JPWO2021055849A5 - - Google Patents
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- Publication number
- JPWO2021055849A5 JPWO2021055849A5 JP2022518190A JP2022518190A JPWO2021055849A5 JP WO2021055849 A5 JPWO2021055849 A5 JP WO2021055849A5 JP 2022518190 A JP2022518190 A JP 2022518190A JP 2022518190 A JP2022518190 A JP 2022518190A JP WO2021055849 A5 JPWO2021055849 A5 JP WO2021055849A5
- Authority
- JP
- Japan
- Prior art keywords
- glycero
- alkyl
- compound according
- phosphocholine
- peg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962902928P | 2019-09-19 | 2019-09-19 | |
| US62/902,928 | 2019-09-19 | ||
| PCT/US2020/051629 WO2021055849A1 (fr) | 2019-09-19 | 2020-09-18 | Composés lipidiques à têtes polaires et compositions pour administration intracellulaire d'agents thérapeutiques |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022548312A JP2022548312A (ja) | 2022-11-17 |
| JPWO2021055849A5 true JPWO2021055849A5 (fr) | 2023-09-26 |
Family
ID=72840615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022518190A Pending JP2022548312A (ja) | 2019-09-19 | 2020-09-18 | 治療剤の細胞内送達のための頭部基脂質化合物及び組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230000773A1 (fr) |
| EP (1) | EP4031527A1 (fr) |
| JP (1) | JP2022548312A (fr) |
| KR (1) | KR20220103923A (fr) |
| CN (1) | CN114746398A (fr) |
| AU (1) | AU2020351225A1 (fr) |
| BR (1) | BR112022004771A2 (fr) |
| CA (1) | CA3154720A1 (fr) |
| IL (1) | IL291375A (fr) |
| MX (1) | MX2022003402A (fr) |
| WO (1) | WO2021055849A1 (fr) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018234828A1 (en) | 2017-03-15 | 2019-09-19 | Modernatx, Inc. | Lipid nanoparticle formulation |
| MX2020013236A (es) | 2018-06-06 | 2021-02-22 | Massachusetts Inst Technology | Acido ribonucleico (arn) circular para traduccion en celulas eucariotas. |
| BR112021023411A2 (pt) | 2019-05-22 | 2022-02-01 | Massachusetts Inst Technology | Composições e métodos de rna circular |
| EP4031524A1 (fr) | 2019-09-19 | 2022-07-27 | ModernaTX, Inc. | Composés lipidiques de queue ramifiés et compositions pour l'administration intracellulaire d'agents thérapeutiques |
| AU2020397956A1 (en) | 2019-12-04 | 2022-07-07 | Orna Therapeutics, Inc. | Circular RNA compositions and methods |
| CA3200234A1 (fr) | 2020-11-25 | 2022-06-02 | Daryl C. Drummond | Nanoparticules lipidiques utilisees pour l'administration d'acides nucleiques, et methodes d'utilisation associees |
| AR125204A1 (es) * | 2021-03-24 | 2023-06-21 | Modernatx Inc | Compuestos de lípidos de cola ramificada y composiciones para la administración intracelular de agentes terapéuticos |
| CN114149337B (zh) * | 2021-07-07 | 2022-04-29 | 天津键凯科技有限公司 | 一种用于核酸递送的新型可电离脂质及其lnp组合物 |
| WO2023018773A1 (fr) * | 2021-08-11 | 2023-02-16 | Modernatx, Inc. | Formulations de nanoparticules lipidiques et leurs méthodes de synthèse |
| CN113461577B (zh) * | 2021-09-01 | 2021-12-14 | 中山大学附属第七医院(深圳) | 一种氨基脂质及其应用 |
| AU2022336209A1 (en) | 2021-09-03 | 2024-01-18 | CureVac SE | Novel lipid nanoparticles for delivery of nucleic acids |
| WO2023073228A1 (fr) | 2021-10-29 | 2023-05-04 | CureVac SE | Arn circulaire amélioré pour exprimer des protéines thérapeutiques |
| AR127892A1 (es) | 2021-12-10 | 2024-03-06 | Modernatx Inc | Compuestos y composiciones para la administración de agentes terapéuticos |
| WO2023144330A1 (fr) | 2022-01-28 | 2023-08-03 | CureVac SE | Inhibiteurs de facteurs de transcription codés par un acide nucleique |
| WO2023154818A1 (fr) | 2022-02-09 | 2023-08-17 | Modernatx, Inc. | Méthodes et formulations d'administration par voie muqueuse |
| CN116813493A (zh) * | 2022-03-21 | 2023-09-29 | 苏州科锐迈德生物医药科技有限公司 | 一种脂质化合物及基于其的脂质载体、核酸脂质纳米粒组合物和药物制剂 |
| KR102560772B1 (ko) * | 2022-03-21 | 2023-07-28 | 주식회사 메디치바이오 | 신규한 이온화지질 및 이를 이용한 지질나노입자 조성물 |
| CN117396537A (zh) * | 2022-04-12 | 2024-01-12 | 厦门赛诺邦格生物科技股份有限公司 | 一种非线性聚乙二醇化脂质及其应用 |
| WO2023227608A1 (fr) | 2022-05-25 | 2023-11-30 | Glaxosmithkline Biologicals Sa | Vaccin à base d'acide nucléique codant pour un polypeptide antigénique fimh d'escherichia coli |
| CN115232128B (zh) * | 2022-08-15 | 2024-03-29 | 中国科学技术大学 | 一种咪唑并吡啶基脂质化合物及其制备方法与应用 |
| CN115557875A (zh) * | 2022-08-19 | 2023-01-03 | 上海耐澄生物科技有限公司 | 一种脂质化合物及脂质纳米颗粒 |
| WO2024089638A1 (fr) | 2022-10-28 | 2024-05-02 | Glaxosmithkline Biologicals Sa | Vaccin à base d'acide nucléique |
| WO2024123978A1 (fr) | 2022-12-08 | 2024-06-13 | Modernatx, Inc. | Lipides ionisables avec des queues de malonate |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102384791B1 (ko) * | 2012-02-24 | 2022-04-08 | 아뷰터스 바이오파마 코포레이션 | 트리알킬 양이온성 지질 및 그의 사용 방법 |
| CN110974981A (zh) * | 2013-07-23 | 2020-04-10 | 野草莓树生物制药公司 | 用于递送信使rna的组合物和方法 |
| JP2018527003A (ja) | 2015-09-17 | 2018-09-20 | モデルナティエックス インコーポレイテッドＭｏｄｅｒｎａＴＸ，Ｉｎｃ． | 安定化尾部領域を含むポリヌクレオチド |
| HRP20220156T1 (hr) * | 2015-09-17 | 2022-04-15 | Modernatx, Inc. | Spojevi i pripravci za unutarstaničnu isporuku terapeutskih sredstava |
| AU2016336344A1 (en) | 2015-10-05 | 2018-04-19 | Modernatx, Inc. | Methods for therapeutic administration of messenger ribonucleic acid drugs |
| KR20190132405A (ko) * | 2017-03-15 | 2019-11-27 | 모더나티엑스, 인크. | 치료제의 세포내 전달을 위한 화합물 및 조성물 |
| EP3746052A1 (fr) * | 2018-01-30 | 2020-12-09 | Modernatx, Inc. | Compositions et procédés destinés à l'administration d'agents à des cellules immunitaires |
| WO2020061367A1 (fr) * | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | Composés et compositions pour l'administration intracellulaire d'agents thérapeutiques |
-
2020
- 2020-09-18 MX MX2022003402A patent/MX2022003402A/es unknown
- 2020-09-18 JP JP2022518190A patent/JP2022548312A/ja active Pending
- 2020-09-18 BR BR112022004771A patent/BR112022004771A2/pt not_active Application Discontinuation
- 2020-09-18 CN CN202080080284.3A patent/CN114746398A/zh active Pending
- 2020-09-18 CA CA3154720A patent/CA3154720A1/fr active Pending
- 2020-09-18 WO PCT/US2020/051629 patent/WO2021055849A1/fr unknown
- 2020-09-18 EP EP20790094.5A patent/EP4031527A1/fr active Pending
- 2020-09-18 KR KR1020227012687A patent/KR20220103923A/ko unknown
- 2020-09-18 US US17/761,863 patent/US20230000773A1/en active Pending
- 2020-09-18 AU AU2020351225A patent/AU2020351225A1/en active Pending
-
2022
- 2022-03-15 IL IL291375A patent/IL291375A/en unknown
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