JPWO2021046653A5 - - Google Patents

Info

Publication number

JPWO2021046653A5

JPWO2021046653A5 JP2022516107A JP2022516107A JPWO2021046653A5 JP WO2021046653 A5 JPWO2021046653 A5 JP WO2021046653A5 JP 2022516107 A JP2022516107 A JP 2022516107A JP 2022516107 A JP2022516107 A JP 2022516107A JP WO2021046653 A5 JPWO2021046653 A5 JP WO2021046653A5

Authority

JP

Japan

Prior art keywords

amino acid

acid sequence

seq

antibody

polypeptide

Prior art date

2023-09-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 125000003275 alpha amino acid group Chemical group 0.000 claims description 211
• 229920001184 polypeptide Polymers 0.000 claims description 94
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 94
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 94
• 210000004027 cell Anatomy 0.000 claims description 61
• 238000000034 method Methods 0.000 claims description 58
• 239000000427 antigen Substances 0.000 claims description 57
• 108091007433 antigens Proteins 0.000 claims description 57
• 102000036639 antigens Human genes 0.000 claims description 57
• 241000700618 Vaccinia virus Species 0.000 claims description 50
• 108020001507 fusion proteins Proteins 0.000 claims description 29
• 102000037865 fusion proteins Human genes 0.000 claims description 29
• 239000008194 pharmaceutical composition Substances 0.000 claims description 29
• 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 28
• 206010028980 Neoplasm Diseases 0.000 claims description 26
• 201000011510 cancer Diseases 0.000 claims description 26
• 102000039446 nucleic acids Human genes 0.000 claims description 20
• 108020004707 nucleic acids Proteins 0.000 claims description 20
• 150000007523 nucleic acids Chemical class 0.000 claims description 20
• 101710160107 Outer membrane protein A Proteins 0.000 claims description 18
• 210000002865 immune cell Anatomy 0.000 claims description 12
• 239000003795 chemical substances by application Substances 0.000 claims description 11
• 210000001744 T-lymphocyte Anatomy 0.000 claims description 9
• 239000013604 expression vector Substances 0.000 claims description 8
• 239000003937 drug carrier Substances 0.000 claims description 7
• 210000002540 macrophage Anatomy 0.000 claims description 5
• 239000012642 immune effector Substances 0.000 claims description 4
• 229940121354 immunomodulator Drugs 0.000 claims description 4
• 230000004936 stimulating effect Effects 0.000 claims description 4
• 239000002246 antineoplastic agent Substances 0.000 claims description 3
• 229940127089 cytotoxic agent Drugs 0.000 claims description 3
• 230000004068 intracellular signaling Effects 0.000 claims description 3
• 230000001225 therapeutic effect Effects 0.000 claims description 3
• 239000003053 toxin Substances 0.000 claims description 3
• 231100000765 toxin Toxicity 0.000 claims description 3
• 108700012359 toxins Proteins 0.000 claims description 3
• 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 2
• 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 2
• 101900337606 Vaccinia virus Protein B5 Proteins 0.000 claims description 2
• 238000012258 culturing Methods 0.000 claims description 2
• 239000003814 drug Substances 0.000 claims description 2
• 229940079593 drug Drugs 0.000 claims description 2
• 210000000822 natural killer cell Anatomy 0.000 claims description 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 244000309459 oncolytic virus Species 0.000 description 45
• 241000700584 Simplexvirus Species 0.000 description 5
• 239000012216 imaging agent Substances 0.000 description 5
• 238000011503 in vivo imaging Methods 0.000 description 5
• 241000711404 Avian avulavirus 1 Species 0.000 description 3
• 241000991587 Enterovirus C Species 0.000 description 3
• 241001372913 Maraba virus Species 0.000 description 3
• 241000712079 Measles morbillivirus Species 0.000 description 3
• 241001183012 Modified Vaccinia Ankara virus Species 0.000 description 3
• 241000702263 Reovirus sp. Species 0.000 description 3
• 241000837158 Senecavirus A Species 0.000 description 3
• 241000711975 Vesicular stomatitis virus Species 0.000 description 3
• 230000008685 targeting Effects 0.000 description 3
• 241000701161 unidentified adenovirus Species 0.000 description 3
• 102000005600 Cathepsins Human genes 0.000 description 2
• 108010084457 Cathepsins Proteins 0.000 description 2
• 241000709687 Coxsackievirus Species 0.000 description 2
• 108091005804 Peptidases Proteins 0.000 description 2
• 239000004365 Protease Substances 0.000 description 2
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 2
• 239000002552 dosage form Substances 0.000 description 2
• 230000002132 lysosomal effect Effects 0.000 description 2
• 229940012957 plasmin Drugs 0.000 description 2
• 238000003384 imaging method Methods 0.000 description 1
• 230000002285 radioactive effect Effects 0.000 description 1
• QCWXUUIWCKQGHC-YPZZEJLDSA-N zirconium-89 Chemical compound [89Zr] QCWXUUIWCKQGHC-YPZZEJLDSA-N 0.000 description 1