JPWO2020210710A5 - - Google Patents
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- JPWO2020210710A5 JPWO2020210710A5 JP2021559803A JP2021559803A JPWO2020210710A5 JP WO2020210710 A5 JPWO2020210710 A5 JP WO2020210710A5 JP 2021559803 A JP2021559803 A JP 2021559803A JP 2021559803 A JP2021559803 A JP 2021559803A JP WO2020210710 A5 JPWO2020210710 A5 JP WO2020210710A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- subject
- lymph node
- needle
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000001165 lymph node Anatomy 0.000 claims description 131
- 210000004027 cell Anatomy 0.000 claims description 115
- 238000000034 method Methods 0.000 claims description 89
- 208000016216 Choristoma Diseases 0.000 claims description 22
- 210000001519 tissue Anatomy 0.000 claims description 19
- 210000001635 urinary tract Anatomy 0.000 claims description 15
- 239000012634 fragment Substances 0.000 claims description 14
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 13
- 239000000725 suspension Substances 0.000 claims description 12
- 208000019423 liver disease Diseases 0.000 claims description 10
- 230000002992 thymic effect Effects 0.000 claims description 10
- 210000003494 hepatocyte Anatomy 0.000 claims description 8
- 238000002604 ultrasonography Methods 0.000 claims description 8
- 238000003384 imaging method Methods 0.000 claims description 7
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 6
- 238000002591 computed tomography Methods 0.000 claims description 6
- 210000004072 lung Anatomy 0.000 claims description 6
- 210000005084 renal tissue Anatomy 0.000 claims description 6
- 239000000523 sample Substances 0.000 claims description 6
- 238000012285 ultrasound imaging Methods 0.000 claims description 6
- 230000009278 visceral effect Effects 0.000 claims description 6
- 210000005228 liver tissue Anatomy 0.000 claims description 5
- 210000003200 peritoneal cavity Anatomy 0.000 claims description 5
- 210000000115 thoracic cavity Anatomy 0.000 claims description 5
- 206010057573 Chronic hepatic failure Diseases 0.000 claims description 4
- 201000003883 Cystic fibrosis Diseases 0.000 claims description 4
- 208000010334 End Stage Liver Disease Diseases 0.000 claims description 4
- 208000019693 Lung disease Diseases 0.000 claims description 4
- 208000011444 chronic liver failure Diseases 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 230000004064 dysfunction Effects 0.000 claims description 4
- 230000003914 insulin secretion Effects 0.000 claims description 4
- 210000004153 islets of langerhan Anatomy 0.000 claims description 4
- 210000003292 kidney cell Anatomy 0.000 claims description 4
- 208000017169 kidney disease Diseases 0.000 claims description 4
- 210000004185 liver Anatomy 0.000 claims description 4
- 210000005265 lung cell Anatomy 0.000 claims description 4
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 3
- 210000000683 abdominal cavity Anatomy 0.000 claims description 3
- 238000002595 magnetic resonance imaging Methods 0.000 claims description 3
- 230000003393 splenic effect Effects 0.000 claims description 3
- 201000011374 Alagille syndrome Diseases 0.000 claims description 2
- 102100022712 Alpha-1-antitrypsin Human genes 0.000 claims description 2
- 206010003827 Autoimmune hepatitis Diseases 0.000 claims description 2
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims description 2
- 208000033222 Biliary cirrhosis primary Diseases 0.000 claims description 2
- 206010006458 Bronchitis chronic Diseases 0.000 claims description 2
- 206010006500 Brucellosis Diseases 0.000 claims description 2
- 208000007257 Budd-Chiari syndrome Diseases 0.000 claims description 2
- 208000000668 Chronic Pancreatitis Diseases 0.000 claims description 2
- 206010010317 Congenital absence of bile ducts Diseases 0.000 claims description 2
- 208000001819 Crigler-Najjar Syndrome Diseases 0.000 claims description 2
- 206010063044 Ectopic kidney Diseases 0.000 claims description 2
- 206010014561 Emphysema Diseases 0.000 claims description 2
- 208000018505 Endocrine pancreatic disease Diseases 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- 206010053487 Exposure to toxic agent Diseases 0.000 claims description 2
- 208000034846 Familial Amyloid Neuropathies Diseases 0.000 claims description 2
- 208000027472 Galactosemias Diseases 0.000 claims description 2
- 208000018565 Hemochromatosis Diseases 0.000 claims description 2
- 208000005176 Hepatitis C Diseases 0.000 claims description 2
- 208000005331 Hepatitis D Diseases 0.000 claims description 2
- 208000002972 Hepatolenticular Degeneration Diseases 0.000 claims description 2
- 208000031953 Hereditary hemorrhagic telangiectasia Diseases 0.000 claims description 2
- 206010019889 Hereditary neuropathic amyloidosis Diseases 0.000 claims description 2
- 208000008852 Hyperoxaluria Diseases 0.000 claims description 2
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims description 2
- 208000030162 Maple syrup disease Diseases 0.000 claims description 2
- 241000208125 Nicotiana Species 0.000 claims description 2
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims description 2
- 208000016222 Pancreatic disease Diseases 0.000 claims description 2
- 206010033649 Pancreatitis chronic Diseases 0.000 claims description 2
- 208000030852 Parasitic disease Diseases 0.000 claims description 2
- 201000011252 Phenylketonuria Diseases 0.000 claims description 2
- 208000012654 Primary biliary cholangitis Diseases 0.000 claims description 2
- 206010039163 Right ventricular failure Diseases 0.000 claims description 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 2
- 208000018839 Wilson disease Diseases 0.000 claims description 2
- 230000003187 abdominal effect Effects 0.000 claims description 2
- 230000000735 allogeneic effect Effects 0.000 claims description 2
- 108010050122 alpha 1-Antitrypsin Proteins 0.000 claims description 2
- 208000006682 alpha 1-Antitrypsin Deficiency Diseases 0.000 claims description 2
- 229940024142 alpha 1-antitrypsin Drugs 0.000 claims description 2
- 201000005271 biliary atresia Diseases 0.000 claims description 2
- 230000036770 blood supply Effects 0.000 claims description 2
- 206010006451 bronchitis Diseases 0.000 claims description 2
- 208000023819 chronic asthma Diseases 0.000 claims description 2
- 208000007451 chronic bronchitis Diseases 0.000 claims description 2
- 230000001684 chronic effect Effects 0.000 claims description 2
- 208000020832 chronic kidney disease Diseases 0.000 claims description 2
- 208000019425 cirrhosis of liver Diseases 0.000 claims description 2
- 238000005138 cryopreservation Methods 0.000 claims description 2
- 208000028208 end stage renal disease Diseases 0.000 claims description 2
- 201000000523 end stage renal failure Diseases 0.000 claims description 2
- 239000003344 environmental pollutant Substances 0.000 claims description 2
- 239000003517 fume Substances 0.000 claims description 2
- 230000002496 gastric effect Effects 0.000 claims description 2
- 208000007345 glycogen storage disease Diseases 0.000 claims description 2
- 230000002440 hepatic effect Effects 0.000 claims description 2
- 208000005252 hepatitis A Diseases 0.000 claims description 2
- 208000002672 hepatitis B Diseases 0.000 claims description 2
- 230000036737 immune function Effects 0.000 claims description 2
- 210000000987 immune system Anatomy 0.000 claims description 2
- 229940125721 immunosuppressive agent Drugs 0.000 claims description 2
- 239000003018 immunosuppressive agent Substances 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 230000003601 intercostal effect Effects 0.000 claims description 2
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims description 2
- 208000024393 maple syrup urine disease Diseases 0.000 claims description 2
- 208000030159 metabolic disease Diseases 0.000 claims description 2
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims description 2
- 235000006408 oxalic acid Nutrition 0.000 claims description 2
- 210000004923 pancreatic tissue Anatomy 0.000 claims description 2
- 231100000719 pollutant Toxicity 0.000 claims description 2
- 239000000779 smoke Substances 0.000 claims description 2
- 208000011580 syndromic disease Diseases 0.000 claims description 2
- 208000006379 syphilis Diseases 0.000 claims description 2
- 210000001541 thymus gland Anatomy 0.000 claims description 2
- 238000002054 transplantation Methods 0.000 claims description 2
- 201000007905 transthyretin amyloidosis Diseases 0.000 claims description 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 2
- 201000011296 tyrosinemia Diseases 0.000 claims description 2
- 102000012437 Copper-Transporting ATPases Human genes 0.000 claims 1
- 208000034189 Sclerosis Diseases 0.000 claims 1
- 208000003167 cholangitis Diseases 0.000 claims 1
- 208000001024 intrahepatic cholestasis Diseases 0.000 claims 1
- 230000007872 intrahepatic cholestasis Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000002563 splenic artery Anatomy 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 206010008609 Cholangitis sclerosing Diseases 0.000 description 1
- 210000002434 celiac artery Anatomy 0.000 description 1
- 230000003833 cell viability Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 208000019298 familial intrahepatic cholestasis Diseases 0.000 description 1
- 210000001370 mediastinum Anatomy 0.000 description 1
- 210000000713 mesentery Anatomy 0.000 description 1
- 201000000742 primary sclerosing cholangitis Diseases 0.000 description 1
- 208000010157 sclerosing cholangitis Diseases 0.000 description 1
Images
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024119461A JP2024144606A (ja) | 2019-04-11 | 2024-07-25 | インビボ器官形成の発生を誘導するための最小侵襲の細胞移植手技 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962832492P | 2019-04-11 | 2019-04-11 | |
| US62/832,492 | 2019-04-11 | ||
| PCT/US2020/027783 WO2020210710A1 (en) | 2019-04-11 | 2020-04-10 | Minimally invasive cell transplant procedure to induce the development of in vivo organogenesis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024119461A Division JP2024144606A (ja) | 2019-04-11 | 2024-07-25 | インビボ器官形成の発生を誘導するための最小侵襲の細胞移植手技 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022528921A JP2022528921A (ja) | 2022-06-16 |
| JPWO2020210710A5 true JPWO2020210710A5 (https=) | 2023-04-21 |
| JP2022528921A5 JP2022528921A5 (https=) | 2023-04-21 |
| JP7672704B2 JP7672704B2 (ja) | 2025-05-08 |
Family
ID=72752119
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021559803A Active JP7672704B2 (ja) | 2019-04-11 | 2020-04-10 | インビボ器官形成の発生を誘導するための最小侵襲の細胞移植手技 |
| JP2024119461A Pending JP2024144606A (ja) | 2019-04-11 | 2024-07-25 | インビボ器官形成の発生を誘導するための最小侵襲の細胞移植手技 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024119461A Pending JP2024144606A (ja) | 2019-04-11 | 2024-07-25 | インビボ器官形成の発生を誘導するための最小侵襲の細胞移植手技 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12569276B2 (https=) |
| EP (2) | EP4427813A3 (https=) |
| JP (2) | JP7672704B2 (https=) |
| KR (1) | KR20210155390A (https=) |
| CN (1) | CN114340646A (https=) |
| AU (1) | AU2020271121B2 (https=) |
| BR (1) | BR112021020451A2 (https=) |
| CA (1) | CA3136471A1 (https=) |
| ES (1) | ES2983230T3 (https=) |
| GB (1) | GB2600256B (https=) |
| IL (2) | IL324627A (https=) |
| MX (1) | MX2021012314A (https=) |
| WO (1) | WO2020210710A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023023353A1 (en) * | 2021-08-19 | 2023-02-23 | Kassab Ghassan S | Intranodal needle and method of using the same |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6610288B1 (en) | 1995-05-26 | 2003-08-26 | Diacrin, Inc. | Porcine hepatocytes for use in treatment of disorders characterized by insufficient liver function |
| US6154560A (en) | 1996-08-30 | 2000-11-28 | The Cleveland Clinic Foundation | System and method for staging regional lymph nodes using quantitative analysis of endoscopic ultrasound images |
| JP2000107299A (ja) * | 1998-10-06 | 2000-04-18 | Machida Endscope Co Ltd | 内視鏡用注射針装置 |
| SG155053A1 (en) | 2002-07-19 | 2009-09-30 | Vesta Therapeutics Inc | Method of obtaining viable human liver cells, including hepatic stem/progenitor cells |
| US7653427B2 (en) | 2004-11-12 | 2010-01-26 | Intra-Medical Imaging LLC | Method and instrument for minimally invasive sentinel lymph node location and biopsy |
| US7824376B2 (en) * | 2004-12-24 | 2010-11-02 | Olympus Corporation | Injection needle apparatus for making injection in tissue in body cavity |
| US7804990B2 (en) | 2006-01-25 | 2010-09-28 | Siemens Medical Solutions Usa, Inc. | System and method for labeling and identifying lymph nodes in medical images |
| US11191785B2 (en) * | 2008-03-07 | 2021-12-07 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Lymph node as a site for transplantation, organogenesis and function for multiple tissues and organs |
| WO2014138486A1 (en) * | 2013-03-06 | 2014-09-12 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Lymph node as a site for transplantation, organogenesis and function for multiple tissues and organs |
| WO2009111778A2 (en) | 2008-03-07 | 2009-09-11 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Lymph nodes as a site for regeneration |
| US20120045764A1 (en) | 2009-05-01 | 2012-02-23 | Markus Grompe | Method of expanding human hepatocytes in vivo |
| WO2013069143A1 (ja) * | 2011-11-10 | 2013-05-16 | 株式会社高研 | 超音波気管支内視鏡用トレーニングモデル |
| CN202761247U (zh) * | 2012-07-25 | 2013-03-06 | 西安交通大学医学院第一附属医院 | 一种医用内窥镜注射器 |
| CN113913366B (zh) * | 2013-02-18 | 2025-01-10 | 大学健康网络 | 由多能干细胞生成肝细胞和胆管细胞的方法 |
| US9533013B2 (en) * | 2013-03-13 | 2017-01-03 | University Of North Carolina At Chapel Hill | Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree |
| EP4299721A3 (en) | 2013-05-08 | 2024-04-24 | ProKidney | Organoids comprising isolated renal cells and uses thereof |
| JP6383938B2 (ja) | 2014-02-04 | 2018-09-05 | 国立大学法人名古屋大学 | 高濃度脂肪組織由来間葉系幹細胞含有脂肪による声門閉鎖不全の治療 |
| SG10202009095VA (en) * | 2014-11-26 | 2020-10-29 | Accelerated Biosciences Corp | Induced hepatocytes and uses thereof |
| JP6594133B2 (ja) * | 2015-09-16 | 2019-10-23 | 富士フイルム株式会社 | 内視鏡位置特定装置、内視鏡位置特定装置の作動方法および内視鏡位置特定プログラム |
| WO2018134729A1 (en) | 2017-01-18 | 2018-07-26 | Technion Research & Development Foundation Ltd. | Sparsity-based ultrasound super-resolution imaging |
| JP2020508298A (ja) * | 2017-02-17 | 2020-03-19 | ユニバーシティ オブ ピッツバーグ −オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 移植、組織再生、器官形成及び複数の組織に対する機能のための部位としての脂肪関連リンパ球集積（ｆａｔ−ａｓｓｏｃｉａｔｅｄ ｌｙｍｐｈｏｉｄ ｃｌｕｓｔｅｒ） |
| EP4349263B1 (en) | 2017-05-31 | 2026-03-04 | Mayo Foundation for Medical Education and Research | Methods for super-resolution ultrasound imaging of microvessels |
| EP3634514A4 (en) | 2017-06-09 | 2021-03-10 | President and Fellows of Harvard College | METHODS FOR IMPROVING THE DEVELOPMENT OF RENAL ORGANOIDS AND METHODS OF USING THEREOF |
| WO2019006127A1 (en) | 2017-06-28 | 2019-01-03 | Rutgers, The State University Of New Jersey | ORGANOIDS DERIVED FROM A SINGLE RENAL CELL |
| US10456164B2 (en) * | 2017-10-02 | 2019-10-29 | URO-1, Inc. | Anti-microbial medical injection assemblies for onabotulinumtoxina delivery and methods of use thereof |
-
2020
- 2020-04-10 ES ES20788083T patent/ES2983230T3/es active Active
- 2020-04-10 MX MX2021012314A patent/MX2021012314A/es unknown
- 2020-04-10 IL IL324627A patent/IL324627A/en unknown
- 2020-04-10 BR BR112021020451A patent/BR112021020451A2/pt unknown
- 2020-04-10 JP JP2021559803A patent/JP7672704B2/ja active Active
- 2020-04-10 CA CA3136471A patent/CA3136471A1/en active Pending
- 2020-04-10 KR KR1020217036664A patent/KR20210155390A/ko not_active Ceased
- 2020-04-10 CN CN202080043054.XA patent/CN114340646A/zh active Pending
- 2020-04-10 EP EP24174926.6A patent/EP4427813A3/en active Pending
- 2020-04-10 WO PCT/US2020/027783 patent/WO2020210710A1/en not_active Ceased
- 2020-04-10 EP EP20788083.2A patent/EP3952895B8/en active Active
- 2020-04-10 GB GB2115372.1A patent/GB2600256B/en active Active
- 2020-04-10 AU AU2020271121A patent/AU2020271121B2/en active Active
-
2021
- 2021-10-10 IL IL287125A patent/IL287125A/en unknown
- 2021-10-11 US US17/498,168 patent/US12569276B2/en active Active
-
2024
- 2024-07-25 JP JP2024119461A patent/JP2024144606A/ja active Pending
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