JPWO2021041392A5 - - Google Patents

Info

Publication number

JPWO2021041392A5

JPWO2021041392A5 JP2022513571A JP2022513571A JPWO2021041392A5 JP WO2021041392 A5 JPWO2021041392 A5 JP WO2021041392A5 JP 2022513571 A JP2022513571 A JP 2022513571A JP 2022513571 A JP2022513571 A JP 2022513571A JP WO2021041392 A5 JPWO2021041392 A5 JP WO2021041392A5

Authority

JP

Japan

Prior art keywords

compound

pharmaceutical composition

salt

alkyl

formula

Prior art date

2023-09-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 150000001875 compounds Chemical class 0.000 claims 18
• 150000003839 salts Chemical class 0.000 claims 16
• 239000008194 pharmaceutical composition Substances 0.000 claims 15
• 125000000217 alkyl group Chemical group 0.000 claims 6
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 5
• 208000023275 Autoimmune disease Diseases 0.000 claims 4
• 208000026935 allergic disease Diseases 0.000 claims 4
• 230000000172 allergic effect Effects 0.000 claims 4
• 208000027866 inflammatory disease Diseases 0.000 claims 4
• 230000002757 inflammatory effect Effects 0.000 claims 4
• 125000004093 cyano group Chemical group *C#N 0.000 claims 3
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
• 229910052736 halogen Inorganic materials 0.000 claims 3
• 125000005843 halogen group Chemical group 0.000 claims 3
• 229910052739 hydrogen Inorganic materials 0.000 claims 3
• 239000001257 hydrogen Substances 0.000 claims 3
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
• 206010012434 Dermatitis allergic Diseases 0.000 claims 2
• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
• 239000003889 eye drop Substances 0.000 claims 2
• 229940012356 eye drops Drugs 0.000 claims 2
• 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 2
• 150000002431 hydrogen Chemical class 0.000 claims 2
• 244000144972 livestock Species 0.000 claims 2
• 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 2
• 125000006661 (C4-C6) heterocyclic group Chemical group 0.000 claims 1
• 208000004232 Enteritis Diseases 0.000 claims 1
• 101000997832 Homo sapiens Tyrosine-protein kinase JAK2 Proteins 0.000 claims 1
• 101000934996 Homo sapiens Tyrosine-protein kinase JAK3 Proteins 0.000 claims 1
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
• 206010020751 Hypersensitivity Diseases 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 208000003251 Pruritus Diseases 0.000 claims 1
• 201000004681 Psoriasis Diseases 0.000 claims 1
• 102100033444 Tyrosine-protein kinase JAK2 Human genes 0.000 claims 1
• 102100025387 Tyrosine-protein kinase JAK3 Human genes 0.000 claims 1
• 239000000443 aerosol Substances 0.000 claims 1
• 208000030961 allergic reaction Diseases 0.000 claims 1
• 206010003246 arthritis Diseases 0.000 claims 1
• 208000006673 asthma Diseases 0.000 claims 1
• 201000008937 atopic dermatitis Diseases 0.000 claims 1
• 208000010668 atopic eczema Diseases 0.000 claims 1
• 125000002393 azetidinyl group Chemical group 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 239000002775 capsule Substances 0.000 claims 1
• 239000006071 cream Substances 0.000 claims 1
• 125000000753 cycloalkyl group Chemical group 0.000 claims 1
• 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• 208000030533 eye disease Diseases 0.000 claims 1
• 239000000499 gel Substances 0.000 claims 1
• 125000005842 heteroatom Chemical group 0.000 claims 1
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 125000002757 morpholinyl group Chemical group 0.000 claims 1
• 230000004770 neurodegeneration Effects 0.000 claims 1
• 208000015122 neurodegenerative disease Diseases 0.000 claims 1
• 230000000414 obstructive effect Effects 0.000 claims 1
• 229910052760 oxygen Inorganic materials 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
• 239000006187 pill Substances 0.000 claims 1
• 125000004193 piperazinyl group Chemical group 0.000 claims 1
• 125000003386 piperidinyl group Chemical group 0.000 claims 1
• 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
• 208000023504 respiratory system disease Diseases 0.000 claims 1
• 208000017520 skin disease Diseases 0.000 claims 1
• 239000007921 spray Substances 0.000 claims 1
• 229910052717 sulfur Inorganic materials 0.000 claims 1
• 239000006188 syrup Substances 0.000 claims 1
• 235000020357 syrup Nutrition 0.000 claims 1
• 239000003826 tablet Substances 0.000 claims 1
• 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
• 125000003507 tetrahydrothiofenyl group Chemical group 0.000 claims 1
• 125000004568 thiomorpholinyl group Chemical group 0.000 claims 1
• -1 transdermal patch Substances 0.000 claims 1