JPWO2020257707A5 - - Google Patents
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- JPWO2020257707A5 JPWO2020257707A5 JP2021576258A JP2021576258A JPWO2020257707A5 JP WO2020257707 A5 JPWO2020257707 A5 JP WO2020257707A5 JP 2021576258 A JP2021576258 A JP 2021576258A JP 2021576258 A JP2021576258 A JP 2021576258A JP WO2020257707 A5 JPWO2020257707 A5 JP WO2020257707A5
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- JP
- Japan
- Prior art keywords
- residue
- seq
- residue corresponding
- host cell
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 210000004027 cell Anatomy 0.000 claims 27
- 108010028658 Leucine Dehydrogenase Proteins 0.000 claims 8
- 108091033319 polynucleotide Proteins 0.000 claims 7
- 102000040430 polynucleotide Human genes 0.000 claims 7
- 239000002157 polynucleotide Substances 0.000 claims 7
- 108090000790 Enzymes Proteins 0.000 claims 5
- 102000004190 Enzymes Human genes 0.000 claims 5
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 3
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 3
- 150000001413 amino acids Chemical group 0.000 claims 3
- 230000001580 bacterial effect Effects 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 2
- PHTQWCKDNZKARW-UHFFFAOYSA-N isoamylol Chemical compound CC(C)CCO PHTQWCKDNZKARW-UHFFFAOYSA-N 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 241000193830 Bacillus <bacterium> Species 0.000 claims 1
- 101710097568 Branched-chain amino acid transport system 2 carrier protein Proteins 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962864875P | 2019-06-21 | 2019-06-21 | |
| US201962865129P | 2019-06-21 | 2019-06-21 | |
| US62/865,129 | 2019-06-21 | ||
| US62/864,875 | 2019-06-21 | ||
| PCT/US2020/038813 WO2020257707A1 (en) | 2019-06-21 | 2020-06-19 | Biosynthesis of enzymes for use in treatment of maple syrup urine disease (msud) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022537214A JP2022537214A (ja) | 2022-08-24 |
| JP2022537214A5 JP2022537214A5 (https=) | 2023-06-27 |
| JPWO2020257707A5 true JPWO2020257707A5 (https=) | 2023-06-27 |
Family
ID=74037433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021576258A Pending JP2022537214A (ja) | 2019-06-21 | 2020-06-19 | メープルシロップ尿症（ｍｓｕｄ）の処置のおける使用のための酵素の生合成 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20220348933A1 (https=) |
| EP (2) | EP3986432A4 (https=) |
| JP (1) | JP2022537214A (https=) |
| KR (1) | KR20220042350A (https=) |
| CN (1) | CN114450403A (https=) |
| AU (1) | AU2020297586A1 (https=) |
| CA (1) | CA3144416A1 (https=) |
| IL (1) | IL289123A (https=) |
| WO (2) | WO2020257610A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11208649B2 (en) | 2015-12-07 | 2021-12-28 | Zymergen Inc. | HTP genomic engineering platform |
| US9988624B2 (en) | 2015-12-07 | 2018-06-05 | Zymergen Inc. | Microbial strain improvement by a HTP genomic engineering platform |
| US20220031771A1 (en) * | 2020-07-31 | 2022-02-03 | Iowa State University Research Foundation, Inc. | Microencapsulated and chromosome integrated compositions for l-dopa microbiome therapy |
| CN113484435B (zh) * | 2021-07-05 | 2023-04-07 | 中国人民解放军空军军医大学 | 检测血浆支链氨基酸和支链a酮酸水平的物质的应用及产品 |
| WO2024064918A2 (en) * | 2022-09-23 | 2024-03-28 | Novome Biotechnologies, Inc. | Recombinant fusion polypeptides for secreting soluble, heterologous cargo |
| WO2025046062A1 (en) | 2023-08-31 | 2025-03-06 | Snipr Biome Aps | A novel type of crispr/cas system |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6119738B2 (ja) * | 2012-03-30 | 2017-04-26 | 味の素株式会社 | 改変ロイシン脱水素酵素 |
| WO2014028642A1 (en) * | 2012-08-17 | 2014-02-20 | Easel Biotechnologies, Llc | Two stage production of higher alcohols |
| US10059969B1 (en) * | 2014-10-03 | 2018-08-28 | Abbvie Inc. | Process for the preparation of (S)-2-amino-non-8-enoic acid |
| US10610546B2 (en) * | 2015-05-13 | 2020-04-07 | Synlogic Operating Company Inc. | Bacteria engineered to reduce hyperphenylalaninemia |
| CN104774813B (zh) * | 2015-04-20 | 2019-02-26 | 南京工业大学 | 一种亮氨酸脱氢酶及其制备方法和应用 |
| IL256216B (en) * | 2015-06-10 | 2022-07-01 | Synlogic Operating Co Inc | Bacteria engineered to treat disorders involving the catabolism of a branched chain amino acid |
| WO2017123676A1 (en) * | 2016-01-11 | 2017-07-20 | Synlogic, Inc. | Recombinant bacteria engineered to treat diseases and disorders associated with amino acid metabolism and methods of use thereof |
| CN108103038B (zh) * | 2017-12-15 | 2021-03-02 | 江南大学 | 一种合成l-苯甘氨酸的单细胞工厂及其构建与应用 |
| CN108559735B (zh) * | 2018-05-10 | 2020-07-07 | 江南大学 | 一种亮氨酸脱氢酶突变体的构建及其应用 |
| CN109321538A (zh) * | 2018-09-07 | 2019-02-12 | 江南大学 | 一种基于数据库基因挖掘方法获得的亮氨酸脱氢酶 |
| CN109679978B (zh) * | 2018-12-12 | 2020-12-29 | 浙江工业大学 | 一种用于制备l-2-氨基丁酸的重组共表达体系及其应用 |
| WO2021146394A1 (en) * | 2020-01-14 | 2021-07-22 | Synlogic Operating Company, Inc. | Optimized bacteria engineered to treat disorders involving the catabolism of leucine, isoleucine, and/or valine |
-
2020
- 2020-06-19 CN CN202080058809.3A patent/CN114450403A/zh active Pending
- 2020-06-19 JP JP2021576258A patent/JP2022537214A/ja active Pending
- 2020-06-19 WO PCT/US2020/038675 patent/WO2020257610A1/en not_active Ceased
- 2020-06-19 AU AU2020297586A patent/AU2020297586A1/en not_active Abandoned
- 2020-06-19 US US17/621,214 patent/US20220348933A1/en not_active Abandoned
- 2020-06-19 EP EP20825572.9A patent/EP3986432A4/en not_active Withdrawn
- 2020-06-19 KR KR1020227002234A patent/KR20220042350A/ko not_active Ceased
- 2020-06-19 WO PCT/US2020/038813 patent/WO2020257707A1/en not_active Ceased
- 2020-06-19 US US17/621,121 patent/US20220362311A1/en not_active Abandoned
- 2020-06-19 EP EP20827890.3A patent/EP3987037A4/en not_active Withdrawn
- 2020-06-19 CA CA3144416A patent/CA3144416A1/en active Pending
-
2021
- 2021-12-19 IL IL289123A patent/IL289123A/en unknown
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