JPWO2020219843A5 - - Google Patents
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- JPWO2020219843A5 JPWO2020219843A5 JP2021563033A JP2021563033A JPWO2020219843A5 JP WO2020219843 A5 JPWO2020219843 A5 JP WO2020219843A5 JP 2021563033 A JP2021563033 A JP 2021563033A JP 2021563033 A JP2021563033 A JP 2021563033A JP WO2020219843 A5 JPWO2020219843 A5 JP WO2020219843A5
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- JP
- Japan
- Prior art keywords
- composition
- car
- subject
- cells
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 26
- 210000004027 cell Anatomy 0.000 claims 15
- 210000001744 T-lymphocyte Anatomy 0.000 claims 14
- 238000000034 method Methods 0.000 claims 14
- 102000039446 nucleic acids Human genes 0.000 claims 13
- 108020004707 nucleic acids Proteins 0.000 claims 13
- 150000007523 nucleic acids Chemical class 0.000 claims 13
- 239000000427 antigen Substances 0.000 claims 12
- 102000036639 antigens Human genes 0.000 claims 12
- 108091007433 antigens Proteins 0.000 claims 12
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 7
- 208000015181 infectious disease Diseases 0.000 claims 7
- 239000012634 fragment Substances 0.000 claims 6
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 4
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 4
- 230000028993 immune response Effects 0.000 claims 4
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims 3
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 108091008874 T cell receptors Proteins 0.000 claims 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 2
- 230000009257 reactivity Effects 0.000 claims 2
- 108700012439 CA9 Proteins 0.000 claims 1
- 102100024423 Carbonic anhydrase 9 Human genes 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000018697 Membrane Proteins Human genes 0.000 claims 1
- 108010052285 Membrane Proteins Proteins 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- 210000000068 Th17 cell Anatomy 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 210000000581 natural killer T-cell Anatomy 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 108010043277 recombinant soluble CD4 Proteins 0.000 claims 1
- 210000003289 regulatory T cell Anatomy 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025046395A JP2025106309A (ja) | 2019-04-26 | 2025-03-21 | キメラ抗原受容体構築物およびｃａｒ－ｔ細胞におけるそれらの使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962839175P | 2019-04-26 | 2019-04-26 | |
| US62/839,175 | 2019-04-26 | ||
| PCT/US2020/029768 WO2020219843A1 (en) | 2019-04-26 | 2020-04-24 | Chimeric antigen receptor constructs and their use in car-t cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025046395A Division JP2025106309A (ja) | 2019-04-26 | 2025-03-21 | キメラ抗原受容体構築物およびｃａｒ－ｔ細胞におけるそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022529380A JP2022529380A (ja) | 2022-06-21 |
| JPWO2020219843A5 true JPWO2020219843A5 (https=) | 2023-04-14 |
| JP2022529380A5 JP2022529380A5 (https=) | 2023-04-14 |
Family
ID=72941305
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021563033A Pending JP2022529380A (ja) | 2019-04-26 | 2020-04-24 | キメラ抗原受容体構築物およびｃａｒ－ｔ細胞におけるそれらの使用 |
| JP2025046395A Pending JP2025106309A (ja) | 2019-04-26 | 2025-03-21 | キメラ抗原受容体構築物およびｃａｒ－ｔ細胞におけるそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025046395A Pending JP2025106309A (ja) | 2019-04-26 | 2025-03-21 | キメラ抗原受容体構築物およびｃａｒ－ｔ細胞におけるそれらの使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US12479890B2 (https=) |
| EP (1) | EP3959236A4 (https=) |
| JP (2) | JP2022529380A (https=) |
| CN (1) | CN114269777A (https=) |
| WO (1) | WO2020219843A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110225760B (zh) * | 2016-09-15 | 2023-11-07 | 埃里西拉医疗公司 | T细胞免疫疗法 |
| TW202332765A (zh) * | 2021-09-20 | 2023-08-16 | 美商英麥提克斯股份有限公司 | 用於ｔ細胞療法之ｔ細胞群體的單核球耗盡 |
| KR20250097810A (ko) * | 2022-09-13 | 2025-06-30 | 가부시키가이샤 사이토-팩토 | 이식을 위한 t 세포 및 이의 제조 방법 |
| WO2024236547A1 (en) * | 2023-05-18 | 2024-11-21 | Inceptor Bio, Llc | Modified phagocytic cells expressing chimeric antigen receptors comprising a herpes virus entry mediator (hvem) co-stimulatory domain and uses thereof |
| WO2026047626A1 (en) * | 2024-08-30 | 2026-03-05 | Inceptor Bio, Llc | Compositions and methods involving immune cells engineered for binding bispecific antibodies for use in cell therapy |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170241877A1 (en) * | 2002-03-11 | 2017-08-24 | Janusz B. Pawliszyn | System and method for desorbing and detecting an analyte sorbed on a solid phase microextraction device |
| US10246505B2 (en) * | 2013-11-25 | 2019-04-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric antigen receptors to control HIV infection |
| WO2015092024A2 (en) | 2013-12-20 | 2015-06-25 | Cellectis | Method of engineering multi-input signal sensitive t cell for immunotherapy |
| EP3593812A3 (en) * | 2014-03-15 | 2020-05-27 | Novartis AG | Treatment of cancer using chimeric antigen receptor |
| KR20250067191A (ko) * | 2014-09-17 | 2025-05-14 | 노파르티스 아게 | 입양 면역요법을 위한 키메라 수용체에 의한 세포독성 세포의 표적화 |
| WO2016081518A2 (en) | 2014-11-17 | 2016-05-26 | Adicet Bio, Inc. | Engineered gamma delta t-cells |
| BR112017013176A2 (en) * | 2014-12-19 | 2018-05-15 | Dana-Farber Cancer Institute Inc. | chimeric antigen receptors and methods for using them |
| US20180258149A1 (en) | 2015-09-17 | 2018-09-13 | Novartis Ag | Car t cell therapies with enhanced efficacy |
| JP7068169B2 (ja) * | 2016-01-08 | 2022-05-16 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 条件付活性ヘテロ二量体ポリペプチド及びその使用方法 |
| AU2017225733A1 (en) | 2016-03-04 | 2018-09-27 | Novartis Ag | Cells expressing multiple chimeric antigen receptor (CAR) molecules and uses therefore |
| WO2017172952A1 (en) * | 2016-04-01 | 2017-10-05 | Promab Biotechnologies, Inc. | Flag tagged cd19-car-t cells |
| EP3336107A1 (en) * | 2016-12-15 | 2018-06-20 | Miltenyi Biotec GmbH | Immune cells expressing an antigen binding receptor and a chimeric costimulatory receptor |
| SG10202107808SA (en) * | 2017-01-18 | 2021-08-30 | F1 Oncology Inc | Chimeric antigen receptors against axl or ror2 and methods of use thereof |
| CN110615842B (zh) * | 2018-06-20 | 2023-05-09 | 上海隆耀生物科技有限公司 | 一种包含共刺激受体的嵌合抗原受体及应用 |
-
2020
- 2020-04-24 JP JP2021563033A patent/JP2022529380A/ja active Pending
- 2020-04-24 EP EP20796240.8A patent/EP3959236A4/en active Pending
- 2020-04-24 WO PCT/US2020/029768 patent/WO2020219843A1/en not_active Ceased
- 2020-04-24 CN CN202080047342.2A patent/CN114269777A/zh active Pending
- 2020-04-24 US US17/605,890 patent/US12479890B2/en active Active
-
2025
- 2025-03-21 JP JP2025046395A patent/JP2025106309A/ja active Pending
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