JP2022529380A - キメラ抗原受容体構築物およびｃａｒ－ｔ細胞におけるそれらの使用 - Google Patents

キメラ抗原受容体構築物およびｃａｒ－ｔ細胞におけるそれらの使用 Download PDF

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JP2022529380A
JP2022529380A JP2021563033A JP2021563033A JP2022529380A JP 2022529380 A JP2022529380 A JP 2022529380A JP 2021563033 A JP2021563033 A JP 2021563033A JP 2021563033 A JP2021563033 A JP 2021563033A JP 2022529380 A JP2022529380 A JP 2022529380A
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リーシャン スー
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University of North Carolina at Chapel Hill
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JP2021563033A 2019-04-26 2020-04-24 キメラ抗原受容体構築物およびｃａｒ－ｔ細胞におけるそれらの使用 Pending JP2022529380A (ja)

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JP2025046395A JP2025106309A (ja) 2019-04-26 2025-03-21 キメラ抗原受容体構築物およびｃａｒ－ｔ細胞におけるそれらの使用

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US201962839175P 2019-04-26 2019-04-26
US62/839,175 2019-04-26
PCT/US2020/029768 WO2020219843A1 (en) 2019-04-26 2020-04-24 Chimeric antigen receptor constructs and their use in car-t cells

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JPWO2020219843A5 JPWO2020219843A5 (https=) 2023-04-14
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JP2025046395A Pending JP2025106309A (ja) 2019-04-26 2025-03-21 キメラ抗原受容体構築物およびｃａｒ－ｔ細胞におけるそれらの使用

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US (1) US12479890B2 (https=)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024058234A1 (ja) * 2022-09-13 2024-03-21 株式会社サイト－ファクト 移植用ｔ細胞およびその製造方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110225760B (zh) * 2016-09-15 2023-11-07 埃里西拉医疗公司 T细胞免疫疗法
TW202332765A (zh) * 2021-09-20 2023-08-16 美商英麥提克斯股份有限公司 用於ｔ細胞療法之ｔ細胞群體的單核球耗盡
WO2024236547A1 (en) * 2023-05-18 2024-11-21 Inceptor Bio, Llc Modified phagocytic cells expressing chimeric antigen receptors comprising a herpes virus entry mediator (hvem) co-stimulatory domain and uses thereof
WO2026047626A1 (en) * 2024-08-30 2026-03-05 Inceptor Bio, Llc Compositions and methods involving immune cells engineered for binding bispecific antibodies for use in cell therapy

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017535292A (ja) * 2014-11-17 2017-11-30 アディセット バイオ， インコーポレイテッド 改変γδＴ細胞
WO2018136570A1 (en) * 2017-01-18 2018-07-26 F1 Oncology, Inc. Chimeric antigen receptors against axl or ror2 and methods of use thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170241877A1 (en) * 2002-03-11 2017-08-24 Janusz B. Pawliszyn System and method for desorbing and detecting an analyte sorbed on a solid phase microextraction device
US10246505B2 (en) * 2013-11-25 2019-04-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chimeric antigen receptors to control HIV infection
WO2015092024A2 (en) 2013-12-20 2015-06-25 Cellectis Method of engineering multi-input signal sensitive t cell for immunotherapy
EP3593812A3 (en) * 2014-03-15 2020-05-27 Novartis AG Treatment of cancer using chimeric antigen receptor
KR20250067191A (ko) * 2014-09-17 2025-05-14 노파르티스 아게 입양 면역요법을 위한 키메라 수용체에 의한 세포독성 세포의 표적화
BR112017013176A2 (en) * 2014-12-19 2018-05-15 Dana-Farber Cancer Institute Inc. chimeric antigen receptors and methods for using them
US20180258149A1 (en) 2015-09-17 2018-09-13 Novartis Ag Car t cell therapies with enhanced efficacy
JP7068169B2 (ja) * 2016-01-08 2022-05-16 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 条件付活性ヘテロ二量体ポリペプチド及びその使用方法
AU2017225733A1 (en) 2016-03-04 2018-09-27 Novartis Ag Cells expressing multiple chimeric antigen receptor (CAR) molecules and uses therefore
WO2017172952A1 (en) * 2016-04-01 2017-10-05 Promab Biotechnologies, Inc. Flag tagged cd19-car-t cells
EP3336107A1 (en) * 2016-12-15 2018-06-20 Miltenyi Biotec GmbH Immune cells expressing an antigen binding receptor and a chimeric costimulatory receptor
CN110615842B (zh) * 2018-06-20 2023-05-09 上海隆耀生物科技有限公司 一种包含共刺激受体的嵌合抗原受体及应用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017535292A (ja) * 2014-11-17 2017-11-30 アディセット バイオ， インコーポレイテッド 改変γδＴ細胞
WO2018136570A1 (en) * 2017-01-18 2018-07-26 F1 Oncology, Inc. Chimeric antigen receptors against axl or ror2 and methods of use thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NUNOYA J. ET AL.: "Chimeric antigen receptor T cell bearing herpes virus entry mediator costimulatory signal domain rxh", MOLECULAR THERAPY: ONCOLYTICS, vol. 14, JPN7024001202, 23 March 2019 (2019-03-23), pages 27 - 37, ISSN: 0005465622 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024058234A1 (ja) * 2022-09-13 2024-03-21 株式会社サイト－ファクト 移植用ｔ細胞およびその製造方法

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