CN114761011B - 用作jak1抑制剂的取代的(7h-吡咯并[2,3-d]嘧啶-4-基)氨基化合物 - Google Patents

用作jak1抑制剂的取代的(7h-吡咯并[2,3-d]嘧啶-4-基)氨基化合物 Download PDF

Info

Publication number
CN114761011B
CN114761011B CN202080074639.8A CN202080074639A CN114761011B CN 114761011 B CN114761011 B CN 114761011B CN 202080074639 A CN202080074639 A CN 202080074639A CN 114761011 B CN114761011 B CN 114761011B
Authority
CN
China
Prior art keywords
compound
pharmaceutically acceptable
medicament
acceptable salt
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202080074639.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN114761011A (zh
Inventor
苏西平
梁熙
皮特·J·沃思
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kenworth Co
Original Assignee
Kenworth Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kenworth Co filed Critical Kenworth Co
Publication of CN114761011A publication Critical patent/CN114761011A/zh
Application granted granted Critical
Publication of CN114761011B publication Critical patent/CN114761011B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN202080074639.8A 2019-08-26 2020-08-25 用作jak1抑制剂的取代的(7h-吡咯并[2,3-d]嘧啶-4-基)氨基化合物 Active CN114761011B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962891706P 2019-08-26 2019-08-26
US62/891,706 2019-08-26
PCT/US2020/047767 WO2021041392A1 (en) 2019-08-26 2020-08-25 Substituted (7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino compounds useful as jak1 inhibitors

Publications (2)

Publication Number Publication Date
CN114761011A CN114761011A (zh) 2022-07-15
CN114761011B true CN114761011B (zh) 2024-06-14

Family

ID=74685810

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080074639.8A Active CN114761011B (zh) 2019-08-26 2020-08-25 用作jak1抑制剂的取代的(7h-吡咯并[2,3-d]嘧啶-4-基)氨基化合物

Country Status (9)

Country Link
US (1) US12492204B2 (https=)
EP (1) EP4021452B1 (https=)
JP (1) JP7671738B2 (https=)
CN (1) CN114761011B (https=)
AU (1) AU2020338043B2 (https=)
CA (1) CA3152021A1 (https=)
ES (1) ES2974946T3 (https=)
PL (1) PL4021452T3 (https=)
WO (1) WO2021041392A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020338043B2 (en) * 2019-08-26 2025-12-18 Chemwerth, Inc. Substituted (7H-pyrrolo[2,3-D]pyrimidin-4-yl)amino compounds useful as JAK1 inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102014627A (zh) * 2008-04-30 2011-04-13 国家卫生研究院 作为极光激酶抑制剂的稠合双环嘧啶化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2776028C (en) 2009-10-15 2015-12-01 Pfizer Inc. Pyrrolo[2,3-d]pyrimidine compounds
KR102032934B1 (ko) * 2011-12-21 2019-10-16 지앙수 헨그루이 메디슨 컴퍼니 리미티드 피롤 6원 헤테로아릴 고리 유도체, 그의 제조 방법, 및 그의 의약 용도
US9926327B2 (en) 2016-02-16 2018-03-27 Zoetis Services Llc Process for preparing 7H-pyrrolo[2,3-D]pyrimidine compounds
JP6944496B2 (ja) 2018-10-22 2021-10-06 ファイザー・インク ピロロ［２，３−ｄ］ピリミジントシル酸塩、その結晶形態、ならびにその製造方法および中間体
AU2020338043B2 (en) * 2019-08-26 2025-12-18 Chemwerth, Inc. Substituted (7H-pyrrolo[2,3-D]pyrimidin-4-yl)amino compounds useful as JAK1 inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102014627A (zh) * 2008-04-30 2011-04-13 国家卫生研究院 作为极光激酶抑制剂的稠合双环嘧啶化合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Michael L. Vazquez等."Identification of N‑{cis-3-[Methyl(7H‑pyrrolo[2,3‑d]pyrimidin-4- yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases".《Journal of Medicinal Chemistry》.第61卷1130−1152. *

Also Published As

Publication number Publication date
PL4021452T3 (pl) 2024-05-06
AU2020338043A1 (en) 2022-03-31
US20220274992A1 (en) 2022-09-01
US12492204B2 (en) 2025-12-09
JP7671738B2 (ja) 2025-05-02
AU2020338043B2 (en) 2025-12-18
WO2021041392A1 (en) 2021-03-04
JP2022545836A (ja) 2022-10-31
ES2974946T3 (es) 2024-07-02
CN114761011A (zh) 2022-07-15
EP4021452A1 (en) 2022-07-06
CA3152021A1 (en) 2021-03-04
EP4021452A4 (en) 2023-01-04
EP4021452B1 (en) 2023-12-20

Similar Documents

Publication Publication Date Title
US11459327B1 (en) Cycloalkyl and hetero-cycloalkyl inhibitors, preparation methods therefor, and use thereof
US12398141B2 (en) JAK kinase inhibitor, preparation method for same, and applications thereof in field of medicine
US8372854B2 (en) Pyrrolo[2,3-D]pyrimidine compounds
JP2022546520A (ja) Ｒｉｐ１阻害化合物ならびにそれを作製および使用するための方法
JP2023508772A (ja) Ｊａｋ阻害剤化合物及びその使用
WO2022237843A1 (zh) Axl抑制剂
CN102131812A (zh) 吡咯并[2，3-d]嘧啶化合物
JP2023501399A (ja) ヘテロ環式ｒｉｐ１阻害化合物
CN108349974B (zh) 一种取代的吡啶酰胺类化合物及其应用
CN114761011B (zh) 用作jak1抑制剂的取代的(7h-吡咯并[2,3-d]嘧啶-4-基)氨基化合物
WO2019042442A1 (zh) 一类具有抑制并降解酪氨酸蛋白激酶jak1或jak2活性的化合物
CN111518082A (zh) 一种氨基嘧啶类化合物及包含该化合物的组合物及其用途
CN109422751B (zh) 一类具有降解酪氨酸蛋白激酶jak3活性的化合物
HK40077311B (en) Substituted (7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino compounds useful as jak1 inhibitors
HK40077311A (en) Substituted (7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino compounds useful as jak1 inhibitors
KR20230141787A (ko) 피라졸아미드 유도체
US11591333B2 (en) Substituted pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
AU2024323272A1 (en) Jak inhibitor compound and use thereof
CN117903159A (zh) 一种内酰胺类衍生物、其制备方法及用途
WO2022117012A1 (zh) 螺环jak抑制剂、含其的药物组合物及其应用
CN116063325A (zh) 具有btk调节作用的大环化合物及其用途
HK40004455B (en) Heterocyclic compound as jak inhibitor, and salts and therapeutic use thereof
HK40004455A (en) Heterocyclic compound as jak inhibitor, and salts and therapeutic use thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant