JPWO2020261144A5 - - Google Patents

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Publication number
JPWO2020261144A5
JPWO2020261144A5 JP2021576779A JP2021576779A JPWO2020261144A5 JP WO2020261144 A5 JPWO2020261144 A5 JP WO2020261144A5 JP 2021576779 A JP2021576779 A JP 2021576779A JP 2021576779 A JP2021576779 A JP 2021576779A JP WO2020261144 A5 JPWO2020261144 A5 JP WO2020261144A5
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JP
Japan
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compound
pharmaceutically acceptable
acceptable salt
chloro
fluoro
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Pending
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JP2021576779A
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English (en)
Japanese (ja)
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JP7498199B2 (ja
JP2022538576A5 (https=
JP2022538576A (ja
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Priority claimed from PCT/IB2020/055974 external-priority patent/WO2020261144A1/en
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Publication of JP2022538576A5 publication Critical patent/JP2022538576A5/ja
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JP2021576779A 2019-06-28 2020-06-24 種々の疾患を処置するために有用なbckdk阻害剤としての5-(チオフェン-2-イル)-1h-テトラゾール誘導体 Active JP7498199B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962868542P 2019-06-28 2019-06-28
US62/868,542 2019-06-28
US202062960824P 2020-01-14 2020-01-14
US62/960,824 2020-01-14
PCT/IB2020/055974 WO2020261144A1 (en) 2019-06-28 2020-06-24 5-(thiophen-2-yl)-1h-tetrazole derivatives as bckdk inhibitors useful for treating various diseases

Publications (4)

Publication Number Publication Date
JP2022538576A JP2022538576A (ja) 2022-09-05
JPWO2020261144A5 true JPWO2020261144A5 (https=) 2023-06-02
JP2022538576A5 JP2022538576A5 (https=) 2023-06-02
JP7498199B2 JP7498199B2 (ja) 2024-06-11

Family

ID=71738227

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021576779A Active JP7498199B2 (ja) 2019-06-28 2020-06-24 種々の疾患を処置するために有用なbckdk阻害剤としての5-(チオフェン-2-イル)-1h-テトラゾール誘導体

Country Status (5)

Country Link
US (1) US20220363673A1 (https=)
EP (1) EP3990452A1 (https=)
JP (1) JP7498199B2 (https=)
CA (1) CA3144848C (https=)
WO (1) WO2020261144A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CR20240183A (es) * 2021-12-01 2024-06-07 Pfizer Inhibidores y/o degradadores de bckdk
CN116574084A (zh) * 2023-04-17 2023-08-11 华南理工大学 一种噻吩衍生物及其合成方法与应用

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
CA1146866A (en) 1979-07-05 1983-05-24 Yamanouchi Pharmaceutical Co. Ltd. Process for the production of sustained release pharmaceutical composition of solid medical material
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
DE3438830A1 (de) 1984-10-23 1986-04-30 Rentschler Arzneimittel Nifedipin enthaltende darreichungsform und verfahren zu ihrer herstellung
JPH03204875A (ja) * 1989-10-03 1991-09-06 Wakamoto Pharmaceut Co Ltd テトラゾール酢酸誘導体、及び該誘導体を有効成分とするアルドースレダクターゼ阻害剤
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
KR0182801B1 (ko) 1991-04-16 1999-05-01 아만 히데아키 고체 분산체의 제조방법
US5340591A (en) 1992-01-24 1994-08-23 Fujisawa Pharmaceutical Co., Ltd. Method of producing a solid dispersion of the sparingly water-soluble drug, nilvadipine
JP3265680B2 (ja) 1992-03-12 2002-03-11 大正製薬株式会社 経口製剤用組成物
US5612359A (en) 1994-08-26 1997-03-18 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
DE19504832A1 (de) 1995-02-14 1996-08-22 Basf Ag Feste Wirkstoff-Zubereitungen
TW536540B (en) 1997-01-30 2003-06-11 Bristol Myers Squibb Co Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
ATE364374T1 (de) 1997-08-11 2007-07-15 Pfizer Prod Inc Feste pharmazeutische dispersionen mit erhöhter bioverfügbarkeit
WO2000001389A1 (en) 1998-07-06 2000-01-13 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
DE10306502B4 (de) * 2003-02-17 2005-03-17 Aventis Pharma Deutschland Gmbh Substituierte 3-(Benzoylureido)-thiophenderivate und sie enthaltende Arzneimittel
KR100869616B1 (ko) 2004-05-12 2008-11-21 화이자 프로덕츠 인코포레이티드 프롤린 유도체 및 그의 다이펩티딜 펩티다제-iv저해제로서의 용도
JP5190448B2 (ja) 2006-04-20 2013-04-24 ファイザー・プロダクツ・インク グルコキナーゼ仲介疾患を予防および治療するための縮合フェニルアミド複素環化合物
US20090036425A1 (en) 2007-08-02 2009-02-05 Pfizer Inc Substituted bicyclolactam compounds
JP5596026B2 (ja) * 2008-06-19 2014-09-24 ミレニアム ファーマシューティカルズ, インコーポレイテッド チオフェン又はチアゾール誘導体及びpi3k阻害剤としてのそれらの使用
EP2318370A1 (en) 2008-07-29 2011-05-11 Pfizer Inc. Fluorinated heteroaryls
MY155418A (en) 2008-08-28 2015-10-15 Pfizer Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives
EP2332375B1 (en) 2008-09-29 2018-08-15 Nokia Solutions and Networks Oy Apparatus, method, system and program for power control or power setting
WO2010086820A1 (en) 2009-02-02 2010-08-05 Pfizer Inc. 4-amino-5-oxo-7, 8-dihydropyrimido [5,4-f] [1,4] oxazepin-6 (5h) -yl) phenyl derivatives, pharmaceutical compositions and uses thereof
MY151246A (en) 2009-03-11 2014-04-30 Pfizer Benzofuranyl derivatives
WO2010106457A2 (en) 2009-03-20 2010-09-23 Pfizer Inc. 3-oxa-7-azabicyclo[3.3.1]nonanes
CA2759843A1 (en) 2009-05-08 2010-11-10 Pfizer Inc. Gpr 119 modulators
WO2010128414A1 (en) 2009-05-08 2010-11-11 Pfizer Inc. Gpr 119 modulators
NZ596467A (en) 2009-06-05 2014-01-31 Pfizer L- ( piperidin-4-yl) -pyrazole derivatives as gpr 119 modulators
WO2011005611A1 (en) 2009-07-09 2011-01-13 Merck Sharp & Dohme Corp. Neuromedin u receptor agonists and uses thereof
EP2954780A1 (en) 2009-07-24 2015-12-16 Baylor College Of Medicine Methods of modulation of branched chain acids and uses thereof
WO2011073298A1 (en) * 2009-12-18 2011-06-23 Neurosearch A/S Tetrazole derivatives as nicotinic acetylcholine receptor modulators
CN103619836A (zh) * 2011-03-03 2014-03-05 德诺瓦姆德有限公司 抗菌剂/抗菌佐剂化合物及其方法
CN108779495A (zh) * 2016-04-06 2018-11-09 雀巢产品技术援助有限公司 调节bckdh的方法
EP3555064B9 (en) 2016-12-16 2023-03-01 Pfizer Inc. Glp-1 receptor agonists and uses thereof

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