JP7671738B2 - Ｊａｋ１阻害剤として有用な置換（７ｈ－ピロロ［２，３－ｄ］ピリミジン－４－イル）アミノ化合物 - Google Patents
Ｊａｋ１阻害剤として有用な置換（７ｈ－ピロロ［２，３－ｄ］ピリミジン－４－イル）アミノ化合物 Download PDFInfo
- Publication number
- JP7671738B2 JP7671738B2 JP2022513571A JP2022513571A JP7671738B2 JP 7671738 B2 JP7671738 B2 JP 7671738B2 JP 2022513571 A JP2022513571 A JP 2022513571A JP 2022513571 A JP2022513571 A JP 2022513571A JP 7671738 B2 JP7671738 B2 JP 7671738B2
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- JP
- Japan
- Prior art keywords
- compound
- alkyl
- pharmaceutical composition
- formula
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962891706P | 2019-08-26 | 2019-08-26 | |
| US62/891,706 | 2019-08-26 | ||
| PCT/US2020/047767 WO2021041392A1 (en) | 2019-08-26 | 2020-08-25 | Substituted (7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino compounds useful as jak1 inhibitors |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022545836A JP2022545836A (ja) | 2022-10-31 |
| JP2022545836A5 JP2022545836A5 (https=) | 2023-09-06 |
| JPWO2021041392A5 JPWO2021041392A5 (https=) | 2023-09-06 |
| JP7671738B2 true JP7671738B2 (ja) | 2025-05-02 |
Family
ID=74685810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022513571A Active JP7671738B2 (ja) | 2019-08-26 | 2020-08-25 | Ｊａｋ１阻害剤として有用な置換（７ｈ－ピロロ［２，３－ｄ］ピリミジン－４－イル）アミノ化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US12492204B2 (https=) |
| EP (1) | EP4021452B1 (https=) |
| JP (1) | JP7671738B2 (https=) |
| CN (1) | CN114761011B (https=) |
| AU (1) | AU2020338043B2 (https=) |
| CA (1) | CA3152021A1 (https=) |
| ES (1) | ES2974946T3 (https=) |
| PL (1) | PL4021452T3 (https=) |
| WO (1) | WO2021041392A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2020338043B2 (en) * | 2019-08-26 | 2025-12-18 | Chemwerth, Inc. | Substituted (7H-pyrrolo[2,3-D]pyrimidin-4-yl)amino compounds useful as JAK1 inhibitors |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013508266A (ja) | 2009-10-15 | 2013-03-07 | ファイザー・インク | ピロロ［２，３−ｄ］ピリミジン化合物 |
| JP2015500845A (ja) | 2011-12-21 | 2015-01-08 | ジエンス ヘンルイ メデイシンカンパニー リミテッドＪｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．，Ｌｔｄ． | ピロール−６員ヘテロアリール環誘導体、その合成法およびその医薬用途 |
| JP2019505547A (ja) | 2016-02-16 | 2019-02-28 | ゾエティス・サービシーズ・エルエルシー | ７Ｈ−ピロロ［２，３−ｄ］ピリミジン化合物の調製方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101667822B1 (ko) * | 2008-04-30 | 2016-10-19 | 내셔날 헬스 리서치 인스티튜트 | 오로라 키나아제 저해제용 접합 2고리 피리미딘 화합물 |
| JP6944496B2 (ja) | 2018-10-22 | 2021-10-06 | ファイザー・インク | ピロロ［２，３−ｄ］ピリミジントシル酸塩、その結晶形態、ならびにその製造方法および中間体 |
| AU2020338043B2 (en) * | 2019-08-26 | 2025-12-18 | Chemwerth, Inc. | Substituted (7H-pyrrolo[2,3-D]pyrimidin-4-yl)amino compounds useful as JAK1 inhibitors |
-
2020
- 2020-08-25 AU AU2020338043A patent/AU2020338043B2/en active Active
- 2020-08-25 CN CN202080074639.8A patent/CN114761011B/zh active Active
- 2020-08-25 PL PL20858240.3T patent/PL4021452T3/pl unknown
- 2020-08-25 CA CA3152021A patent/CA3152021A1/en active Pending
- 2020-08-25 JP JP2022513571A patent/JP7671738B2/ja active Active
- 2020-08-25 EP EP20858240.3A patent/EP4021452B1/en active Active
- 2020-08-25 ES ES20858240T patent/ES2974946T3/es active Active
- 2020-08-25 US US17/638,074 patent/US12492204B2/en active Active
- 2020-08-25 WO PCT/US2020/047767 patent/WO2021041392A1/en not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013508266A (ja) | 2009-10-15 | 2013-03-07 | ファイザー・インク | ピロロ［２，３−ｄ］ピリミジン化合物 |
| JP2015500845A (ja) | 2011-12-21 | 2015-01-08 | ジエンス ヘンルイ メデイシンカンパニー リミテッドＪｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．，Ｌｔｄ． | ピロール−６員ヘテロアリール環誘導体、その合成法およびその医薬用途 |
| JP2019505547A (ja) | 2016-02-16 | 2019-02-28 | ゾエティス・サービシーズ・エルエルシー | ７Ｈ−ピロロ［２，３−ｄ］ピリミジン化合物の調製方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| PL4021452T3 (pl) | 2024-05-06 |
| AU2020338043A1 (en) | 2022-03-31 |
| US20220274992A1 (en) | 2022-09-01 |
| US12492204B2 (en) | 2025-12-09 |
| AU2020338043B2 (en) | 2025-12-18 |
| WO2021041392A1 (en) | 2021-03-04 |
| JP2022545836A (ja) | 2022-10-31 |
| ES2974946T3 (es) | 2024-07-02 |
| CN114761011A (zh) | 2022-07-15 |
| EP4021452A1 (en) | 2022-07-06 |
| CN114761011B (zh) | 2024-06-14 |
| CA3152021A1 (en) | 2021-03-04 |
| EP4021452A4 (en) | 2023-01-04 |
| EP4021452B1 (en) | 2023-12-20 |
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