JPWO2021127214A5 - - Google Patents
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- Publication number
- JPWO2021127214A5 JPWO2021127214A5 JP2022537683A JP2022537683A JPWO2021127214A5 JP WO2021127214 A5 JPWO2021127214 A5 JP WO2021127214A5 JP 2022537683 A JP2022537683 A JP 2022537683A JP 2022537683 A JP2022537683 A JP 2022537683A JP WO2021127214 A5 JPWO2021127214 A5 JP WO2021127214A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- salt
- preparing
- converted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 136
- 238000000034 method Methods 0.000 claims 50
- 150000003839 salts Chemical class 0.000 claims 36
- 239000002904 solvent Substances 0.000 claims 13
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 8
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 6
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 6
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 6
- 230000008878 coupling Effects 0.000 claims 6
- 238000010168 coupling process Methods 0.000 claims 6
- 238000005859 coupling reaction Methods 0.000 claims 6
- 239000003054 catalyst Substances 0.000 claims 4
- 208000037262 Hepatitis delta Diseases 0.000 claims 3
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 claims 3
- 229940126214 compound 3 Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 208000029570 hepatitis D virus infection Diseases 0.000 claims 3
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 claims 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims 2
- 125000006242 amine protecting group Chemical group 0.000 claims 2
- 150000008064 anhydrides Chemical class 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000000368 destabilizing effect Effects 0.000 claims 2
- VFRSADQPWYCXDG-LEUCUCNGSA-N ethyl (2s,5s)-5-methylpyrrolidine-2-carboxylate;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CCOC(=O)[C@@H]1CC[C@H](C)N1 VFRSADQPWYCXDG-LEUCUCNGSA-N 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims 2
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims 2
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- HSDAJNMJOMSNEV-UHFFFAOYSA-N benzyl chloroformate Chemical compound ClC(=O)OCC1=CC=CC=C1 HSDAJNMJOMSNEV-UHFFFAOYSA-N 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 210000000234 capsid Anatomy 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 238000011097 chromatography purification Methods 0.000 claims 1
- 238000004440 column chromatography Methods 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- -1 nitrobenzyloxycarbonyl Chemical group 0.000 claims 1
- 229910000027 potassium carbonate Inorganic materials 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962951836P | 2019-12-20 | 2019-12-20 | |
US62/951,836 | 2019-12-20 | ||
PCT/US2020/065666 WO2021127214A1 (en) | 2019-12-20 | 2020-12-17 | Synthetic processes and intermediates |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2023510109A JP2023510109A (ja) | 2023-03-13 |
JPWO2021127214A5 true JPWO2021127214A5 (pt) | 2023-12-25 |
Family
ID=76478539
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2022537683A Pending JP2023510109A (ja) | 2019-12-20 | 2020-12-17 | 合成プロセス及び中間体 |
Country Status (12)
Country | Link |
---|---|
US (1) | US20230113948A1 (pt) |
EP (1) | EP4077473A4 (pt) |
JP (1) | JP2023510109A (pt) |
KR (1) | KR20220119052A (pt) |
CN (1) | CN114846051A (pt) |
AU (1) | AU2020408039A1 (pt) |
BR (1) | BR112022012226A2 (pt) |
CA (1) | CA3165101A1 (pt) |
IL (1) | IL294064A (pt) |
MX (1) | MX2022007738A (pt) |
TW (1) | TW202136227A (pt) |
WO (1) | WO2021127214A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023143374A1 (zh) * | 2022-01-30 | 2023-08-03 | 成都凌泰氪生物技术有限公司 | 一种配体、其制备方法及应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0505969D0 (en) * | 2005-03-23 | 2005-04-27 | Novartis Ag | Organic compounds |
JP2014512364A (ja) * | 2011-04-07 | 2014-05-22 | コーネル ユニバーシティー | 水溶液中で二量体化できる単量体、およびその使用法 |
MA45478A (fr) * | 2016-04-11 | 2019-02-20 | Arbutus Biopharma Corp | Compositions de conjugués d'acides nucléiques ciblés |
CA3059426A1 (en) * | 2017-04-11 | 2018-10-18 | Arbutus Biopharma Corporation | Targeted compositions |
KR20210120988A (ko) * | 2018-11-02 | 2021-10-07 | 제네반트 사이언시즈 게엠베하 | 치료 방법 |
-
2020
- 2020-12-17 WO PCT/US2020/065666 patent/WO2021127214A1/en unknown
- 2020-12-17 CN CN202080089979.8A patent/CN114846051A/zh active Pending
- 2020-12-17 EP EP20903872.8A patent/EP4077473A4/en active Pending
- 2020-12-17 AU AU2020408039A patent/AU2020408039A1/en active Pending
- 2020-12-17 IL IL294064A patent/IL294064A/en unknown
- 2020-12-17 US US17/787,089 patent/US20230113948A1/en active Pending
- 2020-12-17 CA CA3165101A patent/CA3165101A1/en active Pending
- 2020-12-17 KR KR1020227022805A patent/KR20220119052A/ko unknown
- 2020-12-17 BR BR112022012226A patent/BR112022012226A2/pt unknown
- 2020-12-17 MX MX2022007738A patent/MX2022007738A/es unknown
- 2020-12-17 JP JP2022537683A patent/JP2023510109A/ja active Pending
- 2020-12-18 TW TW109145121A patent/TW202136227A/zh unknown
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