JPWO2021112235A5 - - Google Patents

Info

Publication number

JPWO2021112235A5

JPWO2021112235A5 JP2021562750A JP2021562750A JPWO2021112235A5 JP WO2021112235 A5 JPWO2021112235 A5 JP WO2021112235A5 JP 2021562750 A JP2021562750 A JP 2021562750A JP 2021562750 A JP2021562750 A JP 2021562750A JP WO2021112235 A5 JPWO2021112235 A5 JP WO2021112235A5

Authority

JP

Japan

Prior art keywords

peptide

adrenomedullin

amino acid

acid sequence

group

Prior art date

2020-12-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 108090000765 processed proteins & peptides Proteins 0.000 claims 38
• ULCUCJFASIJEOE-NPECTJMMSA-N adrenomedullin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCC(=O)N[C@@H]1C(N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CSSC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)[C@@H](C)O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 ULCUCJFASIJEOE-NPECTJMMSA-N 0.000 claims 24
• 102000004379 Adrenomedullin Human genes 0.000 claims 19
• 101800004616 Adrenomedullin Proteins 0.000 claims 19
• 125000003275 alpha amino acid group Chemical group 0.000 claims 19
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 14
• 239000003814 drug Substances 0.000 claims 5
• 230000000694 effects Effects 0.000 claims 4
• 102000004196 processed proteins & peptides Human genes 0.000 claims 4
• 150000003839 salts Chemical class 0.000 claims 4
• 239000012453 solvate Substances 0.000 claims 4
• 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 3
• 125000005647 linker group Chemical group 0.000 claims 3
• 230000004048 modification Effects 0.000 claims 3
• 238000012986 modification Methods 0.000 claims 3
• 239000002202 Polyethylene glycol Substances 0.000 claims 2
• 125000000539 amino acid group Chemical group 0.000 claims 2
• 150000001875 compounds Chemical class 0.000 claims 2
• 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims 2
• 125000003827 glycol group Chemical group 0.000 claims 2
• 229920001223 polyethylene glycol Polymers 0.000 claims 2
• 108060003951 Immunoglobulin Proteins 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 125000003277 amino group Chemical group 0.000 claims 1
• 229910052799 carbon Inorganic materials 0.000 claims 1
• 125000004432 carbon atom Chemical group C* 0.000 claims 1
• 102000018358 immunoglobulin Human genes 0.000 claims 1
• 208000017169 kidney disease Diseases 0.000 claims 1
• 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 1
• 229910052757 nitrogen Inorganic materials 0.000 claims 1
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 1