AU2020338043B2 - Substituted (7H-pyrrolo[2,3-D]pyrimidin-4-yl)amino compounds useful as JAK1 inhibitors - Google Patents

Substituted (7H-pyrrolo[2,3-D]pyrimidin-4-yl)amino compounds useful as JAK1 inhibitors

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Publication number
AU2020338043B2
AU2020338043B2 AU2020338043A AU2020338043A AU2020338043B2 AU 2020338043 B2 AU2020338043 B2 AU 2020338043B2 AU 2020338043 A AU2020338043 A AU 2020338043A AU 2020338043 A AU2020338043 A AU 2020338043A AU 2020338043 B2 AU2020338043 B2 AU 2020338043B2
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Australia
Prior art keywords
compound
salt
formula
amino
patient
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Active
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AU2020338043A
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English (en)
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AU2020338043A1 (en
Inventor
Sidney Xi Liang
Xiping Su
Peter J. WERTH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemwerth Inc
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CHEMWERTH Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
AU2020338043A 2019-08-26 2020-08-25 Substituted (7H-pyrrolo[2,3-D]pyrimidin-4-yl)amino compounds useful as JAK1 inhibitors Active AU2020338043B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962891706P 2019-08-26 2019-08-26
US62/891,706 2019-08-26
PCT/US2020/047767 WO2021041392A1 (en) 2019-08-26 2020-08-25 Substituted (7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino compounds useful as jak1 inhibitors

Publications (2)

Publication Number Publication Date
AU2020338043A1 AU2020338043A1 (en) 2022-03-31
AU2020338043B2 true AU2020338043B2 (en) 2025-12-18

Family

ID=74685810

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020338043A Active AU2020338043B2 (en) 2019-08-26 2020-08-25 Substituted (7H-pyrrolo[2,3-D]pyrimidin-4-yl)amino compounds useful as JAK1 inhibitors

Country Status (9)

Country Link
US (1) US12492204B2 (https=)
EP (1) EP4021452B1 (https=)
JP (1) JP7671738B2 (https=)
CN (1) CN114761011B (https=)
AU (1) AU2020338043B2 (https=)
CA (1) CA3152021A1 (https=)
ES (1) ES2974946T3 (https=)
PL (1) PL4021452T3 (https=)
WO (1) WO2021041392A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3152021A1 (en) * 2019-08-26 2021-03-04 Chemwerth, Inc. Substituted (7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino compounds useful as jak1 inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2796460A1 (en) * 2011-12-21 2014-10-29 Jiangsu Hengrui Medicine Co. Ltd. Pyrrole six-membered heteroaryl ring derivative, preparation method therefor, and medicinal uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102014627B (zh) 2008-04-30 2014-10-29 国家卫生研究院 作为极光激酶抑制剂的稠合双环嘧啶化合物
ES2426407T3 (es) * 2009-10-15 2013-10-23 Pfizer Inc. Compuestos de pirrolo[2,3-d]pirimidina
EP3416965B1 (en) 2016-02-16 2020-10-07 Zoetis Services LLC Process for preparing 7h-pyrrolo [2,3-d]pyrimidine compounds
JP6944496B2 (ja) 2018-10-22 2021-10-06 ファイザー・インク ピロロ［２，３−ｄ］ピリミジントシル酸塩、その結晶形態、ならびにその製造方法および中間体
CA3152021A1 (en) * 2019-08-26 2021-03-04 Chemwerth, Inc. Substituted (7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino compounds useful as jak1 inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2796460A1 (en) * 2011-12-21 2014-10-29 Jiangsu Hengrui Medicine Co. Ltd. Pyrrole six-membered heteroaryl ring derivative, preparation method therefor, and medicinal uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Vazquez, M. L., et al., Journal of Medicinal Chemistry, 2018, 61(3), p 1130-1152. *

Also Published As

Publication number Publication date
CN114761011B (zh) 2024-06-14
AU2020338043A1 (en) 2022-03-31
CN114761011A (zh) 2022-07-15
EP4021452A4 (en) 2023-01-04
US20220274992A1 (en) 2022-09-01
EP4021452B1 (en) 2023-12-20
ES2974946T3 (es) 2024-07-02
WO2021041392A1 (en) 2021-03-04
JP2022545836A (ja) 2022-10-31
EP4021452A1 (en) 2022-07-06
US12492204B2 (en) 2025-12-09
CA3152021A1 (en) 2021-03-04
PL4021452T3 (pl) 2024-05-06
JP7671738B2 (ja) 2025-05-02

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