US2021/016698 patent/WO2021158840A1/en not_active Ceased
- 2021-02-05 US US17/760,309 patent/US12492202B2/en active Active
- 2021-02-05 JP JP2022547846A patent/JP7711073B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021534108A5 (https=) | ||
| JP2021534106A5 (https=) | ||
| JP2021534097A5 (https=) | ||
| RU97105381A (ru) | Соединения и способы для лечения рака | |
| KR970705393A (ko) | 암 치료를 위한 화합물 및 방법(compounds and methods for the treatment of cancer) | |
| GB2607514A (en) | Functionalized peptides as antiviral agents | |
| JP2003515601A5 (https=) | ||
| JP2020122016A5 (https=) | ||
| JP2021532109A5 (https=) | ||
| JP2012505235A5 (https=) | ||
| JP2009543802A5 (https=) | ||
| JP2001514167A5 (https=) | ||
| JP2005525315A5 (https=) | ||
| JP2001526222A5 (https=) | ||
| JP2005500311A5 (https=) | ||
| JPWO2021158840A5 (https=) | ||
| JP2005505499A5 (https=) | ||
| JP2002525329A5 (https=) | ||
| RU95121694A (ru) | Применение аналогов ацилфульвена и фармацевтическая композиция на их основе | |
| JP2006514960A5 (https=) | ||
| JPWO2020033520A5 (https=) | ||
| JPWO2022235822A5 (https=) | ||
| JP2007505044A5 (https=) | ||
| JPWO2020023560A5 (https=) | ||
| JPWO2019168999A5 (https=) |